TY  - JOUR
AU  - Cai, Xiu-Yu
AU  - Guo, Jian-Gui
AU  - Shen, Xiao-Ming
AU  - Dong, Jun
AU  - Hu, Wei-Han
AU  - Guo, Gui-Fang
AU  - He, Xiang-Zi
AU  - Xia, Liang-Ping
AU  - Hu, Pei-Li
AU  - Qiu, Hui-Juan
AU  - Liu, Shou-Sheng
AU  - Zhou, Yi-Xin
AU  - Rong, Yu-Ming
AU  - Wang, Wei
AU  - Dai, Ni
AU  - Jiang, Wen-Qi
AU  - Zhang, Bei
PY  - 2016
TI  - The MMP-7-181A/G gene polymorphism is a prognostic indicator in patients with gastric cancer
JF  - Translational Cancer Research; Vol 5, No 6 (December 29, 2016): Translational Cancer Research (Focused Issue: p53 Biology and Cancer)
Y2  - 2016
KW  - 
N2  - Background: This study was designed to investigate the prognostic role of the MMP-7-181A/G gene polymorphism in patients with gastric cancer and to correlate the genotype with clinicopathological features.  Methods: The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect the MMP-7-181A/G gene polymorphism, and prognostic analyses were performed to elucidate the prognostic role of the gene polymorphism.  Results: The MMP-7-181A/A genotype was detected in 83.8% (176/210) of cases, A/G genotype in 16.2% (34/210) of cases and G/G genotype in 0% (0/210) of cases. The MMP-7-181A/G polymorphism was closely correlated with lymph node metastasis (P=0.037). A/G genotype carriers exhibit lymph node metastasis more frequently than A/A genotype carriers. The MMP-7-181A/G polymorphism was also strongly correlated with vascular invasion (P=0.003), and A/G genotype carriers show an increase in vascular invasion over A/A genotype carriers. The 5-year overall survival rates of A/A genotype carriers and A/G genotype carriers were 59.56% and 33.33%, respectively. The discrepancy was significant (P=0.0164). The prognosis of A/G genotype carriers was significantly worse than that of A/A genotype carriers. Multivariate survival analysis by Cox regression model confirmed that the MMP-7-181A/G genotype was an independent prognostic factor of gastric cancer (HR =2.10; 95% CI: 1.09–4.05; P=0.027).   Conclusions: The MMP-7-181A/G genotype was closely correlated with malignant biological behaviors and prognosis of gastric cancer. The MMP-7-181A/G genotype may serve as valuable prognostic indicator of gastric cancer.
UR  - https://tcr.amegroups.org/article/view/9781