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Guideline for Responsible AI Usage

Artificial intelligence (AI) is widely used in scholarly publishing. While improving the efficiency of scientific research and publishing operations, it has also introduced a serie... More >>

Join us at the IASLC 2026 World Conference on Lung Cancer

The IASLC 2026 World Conference on Lung Cancer (WCLC) is going to be held in Seoul, Republic of Korea from September 12th to 15th, 2026: https://wclc.iaslc.org/ More >>

New Impact Factor for Translational Cancer Research: 2.1

We are pleased to announce that Translational Cancer Research (TCR) has attained its latest impact factor update for the 2025 citation year: 2.1. More >>

Commentary

Response-adapted de-escalation in human papilloma virus-related oropharyngeal squamous cell carcinoma
John W.R. Kincaid, Jonathan D. Schoenfeld, Mina Bakhtiar
Translational Cancer Research  
2026;
15
(10)
:723
.
Combination therapy using durvalumab in patients with advanced soft tissue sarcoma: is doxorubicin best?
Tomoki Nakamura, Masahiro Hasegawa
Translational Cancer Research  
2026;
15
(10)
:724
.
Mammary gland involution: a potential link to pregnancy and postpartum breast cancer risk
Kate Ormiston, Daniel G. Stover
Translational Cancer Research  
2026;
15
(10)
:725
.
Rational triplet therapy after CDK4/6 inhibition: what TAKTIC adds and what it cannot resolve
Jessé Lopes da Silva, Thales de Sousa Ferreira da Silva, Andréia Cristina de Melo
Translational Cancer Research  
2026;
15
(10)
:726
.
ATHENA-MONO at five years: interpreting rucaparib maintenance through post-progression outcomes
Hiromichi Nakajima
Translational Cancer Research  
2026;
15
(10)
:727
.

Original Article

A multiparametric magnetic resonance imaging-based composite index for non-invasive discrimination of breast cancer molecular subtypes
Meiling Gao, Fujun Liu, Kaijie An, Yinfeng Qian
Translational Cancer Research  
2026;
15
(10)
:728
.
Microvascular invasion-associated serum glutaminolysis index and recurrence risk after liver transplantation for hepatocellular carcinoma
Hangbo Mo, Yiming Su, Yajie Zhou, Jinyan Chen, Huigang Li, Ruijie Zhao, Jianyong Zhuo, Chiyu He, Wei Shen, Peiru Zhang, Yuhang Li, Zuyuan Lin, Shusen Zheng, Di Lu
Translational Cancer Research  
2026;
15
(10)
:729
.
Analysis of prognostic features associated with extracellular matrix and lymph node metastasis in colorectal cancer
Xuefang Chen, Feng Qiu, Rujie Peng, Zhihua Chen, Chengchao Zheng, Yuling Shen, Qingxin Zeng
Translational Cancer Research  
2026;
15
(10)
:730
.
Lycopene suppresses lung cancer progression via PI3K/AKT pathway inhibition and apoptosis induction: mechanistic and safety insights from preclinical models
Haibo Gu, Chengyu Pan, Qi Xu, Jingjing Lu, Tian Zhao, Keyan Fu, Xianting Yan, Yun Xu, Jian Ye
Translational Cancer Research  
2026;
15
(10)
:731
.
Development and internal validation of a nomogram for predicting short- and long-term overall survival in patients with breast cancer liver metastasis: a SEER-based prognostic study
Lei Zhang, Peng Gu, Wentao Ding, Wenting Zhu, Ruitao Wang, Wei Wang, Xing Sun
Translational Cancer Research  
2026;
15
(10)
:732
.
Beta-blockers, renin-angiotensin system inhibitors, and cardiovascular outcomes during trastuzumab therapy for HER2-positive breast cancer: a systematic review and meta-analysis of randomized controlled trials
Yukun Liu, Linlin Zhang, Jie Guan, Zhimei Wang, Xiaodong Luan
Translational Cancer Research  
2026;
15
(10)
:733
.
Immunotherapy maintenance in extensive-stage small-cell lung cancer: a real-world retrospective study
Xiang Lin, Nan Lin, Qian Zhang, Shengxin Zhang, Xiao Liang, Beinuo Wang, Zhenghao Dong, Yu Tong, Yanlin Zhang, Xuelei Ma, Hu Liao
Translational Cancer Research  
2026;
15
(10)
:734
.
Vitamin D receptor is associated with farnesyl diphosphate synthase protein stability and malignant phenotypes in esophageal squamous cell carcinoma cells
Siying Liu, Yongjun Wang, Nan Zhang
Translational Cancer Research  
2026;
15
(10)
:735
.
An improved scoring method for human epidermal growth factor receptor-2 immunohistochemical staining in breast cancer
Rui Guo, Yi Tian, Qiaoling Yu, Hong Huang, Xiaozhong Huang, Jun Yang
Translational Cancer Research  
2026;
15
(10)
:736
.
A population-based prediction model for lymph node metastasis in patients aged ≥70 years with non-small cell lung cancer
Hongquan Xing, Weichang Yang, Sunying Li, Yang Huang, Xiaoqun Ye, Guofeng Zhu
Translational Cancer Research  
2026;
15
(10)
:737
.
High glucose drives non-small cell lung cancer progression via OGT-mediated O-GlcNAcylation and PI3K/AKT/mTOR pathway activation
Guo-Dong Shi, Hui-Jiang Gao, Dong Wang, Yu-Cheng Wei, Peng Zhang
Translational Cancer Research  
2026;
15
(10)
:738
.
C18H17NO6 inhibits proliferation and induces apoptosis in human osteosarcoma U2OS cells via the PI3K/AKT signaling pathway
Qianqian Qu, Enzi Feng, Shiwen Zhang, Zhongshun He, Jing Pan, Jin Wang, Yanli Yang
Translational Cancer Research  
2026;
15
(10)
:739
.
Non-contrast dual-layer spectral detector CT combined with laboratory indicators for differentiating hepatic hemangiomas from malignant liver tumours: development and internal validation of a diagnostic prediction model
Qinghong Yan, Rui Guo, Ke Chang, Xinyue Xu, Danni Wang, Tuona Di, Yunhang Jing
Translational Cancer Research  
2026;
15
(10)
:740
.
Non-fluorouracil/cisplatin versus fluorouracil/cisplatin regimens in chemoradiation for esophageal cancer: a systematic review and meta-analysis
Ming Chen, JunTao Ran, Fan Ding, Mingjun Zhao
Translational Cancer Research  
2026;
15
(10)
:741
.
Network perturbation of lactate metabolism identifies an aggressive hepatocellular carcinoma subtype with distinct immune and microbial features
Tao Guo, Huahua Du
Translational Cancer Research  
2026;
15
(10)
:742
.
Development and external clinical validation of a histology-inclusive prognostic nomogram for vulvar cancer based on the Surveillance, Epidemiology, and End Results database
Hongqian Ke, Ning Xie, Qian Wu, Bin Zhan
Translational Cancer Research  
2026;
15
(10)
:743
.
Survival outcomes of radiotherapy in elderly patients with unresectable stage III hepatocellular carcinoma: a population-based retrospective cohort study
Shuai Hao, Jingjing Tuo, Ziyi Xie, Nan Lou, Feng Li, Ming Liu, Xiaohui Cao, Nan Li
Translational Cancer Research  
2026;
15
(10)
:744
.
Development and validation of a phase-stable computed tomography radiomics model for brain metastasis risk stratification in non-small cell lung cancer
Zimeng Li, Xiaoying Xia, Jinmiao Chen, Yifei Du, Jiaxuan Zhou, Yeqing Zhu, Xinchun Li, Qi Wan
Translational Cancer Research  
2026;
15
(10)
:745
.
Clinicogenomic characterization and targeted therapy efficacy in Chinese patients with NTRK fusion-positive thyroid cancer: a preliminary retrospective cohort study
Zhiyuan Shi, Yuan Liu, Yu Xiao, Xiang Wang, Lin Zhao, Yonghui Chen
Translational Cancer Research  
2026;
15
(10)
:746
.
A survival-informed CD8+ T cell-associated gene signature and its prognostic relevance in clear cell renal cell carcinoma
Hui Wang, Fan Li, Yi Lu, Lifeng Ding
Translational Cancer Research  
2026;
15
(10)
:747
.
A retrospective analysis of TACE-based multimodal liver-directed therapy for unresectable gastroenteropancreatic neuroendocrine carcinoma with liver metastases
Siyi Luo, Baojiang Liu, Aiwei Feng, Peng Liu, Fuxin Kou, Guang Cao, Song Gao, Jianhai Guo, Xin Zhang, Xiaodong Wang, Hui Chen, Haifeng Xu, Qinzong Gao, Jie Li, Xu Zhu
Translational Cancer Research  
2026;
15
(10)
:748
.
Development and internal validation of a prognostic nomogram for cancer-specific survival in Ewing sarcoma: a SEER-based study
Shilong Wang, Long Jia
Translational Cancer Research  
2026;
15
(10)
:749
.
Development and external validation of an 18-gene tertiary lymphoid structure-related prognostic signature in gastric cancer
Xiaying Han, Qimiao Chen, Zhixing Hao, Jing Chen, Jia Qi, Jian Chen
Translational Cancer Research  
2026;
15
(10)
:750
.
Molecular subtyping, prognostic evaluation, and tumor immune microenvironment heterogeneity in intrahepatic cholangiocarcinoma based on epithelial-mesenchymal transition and mitophagy-related genes
Yecheng Wang, Dongbin Liu, Kuo Liang, Zhenshun Wang
Translational Cancer Research  
2026;
15
(10)
:751
.
Integration of single-cell and bulk transcriptomics for deciphering prognostic value and immunotherapeutic features of floatptosis-mediated cell death in lung adenocarcinoma
Hanyang Wang, Yilun Shi, Qili Xue, Yu Jiao, Junnan Qian, Ziyue Liu, Zongyu Xie, Lei Zhang, Wenrui Wang
Translational Cancer Research  
2026;
15
(10)
:752
.
CT-guided transvaginal posterior fornix gel injection training based on a novel simulation model
Jia-Wei Zhu, Xi-Lin Yang, Yun-Can Zhou, Xiao-Rong Hou, Yu-Liang Sun, Bing Zhou, Wei-Ping Wang, Kang Ren, Zhen Pan, Ya-Li Wang, Hong-Gui Zhang, Jun-Fang Yan, Ke Hu, Fu-Quan Zhang
Translational Cancer Research  
2026;
15
(10)
:753
.
Diagnostic accuracy of PET/CT parameters for noninvasive prediction of isocitrate dehydrogenase mutation status in glioma: a systematic review and meta-analysis
Xulu Zhao, Yiran Chen, Zhi Zhang, Zhenping Ge, Ziyang Ren, Tao Hu
Translational Cancer Research  
2026;
15
(10)
:754
.
Therapeutic value of PD-1/PD-L1 blockade plus chemotherapy in advanced or metastatic triple-negative breast cancer: a systematic review and meta-analysis of randomized controlled trials
Wanli Qian, Guozhong Chen, Xiaohe Cai, Shuting Yao
Translational Cancer Research  
2026;
15
(10)
:755
.
A novel tumor cell origin-based risk score (TCOMRS) to predict liver metastasis and guide treatment in colon adenocarcinoma
Liping Gao, Lingxiu Zeng, Yabing Huo, Hao Liu, Jing Liu, Yong Li
Translational Cancer Research  
2026;
15
(10)
:756
.
Association of fatty acid binding protein 4 with altered immune composition and ferroptosis related signatures in metastatic medullary thyroid cancer
Xiu Chen, Ying Yang, Yuxin Song, Hui Lu, Rong Fu
Translational Cancer Research  
2026;
15
(10)
:757
.
Eriodyctiol induces P53-dependent apoptosis in pancreatic cancer through disruption of MDM2-P53 interaction and synergistically enhances gemcitabine efficacy
Zhe Liu, Long Yang, Xiaorong Zhu, Ting Dai, Lihui Cheng, Xiaoyan Hu
Translational Cancer Research  
2026;
15
(10)
:758
.
Joint neutrophil-to-lymphocyte ratio-systemic inflammation response index score as an independent prognostic biomarker for immunotherapy-treated intrahepatic cholangiocarcinoma
Kena Lian, Honggang Cao, Zizhuang Si, Jian Ma, Bingbing Qiao
Translational Cancer Research  
2026;
15
(10)
:759
.
Nomograms predicting overall survival and cancer-specific survival in patients with squamous cell carcinoma based on the Surveillance, Epidemiology, and End Results (SEER) database
Ying Peng, Zhixiong Chen
Translational Cancer Research  
2026;
15
(10)
:760
.
Targeting miR-506 in leiomyosarcoma therapy: simultaneous suppression of metastatic potential and potentiation of pirarubicin efficacy
Ting Li, Ruwei Xing, Feng Li, Jilong Yang
Translational Cancer Research  
2026;
15
(10)
:761
.
A non-small cell lung cancer-associated circulating nine-microRNA signature for non-invasive lung cancer detection: integrated bioinformatics, machine learning, external validation, and exploratory regulatory network analysis
Qiuyue Wu, Penglong Zhao, Qian Wan, Weinan Li, Longxiao Cai, Lan Luo
Translational Cancer Research  
2026;
15
(10)
:762
.
Spatial transcriptomics reveals PDIA6 as a tumor-intrinsic driver of mesenchymal plasticity and vascular microenvironment remodeling in glioblastoma
Changyang Zuo, Guozheng Zhao, Jie Lu, Junwei Ren, Yangqing Zhu, Xin Wu, Zhengquan Yu
Translational Cancer Research  
2026;
15
(10)
:763
.
Predictive performance of diffusion kurtosis imaging combined with magnetic resonance imaging morphological features for MGMT promoter status in glioma
Yin Gao, Zhenyu Song, Ping Wang, Huan Huang
Translational Cancer Research  
2026;
15
(10)
:764
.
Development and biological characterization of a random survival forest prognostic model for colon adenocarcinoma using eight machine learning algorithms
Jiqiao Zhang, Jiawu Tan, Mingjun Lu, Dan Luo, Mouguan Yang, Feng Gao, Chan He, Maoyin He, Lifeng Qin
Translational Cancer Research  
2026;
15
(10)
:765
.
TMBIM4 acts as a novel prognostic biomarker for glioblastoma and is associated with temozolomide chemoresistance
Jianeng Pu, Tianhua Li, Shuai Zhou, Hu Zhou
Translational Cancer Research  
2026;
15
(10)
:766
.
Global trends and translational evolution of regulatory T cell research in gastric cancer: a bibliometric mapping (2005–2025)
Houshu Tu, Menglin Chen, Panpan Zhu, Jing Hong, Ling He
Translational Cancer Research  
2026;
15
(10)
:767
.
The DNA mismatch repair landscape in pancreatic adenocarcinoma: a novel prognostic signature with implications for immune microenvironment and chemotherapy response
Hui Tang, Xuping Yang, Xiao Duan, Jia Feng, Changjing Xu, Yilan Huang, Longyang Jiang
Translational Cancer Research  
2026;
15
(10)
:768
.
Nutritional factors in predicting severe myelosuppression during concurrent chemoradiotherapy for esophageal cancer: development and internal validation of a pre-treatment nomogram
Zimu Li, Kuaile Zhao, Zhuting Tong
Translational Cancer Research  
2026;
15
(10)
:769
.
Inhibition of malignant progression in mesenchymal glioblastoma by PARP1 inhibitors
Hailin Zhang, Qiao Li, Xuan Yao, Bo Wang, Yawen Pan, Guoqiang Yuan
Translational Cancer Research  
2026;
15
(10)
:770
.
KRT5 and SERPINB5 cooperatively regulate the p53 pathway to inhibit cell adhesion and cell cycle abnormalities, suppressing skin melanoma progression
Bi-Shun Yi, Yan-Shan Fan
Translational Cancer Research  
2026;
15
(10)
:771
.
Development and validation of a competitive risk model for the progression of papillary microcarcinoma of the thyroid—based on the Surveillance, Epidemiology, and End Results database and real-world study
Fang Xiong, Juan Liu, Ke Gong
Translational Cancer Research  
2026;
15
(10)
:772
.
Screening and experimental validation of prognostic genes associated with B cell exhaustion in lung adenocarcinoma based on ordinary transcriptome data
Bo Yang, Guang-Shun Wang, Liang Zhang, Pan Yang, Jia-Qi Bao, Lin-Xiao Li, Lei Li, Ben Gao, Wei Li, Xiao-He Li
Translational Cancer Research  
2026;
15
(10)
:773
.
Cancer ratio plus and malignant pleural effusion: a systematic review and meta-analysis of diagnostic test accuracy study
Wen-Jie Hou, Xu-Lei Hao, Yue Gao, Rui Niu, Qiu-Fen Tian, Ran-Tong Bao, Lu Tong, Ya-Ning Shi, Ya-Nan Xu, Li Yan, Wen-Qi Zheng, Zhi-De Hu, Mei-Ying Wang
Translational Cancer Research  
2026;
15
(10)
:774
.
Development and validation of machine learning-based models for identifying synchronous distant metastasis at initial diagnosis in cutaneous melanoma using the SEER database
Heng Wang, Jiangfeng Li, Fuguang Zhang, Yuelu Yang, Jianwu Chen, Guangtao Huang
Translational Cancer Research  
2026;
15
(10)
:775
.
BECN1/CAV-1 axis regulates neuronal function in the microenvironment of osteosarcoma through ERK/CREB signaling
Jianyun Ge, Tianyu Gu, Mengmeng Cai, Xu Liu, Xin Sun, Qian Su, Jie Song
Translational Cancer Research  
2026;
15
(10)
:776
.
Clinicopathologic features and prognosis of human papillomavirus-negative cervical cancer: a single-center analysis of 33 cases
Xinqiao Du, He Li, Guo Zhang
Translational Cancer Research  
2026;
15
(10)
:777
.
A tumor-infiltrating lymphocyte-related prognostic signature for lung adenocarcinoma
Kang Tian, Xinjie Zhao, Jiajun Du, Fenglong Bie
Translational Cancer Research  
2026;
15
(10)
:778
.
Radiotherapy and immune checkpoint inhibitors in small cell lung cancer: a Web of Science Core Collection-based bibliometric analysis
Weihan Wang, Zhonghua Chen, Yang Wang, Changguo Shi, Xiaohong Zhou
Translational Cancer Research  
2026;
15
(10)
:779
.
Identification of diagnostic and prognostic biomarkers for hepatocellular carcinoma: a focus on FIGNL1
Yanan Xi, Suisui Shi, Mingzhu He, Licui Zhang, Gaojie Li
Translational Cancer Research  
2026;
15
(10)
:780
.
Astragalus polysaccharide exerts anti-tumor effects associated with altered TIGIT-CD155 axis expression in Lewis lung carcinoma models
Bing Wang, Ping Wang, Zuowei Hu
Translational Cancer Research  
2026;
15
(10)
:781
.
Real-world efficacy and safety of blinatumomab across three clinical settings in pediatric B-cell acute lymphoblastic leukemia: a single-center retrospective cohort study
Shan Gao, Tianping Chen, Lijun Qu, Jian Wang, Wenjia Tong
Translational Cancer Research  
2026;
15
(10)
:782
.
The pharmacological potential and metabolic risks of Xiaojin Pill in sorafenib-resistant papillary thyroid carcinoma: an integrated network analysis
Junhao Zhang, Jiajun Chen, Kaibo Su, Qingxuan Wang, Chunjue Ni, Endong Chen, Boxi Wang, Man Li, Zhaokai Dong, Yihan Cai, Huazhen Mei, Tianyu Han, Haozhuo Huang, Yefeng Cai, Quan Li
Translational Cancer Research  
2026;
15
(10)
:783
.
SLC12A4 promoter methylation in plasma cell-free DNA as a candidate biomarker for thyroid cancer
Wei Wu, Ye Wang, Ying Qu, Changan Han, Peng Xia, Bin Huang, Jie Liu, Lingxiang Wu, Ruohan Zhang, Qianghu Wang, Zhi Zhang
Translational Cancer Research  
2026;
15
(10)
:784
.
Suppression of the cuproptosis mechanism by the oncogene RASGRP2 in driving osteosarcoma progression
Jinquan Chen, Dandong Luo, Jie Cui, Zhiyong Shu, Cheng Wang, Yuwen Jiang, Huajun Wang, Xiaofei Zheng
Translational Cancer Research  
2026;
15
(10)
:785
.

Review Article

Navigating the current and future perioperative treatment landscape of muscle-invasive bladder cancer (MIBC)
Farhan Azad, Eseoghene Kevu, Jeanny B. Aragon-Ching
Translational Cancer Research  
2026;
15
(10)
:786
.
Cancer-related pain management update in 2025: refining established therapies and expanding toward integrated multimodal and longitudinal management
Yufeng Li, Jing Cang, Fang Fang
Translational Cancer Research  
2026;
15
(10)
:787
.
Spasmolytic polypeptide-expressing metaplasia in the progression of gastric precancerous lesions: mechanisms and therapeutic opportunities—a narrative review
Xiangye Zhang, Keyan Shi, Jian Gao
Translational Cancer Research  
2026;
15
(10)
:788
.
Messenger RNA vaccine platforms from molecular optimization to infectious disease and cancer immunotherapy: a narrative review
Qian Wang, Zhangzhang Sun, Heyong Liu
Translational Cancer Research  
2026;
15
(10)
:789
.
Exploring immunotherapy resistance in bone metastasis: mechanisms and optimization of combined treatment strategies—a narrative review
Junquan Zhu, Min Li
Translational Cancer Research  
2026;
15
(10)
:790
.

Erratum

Erratum: Tirzepatide attenuates doxorubicin-induced cardiotoxicity via mitochondrial function improvement
Editorial Office
Translational Cancer Research  
2026;
15
(10)
:791
.
Review Article 
The management of brain necrosis as a result of SRS treatment for intra-cranial tumors
Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen
Published online: 28 August 2014
Meta-Analysis 
Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu
Published online: 05 March 2013
Review Article 
Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai
Published online: 05 March 2013
Original Article 
Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review
Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi
Published online: 28 April 2017
Biological basis of IORT 
Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects
Ithaisa Sologuren, Carlos Rodríguez-Gallego, Pedro Carlos Lara
Published online: 25 February 2014
Review Articles 
Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer
Deep Kwatra, Anand Venugopal, Shrikant Anant
Published online: 26 September 2013
Review Article 
EGFR first- and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients
Niki Karachaliou, Manuel Fernandez-Bruno, Jillian Wilhelmina Paulina Bracht, Rafael Rosell
Published online: 19 January 2019
Review Article 
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
Published online: 18 June 2015
Review Articles 
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Published online: 26 September 2013
Biological basis of IORT 
Cell and molecular response to IORT treatment
Luigi Minafra, Valentina Bravatà
Published online: 25 February 2014
Review Articles 
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
Published online: 19 June 2013
Review Article 
Urological complications after radiation therapy—nothing ventured, nothing gained: a Narrative Review
Joanna Chorbińska, Wojciech Krajewski, Romuald Zdrojowy
Published online: 26 February 2021
Review Articles 
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Published online: 19 June 2013
Review Article 
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Published online: 30 June 2017
Review Article 
EGFR and HER2: is there a role in ovarian cancer?
Eleonora Teplinsky, Franco Muggia
Published online: 13 February 2015
Review Article 
Multiple keratoacanthoma centrifugum marginatum—a case report and systematic review
Yiman Wang, Wenling Zhao, Yueping Zeng, Li Li, Hongzhong Jin
Published online: 30 December 2018

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park
How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis
Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao
Alcohol intake patterns for cancer and non-cancer individuals: a population study
Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng
Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial
Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu
Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management
Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas
Exosomal lncRNAs as new players in cell-to-cell communication
Mihnea Dragomir, Baoqing Chen, George A. Calin
Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy
Souparno Bhattacharya, Aroumougame Asaithamby
Translational research in radiation-induced DNA damage signaling and repair
Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue
Genetically engineered mouse models for studying radiation biology
Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Advances on immunotherapy in genitourinary and renal cell carcinoma
Gregory P. Botta, Eric Granowicz, Carrie Costantini
The role of novel immunotherapies in non-Hodgkin lymphoma
Allyson Pishko, Sunita D. Nasta
MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan
Do p53 stress responses impact organismal aging?
Paul Hasty, Judith Campisi, Z. Dave Sharp
Pharmacological targeting of mutant p53
Samuel Kogan, Darren Carpizo
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Michael I. Carr, Stephen N. Jones
Regulation of cytotoxic T-cell responses by p53 in cancer
Mitchell W. Braun, Tomoo Iwakuma
The IGF-1R/AKT pathway determines cell fate in response to p53
Lei Duan, Carl G. Maki
Intra molecular interactions in the regulation of p53 pathway
Jiandong Chen
TP53 mutations in epithelial ovarian cancer
Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu
Modulation of the p53 family network by RNA-binding proteins
Chris Lucchesi, Jin Zhang, Xinbin Chen
Radiomics in head and neck cancer: from exploration to application
Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller
Prostate cancer radiomics and the promise of radiogenomics
Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack
Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies
Wei Lu, Wengen Chen
The emerging field of radiomics in esophageal cancer: current evidence and future potential
Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin
Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
Jung H. Suh, Julie D. Saba
Computational methods and opportunities for phosphorylation network medicine
Yian Ann Chen, Steven A. Eschrich

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
New light on the pancreatic cyst conundrum
Nathan A. Berger
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?
Andrew J. Scott, John C. Wilkinson
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
Nan Ding, Qianzheng Zhu
Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?
Apar Gupta, Nisha Ohri, Bruce G. Haffty
Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents
Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi
CRISPR-based genetic interaction maps inform therapeutic strategies in cancer
Poornima Ramkumar, Martin Kampmann
Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study
Melin J. Khandekar, Rakesh Jain
The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin
Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed
Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer
Joanne P. Young, Timothy J. Price, Susan Parry
Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response
R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang
Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes
Theresa L. Whiteside
TIC10/ONC201—a potential therapeutic in glioblastoma
Georg Karpel-Massler, Markus D. Siegelin
IDH mutational status and the immune system in gliomas: a tale of two tumors?
Bryan D. Choi, William T. Curry
ONC201: a new treatment option being tested clinically for recurrent glioblastoma
Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry
When better still might not be good enough
Waldemar Debinski
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy
Vincent C. O. Njar
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28
Leonardo Chicaybam, Prasad S. Adusumilli
Exosome mediated phenotypic changes in lung cancer pathophysiology
Yoshihisa Shimada, John D. Minna
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aaron D. DeWard, Rebecca J. Critchley-Thorne
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein
Felicia L. Lenzo, William G. Cance
New incriminating evidence against IGF2
Wen Ding, Lina A. Shehadeh
Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect
Paul Grippo, Ajay V. Maker
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger
RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver
Satomi Yamamoto, Tomoo Iwakuma
Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy
Michael J. Baine, Chi Lin
Rogue one: another faction of the Wnt empire implicated in assisting GBM progression
Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed
Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway
Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems
Li Tian, Ashley Chang, Marites P. Melancon
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
James P. White
Low-frequency ultrasound may improve drug penetration in colonic mucosa
Qiubing Chen, Bo Xiao, Didier Merlin
Dividing and conquering the variation among variants in EML4-ALK lung cancer
Trever G. Bivona
Unlocking the epigenetic code of T cell exhaustion
Jiazhu Wu, Huidong Shi
KDM1 links nuclear GSK3β to epigenetic alterations
Weijie Guo, Binhua P. Zhou
Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease
Deepa Rangachari, Daniel B. Costa
Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy
Bhagelu R. Achyut, Ali S. Arbab
Neuroendocrine differentiation in prostate cancer: key epigenetic players
Karishma Gupta, Sanjay Gupta
PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression
Kim A. Brogden, Shireen Vali, Taher Abbasi
Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy
Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias
The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies
Keith T. Schmidt, William D. Figg
Information-dense analysis for information-dense understanding
Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
Fabiana Perna, Michel Sadelain
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells
Alex J. Gooding, William P. Schiemann
Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?
Nathan A. Berger
Microtubule targeting agents in glioma
Anda-Alexandra Calinescu, Maria G. Castro
Moving molecular subtypes to the clinic in gastric cancer
Joseph Chao, Jeeyun Lee, Samuel J. Klempner
Intraoperative subtyping of lung adenocarcinoma: an unmet need
Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli
Emerging roles of FGF signaling in hepatocellular carcinoma
Nana Zheng, Wenyi Wei, Zhiwei Wang
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
Brandon J. Manley, James J. Hsieh
Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer
Salma Kaochar, Nicholas Mitsiades

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike
Jeffrey J. Tosoian, Emmanuel S. Antonarakis
A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer
Sawsan Rashdan, David E. Gerber
MOAP-1, UBR5 and cisplatin resistance in ovarian cancer
Scott T. Eblen, Amber Bradley
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer
Weimin Gao
The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)
Theresa L. Whiteside
[18F]-choline PET/CT as an imaging biomarker for primary liver cancers
Zhenghong Lee
Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best
Yoshio Yamaoka, David Y. Graham
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function
Theodoros Karantanos, Vassiliki A. Boussiotis
Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer
Angel Qin, Gregory P. Kalemkerian
Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered
Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham
Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells
Praveen Kumar Vemula, Venkatakrishna Rao Jala
Helios—controller of Treg stability and function
Claire Chougnet, David Hildeman
Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation
Jon K. Obst, Marianne D. Sadar
Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird
Fat lure: adipocytes attract cancer cells out of the prostate
Alexandra M. Blee, Haojie Huang
Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers
Guoli Chen, Ming-Tseh Lin

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
The STAMPEDE trial: paradigm-changing data through innovative trial design
Bradley C. Carthon, Emmanuel S. Antonarakis
Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway
Derek B. Oien, Jeremy Chien, Nikki Cheng
Feed your gut with caution!
Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar
Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma
Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma
Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen