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Join us at the IASLC 2026 World Conference on Lung Cancer

The IASLC 2026 World Conference on Lung Cancer (WCLC) is going to be held in Seoul, Republic of Korea from September 12th to 15th, 2026: https://wclc.iaslc.org/ More >>

New Impact Factor for Translational Cancer Research: 2.1

We are pleased to announce that Translational Cancer Research (TCR) has attained its latest impact factor update for the 2025 citation year: 2.1. More >>

Translational Cancer Research 2025 CiteScore Released: 2.6

We are pleased to announce that the Translational Cancer Research (TCR) has achieved its 2025 CiteScore: 2.6. More >>

Original Article

Disulfidptosis-related genes and long non-coding RNAs define a prognostic model for liver cancer
Wenqi Zhang, Xiangran Gu, Zhengrong Yuan, Haiyan Zhang
Translational Cancer Research  
2026;
15
(9)
:676
.
 (30 September 2026) 
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Global research trends in oncolytic virotherapy for sarcomas of bone and soft tissue (2000–2024): a bibliometric and visualization study
Guangjian Bai, Jian Cui, Zhitao Han, Xingdan Pan, Pan Gao, Baoquan Xin, Qingwei Geng, Tielong Liu
Translational Cancer Research  
2026;
15
(9)
:677
.
 (30 September 2026) 
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Multi-omics integration identifies PON2 as a prognostic biomarker and mediator of tumor microenvironment remodeling in gallbladder cancer
Jian Yang, Lingbo Hu, Chao Yang, Haoyang Bei, Yulian Wu
Translational Cancer Research  
2026;
15
(9)
:678
.
 (30 September 2026) 
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A nomogram for suicide-specific mortality risk stratification in patients with tongue cancer: a Surveillance, Epidemiology, and End Results (SEER)-based study, 2004–2017
Sha-Sha Du, Hai-Ping You, Yu-Ling Zhang, Nan-Jun Chen, Chen Ren, Heng-Wen Sun, Fei Xu, Xin Hua
Translational Cancer Research  
2026;
15
(9)
:679
.
 (30 September 2026) 
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Multi-cohort validation of BRAF-PTPRT co-mutation as a predictor of favorable immunotherapy response in melanoma
Dongmei Han, Caihong Wu, Dan Wang, Hao Jin, Weishuai Liu
Translational Cancer Research  
2026;
15
(9)
:680
.
 (30 September 2026) 
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AMOT mediates YAP1 activation and promotes the cell progression and glycolysis in non-small cell lung cancer by modulating the Hippo signaling pathway
Yihao Guo, Wendong Wang, Jinsong Li, Jun Zhang
Translational Cancer Research  
2026;
15
(9)
:681
.
 (30 September 2026) 
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Lnc-TIM3 promotes acute lymphoblastic leukemia progression through miR-5094-mediated regulation of TIM3
Jing Sun, Jiou Zhao, Wenfeng Fu, Huimin Li, Meiyun Kang, Yongjun Fang, Yaping Wang
Translational Cancer Research  
2026;
15
(9)
:682
.
 (30 September 2026) 
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Kinase-based molecular subtyping and a prognostic risk model in colorectal cancer with functional validation of PLK4
Chao Shen, Changmin Ding, Xiaofeng Han, Yanzhao Wang
Translational Cancer Research  
2026;
15
(9)
:683
.
 (30 September 2026) 
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Expression, prognostic association, and immune microenvironment correlates of C4orf50 in breast cancer: a The Cancer Genome Atlas Breast Invasive Carcinoma (TCGA-BRCA) bioinformatics study
Sihang Lin, Lixia Liu, Jiayu Guan, Jie Wang, Chuanrong Cen, La Wei, Huawei Yang
Translational Cancer Research  
2026;
15
(9)
:684
.
 (30 September 2026) 
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Efficacy and safety of antibody-drug conjugates in advanced small cell lung cancer: a systematic review and single-arm meta-analysis of prospective clinical trials
Peipei Zhang, Weixing Zhao, Jiayun Ma, Yuan Li, Huiyuan Peng, Jun Jiang
Translational Cancer Research  
2026;
15
(9)
:685
.
 (30 September 2026) 
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FBXO17 regulates the malignant progression of colorectal cancer via the Wnt/β-catenin pathway
Enyan Tang, Yijie Xiao, Xiaohong Qian, Shufei Li, Bin Chen
Translational Cancer Research  
2026;
15
(9)
:686
.
 (30 September 2026) 
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Identification of hepatitis B virus-associated membrane proteins as prognostic biomarkers for hepatocellular carcinoma based on retrospective analysis of integrated membrane proteomics
Zichen Liu, Jiaming Wan, Guoli Deng, Mingzhu Zhang, Shaohua Zhang, Qizhi Liu, Liu Ouyang, Shupeng Liu
Translational Cancer Research  
2026;
15
(9)
:687
.
 (30 September 2026) 
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Development and internal validation of machine learning models for predicting lymph node metastasis in cutaneous head and neck melanoma
Bingyu Cheng, Jianqun Yu, Qiang Ji
Translational Cancer Research  
2026;
15
(9)
:688
.
 (30 September 2026) 
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Personalized prediction of sequential therapeutic responses in HR+/HER2-low breast cancer using patient‐derived organoids
Wei Zhao, Zhongni Wu, Chengpan Li, Hongbo Zhang, Dabing Huang, Lijuan Wang, Xiaodan Zhang, Juanjuan Zhang, Xinyu Ma, Yifan Wen, Joseph Benjamin Holman, Xudong Yuan, Tingting Wang, Wei Wang, Weiping Ding, Yueyin Pan
Translational Cancer Research  
2026;
15
(9)
:689
.
 (30 September 2026) 
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MIF-mediated intercellular crosstalk drives antigen-presenting-like cancer-associated fibroblast differentiation in triple-negative breast cancer via TGF-β signaling
Jun Wang, Yeru Li, Jia Zhu, Dan Ruan, Xinchang Xu, Wei Wang
Translational Cancer Research  
2026;
15
(9)
:690
.
 (30 September 2026) 
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Analysis and validation of prognostic markers for thyroid cancer by single-cell and bulk RNA sequencing
Yang Yang, Liufei Yang, Xianfeng Jiang
Translational Cancer Research  
2026;
15
(9)
:691
.
 (30 September 2026) 
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URGCP promotes osteosarcoma progression by regulating the ESCRT-III subunit CHMP4B
Yue Wang, Yuhuai Wu, Bin Zhou, Jianping Liu
Translational Cancer Research  
2026;
15
(9)
:692
.
 (30 September 2026) 
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LncRNA FGD5-AS1 promotes M2 polarization of tumor-associated macrophages to facilitate the malignant phenotype of non-small cell lung cancer cells
Jing Wang, Hangui Wang, Zheng Song, Lijie Yang, Ning Wang
Translational Cancer Research  
2026;
15
(9)
:693
.
 (30 September 2026) 
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Development and external validation of an XGBoost-based prognostic model for small cell lung cancer with brain metastases
Pei Jiao, Chen Chen, Koudong Zhang, Qian Sun, Can Wang
Translational Cancer Research  
2026;
15
(9)
:694
.
 (30 September 2026) 
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Survival and treatment selection in NUT carcinoma: a population-based study and propensity score-matched comparison with poorly differentiated head and neck squamous cell carcinoma
Guoliang Yang, Tingyao Ma, Yixin Jing, Yiming Ding, Xiaohong Chen, Zhigang Huang
Translational Cancer Research  
2026;
15
(9)
:695
.
 (30 September 2026) 
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The m6A/METTL3 modifies USP11 to promote Warburg effect progression of colon cancer undifferentiated by HIF-1α/YAP signaling pathway
Yingying Wang, Feifei Zhu, Xiaolei Chen, Lei Feng, Zhichen Pu
Translational Cancer Research  
2026;
15
(9)
:696
.
 (30 September 2026) 
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A clinicopathological and hematological biomarker-based nomogram for overall survival in early-onset colorectal cancer: development, external validation, and translational implications
Mingming Su, Changhe Xia, Zhihan Li, Bo Gao, Juan Zhang, Guanglin Wang, Guangquan An, Xiaoling Duan, Jitao Hu, Jiaxu Han, Chenhui Li
Translational Cancer Research  
2026;
15
(9)
:697
.
 (30 September 2026) 
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Selenium metabolism-related gene TXNRD1 drives tumor progression and microenvironment remodeling in oral squamous cell carcinoma
Jun Zhan, Qixiang Sun, Wenyuan Zhu, Xiao Lu, Yao He
Translational Cancer Research  
2026;
15
(9)
:698
.
 (30 September 2026) 
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Multi-omics analysis of GBP2 as a prognostic and immune-associated biomarker in papillary thyroid carcinoma
Zhanwei Du, Liu Wang, Yixiao Zhang, Jing Han, Zhijun Ma
Translational Cancer Research  
2026;
15
(9)
:699
.
 (30 September 2026) 
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PM2.5 promotes migration of hepatocellular carcinoma by targeting miR-25
Qiaoxin Li, Yuxuan Lu, Quanyu Guo, Tianle Jin, Le Lu, Hao Shang, Meng Fan, Jiantao Mo, Hua Zhang, Wanying Feng, Xuanbo Da, Hongwei Lu
Translational Cancer Research  
2026;
15
(9)
:700
.
 (30 September 2026) 
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Glaucocalyxin A sensitizes ovarian cancer cells to PARP inhibitors by inducing DNA damage
Lingling Zhuang, Lanyan Hu, Qi Chen
Translational Cancer Research  
2026;
15
(9)
:701
.
 (30 September 2026) 
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Telmisartan enhances anti-PD-1 efficacy in MSS colorectal cancer via modulation of PD-L1 and STAT3 signaling
Xin Lin, Jingying Li, Wei Lin
Translational Cancer Research  
2026;
15
(9)
:702
.
 (30 September 2026) 
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MRI-derived habitat radiomics integrated with transformer deep learning for preoperative prediction of high CD9 expression: a novel prognostic marker in adult-type diffuse gliomas
Bingxin Pang, Mengyuan Yuan, Ying Yan, Jie Li, Jing Xue, Lina Jing, Bo Jiang, Shengjun Sun
Translational Cancer Research  
2026;
15
(9)
:703
.
 (30 September 2026) 
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A pathomics model for predicting lactate-related prognostic risk groups and their biological mechanisms in lung adenocarcinoma
Lingling Zhou, Wen Liu, Ye Pan, Wan Lei, Lingfei Yan, Jingfang Zou, Kejian Qian, Fei Wang
Translational Cancer Research  
2026;
15
(9)
:704
.
 (30 September 2026) 
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Development and temporal validation of nomograms and machine learning models for predicting overall and cancer-specific survival in primary distal cholangiocarcinoma: a SEER-based study
Wentao Shang, Xibin Duan
Translational Cancer Research  
2026;
15
(9)
:705
.
 (30 September 2026) 
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Metabolic signature of phosphoethanolamine and arginine pathways predicts prognosis and immunotherapy resistance in lung adenocarcinoma
Tao Wang, Hongwei Li, Fei Ding
Translational Cancer Research  
2026;
15
(9)
:706
.
 (30 September 2026) 
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Association between primary-site surgery and overall survival in non-metastatic and metastatic colorectal cancer: a population-based study using the Surveillance, Epidemiology, and End Results database
Xueru Fan, Tianzi Luo, Zelun Li, Xiaoge Wang, Erping Xu
Translational Cancer Research  
2026;
15
(9)
:707
.
 (30 September 2026) 
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Integrating multimodal data for precise subtyping and prognostication in patients with pulmonary mucinous adenocarcinoma
Weiwei Yang, Chen Chen, Lue Li, Zehao Chen, Ziyi Chen, Hanbo Le, Yongkui Zhang, Wangyu Zhu
Translational Cancer Research  
2026;
15
(9)
:708
.
 (30 September 2026) 
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Magnetic resonance imaging-based radiomics for predicting P53-mutated hepatocellular carcinoma: intratumoral and peritumoral analysis
Jingfei Weng, Dinghua Yao, Qihu Zeng, Yuqing He, Chun Yang, Bin Yang
Translational Cancer Research  
2026;
15
(9)
:709
.
 (30 September 2026) 
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Prognostic value of neutrophil-to-lymphocyte ratio in nasopharyngeal carcinoma: a systematic review and meta-analysis of 30 cohorts through June 30, 2026
Yunliang Lu, Biaoyou Chen, Jingfeng Ye, Xinyi Hu, Tingting Jiang, Zhe Zhang, Tingting Huang
Translational Cancer Research  
2026;
15
(9)
:710
.
 (30 September 2026) 
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Radiomics-based machine learning models decipher heterogeneity of anoikis-related molecular subtypes for prognostic stratification in head and neck squamous cell carcinoma
Linyong Wu, Dayou Wei, Wubiao Chen, Songhua Li, Zhendong Lu, Youwen Fu, Wenci Liu
Translational Cancer Research  
2026;
15
(9)
:711
.
 (30 September 2026) 
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Incidence, characteristics, and exploratory analysis of factors associated with pelvic osteitis/osteoradionecrosis after radiotherapy for cervical cancer: a single-center retrospective cohort study with an unmatched case-control analysis
Sijia Deng, Jie Li, Zexin Wang, Renming Lv, En Long, Yuanyuan Luo, Zihan Chen, Tingting Dai, Rui Huang, Song Qiu, Ruisi Wang, Huijie Wei, Dan Zhou, Yuxi Dong, Shuqiang Zhang, Fengmei Wen, Ruyan Liu
Translational Cancer Research  
2026;
15
(9)
:712
.
 (30 September 2026) 
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Role of podoplanin in tongue squamous cell carcinoma and the regulation of malignant cellular behaviors via the ERK/MMP-2 signaling axis
Xiaowei Sheng, Liping Ding, Qiang Zhang, Yong Lu, Jun Guo
Translational Cancer Research  
2026;
15
(9)
:713
.
 (30 September 2026) 
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Extracellular adenosine triphosphate upregulates S100A4 expression and promotes the migration and invasion of breast cancer cells via P2Y2/SOX9 signaling
Yue Cui, Fengming Ran, Guangxiong Ruan, Sheng Huang, Ying Liu
Translational Cancer Research  
2026;
15
(9)
:714
.
 (30 September 2026) 
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A novel three-CpG signature for lung adenocarcinoma diagnosis: integrating multi-omics, machine learning, and clinical validation
Qianying Liu, Maoting Shen, Lirui Yan, Yongfeng Li, Yi Wang, Junzhe Li, Shuyun Xiong, Jiamin Liao, Weikang Li, Yujuan Xiong, Ji-Cai Chen
Translational Cancer Research  
2026;
15
(9)
:715
.
 (30 September 2026) 
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Sequential chemoradiotherapy vs. radiotherapy alone or concurrent chemoradiotherapy after radical resection of stage IA2–IIA1 cervical cancer: a retrospective cohort study
Jia Yang, Huili Chen, Hui Tao, Xinxin Liu, Yan Chen, Xiang Fan, Pengfeng Zhu, Chao Zhang
Translational Cancer Research  
2026;
15
(9)
:716
.
 (30 September 2026) 
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Review Article

Cellular immunotherapy for lung cancer: current clinical evidence, translational challenges, and future perspectives: a narrative review
Nannan Ma, Chunxiang Shang
Translational Cancer Research  
2026;
15
(9)
:717
.
 (30 September 2026) 
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Engineering an arginine-nitric oxide circuit in Escherichia coli Nissle 1917 to remodel the tumor microenvironment for enhanced immunotherapy: a review
Sujuan Li, Yuanhang Zhang, Pengfei Sun
Translational Cancer Research  
2026;
15
(9)
:718
.
 (30 September 2026) 
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A narrative review of barrier-matched engineering of macrophages for solid tumor immunotherapy: design logic, translational barriers and clinical outlook
Jian Wu, Jiabao Dong, Yi Shen, Haoyun Yu, Miyang Xu, Jiangfeng Zhang, Wei Wei, Xiongfeng Li
Translational Cancer Research  
2026;
15
(9)
:719
.
 (30 September 2026) 
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Case report

Two case reports of gastric signet ring cell carcinoma with pulmonary metastasis manifesting as diffuse ground-glass opacities and pleural involvement: an atypical imaging pattern mimicking lung infection
Yike Wang, Yingbo Xie, Xuan Yao, Pei Ma, Fengnan Wang, Xinqing Lin, Xiaohong Xie, Ming Liu, Chengzhi Zhou, Zhanhong Xie
Translational Cancer Research  
2026;
15
(9)
:720
.
 (30 September 2026) 
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Editorial Commentary

Adjuvant management of resectable stage III/IV melanoma
Nicole Flores, Matthew J. Hadfield
Translational Cancer Research  
2026;
15
(9)
:721
.
 (30 September 2026) 
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Erratum

Erratum: DDR1 in esophageal squamous cell carcinoma: bioinformatics discovery and experimental validation
Editorial Office
Translational Cancer Research  
2026;
15
(9)
:722
.
 (30 September 2026) 
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Review Article 
The management of brain necrosis as a result of SRS treatment for intra-cranial tumors
Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen
Published online: 28 August 2014
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Meta-Analysis 
Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu
Published online: 05 March 2013
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Review Article 
Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai
Published online: 05 March 2013
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Original Article 
Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review
Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi
Published online: 28 April 2017
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Biological basis of IORT 
Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects
Ithaisa Sologuren, Carlos Rodríguez-Gallego, Pedro Carlos Lara
Published online: 25 February 2014
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Review Articles 
Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer
Deep Kwatra, Anand Venugopal, Shrikant Anant
Published online: 26 September 2013
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Review Articles 
Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer
Rositsa Dueva, George Iliakis
Published online: 19 June 2013
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Editorial 
Morphine, when used for treating patients with acute pancreatitis, could be more risky than previously suspected
Juan Iovanna, Maria Cecilia Mallmann
Published online: 24 October 2017
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Review Article 
Do alkaline phosphatases have great potential in the diagnosis, prognosis, and treatment of tumors?
Tingting Jiang, Qun Zeng, Jun He
Published online: 20 October 2023
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Review Article 
EGFR first- and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients
Niki Karachaliou, Manuel Fernandez-Bruno, Jillian Wilhelmina Paulina Bracht, Rafael Rosell
Published online: 19 January 2019
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Review Article 
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
Published online: 18 June 2015
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Review Articles 
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Published online: 26 September 2013
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Biological basis of IORT 
Cell and molecular response to IORT treatment
Luigi Minafra, Valentina Bravatà
Published online: 25 February 2014
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Editorial 
The CROSS road in neoadjuvant therapy for esophageal cancer: long-term results of CROSS trial
Ian Wong, Simon Law
Published online: 29 September 2016
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Review Articles 
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
Published online: 19 June 2013
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Review Articles 
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Published online: 19 June 2013
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Review Article 
Urological complications after radiation therapy—nothing ventured, nothing gained: a Narrative Review
Joanna Chorbińska, Wojciech Krajewski, Romuald Zdrojowy
Published online: 26 February 2021
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Review Article 
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Published online: 30 June 2017
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Review Article 
EGFR and HER2: is there a role in ovarian cancer?
Eleonora Teplinsky, Franco Muggia
Published online: 13 February 2015
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Review Article 
Multiple keratoacanthoma centrifugum marginatum—a case report and systematic review
Yiman Wang, Wenling Zhao, Yueping Zeng, Li Li, Hongzhong Jin
Published online: 30 December 2018
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Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park
How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis
Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao
Alcohol intake patterns for cancer and non-cancer individuals: a population study
Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng
Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial
Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu
Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management
Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas
Exosomal lncRNAs as new players in cell-to-cell communication
Mihnea Dragomir, Baoqing Chen, George A. Calin
Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy
Souparno Bhattacharya, Aroumougame Asaithamby
Translational research in radiation-induced DNA damage signaling and repair
Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue
Genetically engineered mouse models for studying radiation biology
Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Advances on immunotherapy in genitourinary and renal cell carcinoma
Gregory P. Botta, Eric Granowicz, Carrie Costantini
The role of novel immunotherapies in non-Hodgkin lymphoma
Allyson Pishko, Sunita D. Nasta
MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan
Do p53 stress responses impact organismal aging?
Paul Hasty, Judith Campisi, Z. Dave Sharp
Pharmacological targeting of mutant p53
Samuel Kogan, Darren Carpizo
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Michael I. Carr, Stephen N. Jones
Regulation of cytotoxic T-cell responses by p53 in cancer
Mitchell W. Braun, Tomoo Iwakuma
The IGF-1R/AKT pathway determines cell fate in response to p53
Lei Duan, Carl G. Maki
Intra molecular interactions in the regulation of p53 pathway
Jiandong Chen
TP53 mutations in epithelial ovarian cancer
Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu
Modulation of the p53 family network by RNA-binding proteins
Chris Lucchesi, Jin Zhang, Xinbin Chen
Radiomics in head and neck cancer: from exploration to application
Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller
Prostate cancer radiomics and the promise of radiogenomics
Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack
Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies
Wei Lu, Wengen Chen
The emerging field of radiomics in esophageal cancer: current evidence and future potential
Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin
Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
Jung H. Suh, Julie D. Saba
Computational methods and opportunities for phosphorylation network medicine
Yian Ann Chen, Steven A. Eschrich

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
New light on the pancreatic cyst conundrum
Nathan A. Berger
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?
Andrew J. Scott, John C. Wilkinson
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
Nan Ding, Qianzheng Zhu
Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?
Apar Gupta, Nisha Ohri, Bruce G. Haffty
Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents
Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi
CRISPR-based genetic interaction maps inform therapeutic strategies in cancer
Poornima Ramkumar, Martin Kampmann
Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study
Melin J. Khandekar, Rakesh Jain
The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin
Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed
Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer
Joanne P. Young, Timothy J. Price, Susan Parry
Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response
R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang
Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes
Theresa L. Whiteside
TIC10/ONC201—a potential therapeutic in glioblastoma
Georg Karpel-Massler, Markus D. Siegelin
IDH mutational status and the immune system in gliomas: a tale of two tumors?
Bryan D. Choi, William T. Curry
ONC201: a new treatment option being tested clinically for recurrent glioblastoma
Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry
When better still might not be good enough
Waldemar Debinski
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy
Vincent C. O. Njar
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28
Leonardo Chicaybam, Prasad S. Adusumilli
Exosome mediated phenotypic changes in lung cancer pathophysiology
Yoshihisa Shimada, John D. Minna
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aaron D. DeWard, Rebecca J. Critchley-Thorne
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein
Felicia L. Lenzo, William G. Cance
New incriminating evidence against IGF2
Wen Ding, Lina A. Shehadeh
Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect
Paul Grippo, Ajay V. Maker
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger
RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver
Satomi Yamamoto, Tomoo Iwakuma
Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy
Michael J. Baine, Chi Lin
Rogue one: another faction of the Wnt empire implicated in assisting GBM progression
Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed
Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway
Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems
Li Tian, Ashley Chang, Marites P. Melancon
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
James P. White
Low-frequency ultrasound may improve drug penetration in colonic mucosa
Qiubing Chen, Bo Xiao, Didier Merlin
Dividing and conquering the variation among variants in EML4-ALK lung cancer
Trever G. Bivona
Unlocking the epigenetic code of T cell exhaustion
Jiazhu Wu, Huidong Shi
KDM1 links nuclear GSK3β to epigenetic alterations
Weijie Guo, Binhua P. Zhou
Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease
Deepa Rangachari, Daniel B. Costa
Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy
Bhagelu R. Achyut, Ali S. Arbab
Neuroendocrine differentiation in prostate cancer: key epigenetic players
Karishma Gupta, Sanjay Gupta
PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression
Kim A. Brogden, Shireen Vali, Taher Abbasi
Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy
Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias
The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies
Keith T. Schmidt, William D. Figg
Information-dense analysis for information-dense understanding
Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
Fabiana Perna, Michel Sadelain
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells
Alex J. Gooding, William P. Schiemann
Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?
Nathan A. Berger
Microtubule targeting agents in glioma
Anda-Alexandra Calinescu, Maria G. Castro
Moving molecular subtypes to the clinic in gastric cancer
Joseph Chao, Jeeyun Lee, Samuel J. Klempner
Intraoperative subtyping of lung adenocarcinoma: an unmet need
Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli
Emerging roles of FGF signaling in hepatocellular carcinoma
Nana Zheng, Wenyi Wei, Zhiwei Wang
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
Brandon J. Manley, James J. Hsieh
Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer
Salma Kaochar, Nicholas Mitsiades

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike
Jeffrey J. Tosoian, Emmanuel S. Antonarakis
A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer
Sawsan Rashdan, David E. Gerber
MOAP-1, UBR5 and cisplatin resistance in ovarian cancer
Scott T. Eblen, Amber Bradley
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer
Weimin Gao
The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)
Theresa L. Whiteside
[18F]-choline PET/CT as an imaging biomarker for primary liver cancers
Zhenghong Lee
Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best
Yoshio Yamaoka, David Y. Graham
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function
Theodoros Karantanos, Vassiliki A. Boussiotis
Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer
Angel Qin, Gregory P. Kalemkerian
Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered
Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham
Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells
Praveen Kumar Vemula, Venkatakrishna Rao Jala
Helios—controller of Treg stability and function
Claire Chougnet, David Hildeman
Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation
Jon K. Obst, Marianne D. Sadar
Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird
Fat lure: adipocytes attract cancer cells out of the prostate
Alexandra M. Blee, Haojie Huang
Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers
Guoli Chen, Ming-Tseh Lin

Letter to the Editor

Epigenetic regulation of PD-L1 expression and pancreatic cancer response to checkpoint immunotherapy
Chunwan Lu, Kebin Liu
Synthetic lethality vs. synthetic viability due to PARP1 and BRCA2 loss
Xia Ding, Shyam K. Sharan

Correspondence

Targeted attack: mechanisms by which ovarian cancers suppress the immune system
Irina V. Tiper, Tonya J. Webb

Brief Report

The impact of neighborhood disadvantage on health-related quality of life among African American and white cancer survivors
Chien-Ching Li, Alicia K. Matthews, Anjali Asthana, Raj C. Shah

Research Highlight

Butyrate consumption of differentiated colonocytes in the upper crypt promotes homeostatic proliferation of stem and progenitor cells near the crypt base
Scott J. Bultman

Editorials

Into the eye of the storm: breast cancer’s somatic mutation landscape points to DNA damage and repair
Joanne Ngeow, Emily Nizialek, Charis Eng

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
The STAMPEDE trial: paradigm-changing data through innovative trial design
Bradley C. Carthon, Emmanuel S. Antonarakis
Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway
Derek B. Oien, Jeremy Chien, Nikki Cheng
Feed your gut with caution!
Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar
Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma
Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma
Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Journal highlight more

Translational Cancer Research is an international, open access, peer-reviewed journal indexed in Scopus and Science Citation Index Expanded (SCIE), focusing on original, science-based researches on clinical, basic and translational aspects. It publishes laboratory studies of novel therapeutic interventions, clinical trials which evaluate new treatment paradigms for cancer, results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients and etc.

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Translational Cancer Research is indexed and covered by

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Visual Abstract

Visual Absract
Visual abstracts, also called 'graphical abstracts' or 'infographics,' are images that summarize the essential information of manuscripts, providing an easily and expediently understood overview of study findings at a glance. More >>

Reviewers more

In 2026, TCR reviewers continue to make outstanding contributions to the peer review process. More >>
In 2025, TCR reviewers continue to make outstanding contributions to the peer review process. More >>
In 2024, TCR reviewers continue to make outstanding contributions to the peer review process. More >>

Membership

Member since 2021

Publishing Information

Translational Cancer Research is published by AME Publishing Company

AME Publishing Company

Translational Cancer Research is published with support from Wolters Kluwer

Wolters Kluwer

The official journal of Society for Translational Medicine (STM), Hong Kong

Society for Translational Medicine (STM), Hong Kong

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