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TCR 2025 Annual Report

Greetings from the Editorial Office of TCR! More >>

Join us at the 9th World Congress of Pediatric Cardiology & Cardiac Surgery

The 9th World Congress of Pediatric Cardiology & Cardiac Surgery (WCPCCS) is going to be held at the Hong Kong Convention and Exhibition Centre, Hong Kong, China from December 7 to... More >>

AME and Wolters Kluwer aim to expand access to global medical research through new collaboration

The agreement broadens the reach of nearly 50 Open Access titles, contributing globally to over 5,000 articles More >>

Editorial Commentary

Sentinel lymph node biopsy in early oral cancer: interpreting high significance in low-event cohorts
Grégoire B. Morand, Martin W. Huellner
Translational Cancer Research  
2025;
14
(12)
:8218-8220
.
 (31 December 2025) 
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Implementing perioperative immunotherapy for head and neck cancer after KEYNOTE-689: questions and challenges
Brianna Brammer, Jennifer H. Gross, Brian J. Boyce, Nabil F. Saba, Nicole C. Schmitt
Translational Cancer Research  
2025;
14
(12)
:8221-8227
.
 (31 December 2025) 
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Original Article

Stratifying prognosis in stage III colorectal cancer patients: the role of tumor deposits and lymph node ratio
Xiaoqiang Wang, Xufeng Shu, Chendong Yuan, Hao Chen, Haoxiang Xiao, Zhigang Jie, Wensheng Deng
Translational Cancer Research  
2025;
14
(12)
:8228-8242
.
 (31 December 2025) 
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5MPN effectively targets PFKFB4 and inhibits the glucose metabolism process and invasion of glioblastoma
Chen Yu, Zhennan Tao, Tianyu Lu, Hongbin Ni, Weibang Liang
Translational Cancer Research  
2025;
14
(12)
:8243-8253
.
 (31 December 2025) 
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Machine learning screening for disulfidptosis genes- associated immunosuppression status in osteosarcoma and rhabdomyosarcoma
Lin Yu, Fanli Lin
Translational Cancer Research  
2025;
14
(12)
:8254-8270
.
 (31 December 2025) 
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Laparoscopic surgery is effective and safe in high-risk endometrial cancer
Yangyang Dong, He Li, Yibo Dai, Liwei Li, Guo Zhang, Yuan Cheng, Jingyi Zhou, Xingchen Li, Peng Zuo, Jianliu Wang
Translational Cancer Research  
2025;
14
(12)
:8271-8284
.
 (31 December 2025) 
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Activated RARα counteracts the effects of TACC1v25 on the differentiation and invasion of head and neck squamous cell carcinoma
Xiao-Li Ge, Chen-Yang Zhang, Pan Xu, Ran Zhao, Hai-Yan Wang, Wei-Wen Jiang
Translational Cancer Research  
2025;
14
(12)
:8285-8300
.
 (31 December 2025) 
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SLC25A3 promotes hepatocellular carcinoma progression by inducing mitochondrial dysfunction and chromatin remodeling
Shuangya Deng, Jie Fu
Translational Cancer Research  
2025;
14
(12)
:8301-8312
.
 (31 December 2025) 
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Targeted next-generation sequencing reveals genomic differences between male and female breast cancer
Jiyuan Zhu, Shanshan Xu, Wei Hua, Mengdi Wang, Shichao Zhang, Pengtian Lu, He Wu
Translational Cancer Research  
2025;
14
(12)
:8313-8328
.
 (31 December 2025) 
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Research hotspots and frontiers in the tumor microenvironment of gastric cancer: a bibliometric review from 2005 to 2024
Libo Zhang, Xianghong Xu, Yan Wang, Jiarui Zhang, Hui Cai, Tao Qu
Translational Cancer Research  
2025;
14
(12)
:8329-8346
.
 (31 December 2025) 
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Development and validation of a novel palmitoylation-related prognostic signature in head and neck squamous cell carcinoma
Meredith Nuo Zhang, Hongcun Bao, Xiang Ji
Translational Cancer Research  
2025;
14
(12)
:8347-8364
.
 (31 December 2025) 
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Molecular characterization and prognostic modeling of liquid- liquid phase separation-related genes in osteosarcoma based on single-cell sequencing and weighted gene co-expression network analysis
Xinyu Huang, Liang Xiong, Jiaxing Zeng, Shanhang Li, Yangjie Cai, Zhuan Zou, Mingxiu Yang, Hening Li, Yun Liu, Maolin He
Translational Cancer Research  
2025;
14
(12)
:8365-8384
.
 (31 December 2025) 
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Proteomic analysis of altered urinary extracellular vesicle levels in breast cancer patients pre- and post-surgery
Nilobon Jeanmard, Rassanee Bissanum, Sawanya Charoenlappanit, Sittiruk Roytrakul, Raphatphorn Navakanitworakul
Translational Cancer Research  
2025;
14
(12)
:8385-8403
.
 (31 December 2025) 
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Upregulation of spondin-2 indicates poorer clinical outcomes and induces radioresistance in gastric cancer
Yongqin Zhang, Yun Zuo, Dong Hua
Translational Cancer Research  
2025;
14
(12)
:8404-8417
.
 (31 December 2025) 
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Mechanistic study of LINC01296 mediating TRIP13 regulation of neuroblastoma progression
Yuanbin He, Jiansen Fan, Yu Lin, Chao Zheng, Yifan Fang
Translational Cancer Research  
2025;
14
(12)
:8418-8431
.
 (31 December 2025) 
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Examining the effectiveness of follow-up chemotherapy in large cell neuroendocrine carcinoma: special emphasis on stage T1–2N0M0 according to 9th edition TNM guidelines
Hongying Pan, Yin Zhang, Minjie Ying, Chongya Zhai
Translational Cancer Research  
2025;
14
(12)
:8432-8447
.
 (31 December 2025) 
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Glutamine metabolism drives tumor aggressiveness but not chemoresistance in ovarian carcinoma cell lines
Siegfried Hélage, Marie-Céline Blanc-Quintin, Nathalie Neveux, Antonin Ginguay, Jean-Pascal De Bandt, Luc Cynober, Jérôme Alexandre, François Goldwasser, Élisabeth Dion
Translational Cancer Research  
2025;
14
(12)
:8448-8461
.
 (31 December 2025) 
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Interpretable LASSO-Cox model: Hsp90α/albumin ratio predicts hepatocellular carcinoma prognosis
Jiali Chen, Shi Chen, Han Li, Ke Su, Kun He, Nan Deng, Guangwei Yang, Yunwei Han
Translational Cancer Research  
2025;
14
(12)
:8462-8474
.
 (31 December 2025) 
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The value of different machine learning radiomics based on DCE-MRI in predicting axillary lymph node status of breast cancer
Han Wang, Li Gong
Translational Cancer Research  
2025;
14
(12)
:8475-8488
.
 (31 December 2025) 
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Sarcopenia-driven gene model as a clinically actionable prognostic signature for head and neck squamous cell carcinoma
Kun Gao, Zheran Liu, Meng Dou, Ge Song, Jiacheng Li, Ping Ai, Jiagang He, Jitao Zhou
Translational Cancer Research  
2025;
14
(12)
:8489-8502
.
 (31 December 2025) 
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Preoperative prediction of breast cancer Ki-67 status via multimodal ultrasound-clinical nomogram: a single-center study
Xiao-Kai Lu, Nian-Qiu Liu, Yi-Hang Li, Zhi-Yao Li, Dong Chen, Zhi-Rui Chuan, Yin-Xi Qu, Ying-Xian Zhang, Hai-Tao Chen, Xiao-Mao Luo
Translational Cancer Research  
2025;
14
(12)
:8503-8512
.
 (31 December 2025) 
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tRF-29-86J8WPMN1EJ3: a tRNA-derived small RNA promoting esophageal cancer progression
Xinnian Yu, Zhipeng Li, Yuqi Fu, Bin Zhou, Shanliang Zhong
Translational Cancer Research  
2025;
14
(12)
:8513-8525
.
 (31 December 2025) 
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LASSO-based nomograms predict early death in small cell lung cancer (SCLC) patients with brain metastasis
Xiaohao Liu, Long Wang, Linkuan Huangfu, Jiayin Ding, Dandan Wang, Jiayao Xu, Tianqi Li, Yahang Liu, Yue Yu, Yingjuan Zheng
Translational Cancer Research  
2025;
14
(12)
:8526-8541
.
 (31 December 2025) 
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High TERF2 expression is associated with poor prognosis and its suppression attenuates progression in acute myeloid leukemia
Lihua Yao, Xiaozhong Wang
Translational Cancer Research  
2025;
14
(12)
:8542-8555
.
 (31 December 2025) 
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Impact of underlying liver etiology on post-hepatectomy survival outcomes in hepatocellular carcinoma patients
Atsushi Nanashima, Junichi Arai, Naoya Imamura, Masahide Hiyoshi, Yuki Tsuchimochi, Takashi Wada
Translational Cancer Research  
2025;
14
(12)
:8556-8566
.
 (31 December 2025) 
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Targeting the METTL3/PCNA axis with STM2457 overcomes cisplatin resistance in osteosarcoma
Hua Yu, Shaoxing Li, Jinwang Liu
Translational Cancer Research  
2025;
14
(12)
:8567-8578
.
 (31 December 2025) 
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Identification of differentiation markers and immune microenvironment in head and neck squamous cell carcinoma using machine learning combined with single-cell analysis
Zishanbai Zhang, Yue Li, Miao Wang, Yixin Jing, Honglian Hu, Menglin Shi, Yiming Ding, Xiaohong Chen
Translational Cancer Research  
2025;
14
(12)
:8579-8599
.
 (31 December 2025) 
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Multivesicular body subunit 12B (MVB12B) overexpression represses proliferation and migration in bladder urothelial carcinoma
Xiaohong Li, Caize Cen, Rongxin Li, Qisheng Su, Wuning Mo, Faquan Lin
Translational Cancer Research  
2025;
14
(12)
:8600-8615
.
 (31 December 2025) 
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Warfarin and bevacizumab suppress tumor progression in pancreatic ductal adenocarcinoma by targeting EGFR-PI3K-Akt signaling: inhibition of proliferation/migration and apoptosis induction
Jingjing Chen, Jianjie Ju, Jingting Wang, Limei Yang
Translational Cancer Research  
2025;
14
(12)
:8616-8631
.
 (31 December 2025) 
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Development and validation of a novel prognostic signature for osteosarcoma
Xiaowei Wang, Xingyu Zhu, Weiwei Li
Translational Cancer Research  
2025;
14
(12)
:8632-8641
.
 (31 December 2025) 
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Bufalin: a potential drug for regulating EGFR-TKIs resistance in lung cancer via the EGFR-PI3K/Akt-mTOR signaling
Yueqin Bai, Yabin Gong, Ruifang Cui, Qingpeng Deng, Xiaozhen Zhao, Chang Liu, Longke Dong
Translational Cancer Research  
2025;
14
(12)
:8642-8654
.
 (31 December 2025) 
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Association between urinary perchlorate and malignancies of endocrine-related tissues in U.S. adults: analysis of National Health and Nutrition Examination Survey (NHANES) data
Xiaoyun Zang, Kexin Zhang, Yujie Ma, Chengxia Kan, Zhenghui Tian, Guangdong Zhang, Xiaodong Sun
Translational Cancer Research  
2025;
14
(12)
:8655-8666
.
 (31 December 2025) 
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Prognosis and chemotherapy efficacy in small-tumor breast cancer with different immune subtypes: a SEER-based study
Hong Mei Wang, Yue Hui Zhou, Gu Bin Lin, Bi Lian Zheng, Kun Zhang, Xiu Rong Chi, Yi Peng, Xiao Xi Huang, Hua Le Zhang
Translational Cancer Research  
2025;
14
(12)
:8667-8687
.
 (31 December 2025) 
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Development of a fatty acid metabolism (FAM)-related gene signature for prognosis prediction and personalized therapy in lower grade gliomas
Fangfang Du, Yang Guo, Xiangyu Shi, Xiaomin Liu
Translational Cancer Research  
2025;
14
(12)
:8688-8704
.
 (31 December 2025) 
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Prognostic implications of a programmed cell death-related long non-coding RNA signature and its relevance to immune features in esophageal carcinoma
Wentao Xiao, Xinying Fang, Shubin Luo, Jiahui Song, Jie Sun, Junjie Chen, Zhiming Chen
Translational Cancer Research  
2025;
14
(12)
:8705-8724
.
 (31 December 2025) 
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Survival benefit of adjuvant chemotherapy for duodenal adenocarcinoma: a retrospective cohort study and propensity score-matched analysis
Yuting Luo, Yijun Fan, Chengxi Fan, Zhengqiang Chen, Yaotian Fan, Zhen You, Xiwen Ye
Translational Cancer Research  
2025;
14
(12)
:8725-8736
.
 (31 December 2025) 
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An immune checkpoint-based score is a prognostic marker in retrospective cohort study of patients with gastric cancer
Zhao Lu, Jian Xu, Di Mei, Fang Yu, Guifang Yang, Chunwei Peng
Translational Cancer Research  
2025;
14
(12)
:8737-8746
.
 (31 December 2025) 
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Demethylzeylasteral alleviates myeloid leukemia through PERK/eIF2α/ATF4/CHOP-mediated cell apoptosis
Xue Li, Xianchao He, Leyan Zhang, Zhigang Li, Yuanyuan Liu
Translational Cancer Research  
2025;
14
(12)
:8747-8764
.
 (31 December 2025) 
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The prognostic role of radiotherapy in non-surgical gastric cancer: a retrospective cohort study in the SEER database
Mingxing Wang, Jiuhong Wang, Yipeng Song, Shengteng Shao, Yuanyuan Zhao, Chenxi Yuan, Mingxu Li, Xiaowen Qiu
Translational Cancer Research  
2025;
14
(12)
:8765-8777
.
 (31 December 2025) 
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Development and validation of a circulating tumor DNA-based machine learning model for predicting immunotherapy response in non-small cell lung cancer
Ji Xia, Tianchu He, Yong Hu, Daobin Zhou, Dan Zou, Ya Li, Min Zhang, Benlan Li, Minfang Wang, Xian Liu, Zhongjun Huang, Shengfa Su, Jie Peng
Translational Cancer Research  
2025;
14
(12)
:8778-8791
.
 (31 December 2025) 
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Prognostic chromatin remodeling signature stratifies survival outcomes in lung adenocarcinoma patients
Xiongwei Wang, Yuying Liu, Danhe Huang, Mingyu Yuan, Lianqing Hong
Translational Cancer Research  
2025;
14
(12)
:8792-8806
.
 (31 December 2025) 
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OX40L and IL-2 combination strategy for gastric cancer immunotherapy
Benshun Hu, Emanuela Garbarino, Jingjing Ma, Chengyuan Yan, Junli Jia, Hua Xie, Lingyun Li, Cheng Jin, Yuzheng Xue, Huamin Tang
Translational Cancer Research  
2025;
14
(12)
:8807-8824
.
 (31 December 2025) 
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Comprehensive analysis of gene signature linking hypoxia and lactylation for predicting prognosis and immunotherapy response in patients with gastric cancer
Ping Liu, Xiaohong Wang, Ruiheng Xie, Rui Luo, Yizhou Wang, Ping Wang, Ruiyu Wang, Xian Zhou, Xiaowei Tang
Translational Cancer Research  
2025;
14
(12)
:8825-8839
.
 (31 December 2025) 
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A novel prognostic and immune-related biomarker KCNC3 in colorectal cancer: a pan-cancer analysis
Kun Xia, Hong-Chao Zhu, Fang-Ye Lai, Zi-Hao Li, Wei Wang, Nan Wang
Translational Cancer Research  
2025;
14
(12)
:8840-8858
.
 (31 December 2025) 
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SNX24 serves as a potential prognostic biomarker and a therapeutic target in uterine corpus endometrial carcinoma according to bioinformatics and experimentations
Delai Long, Xiaodong Fan, Yingjun Zhu
Translational Cancer Research  
2025;
14
(12)
:8859-8874
.
 (31 December 2025) 
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Albiflorin enhances the antitumor effects of propofol in hepatocellular carcinoma cells by inhibiting the Wnt/β-catenin signaling activation
Tong Ji, Lingling Ye, Cheng Xu, Chenyu Ma, Guoping Yin
Translational Cancer Research  
2025;
14
(12)
:8875-8888
.
 (31 December 2025) 
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Transfer RNA-derived fragment tRF-28-P4R8YP9LOND5 as a novel serum biomarker for gastric cancer: diagnostic efficacy and clinicopathological correlations
Fei Gu, Yuan Yuan, Hui Cong, Xin Chen, Wei Wang, Jie Zhang, Li-Pei Wu, Shi-Hai Xuan
Translational Cancer Research  
2025;
14
(12)
:8889-8907
.
 (31 December 2025) 
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Construction of a prognostic model based on efferocytosis for predicting survival and immunotherapy efficacy in cervical cancer
Li-Li Zhang, Yan-Fei Ji, Jing Li, Wen-Hao Wang, Yong-Li Hou
Translational Cancer Research  
2025;
14
(12)
:8908-8929
.
 (31 December 2025) 
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Combination of Naples prognostic score and pathological factors for evaluating the long-term prognosis of patients with late-onset colorectal cancer: a multicenter machine learning study
Tawfik Ali Hamood Alburiahi, Yan-Hong Yang, Weiqing Liu, Xin Li, Wanrong Lin, Lei Liang, Jun Yang
Translational Cancer Research  
2025;
14
(12)
:8930-8948
.
 (31 December 2025) 
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Tumor-associated neutrophils drive liver-specific metastatic progression in breast cancer through methionine metabolism mediated by methionine adenosyltransferase II alpha
Lifeng Huang, Shuang Zhen, Qi Wang, Yue Sun, Tian Ji, Rui Chen, Jue Wang, Qiannan Zhu, Dongwei Xu, Xiaoming Zha
Translational Cancer Research  
2025;
14
(12)
:8949-8964
.
 (31 December 2025) 
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The influence of CXCL9 on M2 macrophages in lung cancer development
Lin Mi, Liyun Xu, Zhijun Chen, Yeye Zheng
Translational Cancer Research  
2025;
14
(12)
:8965-8978
.
 (31 December 2025) 
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Neutrophil-to-lymphocyte ratio as a prognostic predictor in adrenocortical carcinoma: a retrospective cohort study stratified by cortisol secretion status
Tongxin Zhang, Ruiqing Dong, Axing Li, Beiyan Liu, Zhiqiu Sun, Xuna Kou, Mengyi Li, Jiaojiao Zhang, Jin Shang, Bingyin Shi, Hui Guo, Dapeng Wu, Wei Qiang
Translational Cancer Research  
2025;
14
(12)
:8979-8989
.
 (31 December 2025) 
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Polyethylene glycol-conjugated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) primary prophylaxis significantly reduces the duration of neutropenia in non-Hodgkin’s lymphoma patients treated with chemotherapy: a randomised trial (NCT05834751)
Bowen Wang, Luming Cao, Jia Li, Yangzhi Zhao, Junna Li, Yueyue Wen, Panpan Yan, Wei Guo, Ou Bai
Translational Cancer Research  
2025;
14
(12)
:8990-9001
.
 (31 December 2025) 
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Targeting CLIC6 with theaflavin enhances radiotherapy sensitivity in ER+/HER2− breast cancer
Mengying Suo, Lin Liu, Tiantian She, Chong Chen
Translational Cancer Research  
2025;
14
(12)
:9002-9014
.
 (31 December 2025) 
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Case Series

Diagnostic challenges and clinical management of inflammatory myofibroblastic tumor: a retrospective case series study
Ling-Yu He, Bo Chen, Xiao Yu, Sheng-Han Xu, Cheng Zha, Yue Li, Sui-yang Jin, Xue-Feng Peng, Xin-Wen Wang, Guo-Bing Li, Qiang Wang, Wei Li
Translational Cancer Research  
2025;
14
(12)
:9015-9026
.
 (31 December 2025) 
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Review Article

Targeting MET in advanced and metastatic non-small cell lung cancer: a literature review of the current landscape
Amanda Herrmann, Christopher Grant, Lyudmila Bazhenova
Translational Cancer Research  
2025;
14
(12)
:9027-9052
.
 (31 December 2025) 
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An updated review on systemic therapy for brain metastases in non-small cell lung cancer
Shreya Louis, John Paul Aboubechara, Keshav Saigal, Toni Cao, Seema Nagpal
Translational Cancer Research  
2025;
14
(12)
:9053-9062
.
 (31 December 2025) 
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The role of microRNAs in gastritis, intestinal metaplasia, and gastric cancer: a narrative review
Zi Gao, Kaiyue Fu, Peijuan Li, Zhen Fang, Jin Liu, Liang Shang
Translational Cancer Research  
2025;
14
(12)
:9063-9081
.
 (31 December 2025) 
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Case Report: iMDT Corner

Successful treatment of lung squamous cell carcinoma with envafolimab, a PD-L1 inhibitor combined with chemotherapy: a case report
Xin Sun, Yu Tang, Yue Zhu, Jinrong Wei, Xiaochun Zhang, Atsushi Osoegawa, Rossana Berardi, Fumihiro Yamaguchi, Haibo Cheng
Translational Cancer Research  
2025;
14
(12)
:9082-9090
.
 (31 December 2025) 
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Case Report

Catheter-directed thrombectomy combined with angioplasty and stent implantation for superior vena cava syndrome: a case report
Hao Wang, Zi-Yi Liu, Chang-Yuan Liu, Guang-Sheng Zhao, Shun-Xiong Tang, Jun-Jie Qu, Fang Xu, Jun Zhou
Translational Cancer Research  
2025;
14
(12)
:9091-9098
.
 (31 December 2025) 
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Erratum

Erratum: Neuroepithelial cell transforming 1 as a key regulator in non-small cell lung cancer: unveiling causal links and therapeutic potentials
Editorial Office
Translational Cancer Research  
2025;
14
(12)
:9099
.
 (31 December 2025) 
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Review Article 
The management of brain necrosis as a result of SRS treatment for intra-cranial tumors
Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen
Published online: 28 August 2014
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Meta-Analysis 
Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu
Published online: 05 March 2013
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Review Article 
Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai
Published online: 05 March 2013
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Biological basis of IORT 
Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects
Ithaisa Sologuren, Carlos Rodríguez-Gallego, Pedro Carlos Lara
Published online: 25 February 2014
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Original Article 
Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review
Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi
Published online: 28 April 2017
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Review Articles 
Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer
Deep Kwatra, Anand Venugopal, Shrikant Anant
Published online: 26 September 2013
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Review Articles 
Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer
Rositsa Dueva, George Iliakis
Published online: 19 June 2013
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Editorial 
Morphine, when used for treating patients with acute pancreatitis, could be more risky than previously suspected
Juan Iovanna, Maria Cecilia Mallmann
Published online: 24 October 2017
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Review Article 
Do alkaline phosphatases have great potential in the diagnosis, prognosis, and treatment of tumors?
Tingting Jiang, Qun Zeng, Jun He
Published online: 20 October 2023
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Review Article 
EGFR first- and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients
Niki Karachaliou, Manuel Fernandez-Bruno, Jillian Wilhelmina Paulina Bracht, Rafael Rosell
Published online: 19 January 2019
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Review Article 
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
Published online: 18 June 2015
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Review Articles 
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Published online: 26 September 2013
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Biological basis of IORT 
Cell and molecular response to IORT treatment
Luigi Minafra, Valentina Bravatà
Published online: 25 February 2014
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Editorial 
The CROSS road in neoadjuvant therapy for esophageal cancer: long-term results of CROSS trial
Ian Wong, Simon Law
Published online: 29 September 2016
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Review Articles 
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
Published online: 19 June 2013
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Review Articles 
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Published online: 19 June 2013
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Review Article 
EGFR and HER2: is there a role in ovarian cancer?
Eleonora Teplinsky, Franco Muggia
Published online: 13 February 2015
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Review Article 
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Published online: 30 June 2017
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Review Article 
Multiple keratoacanthoma centrifugum marginatum—a case report and systematic review
Yiman Wang, Wenling Zhao, Yueping Zeng, Li Li, Hongzhong Jin
Published online: 30 December 2018
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Review Articles 
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Published online: 01 August 2012
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Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park
How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis
Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao
Alcohol intake patterns for cancer and non-cancer individuals: a population study
Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng
Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial
Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu
Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management
Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas
Exosomal lncRNAs as new players in cell-to-cell communication
Mihnea Dragomir, Baoqing Chen, George A. Calin
Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy
Souparno Bhattacharya, Aroumougame Asaithamby
Translational research in radiation-induced DNA damage signaling and repair
Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue
Genetically engineered mouse models for studying radiation biology
Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Advances on immunotherapy in genitourinary and renal cell carcinoma
Gregory P. Botta, Eric Granowicz, Carrie Costantini
The role of novel immunotherapies in non-Hodgkin lymphoma
Allyson Pishko, Sunita D. Nasta
MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan
Do p53 stress responses impact organismal aging?
Paul Hasty, Judith Campisi, Z. Dave Sharp
Pharmacological targeting of mutant p53
Samuel Kogan, Darren Carpizo
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Michael I. Carr, Stephen N. Jones
Regulation of cytotoxic T-cell responses by p53 in cancer
Mitchell W. Braun, Tomoo Iwakuma
The IGF-1R/AKT pathway determines cell fate in response to p53
Lei Duan, Carl G. Maki
Intra molecular interactions in the regulation of p53 pathway
Jiandong Chen
TP53 mutations in epithelial ovarian cancer
Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu
Modulation of the p53 family network by RNA-binding proteins
Chris Lucchesi, Jin Zhang, Xinbin Chen
Radiomics in head and neck cancer: from exploration to application
Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller
Prostate cancer radiomics and the promise of radiogenomics
Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack
Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies
Wei Lu, Wengen Chen
The emerging field of radiomics in esophageal cancer: current evidence and future potential
Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin
Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
Jung H. Suh, Julie D. Saba
Computational methods and opportunities for phosphorylation network medicine
Yian Ann Chen, Steven A. Eschrich

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
New light on the pancreatic cyst conundrum
Nathan A. Berger
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?
Andrew J. Scott, John C. Wilkinson
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
Nan Ding, Qianzheng Zhu
Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?
Apar Gupta, Nisha Ohri, Bruce G. Haffty
Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents
Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi
CRISPR-based genetic interaction maps inform therapeutic strategies in cancer
Poornima Ramkumar, Martin Kampmann
Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study
Melin J. Khandekar, Rakesh Jain
The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin
Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed
Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer
Joanne P. Young, Timothy J. Price, Susan Parry
Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response
R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang
Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes
Theresa L. Whiteside
TIC10/ONC201—a potential therapeutic in glioblastoma
Georg Karpel-Massler, Markus D. Siegelin
IDH mutational status and the immune system in gliomas: a tale of two tumors?
Bryan D. Choi, William T. Curry
ONC201: a new treatment option being tested clinically for recurrent glioblastoma
Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry
When better still might not be good enough
Waldemar Debinski
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy
Vincent C. O. Njar
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28
Leonardo Chicaybam, Prasad S. Adusumilli
Exosome mediated phenotypic changes in lung cancer pathophysiology
Yoshihisa Shimada, John D. Minna
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aaron D. DeWard, Rebecca J. Critchley-Thorne
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein
Felicia L. Lenzo, William G. Cance
New incriminating evidence against IGF2
Wen Ding, Lina A. Shehadeh
Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect
Paul Grippo, Ajay V. Maker
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger
RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver
Satomi Yamamoto, Tomoo Iwakuma
Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy
Michael J. Baine, Chi Lin
Rogue one: another faction of the Wnt empire implicated in assisting GBM progression
Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed
Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway
Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems
Li Tian, Ashley Chang, Marites P. Melancon
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
James P. White
Low-frequency ultrasound may improve drug penetration in colonic mucosa
Qiubing Chen, Bo Xiao, Didier Merlin
Dividing and conquering the variation among variants in EML4-ALK lung cancer
Trever G. Bivona
Unlocking the epigenetic code of T cell exhaustion
Jiazhu Wu, Huidong Shi
KDM1 links nuclear GSK3β to epigenetic alterations
Weijie Guo, Binhua P. Zhou
Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease
Deepa Rangachari, Daniel B. Costa
Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy
Bhagelu R. Achyut, Ali S. Arbab
Neuroendocrine differentiation in prostate cancer: key epigenetic players
Karishma Gupta, Sanjay Gupta
PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression
Kim A. Brogden, Shireen Vali, Taher Abbasi
Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy
Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias
The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies
Keith T. Schmidt, William D. Figg
Information-dense analysis for information-dense understanding
Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
Fabiana Perna, Michel Sadelain
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells
Alex J. Gooding, William P. Schiemann
Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?
Nathan A. Berger
Microtubule targeting agents in glioma
Anda-Alexandra Calinescu, Maria G. Castro
Moving molecular subtypes to the clinic in gastric cancer
Joseph Chao, Jeeyun Lee, Samuel J. Klempner
Intraoperative subtyping of lung adenocarcinoma: an unmet need
Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli
Emerging roles of FGF signaling in hepatocellular carcinoma
Nana Zheng, Wenyi Wei, Zhiwei Wang
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
Brandon J. Manley, James J. Hsieh
Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer
Salma Kaochar, Nicholas Mitsiades

Letter to the Editor

Epigenetic regulation of PD-L1 expression and pancreatic cancer response to checkpoint immunotherapy
Chunwan Lu, Kebin Liu
Synthetic lethality vs. synthetic viability due to PARP1 and BRCA2 loss
Xia Ding, Shyam K. Sharan

Correspondence

Targeted attack: mechanisms by which ovarian cancers suppress the immune system
Irina V. Tiper, Tonya J. Webb

Brief Report

The impact of neighborhood disadvantage on health-related quality of life among African American and white cancer survivors
Chien-Ching Li, Alicia K. Matthews, Anjali Asthana, Raj C. Shah

Research Highlight

Butyrate consumption of differentiated colonocytes in the upper crypt promotes homeostatic proliferation of stem and progenitor cells near the crypt base
Scott J. Bultman

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike
Jeffrey J. Tosoian, Emmanuel S. Antonarakis
A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer
Sawsan Rashdan, David E. Gerber
MOAP-1, UBR5 and cisplatin resistance in ovarian cancer
Scott T. Eblen, Amber Bradley
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer
Weimin Gao
The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)
Theresa L. Whiteside
[18F]-choline PET/CT as an imaging biomarker for primary liver cancers
Zhenghong Lee
Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best
Yoshio Yamaoka, David Y. Graham
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function
Theodoros Karantanos, Vassiliki A. Boussiotis
Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer
Angel Qin, Gregory P. Kalemkerian
Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered
Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham
Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells
Praveen Kumar Vemula, Venkatakrishna Rao Jala
Helios—controller of Treg stability and function
Claire Chougnet, David Hildeman
Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation
Jon K. Obst, Marianne D. Sadar
Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird
Fat lure: adipocytes attract cancer cells out of the prostate
Alexandra M. Blee, Haojie Huang
Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers
Guoli Chen, Ming-Tseh Lin

Editorials

Into the eye of the storm: breast cancer’s somatic mutation landscape points to DNA damage and repair
Joanne Ngeow, Emily Nizialek, Charis Eng

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
The STAMPEDE trial: paradigm-changing data through innovative trial design
Bradley C. Carthon, Emmanuel S. Antonarakis
Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway
Derek B. Oien, Jeremy Chien, Nikki Cheng
Feed your gut with caution!
Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar
Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma
Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma
Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

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Translational Cancer Research is an international, open access, peer-reviewed journal indexed in Scopus and Science Citation Index Expanded (SCIE), focusing on original, science-based researches on clinical, basic and translational aspects. It publishes laboratory studies of novel therapeutic interventions, clinical trials which evaluate new treatment paradigms for cancer, results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients and etc.

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Translational Cancer Research is published by AME Publishing Company

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