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Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1

   
@article{TCR9964,
	author = {Jiaxuan Chen and Carolyn A. Haller and Elliot L. Chaikof},
	title = {Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1},
	journal = {Translational Cancer Research},
	volume = {5},
	number = {Suppl 4},
	year = {2016},
	keywords = {},
	abstract = {P-selectin glycoprotein ligand-1 (PSGL-1) is a major selectin ligand expressed by hematopoietic cells and well known for its role in mediating leukocyte trafficking into inflamed tissue. A recent report by Tinoco et al. examines chronic viral infection and melanoma in PSGL-1 deficient mice (Selplg−/−) and suggests a previously unknown and selectin-independent function for PSGL-1 as an immune checkpoint regulator that promotes T cell exhaustion (1).},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/9964}
}