Home - Translational Cancer Research

Join us at the IASLC 2026 World Conference on Lung Cancer

The IASLC 2026 World Conference on Lung Cancer (WCLC) is going to be held in Seoul, Republic of Korea from September 12th to 15th, 2026: https://wclc.iaslc.org/

This year Translational Cancer Research (TCR), along with its sister journals and books published by AME Publishing Company, will be featured at this exciting academic event. We look forward to connecting with our authors, editorial board members, and readers on this exciting occasion. You are warmly invited to visit us at Booth 708. For your convenience, the official exhibition hall floor plan is available for reference.

We look forward to meeting you onsite!

New Impact Factor for Translational Cancer Research: 2.1

We are pleased to announce that Translational Cancer Research (TCR) has attained its latest impact factor update for the 2025 citation year: 2.1.

Translational Cancer Research 2025 CiteScore Released: 2.6

We are pleased to announce that the Translational Cancer Research (TCR) has achieved its 2025 CiteScore: 2.6. TCR ranks as follows across various categories: 275 out of 428 in Oncology, 184 out of 233 in Cancer Research, and 195 out of 361 in Radiology, Nuclear Medicine and Imaging. This milestone underscores our ongoing commitment to publishing impactful research in the field.

Visual Abstract

Visual abstracts, also called 'graphical abstracts' or 'infographics,' are images that summarize the essential information of manuscripts, providing an easily and expediently understood overview of study findings at a glance. They are eye-catching pictural representations that complement the written abstract and effectively convey information of research.

TCR 2025 Annual Report

Greetings from the Editorial Office of TCR!

We are pleased to share the 2025 Annual Report of Translational Cancer Research. We would like to thank you for your support and assistance in improving the journal over the past year, and we certainly look forward to your innovations and contributions in 2026.

We would especially like to express our sincere gratitude to the editorial board members, guest editors, reviewers, authors, and readers for all your support and contributions to TCR. We wish you a happy, healthy and prosperous 2026!

AME and Wolters Kluwer aim to expand access to global medical research through new collaboration

The agreement broadens the reach of nearly 50 Open Access titles, contributing globally to over 5,000 articles

October 2, 2025 — Wolters Kluwer Health announced a new collaboration with AME Publishing Company, an Open Access publisher specializing in medical journals and books, headquartered in Hong Kong, China.

Reviewer of the Month (2026)

In 2026, TCR reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

Interviews with Outstanding Authors (2026)

In 2026, many authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors who have been making immense efforts in their research fields, with a brief interview of their unique perspectives and insightful views as authors.

Interviews with Editorial Board Members

TCR features a distinguished editorial board, the members of which continue to instill the power of their expertise for the journal’s development. By launching this column, we are glad to introduce to you some of them in the form of interviews, in which they will share their unique career experiences and perspectives. We believe their insights will shed light on the knowledge of related fields.

Interviews with Guest Editors

Over the years, a number of TCR guest editors have made valuable contributions to the journal. This column features interviews with our guest editors, who graciously share their experience in scientific careers and provide insightful perspectives on the special series.

‹ ›

Vol 15, No 8 (August, 2026)

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Announcement more

Join us at the IASLC 2026 World Conference on Lung Cancer

The IASLC 2026 World Conference on Lung Cancer (WCLC) is going to be held in Seoul, Republic of Korea from September 12th to 15th, 2026: https://wclc.iaslc.org/ More >>

New Impact Factor for Translational Cancer Research: 2.1

We are pleased to announce that Translational Cancer Research (TCR) has attained its latest impact factor update for the 2025 citation year: 2.1. More >>

Translational Cancer Research 2025 CiteScore Released: 2.6

We are pleased to announce that the Translational Cancer Research (TCR) has achieved its 2025 CiteScore: 2.6. More >>

Original Article

PDZ-binding kinase promotes ovarian cancer cell proliferation and invasion via CCNB1 regulation

Guzhanuer Awuti, Jiapo Wang, Yun Lu, Haonan Jiang, Xiaoqing Guo

Translational Cancer Research

2026;

(8)

:571

(31 August 2026)

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Survival outcomes of postoperative radiotherapy and chemotherapy in early-stage cervical cancer: a Surveillance, Epidemiology, and End Results database-based stratified analysis

Changmei Weng, Yan Wang, Wenbin Chen, Shengchi Chen, Li Zou

Translational Cancer Research

2026;

(8)

:572

(31 August 2026)

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lncRNA JPX promotes radioresistance in nasopharyngeal carcinoma via the miR-1301-3p/PIK3R2-mediated autophagy pathway

Si Ouyang, Jingyao Lv, Yilong Wang, Yongjie Ying, Qiaozhi Jin

Translational Cancer Research

2026;

(8)

:573

(31 August 2026)

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Predicting the prognosis of small intestinal stromal tumors in the post-imatinib era: a study based on the SEER database

Ying Sun, Xia Ren, Xiaodan Xu, Luojie Liu

Translational Cancer Research

2026;

(8)

:574

(31 August 2026)

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Overexpression of TCF7L2 promotes the viability and migration of MHCC-97H human hepatocellular carcinoma cells by upregulating MT-ND4L

Rong Chen, Weijie Liu, Zilong Yang, Wei Hao, Ben Chen, Shuaixing Zhao, Longyi Zheng, Jin Lu

Translational Cancer Research

2026;

(8)

:575

(31 August 2026)

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Genetic insights into lung squamous cell carcinoma: how TP53 and CSMD3 co-mutations shape prognosis and immune response

Dongmei Han, Caihong Wu, Dan Wang, Yinan Dong, Hao Jin

Translational Cancer Research

2026;

(8)

:576

(31 August 2026)

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A three-gene radioresistance signature predicts tumor progression in cervical cancer

Hong Yu, Yuting Xiu, Fanxu Meng, Huan He, Yu Wang, Tengyu Liu, Zhicheng Wang, Zhuo Wang, Kangkang Zhao, Yunlong Wang, Zhishen Chen, Baosheng Sun

Translational Cancer Research

2026;

(8)

:577

(31 August 2026)

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Evaluation of the subtype-specific epigenetic prognostic association of HELLS in non-small cell lung cancer: integrated clinical and molecular insights

Yunha Lee, Junchae Lee, Jae-Hee Park, Jongwan Kim, Jae-Ho Lee

Translational Cancer Research

2026;

(8)

:578

(31 August 2026)

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The prognostic value and molecular mechanisms of Porphyromonas gingivalis infection-associated differentially expressed genes in oral squamous cell carcinoma

Qin Song, Youwen Zhang, Xiaodi Wu, Jiakuan Peng, Yihan Zhao, Yanjun Zhang, Xin Chen

Translational Cancer Research

2026;

(8)

:579

(31 August 2026)

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Prognostic and clinicopathologic significance of FGFR mRNA and protein overexpression in colorectal cancer: a systematic review and meta-analysis

Xinke Chai, Changsheng Li, Yuchen Luo, Qian Shen, Shifeng Wu, Qiulin Huang

Translational Cancer Research

2026;

(8)

:580

(31 August 2026)

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A cuproptosis-related lncRNAs-based risk signature for predicting prognosis and immune status in glioma

Xiangdong Lu, Siquan Zhu, Junzeng Si, Peng Qiu

Translational Cancer Research

2026;

(8)

:581

(31 August 2026)

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The risk factors and patterns for distant metastasis in early-stage cervical adenocarcinoma patients receiving radical surgery and adjuvant radiotherapy: the ATTRACT study

Jia-Wei Zhu, Xi-Lin Yang, Yun-Can Zhou, Yan You, Peng Peng, Hong-Nan Zhen, Xi Wang, Xin Lian, Jun-Fang Yan, Fu-Quan Zhang

Translational Cancer Research

2026;

(8)

:582

(31 August 2026)

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Development and internal validation of a prognostic nomogram for cancer-specific survival among elderly unresected colorectal cancer patients receiving chemotherapy: a retrospective SEER database study

Jinyi Xu, Wei Wang, Xiaoqiang Niu

Translational Cancer Research

2026;

(8)

:583

(31 August 2026)

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SERPINE1-centric inflammatory signature associates with treatment resistance and survival in laryngeal squamous cell carcinoma

Jin Peng, Weiquan Ding, Qingxuan Niu, Wuguo Deng, Fei Lin, Ankui Yang

Translational Cancer Research

2026;

(8)

:584

(31 August 2026)

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Microplastics and nanoplastics-related genes signature predicts prognosis in pancreatic ductal adenocarcinoma and functional validation of interleukin 1 alpha

Gennian Wang, Hua Cheng, Yaping Zhang, Xiaohu Guo, Yumin Li

Translational Cancer Research

2026;

(8)

:585

(31 August 2026)

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Development and internal validation of a six-gene prognostic model based on galactose metabolism for overall survival in lung adenocarcinoma

Feng Zhang, Jian Fu, Xuxu Cui, Xutong Gao, Yanxia Kang

Translational Cancer Research

2026;

(8)

:586

(31 August 2026)

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Development and internal validation of dual overall and cancer-specific survival nomograms for primary spinal and sacropelvic Ewing sarcoma: a population-based study of 346 patients

Haoyu Wang, Zhenyu Shao, Ping Tang, Guanghao Li

Translational Cancer Research

2026;

(8)

:587

(31 August 2026)

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Combined multi-omics profiling and machine learning analysis reveals that Bregs and RPS2 promote bone metastasis in nasopharyngeal carcinoma

Kaifan Yang, Jinye Zhang, Xinyuan Mao, Xintong Chen, Jiandang Huang, Kainan Xie, Xiaoyi Lin, Xin Zhou, Bin Yu, Liang Zhao, Yanling Lin

Translational Cancer Research

2026;

(8)

:588

(31 August 2026)

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Clinical evaluation of low-dose radiation therapy for immunotherapy resistance in advanced non-small cell lung cancer

Dong-Jing Fu, Gao-Wa Daleng, Wen-Juan Wang, Jia-Li Gao, Gao-Wa Wuyun, Ya-Long Han, Dan Tian, Shu-Qin Deng, Quan-Fu Li

Translational Cancer Research

2026;

(8)

:589

(31 August 2026)

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Ultrasound features and clinicopathologic correlations of breast adenoid cystic carcinoma: a retrospective observational study

Jie Chen, Huang Chen

Translational Cancer Research

2026;

(8)

:590

(31 August 2026)

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Midkine restrains T-cell mediated anti-tumor immunity by suppressing macrophage M1 polarization in lung adenocarcinoma

Ting Qian, Zijian Sun, Xin Wang, Yan Sun

Translational Cancer Research

2026;

(8)

:591

(31 August 2026)

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Postoperative radiotherapy or chemoradiotherapy versus surgery only in non-metastatic head and neck adenoid cystic carcinoma: a retrospective analysis

Jinzi Liang, Shuhan Zhao, Alejandro Andree Alcas-Villena, Wenjing Wang, Chao Wan, Xixi Liu, Lu Wen

Translational Cancer Research

2026;

(8)

:592

(31 August 2026)

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CEBPG demonstrates oncogene functions and modulates the expression of genes involved in cervical cancer related pathways

Tingting Qi, Jing Yang, Guzhalinuer Abulizi

Translational Cancer Research

2026;

(8)

:593

(31 August 2026)

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Association between the systemic immune-inflammation index and overall survival in patients with leukemia: a multicenter cohort study

Yiyang Chen, Muchen Ren, Sihui Liu, Tianyi Wang, Heyang Zhang, Junju He, Hanping Shi

Translational Cancer Research

2026;

(8)

:594

(31 August 2026)

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Intratumoral and peritumoral-based radiomics for assessment of lymphovascular invasion in invasive breast cancer: model development and validation

Jiale Li, Di Zhang, Xukai Yang, Dalin Zhu, Xiaoxia Zheng, Yanlong Wang

Translational Cancer Research

2026;

(8)

:595

(31 August 2026)

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The role of KIAA1467 in breast cancer: insights from pan-cancer and single-cell sequencing analysis

Shichen Miao, Xiaoyin Sun, Xiao Wang, Qichao Ni, Weiguo Mao, Zhigang Zhuang, Jun Fang

Translational Cancer Research

2026;

(8)

:596

(31 August 2026)

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Development and internal validation of a nomogram for predicting neoadjuvant therapy efficacy in breast cancer based on the HALP score

Jianping Long, Xiaoke Chai, Tao Zhang, Chongyi Wei, Tao Yang, Haicun Zhou, Xiufen Ma

Translational Cancer Research

2026;

(8)

:597

(31 August 2026)

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Development of m6A-related prognostic models for survival in lung squamous cell carcinoma with different PD-L1 expression levels

Zonghui He, Xinjie Zhao, Guanghui Wang, Fenglong Bie

Translational Cancer Research

2026;

(8)

:598

(31 August 2026)

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CST2 promotes melanoma malignant phenotypes through the IL-6-STAT3-NF-κB signaling axis

Lei Zhao, Jinhua Yan

Translational Cancer Research

2026;

(8)

:599

(31 August 2026)

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Anti-lipid peroxidation restores Schwann cell repair phenotype and attenuates PNI-like behavior in oral squamous cell carcinoma

Jing Long, Youzhi Wang, Mengqi Zou, Gangyong Jiang, Zhongwei Jiang, Wanxiao Peng

Translational Cancer Research

2026;

(8)

:600

(31 August 2026)

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Circulating tumor DNA clearance as a trial-level early efficacy signal in solid tumors: a systematic review and meta-analysis of randomized trials

Sirui Tang, Yujie Chen, Zhonghou Wang, Huiran Zang

Translational Cancer Research

2026;

(8)

:601

(31 August 2026)

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Global research trends in fecal microbiota transplantation combined with immune checkpoint inhibitors for cancer immunotherapy: a bibliometric analysis

Yingying Hu, Maher Hendi, Lijun Du, Xueqin Chen

Translational Cancer Research

2026;

(8)

:602

(31 August 2026)

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In vitro and in vivo studies on the impact of the familial adenomatous polyposis heterogeneous mutation MUC20-S671C on colorectal carcinogenesis and progression

Li Yan, Xinyu He, Ting Li, Ruobing Chen, Jun Yang, Weiqing Liu

Translational Cancer Research

2026;

(8)

:603

(31 August 2026)

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A machine learning-derived intratumoral heterogeneity-related signature predicts the prognosis for and therapeutic response in patients with skin cutaneous melanoma

Feng Ding, Wei Tian, Sarina Bai, Hongmei Jia, Ziying Zhang, Yuchen Jia, Fangxin Zhao, Xingxia Hao, Bing Yi, Lili Niu, Shaojie Zhang

Translational Cancer Research

2026;

(8)

:604

(31 August 2026)

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Efficacy and safety of PD-1/PD-L1 inhibitors plus chemotherapy versus chemotherapy alone in stage IIIB–IV squamous non-small cell lung cancer: a systematic review and meta-analysis of phase 3 randomized controlled trials

Chaolin Pan, Runqi Zhang, Yongshan Niu, Wenxiong Zhang, Maolan Cai

Translational Cancer Research

2026;

(8)

:605

(31 August 2026)

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Pan-cancer characterization of HMGA1 reveals its oncogenic role in tumor microenvironment and stemness: functional validation in pancreatic cancer migration and invasion

Huan Liu, Shiyang Dai, Chaoxiang Lv, Mingming Deng, Xiaopan Zou, Xiaoling Li

Translational Cancer Research

2026;

(8)

:606

(31 August 2026)

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Mitochondria related gene signature serves as prognosis prediction and risk stratification of cholangiocarcinoma

Shenji Li, Wei Xiang, Wei Wei, Hongrong Zhang, Qianyu Xie, Bo Yin, Hongsheng Lin, Shunchi Xu

Translational Cancer Research

2026;

(8)

:607

(31 August 2026)

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STC1 is associated with tumor progression and suppressive niches in laryngeal squamous cell carcinoma

Xiaoxue Chen, Wenjing Li, Yiyao Liu, Lei Zhang, Zhigang Zhao, Yue Wang, Linli Tian

Translational Cancer Research

2026;

(8)

:608

(31 August 2026)

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miR-27b-5p targets RAB27A to regulate exosome secretion and migration of pancreatic cancer cells

Mengxiang Huang, Jie Ji, Ronghua Wang, Yan Kong, Dandan Jin, Junpeng Zhao, Tong Wu, Xuebing Xu, Xudong Xie, Yujie Jiao, Haiou Yan, Mingbing Xiao, Xiaogang Hu

Translational Cancer Research

2026;

(8)

:609

(31 August 2026)

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Global hotspots and trends of stereotactic radiotherapy for pancreatic cancer: a bibliometric analysis and visual analysis from 2015 to 2025

Xiaoqin Huang, Ke Yuan, Yunfei Li, Wen-Qiong Ma

Translational Cancer Research

2026;

(8)

:610

(31 August 2026)

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A model of cellular proliferation and mitochondrial biogenesis predicts prognosis and immunotherapy response in lung adenocarcinoma

Mi Zou, Guangda Zheng, Yanju Bao

Translational Cancer Research

2026;

(8)

:611

(31 August 2026)

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Constructing an in vitro choriocarcinoma model by three-dimensional bioprinting

Ying-Chao Hu, Ming-Hao Sun, Hua Li, Chang-Can Li

Translational Cancer Research

2026;

(8)

:612

(31 August 2026)

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Identification of a novel signature for prognostic stratification and integrative analyses in lung adenocarcinoma

Haoran Li, Peijun Cao, Jialong Li, Peiyu Wang, Ying Yi

Translational Cancer Research

2026;

(8)

:613

(31 August 2026)

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RECQL correlates with immune infiltration and serves as a prognostic biomarker and therapeutic predictor in gastric cancer

Tana Lin, Lu Wang, Xin Wang, Haiqing Hu, Ying Li

Translational Cancer Research

2026;

(8)

:614

(31 August 2026)

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Akkermansia muciniphila attenuates apatinib resistance in hepatocellular carcinoma through NF-κB-mediated reprogramming of tumor-associated macrophages

Xiaoxiao He, Hongying Gan, Fan Wu, Yijie Wang, Heng Zhang

Translational Cancer Research

2026;

(8)

:615

(31 August 2026)

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Single-cell transcriptomic analysis identifies decreased CEBPB and PAX8 expression associated with immune landscape differences between medullary and papillary thyroid carcinoma

Xiu Chen, Linhong Jiang, Yan Si, Wei Chen, Shu Song, Zan Fu, Shanliang Zhong, Heda Zhang

Translational Cancer Research

2026;

(8)

:616

(31 August 2026)

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Bone marrow mesenchymal stem cell-derived exosomal miR-93-5p suppresses esophageal squamous cell carcinoma progression and immune escape through targeting PD-L1

Wenbin Chen, Fangfang Fan, Renliang Fan, Guiju Kong, Yan Wang, Li Zou, Shizhen Wu

Translational Cancer Research

2026;

(8)

:617

(31 August 2026)

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Investigating the mechanisms of PhIP-induced colorectal cancer through network toxicology, machine learning, and molecular dynamics simulation

Yuqi Gao, Qian Ye, Yunhuan Zhen, Yan Wang, Yi Wang, Yuping Zeng, Xiaoqin Liu, Xiaoru Zhou, Weiwei Chen

Translational Cancer Research

2026;

(8)

:618

(31 August 2026)

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Association between primary tumor surgery and survival in patients with de novo stage IV triple-negative breast cancer with visceral metastases: a SEER-based propensity score-matched study

Ruizhe Yue, Zheng Wang, Hao Zhang

Translational Cancer Research

2026;

(8)

:619

(31 August 2026)

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Integrative analysis of single-cell sequencing identifies CD8⁺ TIM3⁺ CD101⁺ T cell-associated genes as prognostic biomarkers in breast cancer

Xuran Zhang, Runfang Gao

Translational Cancer Research

2026;

(8)

:620

(31 August 2026)

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A study on the mechanism of action of B7H4 in HER2-positive gastric cancer and its sensitivity to trastuzumab therapy

Qiangzu Shao, Fan Zhang, Wenjie Wang, Zeping Huang

Translational Cancer Research

2026;

(8)

:621

(31 August 2026)

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Potential benefits of local radiotherapy in addition to adjuvant chemotherapy in female patients with triple-negative breast cancer in the absence of distant metastases: a SEER database analysis

Shubing Jia, Ningfeng Zhang, Haohang Luo, Long Yang, Yina Liang, Jiajing Ma, Fuhai Hui, Rongwu Xiang, Mingyi Zhao, Jingyu Yang

Translational Cancer Research

2026;

(8)

:622

(31 August 2026)

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Machine learning-based prediction of survival in breast cancer patients with lung metastasis: a SEER-based study

Cairong Wu, Guantong Liu, Haijie Xu, Hongguang Liu, Hansheng Wu

Translational Cancer Research

2026;

(8)

:623

(31 August 2026)

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Predictive value of baseline risk factors and early prostate-specific antigen (PSA) kinetics for achieving deep PSA decline in metastatic hormone-sensitive prostate cancer: implications for treatment intensification

Peimin Zhou, Zichuan Han, Yichuan Wang, Rui Yang, Wei Yu

Translational Cancer Research

2026;

(8)

:624

(31 August 2026)

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Epigallocatechin gallate is associated with PDGFRB downregulation and altered PI3K-AKT signaling in gastric cancer

Yubo Zhao, Yuhang Li, Hongqun Zheng

Translational Cancer Research

2026;

(8)

:625

(31 August 2026)

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PSMB8: an immune-related prognostic marker for low-grade gliomas

Xinyu Yang, Zhuofan Li, Luyang Xu, Waner Wei, Zewei Tu, Xiaoyan Long, Jia Liu, Jingying Li, Xingen Zhu

Translational Cancer Research

2026;

(8)

:626

(31 August 2026)

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Mechanism of miR-188-5p enhancing radioresistance in nasopharyngeal carcinoma by targeting PTEN to activate the PI3K/Akt signaling pathway

Fuming Zhou, Jia Wan, Haiyan Zhang, Feng Chen, Jin Wang, Yanli Yang, Huan Wang

Translational Cancer Research

2026;

(8)

:627

(31 August 2026)

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Combining Napsin A expression with circulating tumor cell counts for enhanced identification of pulmonary adenocarcinoma in ground-glass nodules

Suhong Ruan, Hongjie Yu, Zhenyuan Song, Xiang Zhu, Guangda Yuan, Hongya Xie, Chuanyu Zhang, Tengteng Wei

Translational Cancer Research

2026;

(8)

:628

(31 August 2026)

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Non-small cell lung cancer and tumor-educated platelets: screening of biomarkers and construction of a prognostic model

Yandong Zhao, Tianjun Tang, Jie Li, Linxuan Chen, Xin Gu, Qiaofeng Li

Translational Cancer Research

2026;

(8)

:629

(31 August 2026)

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Inflammation-coagulation biomarkers predict catheter-related thrombosis following peripherally inserted central catheter placement in patients with hematologic malignancies: a retrospective cohort study

Lifeng Zhang, Wen Gao, Xin Chang, Fengni Lu, Canyan Li, Chuting Yan, Qiuhui Lan, Jian Fang, Shan Zeng

Translational Cancer Research

2026;

(8)

:630

(31 August 2026)

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CircFN1 promotes invasion of papillary thyroid carcinoma cells by activating the PI3K/AKT pathway via the miR-29a/TRIB2 axis

Ning Zhang, Jingyan Zhang, Xiaonuo Wang, Ming Tao, Gongqi Li, Yanjiao Li, Qingyang Bai, Qiuting Wen

Translational Cancer Research

2026;

(8)

:631

(31 August 2026)

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Hypoxia-inducible factor-1α promotes the malignant progression of cervical cancer cells by regulating lactate dehydrogenase A-mediated glycolysis

Yafang Kang, Yuxuan Huang, Yanlin Chen, Kelvin Stefan Osafo, Leyi Huang, Yuanyuan Chen, Xiaodan Mao

Translational Cancer Research

2026;

(8)

:632

(31 August 2026)

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Distant lymph node metastasis in head and neck cancer: incidence, predictors, and survival outcomes in a population-based cohort

Jianlin Yue, Dayu Liu, Ruijie Sun, Huidong Zhang, Suyuan Sun

Translational Cancer Research

2026;

(8)

:633

(31 August 2026)

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Network toxicology and interpretable modeling identify nicotine-associated neuroendocrine targets and a three-gene prognostic signature in breast cancer

Junyan Weng, Caifeng Ou, Jiamin Yi, Huan Yang, Chiwei Chen, Mei Huang

Translational Cancer Research

2026;

(8)

:634

(31 August 2026)

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Kynurenine metabolism-related gene signature for prognostic stratification in hepatocellular carcinoma

Yurui Liu, Caixia Zhong, Mengshan Cai, Xianghua Lin, Ling Luo

Translational Cancer Research

2026;

(8)

:635

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Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease

Deepa Rangachari, Daniel B. Costa

Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy

Bhagelu R. Achyut, Ali S. Arbab

Neuroendocrine differentiation in prostate cancer: key epigenetic players

Karishma Gupta, Sanjay Gupta

PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression

Kim A. Brogden, Shireen Vali, Taher Abbasi

Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy

Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias

The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies

Keith T. Schmidt, William D. Figg

Information-dense analysis for information-dense understanding

Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen

The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use

Angel Qin, Nithya Ramnath

Immune infiltration, glioma stratification, and therapeutic implications

Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher

Balancing redox stress: anchorage-independent growth requires reductive carboxylation

Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione

Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy

Fabiana Perna, Michel Sadelain

Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells

Alex J. Gooding, William P. Schiemann

Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?

Nathan A. Berger

Microtubule targeting agents in glioma

Anda-Alexandra Calinescu, Maria G. Castro

Moving molecular subtypes to the clinic in gastric cancer

Joseph Chao, Jeeyun Lee, Samuel J. Klempner

Intraoperative subtyping of lung adenocarcinoma: an unmet need

Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli

Emerging roles of FGF signaling in hepatocellular carcinoma

Nana Zheng, Wenyi Wei, Zhiwei Wang

Tregs, Helios and tumor immunity: the sun has not yet risen

Angela M. Thornton, Ethan M. Shevach

Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1

Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof

Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components

Brandon J. Manley, James J. Hsieh

Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer

Salma Kaochar, Nicholas Mitsiades

Letter to the Editor

Epigenetic regulation of PD-L1 expression and pancreatic cancer response to checkpoint immunotherapy

Chunwan Lu, Kebin Liu

Synthetic lethality vs. synthetic viability due to PARP1 and BRCA2 loss

Xia Ding, Shyam K. Sharan

Correspondence

Targeted attack: mechanisms by which ovarian cancers suppress the immune system

Irina V. Tiper, Tonya J. Webb

Brief Report

The impact of neighborhood disadvantage on health-related quality of life among African American and white cancer survivors

Chien-Ching Li, Alicia K. Matthews, Anjali Asthana, Raj C. Shah

Research Highlight

Butyrate consumption of differentiated colonocytes in the upper crypt promotes homeostatic proliferation of stem and progenitor cells near the crypt base

Scott J. Bultman

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike

Jeffrey J. Tosoian, Emmanuel S. Antonarakis

A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer

Sawsan Rashdan, David E. Gerber

MOAP-1, UBR5 and cisplatin resistance in ovarian cancer

Scott T. Eblen, Amber Bradley

Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer

Weimin Gao

The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)

Theresa L. Whiteside

[¹⁸F]-choline PET/CT as an imaging biomarker for primary liver cancers

Zhenghong Lee

Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best

Yoshio Yamaoka, David Y. Graham

JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function

Theodoros Karantanos, Vassiliki A. Boussiotis

Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer

Angel Qin, Gregory P. Kalemkerian

Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered

Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham

Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells

Praveen Kumar Vemula, Venkatakrishna Rao Jala

Helios—controller of Treg stability and function

Claire Chougnet, David Hildeman

Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation

Jon K. Obst, Marianne D. Sadar

Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase

Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird

Fat lure: adipocytes attract cancer cells out of the prostate

Alexandra M. Blee, Haojie Huang

Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers

Guoli Chen, Ming-Tseh Lin

Editorials

Into the eye of the storm: breast cancer’s somatic mutation landscape points to DNA damage and repair

Joanne Ngeow, Emily Nizialek, Charis Eng

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks

Apratim Mitra, Karl Pfeifer, Ki-Sun Park

The STAMPEDE trial: paradigm-changing data through innovative trial design

Bradley C. Carthon, Emmanuel S. Antonarakis

Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway

Derek B. Oien, Jeremy Chien, Nikki Cheng

Feed your gut with caution!

Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar

Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma

Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma

Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients

Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy

Reinhard W. Schulte, Andrew J. Wroe

Externally modulated theranostic nanoparticles

Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi

Intestinal stem cell injury and protection during cancer therapy

Jian Yu

Cancer stem cells in glioma: challenges and opportunities

Jialiang Wang, Yufang Ma, Michael K. Cooper

Tumor microenvironment and nanotherapeutics

Meenakshi Upreti, Amar Jyoti, Pallavi Sethi

Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury

Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou

Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis

Chang-Lung Lee, Jordan M. Blum, David G. Kirsch

DNA ligases as therapeutic targets

Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest

DNA damage tolerance: a double-edged sword guarding the genome

Gargi Ghosal, Junjie Chen

DNA double strand break repair via non-homologous end-joining

Anthony J. Davis, David J. Chen

DNA crosslinking damage and cancer - a tale of friend and foe

Yaling Huang, Lei Li

Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation

Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan

MDM2 and MDMX: alone and together in regulation of p53

Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan

Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase

Lijian Shao, Lixian Wu, Daohong Zhou

Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment

Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen

SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis

Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos

Normal tissue protection for improving radiotherapy: where are the Gaps?

Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman

Improving chemoradiotherapy with nanoparticle therapeutics

Michael Joseph Eblan, Andrew Zhuang Wang

Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization

Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn

Molecular mechanisms involved in tumor repopulation after radiotherapy

Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li

Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules

Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy

Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar

Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma

Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Original Article

Multi‑cohort validation of BRAF-PTPRT co-mutation as a predictor of favorable immunotherapy response in melanoma

Dongmei Han, Caihong Wu, Dan Wang, Hao Jin, Weishuai Liu

Published online: 02 September 2026

Original Article

A Nomogram for Suicide-Specific Mortality Risk Stratification in Patients with Tongue Cancer: A SEER-Based Study, 2004–2017

Sha-Sha Du, Hai-Ping You, Yu-Ling Zhang, Nan-Jun Chen, Chen Ren, Heng-Wen Sun, Fei Xu, Xin Hua

Published online: 31 August 2026

Review Article

Barrier-Matched Engineering of Macrophages for Solid Tumor Immunotherapy: Design Logic, Translational Barriers and Clinical Outlook

Jian Wu, Jiabao Dong, Yi Shen, Haoyun Yu, Miyang Xu, Jiangfeng Zhang, Wei Wei, Xiongfeng Li

Published online: 31 August 2026

Original Article

Multi-omics integration identifies PON2 as a prognostic biomarker and mediator of tumor microenvironment remodeling in gallbladder cancer

Jian Yang, Lingbo Hu, Chao Yang, Haoyang Bei, Yulian Wu

Published online: 31 August 2026

Review Article

Cellular Immunotherapy for Lung Cancer: Current Clinical Evidence, Translational Challenges, and Future Perspectives

Ma Nannan, Shang Chunxiang

Published online: 31 August 2026

Review Article