Home - Translational Cancer Research

Join us at the 9th World Congress of Pediatric Cardiology & Cardiac Surgery

This year Translational Cancer Research (TCR) as well as its sister journals and books published by AME Publishing Company will be on display during this exciting academic event! We would like to seize this great opportunity to meet our authors, editorial board members and readers. You are cordially invited to visit us at Booth 31.

AME and Wolters Kluwer aim to expand access to global medical research through new collaboration

The agreement broadens the reach of nearly 50 Open Access titles, contributing globally to over 5,000 articles

October 2, 2025 — Wolters Kluwer Health announced a new collaboration with AME Publishing Company, an Open Access publisher specializing in medical journals and books, headquartered in Hong Kong, China.

New Impact Factor for Translational Cancer Research: 1.7

We are pleased to announce that Translational Cancer Research (TCR) has attained its latest impact factor update for the 2024 citation year: 1.7.

Translational Cancer Research 2024 CiteScore Released: 2.5

We are pleased to announce that the Translational Cancer Research (TCR) has achieved its 2024 CiteScore: 2.5. TCR ranks as follows across various categories: 261 out of 415 in Oncology, 180 out of 233 in Cancer Research, and 191 out of 346 in Radiology, Nuclear Medicine and Imaging. This milestone underscores our ongoing commitment to publishing impactful research in the field.

Reviewer of the Month (2025)

In 2025, TCR reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

Interviews with Outstanding Authors (2025)

In 2025, many authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors who have been making immense efforts in their research fields, with a brief interview of their unique perspectives and insightful views as authors.

TCR 2024 Annual Report

Greetings from the Editorial Office of TCR!

We are pleased to share the 2024 Annual Report of Translational Cancer Research. 2024 has seen much progress for TCR. We hope 2025 will bring greater things to TCR. We would like to thank you for your support and assistance in improving the journal over the past year, and we certainly look forward to your innovations and contributions in 2025.

We would especially like to express our sincere gratitude to the editorial board members, guest editors, reviewers, authors, and readers for all your support and contributions to TCR. We wish you a happy, healthy and prosperous 2025!

Interviews with Editorial Board Members

TCR features a distinguished editorial board, the members of which continue to instill the power of their expertise for the journal’s development. By launching this column, we are glad to introduce to you some of them in the form of interviews, in which they will share their unique career experiences and perspectives. We believe their insights will shed light on the knowledge of related fields.

Interviews with Guest Editors

Over the years, a number of TCR guest editors have made valuable contributions to the journal. This column features interviews with our guest editors, who graciously share their experience in scientific careers and provide insightful perspectives on the special series.

Ferroptosis and cuproptosis prognostic signature for prediction of prognosis, immunotherapy and drug sensitivity in hepatocellular carcinoma: development and validation based on TCGA and ICGC databases

Identification of differentially expressed genes. (A) Heatmap revealed differentially expressed genes; (B) univariate Cox regression analysis; (C) a protein-protein interaction network showing the relationship between ferroptosis-related genes and cuproptosis-related genes.

Bartholin’s gland carcinoma—the diagnostic and management challenges of a rare malignancy—a case report and review of current literature

FDG-avid right inguinal lymph node on axial CT-PET. The green arrow: FDG-avid right inguinal lymph node on axial CT-PET. FDG, fluorodeoxyglucose; CT-PET, computed tomography-positron-emission tomography.

Development of a novel angiogenesis-related lncRNA signature to predict the prognosis and immunotherapy of glioblastoma multiforme

Differences in risk scores for clinical characteristics. (A-D) The correlations between the risk score and sex, age, MGMT status, and IDH1 status were not significant (P>0.05). (E) Among the subtypes, the proneural subtypes had a significantly lower risk score than did the mesenchymal subtypes (P<0.05). **, P<0.01. IDH1, isocitrate dehydrogenase 1; MGMT, O6-methylguanine-DNA methyltransferase; ns, no significance.

Integrated analysis of single-cell and bulk transcriptome identifies a signature based on NK cell marker genes to predict prognosis and therapeutic response in clear cell renal cell carcinoma

Single-cell sequencing analysis of 20,074 cells from 7 ccRCC samples. (A) Pearson’s correlation between nFeature and nCount. (B) PCA plot colored by different samples. (C) Cells were classified into 25 clusters via UMAP algorithm. (D) Eight cell types were identified and annotated by marker genes. (E) Heatmap visualized top 5 marker genes among 8 cell clusters. (F) Visualization of gene expression in cell clusters. PC, principal component; UMAP, uniform manifold approximation and projection; NK, nature killer; ccRCC, clear cell renal cell carcinoma; PCA, principal component analysis.

Development and validation of nomograms to predict early death in non-small cell lung cancer patients with brain metastasis: a retrospective study in the SEER database

ROC curves for the nomograms of the all-cause early death and the cancer-specific early death in the training cohort (A,B) as well as in the validation cohort (C,D). ROC, receiver operating characteristic; AUC, area under the curve.

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Vol 14, No 11 (November, 2025)

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Announcement more

Join us at the 9th World Congress of Pediatric Cardiology & Cardiac Surgery

The 9th World Congress of Pediatric Cardiology & Cardiac Surgery (WCPCCS) is going to be held at the Hong Kong Convention and Exhibition Centre, Hong Kong, China from December 7 to... More >>

AME and Wolters Kluwer aim to expand access to global medical research through new collaboration

The agreement broadens the reach of nearly 50 Open Access titles, contributing globally to over 5,000 articles More >>

New Impact Factor for Translational Cancer Research: 1.7

We are pleased to announce that Translational Cancer Research (TCR) has attained its latest impact factor update for the 2024 citation year: 1.7. More >>

Editorial Commentary

Combining anti-metabolic treatments with the repurposing of eribulin for glioblastoma: a clinical opportunity?

Étienne Audet-Walsh, Lucas Galey, Samuele Renzi, Nadine Morin, Samer M. I. Hussein, Maxime Richer, Marc-Étienne Huot

PDF Pages: 7463-7466 Full Text (56) Peer Review File COI Form Open Access

Chemotherapy-free combination strategies in recurrent platinum-resistant ovarian cancer: promise, evidence and perspectives

Pauline Corbaux, Gilles Freyer

PDF Pages: 7467-7471 Full Text (46) COI Form Open Access

Translating NSABP B-51 findings into practice: rethinking regional nodal irradiation in breast cancer

Kefah Mokbel, Muharrem Oner

PDF Pages: 7472-7477 Full Text (392) Peer Review File COI Form Open Access

Racial disparities in ovarian cancer survival transcend the somatic mutational landscape

Robert D. Morgan, George J. Burghel

PDF Pages: 7478-7479 Full Text (35) COI Form Open Access

Original Article

Sorting nexin 9 expression and prognostic implications in lung adenocarcinoma: integrative bioinformatic and in vitro validation

Weidi Liu, Yichen Yin, Baozhen Wang, Tao Li, Jing Chen

PDF Pages: 7480-7493 Full Text (84) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Machine learning prediction of overall survival in patients with primary gastrointestinal melanoma

Fuli Gao, Xiaodan Xu

PDF Pages: 7494-7506 Full Text (64) Reporting Checklist Peer Review File COI Form Open Access

LINC02081 as an oncogene promotes cell proliferation and G2/M cycle through p53 signaling pathway in lung adenocarcinoma

Lizhong Zeng, Haimei Wen, Tong Jiao, Ting Jiao, Qiuhong Zhang, Meijuan Han, Yang Chen, Shuanying Yang

PDF Pages: 7507-7520 Full Text (70) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

A novel pyridazinone and thiophene compound IMB5043 activated apoptosis and autophagy in cisplatin-resistant non-small cell lung cancer cells

Yingzheng Hou, Xueting Cao, Rui Cao, Hongmei Tang, Jing Chen

PDF Pages: 7521-7535 Full Text (40) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Ubiquitin-conjugating enzyme E2S serves as a prognostic marker for skin cutaneous melanoma

Guojun Du, Lei Li, Yunhui Jiang, Peipei Yang, Ganglin Xu

PDF Pages: 7536-7549 Full Text (37) Reporting Checklist Peer Review File COI Form Open Access

Clinical characteristics and prognosis of elderly patients with gastric gastrointestinal stromal tumors: a population-based study

Qian Xu, Mingxia Xia, Yiling Ni, Xiao Xu, Zhenguo Qiao, Li Zhou

PDF Pages: 7550-7562 Full Text (39) Reporting Checklist Peer Review File COI Form Open Access

Thermal ablation versus surgical resection for colorectal liver metastases: a Grading of Recommendations, Assessment, Development, and Evaluation (GRADE)-assessed systematic review, survival meta-analysis, and meta-regression

Muhammad Ansab, Sepideh Razi, Shree Rath, Umama Alam, Noor Ul Huda Ramzan, Muhammad Burhan, Asad Iqbal, Anwaar Saeed

PDF Pages: 7563-7579 Full Text (56) Reporting Checklist Peer Review File COI Form Open Access

PM2.5 promotes non-small cell lung cancer tumorigenesis by miR-21-5p targeting PDE4DIP accumulated

Yan-Jun Lin, Yuan-Hao Wu, Jingqing Ma, Lu Fang, Bo Liu, Shu Meng

PDF Pages: 7580-7597 Full Text (32) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

ZBTB7B modulates the androgen receptor as an upstream regulator via colocalization and direct binding in LNCaP prostate cancer cells

Eunji Im, Su-Yeon Park, Deok-Yong Sim, Ah Reum Cho, Bum Ju Kil, Bonglee Kim, Bum-Sang Shim, Sung-Hoon Kim

PDF Pages: 7598-7610 Full Text (43) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Prognostic characteristics and recurrence patterns of grade 1 endometrial carcinoma: a large retrospective analysis of a tertiary center

Negin Sadeghi, Jacopo Conforti, Andreas Zouridis, Ammara Kashif, Ahmed Darwish, Sarah Louise Smyth, Alisha Sattar, Susan Addley, Christina Pappa, Stephen Damato, Mostafa Abdalla, Sean Kehoe, Federico Ferrari, Hooman Soleymani majd

PDF Pages: 7611-7620 Full Text (71) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Neutrophil depletion dampens inflammation and enhances CD8⁺ T cell effect on tumor control but undermines anti-PD-1 therapy

Maike Zheng, He Chang, Shuqin Li, Chaohong Wang, Sibo Long, Yongqiang Wang, Tongmei Zhang, Guirong Wang, Yu Wang, Yan Zhao

PDF Pages: 7621-7640 Full Text (41) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Curcumin induces ferroptosis in hepatocellular carcinoma by regulating PERK/Nrf2/HO-1 signaling pathway

Cheng Yuan, Ruiwen Liu, Xinming Xu, Jun Sun, Yi Zhu, Rongzhu Lu, Yueyu Liu, Jian Chen

PDF Pages: 7641-7653 Full Text (43) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Clinical characteristics and long-term prognosis of primary mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma in the small intestine

Jiayi Ding, Luojie Liu, Ye Ye

PDF Pages: 7654-7668 Full Text (35) Reporting Checklist Peer Review File COI Form Open Access

Genetic insights into colorectal cancer pathogenesis: a multi-omics and immunity perspective

Shengyi Zhou, Xinyi Zhang, Shiwen Wang, Yunfan Zhou, Yizhou Sun

PDF Pages: 7669-7685 Full Text (36) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Development and validation of a pathomics model to predict SOX11 expression and prognosis in hepatocellular carcinoma

Shuna Liu, Yuhui Cai, Boping Zhou

PDF Pages: 7686-7699 Full Text (36) Reporting Checklist Peer Review File COI Form Open Access

Causal relationship between hypertension and cancer: a two‐sample bidirectional Mendelian randomization study

Chenggong Zeng, Juanhua Zhu, Yan Mao, Xi Zhen, Zhiqing Wei, Zijun Zhen

PDF Pages: 7700-7711 Full Text (45) Reporting Checklist Peer Review File COI Form Open Access

Risk factors for refractory malignant pleural effusion and the impact on prognosis in non-small cell lung cancer patients with advanced EGFR mutations: a retrospective cohort study using propensity score matching

Heng-Ning Lian, Guang-Qing Shi, Huan Wang, Zhen-Yan Wu, Li-Jie Ma, Zhen-Liang Xiao, Jing Zhou

PDF Pages: 7712-7724 Full Text (28) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

A new combined prognostic model involving SLC44A4 improves the predictive ability for colorectal cancer patients

Panyuan Li, Xiaoqing Cheng, Yanchuang Wu, Guoxiang Fu, Jia Zhu, Caixia Sheng, Xiaotong Hu, Zhinong Jiang

PDF Pages: 7725-7740 Full Text (71) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Impact of single-site distant metastases on prognosis in advanced ovarian cancer: a Surveillance, Epidemiology, and End Results population-based study

Zhanna Yuan, Peiqin Shi, Wenwen Zhang, Pengpeng Qu

PDF Pages: 7741-7757 Full Text (30) Reporting Checklist Peer Review File COI Form Open Access

Identification and prognostic assessment of clonal and functional heterogeneity in head and neck squamous cell carcinoma

Yibo Guo, Xiuyin Wu, Yi Xu, Yu Zhang, Zheqi Liu, Tong Ji, Jie Hao, Yang Wang

PDF Pages: 7758-7772 Full Text (29) Reporting Checklist Peer Review File COI Form Open Access

Clinicopathological characteristics and long-term prognosis of duodenal signet ring cell carcinoma: a SEER-based analysis

Jiayi Ding, Ye Ye, Luojie Liu

PDF Pages: 7773-7789 Full Text (44) Reporting Checklist Peer Review File COI Form Open Access

Dietary restriction-responsive genes define prognostic subtypes and predict metastasis in colorectal cancer

Qibin Li, Zengtao Wang, Jinyi Long, Ziyang Xu, Jie Zhang

PDF Pages: 7790-7809 Full Text (42) Reporting Checklist Peer Review File COI Form Open Access

ING5-mediated regulation of lung cancer progression via the OIP5-AS1/miR-381-3p/SEC24A axis

Wenxi Cui, Qihao Wang, Xin Gongsun, Junfeng Bai, Yisong Li, Yanda Zhang, Kai Cui

PDF Pages: 7810-7823 Full Text (34) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Bioinformatics-based multi-omics and machine learning analysis identifies stemness-associated molecular subtypes and a prognostic index in breast cancer

Yan-Yu Hou, Wen-Jia Chen, Yang-Zheng Lan, Hua-Tao Wu, Jing Liu

PDF Pages: 7824-7846 Full Text (41) Reporting Checklist Peer Review File COI Form Open Access

MCRS1 is associated with immunosuppressive microenvironments in pan-cancer and promotes hepatocellular carcinoma malignant phenotypes

Qiang Wang, Yuntao Ye, Mengyu Zhang, Bo Li

PDF Pages: 7847-7869 Full Text (54) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Expression and role of PD-L1 and SOX10 in hepatocellular carcinoma

Byoung Chan So, Han Ju Park, Kyoung Min Kim, Ho Sung Park, Kyu Yun Jang, Myoung Ja Chung, Woo Sung Moon, Jae Do Yang, Ae Ri Ahn

PDF Pages: 7870-7880 Full Text (44) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Developing of potential mRNA vaccines based on tumor antigens and immune subtypes of esophageal cancer

Zewei Zhang, Jixiang Hou, Yingxue Wang, Ying Jiang, Wenjuan Wang, Juan Zhao, Gaowa Jin, Lei Zhao, Quanfu Li

PDF Pages: 7881-7902 Full Text (33) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

The influence of tumor location on the onset of endocrine deficits in pediatric brain tumor survivors

Giorgio Attinà, Alberto Romano, Palma Maurizi, Tommaso Verdolotti, Stefano Mastrangelo, Antonio Ruggiero

PDF Pages: 7903-7911 Full Text (28) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Prediction of postoperative survival in patients with head and neck acinic cell carcinoma: a population-based study

Silin Zhang, Weiping Wang, Sa Chen, Xiaowu Huang, Yu Chen, Xiangmin Zhang, Danyi Du

PDF Pages: 7912-7925 Full Text (29) Reporting Checklist Peer Review File COI Form Open Access

Evaluation of nomogram prediction model for postoperative deep vein thrombosis in patients with non-small cell lung cancer

Pengyu Ji, Zhenping Guo, Yong Wang, Hui Wang, Chun Yin

PDF Pages: 7926-7937 Full Text (36) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

NFATc1 activates the Ras/Raf/p38 MAPK pathway to promote the progression of lung adenocarcinoma

Aijuan Sun, Jiayu Yang, Yanhua Chang, Shudong Yang

PDF Pages: 7938-7953 Full Text (39) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Association between cholecystectomy and colorectal cancer: results from the National Health and Nutrition Examination Survey (NHANES) 2017–2023 and Mendelian randomization analyses

Shunchen Zhou, Bosen Zhao, Jiaying Qu, Xingyu Gao, Xiaolin Wang, Chunhui Yang, Qiangsong Tong, Liduan Zheng

PDF Pages: 7954-7966 Full Text (34) Reporting Checklist Peer Review File COI Form Open Access

Development and validation of a delta ultrasomics model for predicting treatment response to neoadjuvant chemotherapy in breast cancer

Zhenhu Lin, Meijuan Zheng, Zhiyong Li, Zhenyan Fang, Huiping Zhang, Xiaoqing Fan, Huanrong Cao, Rongxi Liang

PDF Pages: 7967-7979 Full Text (27) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Significance of the association between hypoxia and pyroptosis-related genes in the prognostic prediction of glioblastoma: insights from model construction and validation

Qiang Chen, Helan Yuan, Weilong Huang, Huichen Li, Yuqing Liao, Qiuhua Jiang, Dong Wang

PDF Pages: 7980-7994 Full Text (34) Reporting Checklist Peer Review File COI Form Open Access

Identification of the key gene for hepatocellular carcinoma based on bioinformatics and machine learning and experimental verification

Jin Lu, Junjie Ma, Can Yu, Shaoyang Lu, Xueying Zhao, Lei Zhang

PDF Pages: 7995-8011 Full Text (57) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

SAMD4B: a novel prognostic biomarker of endometrial carcinoma

Changmin Shin, Tae-Kyu Jang, Changho Song

PDF Pages: 8012-8021 Full Text (38) Reporting Checklist Peer Review File COI Form Open Access

Circulating tumor cells as a recurrence risk marker in glioma: a retrospective study

Xiangqi Huang, Jingrui Guo, Yongmei Cui, Jing Liang, Na Cheng, Yiwang Zhang, Dan He

PDF Pages: 8022-8031 Full Text (25) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Fatty acid metabolism-related signature suggests an oncogenic role of FASN in cervical cancer

Qinli Yang, Jing Zhang, Xiujuan Shang, Bohao Sun, Tong Wang, Yichen Wu, Chunhong Zhu, Wenqing Xiang, Hao Wang

PDF Pages: 8032-8054 Full Text (75) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Application value of a prognostic risk model based on lactate-related genes in non-small cell lung cancer

Jinhua Bao, Jun Gu, Tanao Ji

PDF Pages: 8055-8069 Full Text (38) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Uridine-cytidine kinase 2 as a novel potential prognostic and therapeutic biomarker in gastric cancer

Weilin Sun, Hui Guo, Mingzhi Cai, Gang Ma, Li Zhang, Yang Yu, Hongjie Zhan

PDF Pages: 8070-8085 Full Text (34) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Engineered macrophages accumulate in solid tumors and locally deliver immune-activating proteins to inhibit tumor progression

Yan Xu, Yang Zhou, Jiahe Wang

PDF Pages: 8086-8104 Full Text (30) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Association of the aggregate index of systemic inflammation in cancer survivors with all-cause, cardiovascular, and cancer- related mortality

Yajing Dong, Haiyi Guo, Jie Guo, Lei Sun, Sai Wen, Mingming Guo, Shanshan Fu, Linna Xiao

PDF Pages: 8105-8118 Full Text (34) Reporting Checklist Peer Review File COI Form Open Access

Clinical efficacy and safety of pyrotinib as the first-line treatment of HER2-positive advanced breast cancer in Xinjiang Uygur Autonomous Region of China

Qi Xiao, Dan Liu, Li Li, Zhenhui Zhao, Yan Li, Xiaoping Ma, Bingyu Li, Xiner Zhang, Bing Zhao

PDF Pages: 8119-8131 Full Text (26) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Prognostic potential of N6-methyladenosine methylation-associated genes in lung adenocarcinoma

Yuhan Lei, Jian Wang

PDF Pages: 8132-8141 Full Text (33) Reporting Checklist Peer Review File COI Form Open Access

Review Article

Combination immunotherapy in Japanese patients with advanced renal cell carcinoma: bridging gaps between clinical trials, real-world evidence, and the potential value of adverse events—a narrative review

Koji Iinuma, Masayuki Tomioka, Tomoki Taniguchi, Kota Kawase, Yuki Tobisawa, Keita Nakane, Takuya Koie

PDF Pages: 8142-8153 Full Text (25) Reporting Checklist Peer Review File COI Form Open Access

On the translational potential of atlases in precision oncology

Lucrezia Zorzi, Lucia Casella, Marco Dominietto, Enrico Capobianco

PDF Pages: 8154-8165 Full Text (45) Peer Review File COI Form Open Access

A narrative review of segmentectomy versus lobectomy in elderly patients with early-stage NSCLC: challenging the longstanding standard

Chanwoo Kim, Jae Yeon Kim, Se Eun Park, Sanghyun Han, Sujeong Kim, Dohun Kim

PDF Pages: 8166-8175 Full Text (47) Reporting Checklist Peer Review File COI Form Open Access

Advancing circular economy practices in radiography: a narrative review of sustainable medical imaging

Aanuoluwapo Clement David-Olawade, Oluwayomi B. Rotifa, James Ijiwade, Melissa McLaughlin, David B. Olawade, Stergios Boussios

PDF Pages: 8176-8200 Full Text (63) Reporting Checklist Peer Review File COI Form Open Access

Case Report

Long-term survival in a patient with leptomeningeal metastases from non-small cell lung cancer treated with stereotactic radiotherapy (SRT), programmed cell death protein 1 (PD-1) inhibitor, and granulocyte-macrophage colony-stimulating factor (GM-CSF): a case report

Jiale Huan, Chanchan Shan, Huifeng Gu, Yun Li, Weixiang Qi

PDF Pages: 8201-8209 Full Text (42) Reporting Checklist Peer Review File COI Form Open Access

Clinical case report on the efficacy and safety of savolitinib in elderly patients with non-small cell lung cancer harboring METex14 skipping mutations

Man Sun, Dan Zang, Huan Zhou, Jun Chen

PDF Pages: 8210-8217 Full Text (31) Reporting Checklist Peer Review File COI Form Open Access

Review Article

The management of brain necrosis as a result of SRS treatment for intra-cranial tumors

Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen

Published online: 28 August 2014

PDF Pages: 373-382 Full Text (130041) COI Form Open Access

Meta-Analysis

Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis

Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu

Published online: 05 March 2013

PDF Pages: 25-32 Full Text (77961) COI Form Open Access

Review Article

Common applications of next-generation sequencing technologies in genomic research

Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai

Published online: 05 March 2013

PDF Pages: 33-45 Full Text (68879) COI Form Open Access

Biological basis of IORT

Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects

Ithaisa Sologuren, Carlos Rodríguez-Gallego, Pedro Carlos Lara

Published online: 25 February 2014

PDF Pages: 18-31 Full Text (49040) COI Form Open Access

Original Article

Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review

Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi

Published online: 28 April 2017

PDF Pages: 354-365 Full Text (48626) COI Form Open Access

Review Articles

Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer

Deep Kwatra, Anand Venugopal, Shrikant Anant

Published online: 26 September 2013

PDF Pages: 330-342 Full Text (48340) COI Form Open Access

Review Articles

Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer

Rositsa Dueva, George Iliakis

Published online: 19 June 2013

PDF Pages: 163-177 Full Text (48112) COI Form Open Access

Editorial

Morphine, when used for treating patients with acute pancreatitis, could be more risky than previously suspected

Juan Iovanna, Maria Cecilia Mallmann

Published online: 24 October 2017

PDF Pages: S1166-S1168 Full Text (46844) COI Form Open Access

Review Article

Do alkaline phosphatases have great potential in the diagnosis, prognosis, and treatment of tumors?

Tingting Jiang, Qun Zeng, Jun He

Published online: 20 October 2023

PDF Pages: 2932-2945 Full Text (43690) Peer Review File COI Form Open Access

Review Article

EGFR first- and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients

Niki Karachaliou, Manuel Fernandez-Bruno, Jillian Wilhelmina Paulina Bracht, Rafael Rosell

Published online: 19 January 2019

PDF Pages: S23-S47 Full Text (40465) COI Form Open Access

Review Article

Cancer biomarker discovery and validation

Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida

Published online: 18 June 2015

PDF Pages: 256-269 Full Text (38443) COI Form Open Access

Review Articles

Tumor microenvironment and nanotherapeutics

Meenakshi Upreti, Amar Jyoti, Pallavi Sethi

Published online: 26 September 2013

PDF Pages: 309-319 Full Text (37726) COI Form Open Access

Biological basis of IORT

Cell and molecular response to IORT treatment

Luigi Minafra, Valentina Bravatà

Published online: 25 February 2014

PDF Pages: 32-47 Full Text (35975) COI Form Open Access

Editorial

The CROSS road in neoadjuvant therapy for esophageal cancer: long-term results of CROSS trial

Ian Wong, Simon Law

Published online: 29 September 2016

PDF Pages: S415-S419 Full Text (33010) COI Form Open Access

Review Articles

DNA damage tolerance: a double-edged sword guarding the genome

Gargi Ghosal, Junjie Chen

Published online: 19 June 2013

PDF Pages: 107-129 Full Text (30041) COI Form Open Access

Review Articles

DNA crosslinking damage and cancer - a tale of friend and foe

Yaling Huang, Lei Li

Published online: 19 June 2013

PDF Pages: 144-154 Full Text (29779) COI Form Open Access

Review Article

EGFR and HER2: is there a role in ovarian cancer?

Eleonora Teplinsky, Franco Muggia

Published online: 13 February 2015

PDF Pages: 107-117 Full Text (28947) COI Form Open Access

Review Article

Multiple keratoacanthoma centrifugum marginatum—a case report and systematic review

Yiman Wang, Wenling Zhao, Yueping Zeng, Li Li, Hongzhong Jin

Published online: 30 December 2018

PDF Pages: 1743-1747 Full Text (28984) COI Form Open Access

Review Article

Renal cell carcinoma: the search for a reliable biomarker

Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer

Published online: 30 June 2017

PDF Pages: 620-632 Full Text (28788) COI Form Open Access

Review Articles

MDM2 and MDMX: alone and together in regulation of p53

Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan

Published online: 01 August 2012

PDF Pages: 88-99 Full Text (28680) COI Form Open Access

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A recursively partitioned mixture model for clustering time-course gene expression data

Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman

Statistical strategies for microRNAseq batch effect reduction

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Defining functional changes in the brain caused by targeted stereotaxic radiosurgery

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Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA

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Identification of cancer mechanisms through computational systems modeling

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Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases

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Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines

Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden

Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer

Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park

How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis

Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao

Alcohol intake patterns for cancer and non-cancer individuals: a population study

Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng

Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial

Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura

Review Article

Integrative clustering methods for high-dimensional molecular data

Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley

Sparse principal component analysis in cancer research

Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen

An improved understanding of cancer genomics through massively parallel sequencing

Jamie K. Teer

Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications

Louis Dubeau

Cancer biomarker discovery and validation

Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida

The promise and challenge of ovarian cancer models

Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu

Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management

Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas

Exosomal lncRNAs as new players in cell-to-cell communication

Mihnea Dragomir, Baoqing Chen, George A. Calin

Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy

Souparno Bhattacharya, Aroumougame Asaithamby

Translational research in radiation-induced DNA damage signaling and repair

Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue

Genetically engineered mouse models for studying radiation biology

Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch

Renal cell carcinoma: the search for a reliable biomarker

Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer

Advances on immunotherapy in genitourinary and renal cell carcinoma

Gregory P. Botta, Eric Granowicz, Carrie Costantini

The role of novel immunotherapies in non-Hodgkin lymphoma

Allyson Pishko, Sunita D. Nasta

MDMX under stress: the MDMX-MDM2 complex as stress signals hub

Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan

Do p53 stress responses impact organismal aging?

Paul Hasty, Judith Campisi, Z. Dave Sharp

Pharmacological targeting of mutant p53

Samuel Kogan, Darren Carpizo

Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis

Michael I. Carr, Stephen N. Jones

Regulation of cytotoxic T-cell responses by p53 in cancer

Mitchell W. Braun, Tomoo Iwakuma

The IGF-1R/AKT pathway determines cell fate in response to p53

Lei Duan, Carl G. Maki

Intra molecular interactions in the regulation of p53 pathway

Jiandong Chen

TP53 mutations in epithelial ovarian cancer

Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu

Modulation of the p53 family network by RNA-binding proteins

Chris Lucchesi, Jin Zhang, Xinbin Chen

Radiomics in head and neck cancer: from exploration to application

Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller

Prostate cancer radiomics and the promise of radiogenomics

Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack

Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies

Wei Lu, Wengen Chen

The emerging field of radiomics in esophageal cancer: current evidence and future potential

Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin

Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire

Jung H. Suh, Julie D. Saba

Computational methods and opportunities for phosphorylation network medicine

Yian Ann Chen, Steven A. Eschrich

Editorial

Focusing in on radiation induced brain injury

M. Kerry O’Banion

Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic

Naomi Lomeli, Daniela A. Bota

Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma

David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright

New light on the pancreatic cyst conundrum

Nathan A. Berger

HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?

Andrew J. Scott, John C. Wilkinson

Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts

Kristopher A. Lyon, Jason H. Huang

Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4

Nan Ding, Qianzheng Zhu

Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?

Apar Gupta, Nisha Ohri, Bruce G. Haffty

Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents

Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi

CRISPR-based genetic interaction maps inform therapeutic strategies in cancer

Poornima Ramkumar, Martin Kampmann

Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study

Melin J. Khandekar, Rakesh Jain

The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin

Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed

Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer

Joanne P. Young, Timothy J. Price, Susan Parry

Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response

R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang

Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes

Theresa L. Whiteside

TIC10/ONC201—a potential therapeutic in glioblastoma

Georg Karpel-Massler, Markus D. Siegelin

IDH mutational status and the immune system in gliomas: a tale of two tumors?

Bryan D. Choi, William T. Curry

ONC201: a new treatment option being tested clinically for recurrent glioblastoma

Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry

When better still might not be good enough

Waldemar Debinski

Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy

Vincent C. O. Njar

Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28

Leonardo Chicaybam, Prasad S. Adusumilli

Exosome mediated phenotypic changes in lung cancer pathophysiology

Yoshihisa Shimada, John D. Minna

Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma

Aaron D. DeWard, Rebecca J. Critchley-Thorne

From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein

Felicia L. Lenzo, William G. Cance

New incriminating evidence against IGF2

Wen Ding, Lina A. Shehadeh

Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect

Paul Grippo, Ajay V. Maker

Branched chain amino acid metabolism and cancer: the importance of keeping things in context

Elizabeth M. Selwan, Aimee L. Edinger

RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver

Satomi Yamamoto, Tomoo Iwakuma

Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy

Michael J. Baine, Chi Lin

Rogue one: another faction of the Wnt empire implicated in assisting GBM progression

Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed

Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway

Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano

Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems

Li Tian, Ashley Chang, Marites P. Melancon

IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm

James P. White

Low-frequency ultrasound may improve drug penetration in colonic mucosa

Qiubing Chen, Bo Xiao, Didier Merlin

Dividing and conquering the variation among variants in EML4-ALK lung cancer

Trever G. Bivona

Unlocking the epigenetic code of T cell exhaustion

Jiazhu Wu, Huidong Shi

KDM1 links nuclear GSK3β to epigenetic alterations

Weijie Guo, Binhua P. Zhou

Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease

Deepa Rangachari, Daniel B. Costa

Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy

Bhagelu R. Achyut, Ali S. Arbab

Neuroendocrine differentiation in prostate cancer: key epigenetic players

Karishma Gupta, Sanjay Gupta

PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression

Kim A. Brogden, Shireen Vali, Taher Abbasi

Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy

Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias

The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies

Keith T. Schmidt, William D. Figg

Information-dense analysis for information-dense understanding

Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen

The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use

Angel Qin, Nithya Ramnath

Immune infiltration, glioma stratification, and therapeutic implications

Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher

Balancing redox stress: anchorage-independent growth requires reductive carboxylation

Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione

Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy

Fabiana Perna, Michel Sadelain

Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells

Alex J. Gooding, William P. Schiemann

Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?

Nathan A. Berger

Microtubule targeting agents in glioma

Anda-Alexandra Calinescu, Maria G. Castro

Moving molecular subtypes to the clinic in gastric cancer

Joseph Chao, Jeeyun Lee, Samuel J. Klempner

Intraoperative subtyping of lung adenocarcinoma: an unmet need

Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli

Emerging roles of FGF signaling in hepatocellular carcinoma

Nana Zheng, Wenyi Wei, Zhiwei Wang

Tregs, Helios and tumor immunity: the sun has not yet risen

Angela M. Thornton, Ethan M. Shevach

Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1

Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof

Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components

Brandon J. Manley, James J. Hsieh

Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer

Salma Kaochar, Nicholas Mitsiades

Letter to the Editor

Epigenetic regulation of PD-L1 expression and pancreatic cancer response to checkpoint immunotherapy

Chunwan Lu, Kebin Liu

Synthetic lethality vs. synthetic viability due to PARP1 and BRCA2 loss

Xia Ding, Shyam K. Sharan

Correspondence

Targeted attack: mechanisms by which ovarian cancers suppress the immune system

Irina V. Tiper, Tonya J. Webb

Brief Report

The impact of neighborhood disadvantage on health-related quality of life among African American and white cancer survivors

Chien-Ching Li, Alicia K. Matthews, Anjali Asthana, Raj C. Shah

Research Highlight

Butyrate consumption of differentiated colonocytes in the upper crypt promotes homeostatic proliferation of stem and progenitor cells near the crypt base

Scott J. Bultman

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike

Jeffrey J. Tosoian, Emmanuel S. Antonarakis

A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer

Sawsan Rashdan, David E. Gerber

MOAP-1, UBR5 and cisplatin resistance in ovarian cancer

Scott T. Eblen, Amber Bradley

Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer

Weimin Gao

The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)

Theresa L. Whiteside

[¹⁸F]-choline PET/CT as an imaging biomarker for primary liver cancers

Zhenghong Lee

Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best

Yoshio Yamaoka, David Y. Graham

JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function

Theodoros Karantanos, Vassiliki A. Boussiotis

Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer

Angel Qin, Gregory P. Kalemkerian

Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered

Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham

Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells

Praveen Kumar Vemula, Venkatakrishna Rao Jala

Helios—controller of Treg stability and function

Claire Chougnet, David Hildeman

Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation

Jon K. Obst, Marianne D. Sadar

Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase

Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird

Fat lure: adipocytes attract cancer cells out of the prostate

Alexandra M. Blee, Haojie Huang

Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers

Guoli Chen, Ming-Tseh Lin

Editorials

Into the eye of the storm: breast cancer’s somatic mutation landscape points to DNA damage and repair

Joanne Ngeow, Emily Nizialek, Charis Eng

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks

Apratim Mitra, Karl Pfeifer, Ki-Sun Park

The STAMPEDE trial: paradigm-changing data through innovative trial design

Bradley C. Carthon, Emmanuel S. Antonarakis

Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway

Derek B. Oien, Jeremy Chien, Nikki Cheng

Feed your gut with caution!

Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar

Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma

Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma

Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients

Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy

Reinhard W. Schulte, Andrew J. Wroe

Externally modulated theranostic nanoparticles

Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi

Intestinal stem cell injury and protection during cancer therapy

Jian Yu

Cancer stem cells in glioma: challenges and opportunities

Jialiang Wang, Yufang Ma, Michael K. Cooper

Tumor microenvironment and nanotherapeutics

Meenakshi Upreti, Amar Jyoti, Pallavi Sethi

Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury

Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou

Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis

Chang-Lung Lee, Jordan M. Blum, David G. Kirsch

DNA ligases as therapeutic targets

Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest

DNA damage tolerance: a double-edged sword guarding the genome

Gargi Ghosal, Junjie Chen

DNA double strand break repair via non-homologous end-joining

Anthony J. Davis, David J. Chen

DNA crosslinking damage and cancer - a tale of friend and foe

Yaling Huang, Lei Li

Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation

Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan

MDM2 and MDMX: alone and together in regulation of p53

Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan

Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase

Lijian Shao, Lixian Wu, Daohong Zhou

Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment

Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen

SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis

Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos

Normal tissue protection for improving radiotherapy: where are the Gaps?

Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman

Improving chemoradiotherapy with nanoparticle therapeutics

Michael Joseph Eblan, Andrew Zhuang Wang

Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization

Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn

Molecular mechanisms involved in tumor repopulation after radiotherapy

Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li

Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules

Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy

Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar

Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma

Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Below are the latest Translational Cancer Research articles published online ahead of print publication.

Original Article

Targeting the METTL3/PCNA axis with STM2457 overcomes cisplatin resistance in osteosarcoma

Hua Yu, Shaoxing Li, Jinwang Liu

Published online: 05 December 2025

Journal highlight more

Translational Cancer Research is an international, open access, peer-reviewed journal indexed in Scopus and Science Citation Index Expanded (SCIE), focusing on original, science-based researches on clinical, basic and translational aspects. It publishes laboratory studies of novel therapeutic interventions, clinical trials which evaluate new treatment paradigms for cancer, results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients and etc.