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New Impact Factor for Translational Cancer Research: 2.1

We are pleased to announce that Translational Cancer Research (TCR) has attained its latest impact factor update for the 2025 citation year: 2.1. More >>

Translational Cancer Research 2025 CiteScore Released: 2.6

We are pleased to announce that the Translational Cancer Research (TCR) has achieved its 2025 CiteScore: 2.6. More >>

Welcome to the 2026 Clinical Research Innovation Forum & Editors-in-Chief Meet-and-Greet

We are pleased to invite you to join the 2026 Clinical Research Innovation Forum & Editors-in-Chief Meet-and-Greet co-organized by AME Publishing Company and Wolters Kluwer.The eve... More >>

Editorial Commentary

Transdermal estradiol (tE2) as an alternative androgen deprivation therapy (ADT) in locally advanced prostate cancer
Ame Stephanie Ayemere, Jeanny B. Aragon-Ching
Translational Cancer Research  
2026;
15
(7)
:513
.
 (31 July 2026) 
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The evolution of cancer therapeutics: from “undruggable” to “drugged”
Daniel Neureiter, Matthias Ocker
Translational Cancer Research  
2026;
15
(7)
:514
.
 (31 July 2026) 
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The significance of the 4Kscore in predicting medium- to long-term prostate cancer risk: insights from the European prospective investigation into cancer and nutrition
Yozo Mitsui, Koichi Nakajima
Translational Cancer Research  
2026;
15
(7)
:515
.
 (31 July 2026) 
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Next-generation sequencing-based high-risk genomic stratification in multiple myeloma
Zhou Zhang, Wei Zhang
Translational Cancer Research  
2026;
15
(7)
:516
.
 (31 July 2026) 
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Dual target combination therapy demonstrates promise in extramedullary myeloma
James Behrmann, Faith E. Davies
Translational Cancer Research  
2026;
15
(7)
:517
.
 (31 July 2026) 
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Hepatitis C virus and extrahepatic malignancies: where we stand and how we can advance the field
Ken Sato
Translational Cancer Research  
2026;
15
(7)
:518
.
 (31 July 2026) 
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Original Article

Development and external validation of a machine learning-based multimodal radiomics nomogram for predicting progression-free survival in triple-negative breast cancer
Yanhui Lu, Zhuolin Li, Weiyuan Zhang, Weiming Mao, Fanxin Fu, Wanting Wang, Chunyan Luo, Rongyan Zhou, Yu Guan, Bo He, Jun Li
Translational Cancer Research  
2026;
15
(7)
:519
.
 (31 July 2026) 
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Garcinoic acid promotes ferroptosis-associated growth inhibition in esophageal squamous cell carcinoma through an MDM2-associated mechanism
Li-Ying Sun, Peng Huang, Yan-Hua Su
Translational Cancer Research  
2026;
15
(7)
:520
.
 (31 July 2026) 
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Development and validation of a nomogram for predicting chemotherapy-induced liver injury in breast cancer patients
Meizhen Liang, Dixin Xue, Rusi Su, Weili Wu, Chengliang Chen
Translational Cancer Research  
2026;
15
(7)
:521
.
 (31 July 2026) 
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Prognostic value of gut microbiota-derived metabolites in non-small cell lung cancer: a retrospective cohort study of overall survival
Haitao Pan, Xiangfei Chen, Wan Wu, Meiqin Wang, Yanqing Wang
Translational Cancer Research  
2026;
15
(7)
:522
.
 (31 July 2026) 
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High SRD5A2 expression is associated with poor prognosis and promotes tumor cell progression in colorectal cancer
Meng-Fan Jia, Meng-Nan Dai, Kai-Ye Hua, Si-Yuan Du, Jian Lu, Ying-Wei Zhu
Translational Cancer Research  
2026;
15
(7)
:523
.
 (31 July 2026) 
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An externally validated lactylation-associated prognostic signature for overall survival prediction in lung adenocarcinoma identifies TUBA1C as a candidate gene
Zhi Wang, Nuo Yan, Taohui Ding, Wenxun Xiong, Weiqiang Feng, Yunzhe Wang, Yiping Wei
Translational Cancer Research  
2026;
15
(7)
:524
.
 (31 July 2026) 
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Efficacy of nab-paclitaxel combined with immune checkpoint inhibitors in solid tumors: a systematic review and meta-analysis of randomized controlled trials
Xiao Li, Yaqiong Song, Jianhua Li
Translational Cancer Research  
2026;
15
(7)
:525
.
 (31 July 2026) 
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Development and validation of a multivariable CT-based Delta-radiomics model for predicting efficacy to bevacizumab therapy in patients with colorectal liver metastases
Long Yuan, Shenglin Li, Yuntai Cao, Ming Xu, Huaze Xi, Jingjing Yang, Junlin Zhou
Translational Cancer Research  
2026;
15
(7)
:526
.
 (31 July 2026) 
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In vitro characterization of a novel anti-GD2/ROR1 bispecific antibody exhibiting tumor cell killing efficacy in neuroblastoma cross-cancer activity in ROR1-positive triple-negative breast cancer
Tian Lin, Xinghe Chen, He Huang, Jianxing Zhang, Yali Xu, Junshan Lin
Translational Cancer Research  
2026;
15
(7)
:527
.
 (31 July 2026) 
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The role of apparent diffusion coefficient histogram analysis in improving O-RADS magnetic resonance imaging classification of adnexal lesions: a retrospective diagnostic accuracy study
Yibei Yu, Hongliang Zhao, Yakui Wang, Jing Li, Zhuozhao Zheng
Translational Cancer Research  
2026;
15
(7)
:528
.
 (31 July 2026) 
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The impact of age on survival in stage II colon cancer: a SEER database analysis stratified by chemotherapy status
Zhengrong Zou, Xin Tang, Xinping Hong, Lingting Zou
Translational Cancer Research  
2026;
15
(7)
:529
.
 (31 July 2026) 
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CKMT2 functions as a novel oncogenic gene in osteosarcoma, revealed by bioinformatics and experimental approaches
Xuefei Wu, Fei Ding, Weijie Wu, Honghua Dong
Translational Cancer Research  
2026;
15
(7)
:530
.
 (31 July 2026) 
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A weakly supervised deep learning model for OSCC diagnosis and lesion highlighting in histopathology images
Jun Yan, Lijun Sun, Song Wang
Translational Cancer Research  
2026;
15
(7)
:531
.
 (31 July 2026) 
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PLAU accelerates extracellular matrix remodeling through partial epithelial-mesenchymal transition in head and neck squamous cell carcinoma
Zhichang Liu, Qiaojing Jia, Zhichao Yang, Haizhong Zhang, Jingmiao Wang, Lisha Liu, Dan Lou, Jianxing Wang
Translational Cancer Research  
2026;
15
(7)
:532
.
 (31 July 2026) 
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Elevated TARDBP expression correlates with an unfavorable prognosis, immune evasion, and poor immune efficacy in hepatocellular carcinoma
Jungang Tan, Jiazuo Cai, Zhimin Zhou, Ziqing Sun, Ronghui Zheng, Chengcong Chen
Translational Cancer Research  
2026;
15
(7)
:533
.
 (31 July 2026) 
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METTL17 promotes gastric cancer progression via inhibiting glycogen synthase kinase-3β to activate Wnt/β-catenin signaling
Man Gao, Yixun Zhang, Wenjing Bao, Yilin Shi, Weiyi Chen, Yang Liu, Rumeng Wang, Ning Zhang, Lingli Zhang, Lizhou Jia
Translational Cancer Research  
2026;
15
(7)
:534
.
 (31 July 2026) 
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miR-506-5p targets MAPK7 to impede glioma growth and invasion through suppressing epithelial-mesenchymal transition and matrix metalloproteinases
Tingting Sun, Guojin Wang, Ye Chen, Xin Geng, Xiaofeng Zhu, Houjun Zhou
Translational Cancer Research  
2026;
15
(7)
:535
.
 (31 July 2026) 
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Integrative analysis of HMGB3 in esophageal carcinoma: expression profile, prognostic significance, and immune microenvironment associations
Shen-Bo Fu, Long Jin, Jia Liu, Rong Yang, Jing Liang, Jun-Jun Guo, Li Chen, Bin Zhao
Translational Cancer Research  
2026;
15
(7)
:536
.
 (31 July 2026) 
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Clinicopathological characteristics and prognosis of pulmonary spindle cell carcinoma: a population-based retrospective study using SEER data
Linwei Zhuang, Jianli Gao, Yi Zhang, Jiangbo Lin
Translational Cancer Research  
2026;
15
(7)
:537
.
 (31 July 2026) 
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A comparative analysis of clinical and sonographic features: cutaneous melanoma and melanocytic nevi
Wanli Ye, Yongrui Wang, Hongyan Liu, Yong Jiang, Xingheng Wang, Li Qiu, Yuanjiao Tang
Translational Cancer Research  
2026;
15
(7)
:538
.
 (31 July 2026) 
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Clinical overall survival prediction and disease characteristics of locally advanced non-small cell lung cancer: an integrated analysis based on the SEER and TCGA databases
Yuanhui Tian, Yan Deng, Xiaoli Liao, Shutao Yuan, Ke Li
Translational Cancer Research  
2026;
15
(7)
:539
.
 (31 July 2026) 
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Feasibility study on the application of Raman spectroscopy in the diagnosis of glioma
Zilong Wei, Jincheng Yang, Guanzhong Qiu, Yaodong Zhao
Translational Cancer Research  
2026;
15
(7)
:540
.
 (31 July 2026) 
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HOXD9 prioritization within developmental regulator-related genes suggests stage-adjusted prognostic relevance in hepatocellular carcinoma
Junling Zhu, Xujie Tang, Qianru Zhu, Sen Jiang
Translational Cancer Research  
2026;
15
(7)
:541
.
 (31 July 2026) 
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Interpretable machine learning prediction of 1-year overall survival in pancreatic cancer patients aged 65 years and older
Bo Zeng, Hongyi Liu, Qi Huang
Translational Cancer Research  
2026;
15
(7)
:542
.
 (31 July 2026) 
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TRIM47 promotes cell viability, cell cycle progression, metabolic reprogramming, and inhibits apoptosis of glioma via the NF-κB signaling pathway
Xin Lai, Jin Zhu, Haocheng Jia, Ping Zhang, Bin Wang, Yuping Tang, Qishan Ran
Translational Cancer Research  
2026;
15
(7)
:543
.
 (31 July 2026) 
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A radiotherapy resistance-related prognostic signature predicts survival and the immune landscape in rectal cancer
Tingting Jiang, Liyuan Zhu, Rujin Jiang, Hongchuan Jin, Shijin Yuan
Translational Cancer Research  
2026;
15
(7)
:544
.
 (31 July 2026) 
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PRSS1 promotes gastric cancer invasion and metastasis by induction of the epithelial-mesenchymal transition and activation of the MAPK/ERK pathway
Xiang Bai, Haoyu Zhu, Huiwen Lin, Chao Shi, Chong Tang, Shichun Feng, Fei Wang
Translational Cancer Research  
2026;
15
(7)
:545
.
 (31 July 2026) 
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Clinicopathological characteristics and prognosis of breast carcinoma with apocrine differentiation: a propensity score-matched analysis of the SEER database
Manxiu Li, Liting Jin, Jun Shao, Tiejun Wang, Xinhong Wu
Translational Cancer Research  
2026;
15
(7)
:546
.
 (31 July 2026) 
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Bergamottin demonstrates preclinical effectiveness against pancreatic cancer by modulating PPAR-γ to induce apoptosis
Cheng Wang, Linxiao Sun, Kaixian Deng, Qiangqiang Li
Translational Cancer Research  
2026;
15
(7)
:547
.
 (31 July 2026) 
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Hepatotoxicity of immune checkpoint inhibitor plus targeted therapy versus tyrosine kinase inhibitor monotherapy in unresectable hepatocellular carcinoma: a systematic review and meta-analysis
Shuangyue Wang, Yajuan He, Yingfei Wei, Feng Chen, Min Luo
Translational Cancer Research  
2026;
15
(7)
:548
.
 (31 July 2026) 
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TRIM32 drives head and neck squamous cell carcinoma progression via TP53 suppression and lysosomal/autophagy dysregulation
Langxiong Chen, Yuyang Zhang, Huaying Liao, Weiyan Liang, Weihan Luo, Baiyao Wang, Lei Wang, Hongwei Yu, Ling Cheng, Jingjing Song, Yawei Yuan, Yunhong Tian, Yuchao Wu
Translational Cancer Research  
2026;
15
(7)
:549
.
 (31 July 2026) 
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Differentiating breast cancer lung metastasis from primary lung cancer using clinical and computed tomography radiomics features
Jinhua Huang, Tinglei Shao, Caihong Zheng, Liantao Guo, Chuan Wang, Chunsen Xu, Lili Wang, Zhonghua Han
Translational Cancer Research  
2026;
15
(7)
:550
.
 (31 July 2026) 
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A multi-omics integration of bulk and single-cell transcriptomics identifies and validates a 16-gene epithelial-mesenchymal transition prognostic signature in tongue squamous cell carcinoma
Kai Fu, Lin Li, Ruyv Wang, Juan Li, Weiyi Wang
Translational Cancer Research  
2026;
15
(7)
:551
.
 (31 July 2026) 
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A real-world cohort study reveals the treatment paradox of radiotherapy underuse despite its association with survival advantage
Zhuo Song, Lei Wang, Qianhao Zang, Mingli Ding, Yingjie Wang, Gang Ren, Yupeng Di, Zijie He
Translational Cancer Research  
2026;
15
(7)
:552
.
 (31 July 2026) 
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Bioinformatics-based identification of ferroptosis-related biomarkers and immune infiltration in retinoblastoma
Xingxin Fu, Chengzhen Gong, Jun Zhang, Mingxing Wu, Xuhui Li, Xueshan Dai, Yan Xu
Translational Cancer Research  
2026;
15
(7)
:553
.
 (31 July 2026) 
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Palmitoylation-related gene signature for immune subtyping, prognostic stratification, and immunotherapy guidance in hepatocellular carcinoma
Xiang Gao, Fangzhou Wang, Yuanxu Qu, Yingao Liu, Yamin Zheng
Translational Cancer Research  
2026;
15
(7)
:554
.
 (31 July 2026) 
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ALOX12 suppresses colon cancer progression by promoting p53-mediated ferroptosis through upregulating ROS-induced stress
Junjie Wu, Congxing Liu, Yaya Sun, Guangqing Jiang, Yupeng Zhao, Yihong Zhang, Yiping Yin, Xin Shi
Translational Cancer Research  
2026;
15
(7)
:555
.
 (31 July 2026) 
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Construction of lactate-myeloid-related prognostic risk model and prediction of immune-excluded microenvironment in gastric cancer via integrated scRNA-Seq and bulk RNA-Seq
Xiaying Han, Qimiao Chen, Xijian Huang, Zhixing Hao, Yaxuan Han, Yewei Xu, Jing Chen, Jia Qi, Jian Chen
Translational Cancer Research  
2026;
15
(7)
:556
.
 (31 July 2026) 
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Osteoblast-specific factor 2 reduces glutathione by downregulating PRKRA expression in oral squamous cell carcinoma
Binbin Yu, Shimin Zhao, Jun Wang
Translational Cancer Research  
2026;
15
(7)
:557
.
 (31 July 2026) 
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Real-world retrospective cohort study of three conversion therapy regimens for unresectable locally advanced pancreatic cancer: a single-center 5-year analysis focused on conversion resection rate and survival outcomes
Rui-Zhi He, Min Zhou, Yong-Jun Chen, Xing-Jun Guo
Translational Cancer Research  
2026;
15
(7)
:558
.
 (31 July 2026) 
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Adenylate cyclase 4 suppresses malignant progression of lung adenocarcinoma through interaction with protein kinase C beta
Jieyang Wang, Chaojing Zheng, Wei Shen, Qianshun Chen, Yuyu Lin, Shuwei Huang, Lei Gao, Chen Huang
Translational Cancer Research  
2026;
15
(7)
:559
.
 (31 July 2026) 
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Elevated TMC8 expression correlates with CD8+ T cell infiltration and favorable survival in oral squamous cell carcinoma
Bingyan Zhu, Yuling Chen, Tao Zhou, Yuntao Lin, Bo Lin
Translational Cancer Research  
2026;
15
(7)
:560
.
 (31 July 2026) 
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Cysteine suppresses the progression of oral squamous cell carcinoma via regulating GLDC
Haoran Wang, Le Xu, Mengqi Zhang, Ning Zhang, Dongsheng Zhang, Xiaoqing Zhou
Translational Cancer Research  
2026;
15
(7)
:561
.
 (31 July 2026) 
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Transcriptomic and experimental validation identify biomarkers and regulatory mechanisms associated with the aryl hydrocarbon receptor in nasopharyngeal carcinoma
Qiulin Liang, Changxing Cao, Ziling Zou, Yulan Peng, Chao Feng
Translational Cancer Research  
2026;
15
(7)
:562
.
 (31 July 2026) 
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Identification of prognostic risk factors and construction of nomograms for elderly patients with stage III–IV endometrioid endometrial carcinoma: a study based on the SEER database
Shaohan Zou, Sitian Wei, Guanghui Song, Songying Zhang
Translational Cancer Research  
2026;
15
(7)
:563
.
 (31 July 2026) 
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KLF15-POU3F4 axis activates PI3K/AKT signaling to promote glioma progression
Dong Wang, Wan Yu, Ran Wang, Ning Liu
Translational Cancer Research  
2026;
15
(7)
:564
.
 (31 July 2026) 
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Matching-adjusted indirect comparison between asciminib and flumatinib as first-line treatment for chronic myeloid leukemia in China
Ying Wang, Yan Hui, Li Zhang, Yan Li, Meng Tang, Xue Gao, Bihong Zhen, Abhay Choubey, Soni Gupta, Hui Wei, Bingcheng Liu
Translational Cancer Research  
2026;
15
(7)
:565
.
 (31 July 2026) 
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Review Article

SLC16A3 links tumor metabolism to therapeutic opportunities in hepatocellular carcinoma
Zhiyan Li, Zeyu Zhou, Shuwei Liang, Hao Liu, Qiyu Sun, Jian Li
Translational Cancer Research  
2026;
15
(7)
:566
.
 (31 July 2026) 
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Emerging role of human epidermal growth factor 2-low status in the prognosis and management of triple-negative breast cancer: a narrative review
Nathan Oelschlagel, Hamid Mithoowani, Emily A. Goebel, Farhad Ghasemi, Sarah Knowles, Allison Maciver, Muriel Brackstone, Armen Parsyan
Translational Cancer Research  
2026;
15
(7)
:567
.
 (31 July 2026) 
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Case report

Sequential HER2-targeted antibody-drug conjugate therapy for acquired resistance in a 55-year-old male kidney transplant recipient with metastatic urothelial carcinoma: a case report
Tianying Li, Yinuo Zhang, Genkun Liu, Jun Chen, Sheng Zhang, Mingjuan Sun
Translational Cancer Research  
2026;
15
(7)
:568
.
 (31 July 2026) 
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Precision de-escalation of immunotherapy in extensive-stage small cell lung cancer: a case report on ctDNA-guided management in a long-term survivor
Qiuyi Zhang, Jiesheng Su, Suni Huang, Lihong Guo, Die Dai, Meng Zhang, Shiqi Lyu, Zesong Chen, Jianhua Chang
Translational Cancer Research  
2026;
15
(7)
:569
.
 (31 July 2026) 
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Erratum

Erratum: Pathological features and biomarkers of hepatocellular carcinoma: a bibliometric analysis from 2005 to 2025
Editorial Office
Translational Cancer Research  
2026;
15
(7)
:570
.
 (31 July 2026) 
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Review Article 
The management of brain necrosis as a result of SRS treatment for intra-cranial tumors
Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen
Published online: 28 August 2014
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Meta-Analysis 
Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu
Published online: 05 March 2013
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Review Article 
Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai
Published online: 05 March 2013
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Original Article 
Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review
Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi
Published online: 28 April 2017
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Biological basis of IORT 
Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects
Ithaisa Sologuren, Carlos Rodríguez-Gallego, Pedro Carlos Lara
Published online: 25 February 2014
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Review Articles 
Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer
Deep Kwatra, Anand Venugopal, Shrikant Anant
Published online: 26 September 2013
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Review Articles 
Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer
Rositsa Dueva, George Iliakis
Published online: 19 June 2013
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Editorial 
Morphine, when used for treating patients with acute pancreatitis, could be more risky than previously suspected
Juan Iovanna, Maria Cecilia Mallmann
Published online: 24 October 2017
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Review Article 
Do alkaline phosphatases have great potential in the diagnosis, prognosis, and treatment of tumors?
Tingting Jiang, Qun Zeng, Jun He
Published online: 20 October 2023
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Review Article 
EGFR first- and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients
Niki Karachaliou, Manuel Fernandez-Bruno, Jillian Wilhelmina Paulina Bracht, Rafael Rosell
Published online: 19 January 2019
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Review Article 
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
Published online: 18 June 2015
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Review Articles 
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Published online: 26 September 2013
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Biological basis of IORT 
Cell and molecular response to IORT treatment
Luigi Minafra, Valentina Bravatà
Published online: 25 February 2014
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Editorial 
The CROSS road in neoadjuvant therapy for esophageal cancer: long-term results of CROSS trial
Ian Wong, Simon Law
Published online: 29 September 2016
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Review Articles 
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
Published online: 19 June 2013
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Review Articles 
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Published online: 19 June 2013
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Review Article 
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Published online: 30 June 2017
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Review Article 
Urological complications after radiation therapy—nothing ventured, nothing gained: a Narrative Review
Joanna Chorbińska, Wojciech Krajewski, Romuald Zdrojowy
Published online: 26 February 2021
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Review Article 
EGFR and HER2: is there a role in ovarian cancer?
Eleonora Teplinsky, Franco Muggia
Published online: 13 February 2015
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Review Article 
Multiple keratoacanthoma centrifugum marginatum—a case report and systematic review
Yiman Wang, Wenling Zhao, Yueping Zeng, Li Li, Hongzhong Jin
Published online: 30 December 2018
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Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park
How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis
Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao
Alcohol intake patterns for cancer and non-cancer individuals: a population study
Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng
Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial
Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu
Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management
Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas
Exosomal lncRNAs as new players in cell-to-cell communication
Mihnea Dragomir, Baoqing Chen, George A. Calin
Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy
Souparno Bhattacharya, Aroumougame Asaithamby
Translational research in radiation-induced DNA damage signaling and repair
Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue
Genetically engineered mouse models for studying radiation biology
Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Advances on immunotherapy in genitourinary and renal cell carcinoma
Gregory P. Botta, Eric Granowicz, Carrie Costantini
The role of novel immunotherapies in non-Hodgkin lymphoma
Allyson Pishko, Sunita D. Nasta
MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan
Do p53 stress responses impact organismal aging?
Paul Hasty, Judith Campisi, Z. Dave Sharp
Pharmacological targeting of mutant p53
Samuel Kogan, Darren Carpizo
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Michael I. Carr, Stephen N. Jones
Regulation of cytotoxic T-cell responses by p53 in cancer
Mitchell W. Braun, Tomoo Iwakuma
The IGF-1R/AKT pathway determines cell fate in response to p53
Lei Duan, Carl G. Maki
Intra molecular interactions in the regulation of p53 pathway
Jiandong Chen
TP53 mutations in epithelial ovarian cancer
Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu
Modulation of the p53 family network by RNA-binding proteins
Chris Lucchesi, Jin Zhang, Xinbin Chen
Radiomics in head and neck cancer: from exploration to application
Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller
Prostate cancer radiomics and the promise of radiogenomics
Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack
Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies
Wei Lu, Wengen Chen
The emerging field of radiomics in esophageal cancer: current evidence and future potential
Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin
Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
Jung H. Suh, Julie D. Saba
Computational methods and opportunities for phosphorylation network medicine
Yian Ann Chen, Steven A. Eschrich

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
New light on the pancreatic cyst conundrum
Nathan A. Berger
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?
Andrew J. Scott, John C. Wilkinson
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
Nan Ding, Qianzheng Zhu
Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?
Apar Gupta, Nisha Ohri, Bruce G. Haffty
Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents
Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi
CRISPR-based genetic interaction maps inform therapeutic strategies in cancer
Poornima Ramkumar, Martin Kampmann
Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study
Melin J. Khandekar, Rakesh Jain
The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin
Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed
Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer
Joanne P. Young, Timothy J. Price, Susan Parry
Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response
R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang
Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes
Theresa L. Whiteside
TIC10/ONC201—a potential therapeutic in glioblastoma
Georg Karpel-Massler, Markus D. Siegelin
IDH mutational status and the immune system in gliomas: a tale of two tumors?
Bryan D. Choi, William T. Curry
ONC201: a new treatment option being tested clinically for recurrent glioblastoma
Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry
When better still might not be good enough
Waldemar Debinski
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy
Vincent C. O. Njar
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28
Leonardo Chicaybam, Prasad S. Adusumilli
Exosome mediated phenotypic changes in lung cancer pathophysiology
Yoshihisa Shimada, John D. Minna
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aaron D. DeWard, Rebecca J. Critchley-Thorne
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein
Felicia L. Lenzo, William G. Cance
New incriminating evidence against IGF2
Wen Ding, Lina A. Shehadeh
Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect
Paul Grippo, Ajay V. Maker
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger
RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver
Satomi Yamamoto, Tomoo Iwakuma
Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy
Michael J. Baine, Chi Lin
Rogue one: another faction of the Wnt empire implicated in assisting GBM progression
Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed
Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway
Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems
Li Tian, Ashley Chang, Marites P. Melancon
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
James P. White
Low-frequency ultrasound may improve drug penetration in colonic mucosa
Qiubing Chen, Bo Xiao, Didier Merlin
Dividing and conquering the variation among variants in EML4-ALK lung cancer
Trever G. Bivona
Unlocking the epigenetic code of T cell exhaustion
Jiazhu Wu, Huidong Shi
KDM1 links nuclear GSK3β to epigenetic alterations
Weijie Guo, Binhua P. Zhou
Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease
Deepa Rangachari, Daniel B. Costa
Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy
Bhagelu R. Achyut, Ali S. Arbab
Neuroendocrine differentiation in prostate cancer: key epigenetic players
Karishma Gupta, Sanjay Gupta
PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression
Kim A. Brogden, Shireen Vali, Taher Abbasi
Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy
Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias
The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies
Keith T. Schmidt, William D. Figg
Information-dense analysis for information-dense understanding
Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
Fabiana Perna, Michel Sadelain
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells
Alex J. Gooding, William P. Schiemann
Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?
Nathan A. Berger
Microtubule targeting agents in glioma
Anda-Alexandra Calinescu, Maria G. Castro
Moving molecular subtypes to the clinic in gastric cancer
Joseph Chao, Jeeyun Lee, Samuel J. Klempner
Intraoperative subtyping of lung adenocarcinoma: an unmet need
Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli
Emerging roles of FGF signaling in hepatocellular carcinoma
Nana Zheng, Wenyi Wei, Zhiwei Wang
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
Brandon J. Manley, James J. Hsieh
Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer
Salma Kaochar, Nicholas Mitsiades

Letter to the Editor

Epigenetic regulation of PD-L1 expression and pancreatic cancer response to checkpoint immunotherapy
Chunwan Lu, Kebin Liu
Synthetic lethality vs. synthetic viability due to PARP1 and BRCA2 loss
Xia Ding, Shyam K. Sharan

Correspondence

Targeted attack: mechanisms by which ovarian cancers suppress the immune system
Irina V. Tiper, Tonya J. Webb

Brief Report

The impact of neighborhood disadvantage on health-related quality of life among African American and white cancer survivors
Chien-Ching Li, Alicia K. Matthews, Anjali Asthana, Raj C. Shah

Research Highlight

Butyrate consumption of differentiated colonocytes in the upper crypt promotes homeostatic proliferation of stem and progenitor cells near the crypt base
Scott J. Bultman

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike
Jeffrey J. Tosoian, Emmanuel S. Antonarakis
A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer
Sawsan Rashdan, David E. Gerber
MOAP-1, UBR5 and cisplatin resistance in ovarian cancer
Scott T. Eblen, Amber Bradley
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer
Weimin Gao
The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)
Theresa L. Whiteside
[18F]-choline PET/CT as an imaging biomarker for primary liver cancers
Zhenghong Lee
Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best
Yoshio Yamaoka, David Y. Graham
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function
Theodoros Karantanos, Vassiliki A. Boussiotis
Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer
Angel Qin, Gregory P. Kalemkerian
Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered
Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham
Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells
Praveen Kumar Vemula, Venkatakrishna Rao Jala
Helios—controller of Treg stability and function
Claire Chougnet, David Hildeman
Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation
Jon K. Obst, Marianne D. Sadar
Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird
Fat lure: adipocytes attract cancer cells out of the prostate
Alexandra M. Blee, Haojie Huang
Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers
Guoli Chen, Ming-Tseh Lin

Editorials

Into the eye of the storm: breast cancer’s somatic mutation landscape points to DNA damage and repair
Joanne Ngeow, Emily Nizialek, Charis Eng

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
The STAMPEDE trial: paradigm-changing data through innovative trial design
Bradley C. Carthon, Emmanuel S. Antonarakis
Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway
Derek B. Oien, Jeremy Chien, Nikki Cheng
Feed your gut with caution!
Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar
Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma
Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma
Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Journal highlight more

Translational Cancer Research is an international, open access, peer-reviewed journal indexed in Scopus and Science Citation Index Expanded (SCIE), focusing on original, science-based researches on clinical, basic and translational aspects. It publishes laboratory studies of novel therapeutic interventions, clinical trials which evaluate new treatment paradigms for cancer, results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients and etc.

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Translational Cancer Research is indexed and covered by

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Visual Abstract

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In 2026, TCR reviewers continue to make outstanding contributions to the peer review process. More >>
In 2025, TCR reviewers continue to make outstanding contributions to the peer review process. More >>
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Membership

Member since 2021

Publishing Information

Translational Cancer Research is published by AME Publishing Company

AME Publishing Company

Translational Cancer Research is published with support from Wolters Kluwer

Wolters Kluwer

The official journal of Society for Translational Medicine (STM), Hong Kong

Society for Translational Medicine (STM), Hong Kong

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