Vol 15, No 6 (June 30, 2026): Translational Cancer Research

Editorial Commentary

Dynamic tumor tracking for locally advanced pancreatic cancer: precision in motion
Jason Gurewitz, Jennifer B. Permuth, Sarah Hoffe, Jessica Frakes
Translational Cancer Research  
2026;
15
(6)
:440
.
Angiotensin system inhibitors as adjunctive therapy in esophageal adenocarcinoma: hypothesis-generating insights from incidental use during trimodal treatment
Alberto Carmona-Bayonas, Paula Jimenez-Fonseca
Translational Cancer Research  
2026;
15
(6)
:441
.
Do we need to adapt the American Joint Committee on Cancer staging system after neo-adjuvant treatment in esophageal squamous cell carcinoma?
Christina T. Muijs, Gursah Kats-Ugurlu
Translational Cancer Research  
2026;
15
(6)
:442
.

Original Article

Complement system-related gene signatures implicated in the recurrence of glioma
Yanqi Sun, Xiaozhang Bao, Yuheng Yang, Peinan Zhang, Nan Tian
Translational Cancer Research  
2026;
15
(6)
:443
.
The role of targeted therapy in the management of colorectal cancer liver metastases: a systematic review and meta-analysis
Ming Yan, Rixing Bai, Wenmao Yan
Translational Cancer Research  
2026;
15
(6)
:444
.
Global bibliometric analysis of TP53-mutated acute myeloid leukemia: research hotspots and evolution
Xiaomin Wang, Lan Zhang, Xuhang Fan, Miaohui Wang, Haixia Fan
Translational Cancer Research  
2026;
15
(6)
:445
.
Tumor histologic subtypes and stage impact the risk of cardiovascular diseases death in lung cancer patients after chemotherapy or radiotherapy: a population-based study
Dejin Li, Peipei Wang, Wenjuan Jiang, Jianli Wu, Liqiong Xu, Xin Jin, Lin Luo, Dan Zhao, Anfang Chen
Translational Cancer Research  
2026;
15
(6)
:446
.
Bone morphogenetic protein 5 as a potential diagnostic and prognostic biomarker in lung adenocarcinoma
Caiping Tian, Xiao Jing, Hongyu Luo, Yue Bai
Translational Cancer Research  
2026;
15
(6)
:447
.
Recombinant adeno-associated virus-mediated HSV-TK/GCV gene therapy for ovarian cancer: an experimental study
Yanqiang Xiong, Wu Zhou, Jianlin Yang, Yajun Li, Ye Shen, Yafeng Lv, Chan Meng
Translational Cancer Research  
2026;
15
(6)
:448
.
METTL16-mediated upregulation of LINC00665 inhibits the apoptosis of breast cancer via regulating miR-28-5p/GLG1 axis
Ya Zhou, Jie Ren, Xiaojuan Cai, Shiyu Lu, Hanbing Gu, Weizhe Xu, Xun Zhu
Translational Cancer Research  
2026;
15
(6)
:449
.
METTL3- and IGF2BP1-associated m6A regulation of FADS2 contributes to lipid droplet accumulation and malignant progression in non-small cell lung cancer
Yu Zhang, Lin Wang, Huanhuan Xu, Leping Fang, Yingying Jiang, Weifei Fan, Juqing Xu
Translational Cancer Research  
2026;
15
(6)
:450
.
DDR1 in esophageal squamous cell carcinoma: bioinformatics discovery and experimental validation
Yamen Ahmad Muad, Linxiang Zhang, Weiyan Peng, Lin Ye
Translational Cancer Research  
2026;
15
(6)
:451
.
LINC01614 favors breast cancer progression through the regulation of miR-217/FN1 and mediation in PI3K/AKT signal pathway
Ding Ping, Jiaxin Wang, Dengfeng Li, Lin Fang
Translational Cancer Research  
2026;
15
(6)
:452
.
A LASSO-based nomogram for predicting breast cancer-specific survival in elderly patients after surgery: a large retrospective cohort study
Ziqiang Wang, Haojie Zhang, Qianqian Li
Translational Cancer Research  
2026;
15
(6)
:453
.
CSN3 promotes gastric cancer progression and is associated with immune infiltration and inflammatory signaling
Gang Wang, Dalai Xu, Lei Qiu, Feng Lu, Yongchang Miao
Translational Cancer Research  
2026;
15
(6)
:454
.
Construction of a ferroptosis-related prognostic signature and identification of SRSF9 as a key biomarker in lung adenocarcinoma
Jian Wang, Yixi Wei, Jia Zhang, Wenshu Chai, Yubin Li
Translational Cancer Research  
2026;
15
(6)
:455
.
Combinatorial post-translational modification reprogramming of the endomembrane system in colorectal cancer
Jie Du, Wei Zhang, Wencong Song, Yujie Zhang, Erjiao Hao, Tianyuan Li, Min Feng, Feng Zhu, Yong Dai
Translational Cancer Research  
2026;
15
(6)
:456
.
Treatment strategies and survival outcomes of vestibular schwannoma: a comparative study based on Surveillance, Epidemiology, and End Results (SEER) database
Long Chen, Hai-Yan Zheng, Tao Hou, Yi Ren, Qiao Huang, Lin Shen, Li-Ping Peng, Dun-Chang Mo, Shi-Hua Yin
Translational Cancer Research  
2026;
15
(6)
:457
.
Development and validation of a DYX1C1- and GNAI1-based nomogram for predicting relapse in HER2-positive breast cancer treated with trastuzumab
Junjie Liu, Xiaoqian Li, Ziyan Li, Rui Zhang, Yunpeng Zhang, Wei Zhang, Jianjun He, Huimin Zhang
Translational Cancer Research  
2026;
15
(6)
:458
.
CLCA1 as an immune prognostic biomarker and therapeutic target in colorectal cancer
Zewei Cheng, Yuan Li, Xin Wang, Ben Feng, Yebo Shao, Li Yang, Jiwei Zhang
Translational Cancer Research  
2026;
15
(6)
:459
.
Development and validation of an interpretable model based on ultrasound radiomics for predicting Ki-67 expression levels in breast cancer
Changhong Zhang, Yuxing Zheng, Chengyu Fang, Yanhua Huang, Junping Liu
Translational Cancer Research  
2026;
15
(6)
:460
.
Artificial intelligence-based models for colorectal cancer diagnosis using laboratory tests: an exploratory retrospective case-control study
Jian-Mei Lin, Hai-Yan Huang, Hui-Liu Tan, Shu-Wei Ren, Xue-Ming Lu, Jun Liu, Hui Li, Hui-Zhen Jia, Yan-Hong Xiao
Translational Cancer Research  
2026;
15
(6)
:461
.
Effects of different drugs on radiation-induced oral mucositis in patients with head and neck tumors: a systematic review and a network meta-analysis
Shuchang Lou, Xiaodong Li, Lingyun Shi
Translational Cancer Research  
2026;
15
(6)
:462
.
Identification of GADD45B, HMGB3, LMNB2, and MFAP5 as lactylation-related prognostic markers for survival prediction in esophageal cancer
Shuo Li, Shaomin Quan, Jun Ma, Yunbo Bai, Jing Sun, Yuan Wang, Zhongjing Wang, Juntao Zhang, Song Zhang, Wanjun Li, Zhigang Fan
Translational Cancer Research  
2026;
15
(6)
:463
.
Development and internal validation of a SEER-based prediction model for survival in poorly and undifferentiated colorectal neuroendocrine neoplasms
Qiqiang Huang, Lilin Lin, Minmin Chen, Rui Huang, He Huang, Suyu Chen
Translational Cancer Research  
2026;
15
(6)
:464
.
Ailanthone as a novel AKT1 inhibitor that induces mitochondrial apoptosis and exerts anti-tumor activity in cervical cancer
Shaofeng Huang, Yanlun Song, Yun Zhao, Xin Zhang, Yannan Jiao, Jin Zhang, Yuehua Huang, Junli Wang, Haimei Qin, Fenglian Yang, Rong Wang
Translational Cancer Research  
2026;
15
(6)
:465
.
Si Ni Powder enhances chemotherapy efficacy in sleep-deprived breast cancer via modulation of the tumor microenvironment
Heyuan Jia, Ying Chen, Hao Cheng, Surui Yao, Qingwen Wang, Mengyuan Qian, Cun Ge, Zhaohui Huang, Yanyan Chen
Translational Cancer Research  
2026;
15
(6)
:466
.
Development and validation of a Random Forest prediction model integrating clinical and ultrasound radiomics features for microvascular invasion in hepatocellular carcinoma patients: a retrospective study
Aman Makeshati, Yuying Du, Halida Xiaerfuhazi, Xiaoping Yang
Translational Cancer Research  
2026;
15
(6)
:467
.
The prognostic value of log odds of positive lymph nodes in patients with resectable locally advanced gastric cancer following neoadjuvant therapy: results from the SEER database
Yining Gou, Yuwei Cao, Tao Jin, Zehua Chen, Ershuo Du, Panping Liang, Kun Yang
Translational Cancer Research  
2026;
15
(6)
:468
.
Integrative bioinformatics and experimental analysis identify S100A10 as a diagnostic and prognostic biomarker in pancreatic adenocarcinoma
Pengzhao Song, Tianqi Chen, Qingqun Guo, Yahui Sun, Pengfei Gu, Yong Han
Translational Cancer Research  
2026;
15
(6)
:469
.
WAC is associated with malignant phenotypes and Wnt/β-catenin pathway activity in liver cancer cells
Kejia Yuan, Zexian Ding, Lei Peng, Jinghua Zeng, Han Yang, Qi Yi
Translational Cancer Research  
2026;
15
(6)
:470
.
Endoplasmic reticulum stress promotes colorectal cancer proliferation by regulating autophagy via XBP1s
Di Zhang, Chunxia Wang, Yifeng Chen, Faxin Li, Xuedong Zhang, Tianhu Sun, Shuai Wang, Lixia Zhao, Honglai Zhang, Mingming Chai, Tao Wang
Translational Cancer Research  
2026;
15
(6)
:471
.
Phase separation of MARCH1 promotes rectal adenocarcinoma progression through PHLPP2 ubiquitination
Luyao Ma, Wengang Qiu, Jie Jiang, Haofeng Lu, Liang Meng
Translational Cancer Research  
2026;
15
(6)
:472
.
SDF4: a novel prognostic biomarker and therapeutic target in hepatocellular carcinoma revealed by integrated multi‑omics analysis
Wei Shi, Jing Zhang, Bohao Sun, Panyuan Li
Translational Cancer Research  
2026;
15
(6)
:473
.
KLK6 regulates ferroptosis through YAP/TAZ in lung adenocarcinoma
Junyu Xu, Xinran Xi, Xun Wu, Zhongbo Yu, Xiaoao Yin, Xianghai Wang
Translational Cancer Research  
2026;
15
(6)
:474
.
Survival improvement and widening social disadvantage-related disparities in osteosarcoma: a Surveillance, Epidemiology, and End Results-based retrospective cohort study
Shilin Luo, Chuang Li, Leilei Tian, Rui Shi, Yi Luo
Translational Cancer Research  
2026;
15
(6)
:475
.
Divergent roles of PRR11 and HEPACAM in pleural mesothelioma: PRR11 as a prognostic biomarker and HEPACAM as a stage-associated gene with paradoxical expression
Rong-Xin Zhao, Mei-Ling Zhang, Qian Wang, Kai-Hua Lu
Translational Cancer Research  
2026;
15
(6)
:476
.
Identification of telomere-related gene signatures for immune cell infiltration and prognosis in hepatocellular carcinoma
Juntao Sun, Ye Gao, Ruotong Xu, Hao Fu, Xinyi Ying, An Yan, Sunbin Ling
Translational Cancer Research  
2026;
15
(6)
:477
.
Identification of exhausted CD8+ T-cell signatures for prognosis in multiple myeloma by integrated analysis of single-cell and bulk RNA-sequencing
Huien Zhan, Jing Lai, Jie Chen, Ying Xu, Liye Zhong
Translational Cancer Research  
2026;
15
(6)
:478
.
The evolving landscape of early diagnosis for hepatocellular carcinoma: a bibliometric analysis of global research trends (2016–2026) based on WoSCC database
Lihua Chen, Zhekun Huang, Songbin Lin, Yirui Yin
Translational Cancer Research  
2026;
15
(6)
:479
.
Integrated multi-omics analysis reveals tumor-suppressive phenotypes and associated transcriptomic remodeling upon METTL3 overexpression in A549 lung cancer cells
Zhao Liu, Yanwu Zhou, Chun Li
Translational Cancer Research  
2026;
15
(6)
:480
.
Prognostic and therapeutic implications of PSMD14 in hepatocellular carcinoma: an integrative analysis of transcriptomic and single-cell profiles
Yongfu Lu, Bohao Sun, Jing Zhang, Lihong Tang
Translational Cancer Research  
2026;
15
(6)
:481
.
A Breg-associated lncRNA signature predicts prognosis and immune landscape in esophageal carcinoma
Wen-Tao Xiao, Si-Qi Wu, Ya-Rui Han, Jia-Hui Song, Jun-Yan He
Translational Cancer Research  
2026;
15
(6)
:482
.
A pan-cancer functional atlas of ADH1A reveals its conserved role in the tumor microenvironment and immunity
Yunna Zheng, Fan Yang, Lu Yuan, Jihong Huang, Dong Yu, Junyi Lu, Laiyu Liu, Wenqi Huang
Translational Cancer Research  
2026;
15
(6)
:483
.
A stromal-derived five-gene signature predicts gastric cancer recurrence through integrated bioinformatics and single-cell analysis
Yi Wang, Rui Mao
Translational Cancer Research  
2026;
15
(6)
:484
.
Risk factors for short-term survival in EGFR-mutated non-small cell lung cancer with brain metastasis and prognosis of the leptomeningeal metastasis subgroup: a retrospective cohort study
Jinghaozheng Bo, Zhuoxuan Wu, Yanyan Yang, Weidong Han
Translational Cancer Research  
2026;
15
(6)
:485
.
Potential role of PPARGC1A in linking ulcerative colitis to colorectal cancer: a novel prognostic biomarker and therapeutic target
Bo Fan, Wenzheng Li, Zhiyuan Wei
Translational Cancer Research  
2026;
15
(6)
:486
.
Efficacy and safety of combined RANKL and PD-1 inhibitors in bone metastases: a retrospective study
Wei Zhou, Yuehong Kong, Shicheng Li, Xiangrong Zhao, Liyuan Zhang
Translational Cancer Research  
2026;
15
(6)
:487
.
Multi-omics identification of an antibody dependent cellular phagocytosis related signature for hepatocellular carcinoma
Xisheng Yin, Wenmeng Yin, Qin Yan, Shi Zheng, Yantong Li, Xiaolin Zhong
Translational Cancer Research  
2026;
15
(6)
:488
.
Development and validation of a predictive model for perioperative venous thromboembolism in colorectal cancer patients based on D-dimer combined with fibrinogen levels
Xu Liu, Zhen Feng, Wendan Jing, Jiemin Zhou, Yang Xiang, Hongyu He, Yongfu Xiong
Translational Cancer Research  
2026;
15
(6)
:489
.
A senescence-based machine learning model prognosticates and personalizes therapy in cervical cancer
Gong Chen, Qianqian Jiang, Jingyuan Xu, Tingting He, Minmin Yu, Changsong Lin
Translational Cancer Research  
2026;
15
(6)
:490
.
Association between pan-immune-inflammation value and prognosis in lung cancer patients: a systematic review and meta-analysis
Shuanglong Zhang, Zhongjun Pan, Ming Ding, Youhong Yin, Fan Zhang, Danqing Jiang, Yaxin Ji, Xin Qin, Guoxiang Rong
Translational Cancer Research  
2026;
15
(6)
:491
.
Comparative effectiveness of immune checkpoint inhibitors in squamous vs. non-squamous cervical carcinoma: a systematic review and meta-analysis of randomized controlled trials
Li-Fang Lan, Yu-Jie Chen, Dun-Chang Mo, Wen-Yi Li, Fei Yu
Translational Cancer Research  
2026;
15
(6)
:492
.
Comprehensive bioinformatics analysis identifies DNA methylation signatures associated with immune evasion and predicts immunotherapy response in breast cancer
Yurong Cheng, Jing Wang, Dong Yan
Translational Cancer Research  
2026;
15
(6)
:493
.
Predictive value of the preoperative systemic immune-inflammation index for primary chemotherapy resistance risk in patients with advanced gastric cancer
Xu Liu, Zhen Feng, Yang Xiang, Jiemin Zhou, Wendan Jing, Hongyu He, Gang Yang
Translational Cancer Research  
2026;
15
(6)
:494
.
Venous thromboembolism risk in sarcoma patients receiving combined immune checkpoint inhibitors and VEGF pathway inhibitors: a real-world cohort study
Rahul Kumar, Rohan A. Phadke, Andrew Bouras, Harlene Kaur, Samer G. Salman, Sai Sarnala, Swapna Vaja, Dylan Riley, Samuel W. Rice, Marta Batus, Alan Blank
Translational Cancer Research  
2026;
15
(6)
:495
.
A mitochondrial function-based prognostic model for hepatocellular carcinoma uncovers MRPS15 as a key driver of tumor progression through oxidative phosphorylation
Weifei Liang, Shi Zhang, Yuyang Zhang, Donglin Sun, Fang Wang, Hong Lin, Yunhong Tian
Translational Cancer Research  
2026;
15
(6)
:496
.
Spatial immune profiling of local tissues and its correlation with peripheral blood cytokines in lung squamous cell carcinoma patients with immune-related pneumonitis
Hui He, Yuanyuan Wen, Jiale Yan, Lei Zhou, Haifeng Li
Translational Cancer Research  
2026;
15
(6)
:497
.
A pneumolysin mutant (ΔA146 ply) induces pyroptosis in triple-negative and HER2-positive breast cancer cells via the Caspase-1/GSDME pathway: a potential antibody-drug conjugate payload
Xiaochun Tan, Jing Chen, Qinlong Yu, Junhua Tian, Jiayuan Wang, Weifeng Shen
Translational Cancer Research  
2026;
15
(6)
:498
.
Single-cell mitophagy patterns dictate intercellular crosstalk in the tumor microenvironment to promote osteosarcoma progression
Wei Shi, Lei Zhang, Liying Mei, Chengqi Zhang, Lei Liu, Nan Zhao, Qingyu Liu
Translational Cancer Research  
2026;
15
(6)
:499
.
Tumor-derived CCL20 activates tumor-associated neutrophils, predicting good prognosis in endometrial cancer
Linyan Zhu, Wenwu Luo, Siyu Li, Chengkang Wu, Zhi Wang, Qiang Wu, Keshuo Ding
Translational Cancer Research  
2026;
15
(6)
:500
.
Accuracy of machine learning in detecting lymph node metastasis of esophageal cancer: a systematic review and meta-analysis
Jing Chen, Jiren Weng, Xuefeng Lin
Translational Cancer Research  
2026;
15
(6)
:501
.
Exosome-mediated regulation of the immune microenvironment via JAK/STAT signaling promotes pancreatic cancer progression
Shunxin Hao, Zhi Yao, Can Li, Tao Xiong, Jingxi Song, Yifeng Liu
Translational Cancer Research  
2026;
15
(6)
:502
.
CNTN-1 regulates malignant biological behaviors of lung squamous cell carcinoma (LUSC) via the endoplasmic reticulum stress (ERS)/epithelial-mesenchymal transition (EMT) axis
Kaimei Zhou, Weijie Dong, Shengjin Li, Depeng Jiang, Qi Wu, Zimo Wang, Minchao Li, Ruijie Zhang
Translational Cancer Research  
2026;
15
(6)
:503
.
Low-dose radiotherapy combined with immune checkpoint inhibitors in advanced malignancies: a real-world exploratory study
Kai Xin, Liping Deng, Meiqing Ding, Mengmeng Feng, Xiahui Wu, Lijing Zhu
Translational Cancer Research  
2026;
15
(6)
:504
.
Expression profiling, molecular subtyping and prognostic signature construction of chemokines and chemokine receptors in gastric cancer
Tianshu Feng, Yaoqi Li, Jieyu Hu, Liang Zhao, Xiaobin Yao
Translational Cancer Research  
2026;
15
(6)
:505
.
A nomogram based on systemic inflammatory markers: development and validation for predicting postoperative overall survival in gastric cancer
Liuyi Yang, Xuexian Cao, Yulan Gu, Jinghua Ye
Translational Cancer Research  
2026;
15
(6)
:506
.

Review Article

Mitochondrial dynamics imbalance in hepatocellular carcinoma: from molecular mechanisms to new strategies for targeted therapy
Fuxiang Chen, Chunyang Ma, Xitong Bo, Yilong Zhou, Suqing Zhang
Translational Cancer Research  
2026;
15
(6)
:507
.
Association between the Prognostic Nutritional Index and survival outcomes in hepatocellular carcinoma patients receiving immune checkpoint inhibitors: a systematic review and meta-analysis
Jiajia Qian, Shang Gao, Yunhao Zhu, Jingxia Wu
Translational Cancer Research  
2026;
15
(6)
:508
.
Micro- and nanoplastic exposure and cancer: current evidence, mechanistic pathways, and translational challenges
Yuxin Han, Zihan Chen, Zizhou Zhang, Xiaolan Lv, Yue Han, Liubing Hou, Xiaoying Xue, Huandi Zhou
Translational Cancer Research  
2026;
15
(6)
:509
.

Letter to the Editor

Toward precision immunotherapy in recurrent/metastatic head and neck squamous cell carcinoma: lessons from the FOCUS trial
Christoph Schultheiss, Tobias Andermatt, Anna Brandt, Mascha Binder
Translational Cancer Research  
2026;
15
(6)
:510
.