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New Impact Factor for Translational Cancer Research: 2.1

We are pleased to announce that Translational Cancer Research (TCR) has attained its latest impact factor update for the 2025 citation year: 2.1. More >>

Translational Cancer Research 2025 CiteScore Released: 2.6

We are pleased to announce that the Translational Cancer Research (TCR) has achieved its 2025 CiteScore: 2.6. More >>

Welcome to the 2026 Clinical Research Innovation Forum & Editors-in-Chief Meet-and-Greet

We are pleased to invite you to join the 2026 Clinical Research Innovation Forum & Editors-in-Chief Meet-and-Greet co-organized by AME Publishing Company and Wolters Kluwer.The eve... More >>

Editorial Commentary

Dynamic tumor tracking for locally advanced pancreatic cancer: precision in motion
Jason Gurewitz, Jennifer B. Permuth, Sarah Hoffe, Jessica Frakes
Translational Cancer Research  
2026;
15
(6)
:440
.
Angiotensin system inhibitors as adjunctive therapy in esophageal adenocarcinoma: hypothesis-generating insights from incidental use during trimodal treatment
Alberto Carmona-Bayonas, Paula Jimenez-Fonseca
Translational Cancer Research  
2026;
15
(6)
:441
.
Do we need to adapt the American Joint Committee on Cancer staging system after neo-adjuvant treatment in esophageal squamous cell carcinoma?
Christina T. Muijs, Gursah Kats-Ugurlu
Translational Cancer Research  
2026;
15
(6)
:442
.

Original Article

Complement system-related gene signatures implicated in the recurrence of glioma
Yanqi Sun, Xiaozhang Bao, Yuheng Yang, Peinan Zhang, Nan Tian
Translational Cancer Research  
2026;
15
(6)
:443
.
The role of targeted therapy in the management of colorectal cancer liver metastases: a systematic review and meta-analysis
Ming Yan, Rixing Bai, Wenmao Yan
Translational Cancer Research  
2026;
15
(6)
:444
.
Global bibliometric analysis of TP53-mutated acute myeloid leukemia: research hotspots and evolution
Xiaomin Wang, Lan Zhang, Xuhang Fan, Miaohui Wang, Haixia Fan
Translational Cancer Research  
2026;
15
(6)
:445
.
Tumor histologic subtypes and stage impact the risk of cardiovascular diseases death in lung cancer patients after chemotherapy or radiotherapy: a population-based study
Dejin Li, Peipei Wang, Wenjuan Jiang, Jianli Wu, Liqiong Xu, Xin Jin, Lin Luo, Dan Zhao, Anfang Chen
Translational Cancer Research  
2026;
15
(6)
:446
.
Bone morphogenetic protein 5 as a potential diagnostic and prognostic biomarker in lung adenocarcinoma
Caiping Tian, Xiao Jing, Hongyu Luo, Yue Bai
Translational Cancer Research  
2026;
15
(6)
:447
.
Recombinant adeno-associated virus-mediated HSV-TK/GCV gene therapy for ovarian cancer: an experimental study
Yanqiang Xiong, Wu Zhou, Jianlin Yang, Yajun Li, Ye Shen, Yafeng Lv, Chan Meng
Translational Cancer Research  
2026;
15
(6)
:448
.
METTL16-mediated upregulation of LINC00665 inhibits the apoptosis of breast cancer via regulating miR-28-5p/GLG1 axis
Ya Zhou, Jie Ren, Xiaojuan Cai, Shiyu Lu, Hanbing Gu, Weizhe Xu, Xun Zhu
Translational Cancer Research  
2026;
15
(6)
:449
.
METTL3- and IGF2BP1-associated m6A regulation of FADS2 contributes to lipid droplet accumulation and malignant progression in non-small cell lung cancer
Yu Zhang, Lin Wang, Huanhuan Xu, Leping Fang, Yingying Jiang, Weifei Fan, Juqing Xu
Translational Cancer Research  
2026;
15
(6)
:450
.
DDR1 in esophageal squamous cell carcinoma: bioinformatics discovery and experimental validation
Yamen Ahmad Muad, Linxiang Zhang, Weiyan Peng, Lin Ye
Translational Cancer Research  
2026;
15
(6)
:451
.
LINC01614 favors breast cancer progression through the regulation of miR-217/FN1 and mediation in PI3K/AKT signal pathway
Ding Ping, Jiaxin Wang, Dengfeng Li, Lin Fang
Translational Cancer Research  
2026;
15
(6)
:452
.
A LASSO-based nomogram for predicting breast cancer-specific survival in elderly patients after surgery: a large retrospective cohort study
Ziqiang Wang, Haojie Zhang, Qianqian Li
Translational Cancer Research  
2026;
15
(6)
:453
.
CSN3 promotes gastric cancer progression and is associated with immune infiltration and inflammatory signaling
Gang Wang, Dalai Xu, Lei Qiu, Feng Lu, Yongchang Miao
Translational Cancer Research  
2026;
15
(6)
:454
.
Construction of a ferroptosis-related prognostic signature and identification of SRSF9 as a key biomarker in lung adenocarcinoma
Jian Wang, Yixi Wei, Jia Zhang, Wenshu Chai, Yubin Li
Translational Cancer Research  
2026;
15
(6)
:455
.
Combinatorial post-translational modification reprogramming of the endomembrane system in colorectal cancer
Jie Du, Wei Zhang, Wencong Song, Yujie Zhang, Erjiao Hao, Tianyuan Li, Min Feng, Feng Zhu, Yong Dai
Translational Cancer Research  
2026;
15
(6)
:456
.
Treatment strategies and survival outcomes of vestibular schwannoma: a comparative study based on Surveillance, Epidemiology, and End Results (SEER) database
Long Chen, Hai-Yan Zheng, Tao Hou, Yi Ren, Qiao Huang, Lin Shen, Li-Ping Peng, Dun-Chang Mo, Shi-Hua Yin
Translational Cancer Research  
2026;
15
(6)
:457
.
Development and validation of a DYX1C1- and GNAI1-based nomogram for predicting relapse in HER2-positive breast cancer treated with trastuzumab
Junjie Liu, Xiaoqian Li, Ziyan Li, Rui Zhang, Yunpeng Zhang, Wei Zhang, Jianjun He, Huimin Zhang
Translational Cancer Research  
2026;
15
(6)
:458
.
CLCA1 as an immune prognostic biomarker and therapeutic target in colorectal cancer
Zewei Cheng, Yuan Li, Xin Wang, Ben Feng, Yebo Shao, Li Yang, Jiwei Zhang
Translational Cancer Research  
2026;
15
(6)
:459
.
Development and validation of an interpretable model based on ultrasound radiomics for predicting Ki-67 expression levels in breast cancer
Changhong Zhang, Yuxing Zheng, Chengyu Fang, Yanhua Huang, Junping Liu
Translational Cancer Research  
2026;
15
(6)
:460
.
Artificial intelligence-based models for colorectal cancer diagnosis using laboratory tests: an exploratory retrospective case-control study
Jian-Mei Lin, Hai-Yan Huang, Hui-Liu Tan, Shu-Wei Ren, Xue-Ming Lu, Jun Liu, Hui Li, Hui-Zhen Jia, Yan-Hong Xiao
Translational Cancer Research  
2026;
15
(6)
:461
.
Effects of different drugs on radiation-induced oral mucositis in patients with head and neck tumors: a systematic review and a network meta-analysis
Shuchang Lou, Xiaodong Li, Lingyun Shi
Translational Cancer Research  
2026;
15
(6)
:462
.
Identification of GADD45B, HMGB3, LMNB2, and MFAP5 as lactylation-related prognostic markers for survival prediction in esophageal cancer
Shuo Li, Shaomin Quan, Jun Ma, Yunbo Bai, Jing Sun, Yuan Wang, Zhongjing Wang, Juntao Zhang, Song Zhang, Wanjun Li, Zhigang Fan
Translational Cancer Research  
2026;
15
(6)
:463
.
Development and internal validation of a SEER-based prediction model for survival in poorly and undifferentiated colorectal neuroendocrine neoplasms
Qiqiang Huang, Lilin Lin, Minmin Chen, Rui Huang, He Huang, Suyu Chen
Translational Cancer Research  
2026;
15
(6)
:464
.
Ailanthone as a novel AKT1 inhibitor that induces mitochondrial apoptosis and exerts anti-tumor activity in cervical cancer
Shaofeng Huang, Yanlun Song, Yun Zhao, Xin Zhang, Yannan Jiao, Jin Zhang, Yuehua Huang, Junli Wang, Haimei Qin, Fenglian Yang, Rong Wang
Translational Cancer Research  
2026;
15
(6)
:465
.
Si Ni Powder enhances chemotherapy efficacy in sleep-deprived breast cancer via modulation of the tumor microenvironment
Heyuan Jia, Ying Chen, Hao Cheng, Surui Yao, Qingwen Wang, Mengyuan Qian, Cun Ge, Zhaohui Huang, Yanyan Chen
Translational Cancer Research  
2026;
15
(6)
:466
.
Development and validation of a Random Forest prediction model integrating clinical and ultrasound radiomics features for microvascular invasion in hepatocellular carcinoma patients: a retrospective study
Aman Makeshati, Yuying Du, Halida Xiaerfuhazi, Xiaoping Yang
Translational Cancer Research  
2026;
15
(6)
:467
.
The prognostic value of log odds of positive lymph nodes in patients with resectable locally advanced gastric cancer following neoadjuvant therapy: results from the SEER database
Yining Gou, Yuwei Cao, Tao Jin, Zehua Chen, Ershuo Du, Panping Liang, Kun Yang
Translational Cancer Research  
2026;
15
(6)
:468
.
Integrative bioinformatics and experimental analysis identify S100A10 as a diagnostic and prognostic biomarker in pancreatic adenocarcinoma
Pengzhao Song, Tianqi Chen, Qingqun Guo, Yahui Sun, Pengfei Gu, Yong Han
Translational Cancer Research  
2026;
15
(6)
:469
.
WAC is associated with malignant phenotypes and Wnt/β-catenin pathway activity in liver cancer cells
Kejia Yuan, Zexian Ding, Lei Peng, Jinghua Zeng, Han Yang, Qi Yi
Translational Cancer Research  
2026;
15
(6)
:470
.
Endoplasmic reticulum stress promotes colorectal cancer proliferation by regulating autophagy via XBP1s
Di Zhang, Chunxia Wang, Yifeng Chen, Faxin Li, Xuedong Zhang, Tianhu Sun, Shuai Wang, Lixia Zhao, Honglai Zhang, Mingming Chai, Tao Wang
Translational Cancer Research  
2026;
15
(6)
:471
.
Phase separation of MARCH1 promotes rectal adenocarcinoma progression through PHLPP2 ubiquitination
Luyao Ma, Wengang Qiu, Jie Jiang, Haofeng Lu, Liang Meng
Translational Cancer Research  
2026;
15
(6)
:472
.
SDF4: a novel prognostic biomarker and therapeutic target in hepatocellular carcinoma revealed by integrated multi‑omics analysis
Wei Shi, Jing Zhang, Bohao Sun, Panyuan Li
Translational Cancer Research  
2026;
15
(6)
:473
.
KLK6 regulates ferroptosis through YAP/TAZ in lung adenocarcinoma
Junyu Xu, Xinran Xi, Xun Wu, Zhongbo Yu, Xiaoao Yin, Xianghai Wang
Translational Cancer Research  
2026;
15
(6)
:474
.
Survival improvement and widening social disadvantage-related disparities in osteosarcoma: a Surveillance, Epidemiology, and End Results-based retrospective cohort study
Shilin Luo, Chuang Li, Leilei Tian, Rui Shi, Yi Luo
Translational Cancer Research  
2026;
15
(6)
:475
.
Divergent roles of PRR11 and HEPACAM in pleural mesothelioma: PRR11 as a prognostic biomarker and HEPACAM as a stage-associated gene with paradoxical expression
Rong-Xin Zhao, Mei-Ling Zhang, Qian Wang, Kai-Hua Lu
Translational Cancer Research  
2026;
15
(6)
:476
.
Identification of telomere-related gene signatures for immune cell infiltration and prognosis in hepatocellular carcinoma
Juntao Sun, Ye Gao, Ruotong Xu, Hao Fu, Xinyi Ying, An Yan, Sunbin Ling
Translational Cancer Research  
2026;
15
(6)
:477
.
Identification of exhausted CD8+ T-cell signatures for prognosis in multiple myeloma by integrated analysis of single-cell and bulk RNA-sequencing
Huien Zhan, Jing Lai, Jie Chen, Ying Xu, Liye Zhong
Translational Cancer Research  
2026;
15
(6)
:478
.
The evolving landscape of early diagnosis for hepatocellular carcinoma: a bibliometric analysis of global research trends (2016–2026) based on WoSCC database
Lihua Chen, Zhekun Huang, Songbin Lin, Yirui Yin
Translational Cancer Research  
2026;
15
(6)
:479
.
Integrated multi-omics analysis reveals tumor-suppressive phenotypes and associated transcriptomic remodeling upon METTL3 overexpression in A549 lung cancer cells
Zhao Liu, Yanwu Zhou, Chun Li
Translational Cancer Research  
2026;
15
(6)
:480
.
Prognostic and therapeutic implications of PSMD14 in hepatocellular carcinoma: an integrative analysis of transcriptomic and single-cell profiles
Yongfu Lu, Bohao Sun, Jing Zhang, Lihong Tang
Translational Cancer Research  
2026;
15
(6)
:481
.
A Breg-associated lncRNA signature predicts prognosis and immune landscape in esophageal carcinoma
Wen-Tao Xiao, Si-Qi Wu, Ya-Rui Han, Jia-Hui Song, Jun-Yan He
Translational Cancer Research  
2026;
15
(6)
:482
.
A pan-cancer functional atlas of ADH1A reveals its conserved role in the tumor microenvironment and immunity
Yunna Zheng, Fan Yang, Lu Yuan, Jihong Huang, Dong Yu, Junyi Lu, Laiyu Liu, Wenqi Huang
Translational Cancer Research  
2026;
15
(6)
:483
.
A stromal-derived five-gene signature predicts gastric cancer recurrence through integrated bioinformatics and single-cell analysis
Yi Wang, Rui Mao
Translational Cancer Research  
2026;
15
(6)
:484
.
Risk factors for short-term survival in EGFR-mutated non-small cell lung cancer with brain metastasis and prognosis of the leptomeningeal metastasis subgroup: a retrospective cohort study
Jinghaozheng Bo, Zhuoxuan Wu, Yanyan Yang, Weidong Han
Translational Cancer Research  
2026;
15
(6)
:485
.
Potential role of PPARGC1A in linking ulcerative colitis to colorectal cancer: a novel prognostic biomarker and therapeutic target
Bo Fan, Wenzheng Li, Zhiyuan Wei
Translational Cancer Research  
2026;
15
(6)
:486
.
Efficacy and safety of combined RANKL and PD-1 inhibitors in bone metastases: a retrospective study
Wei Zhou, Yuehong Kong, Shicheng Li, Xiangrong Zhao, Liyuan Zhang
Translational Cancer Research  
2026;
15
(6)
:487
.
Multi-omics identification of an antibody dependent cellular phagocytosis related signature for hepatocellular carcinoma
Xisheng Yin, Wenmeng Yin, Qin Yan, Shi Zheng, Yantong Li, Xiaolin Zhong
Translational Cancer Research  
2026;
15
(6)
:488
.
Development and validation of a predictive model for perioperative venous thromboembolism in colorectal cancer patients based on D-dimer combined with fibrinogen levels
Xu Liu, Zhen Feng, Wendan Jing, Jiemin Zhou, Yang Xiang, Hongyu He, Yongfu Xiong
Translational Cancer Research  
2026;
15
(6)
:489
.
A senescence-based machine learning model prognosticates and personalizes therapy in cervical cancer
Gong Chen, Qianqian Jiang, Jingyuan Xu, Tingting He, Minmin Yu, Changsong Lin
Translational Cancer Research  
2026;
15
(6)
:490
.
Association between pan-immune-inflammation value and prognosis in lung cancer patients: a systematic review and meta-analysis
Shuanglong Zhang, Zhongjun Pan, Ming Ding, Youhong Yin, Fan Zhang, Danqing Jiang, Yaxin Ji, Xin Qin, Guoxiang Rong
Translational Cancer Research  
2026;
15
(6)
:491
.
Comparative effectiveness of immune checkpoint inhibitors in squamous vs. non-squamous cervical carcinoma: a systematic review and meta-analysis of randomized controlled trials
Li-Fang Lan, Yu-Jie Chen, Dun-Chang Mo, Wen-Yi Li, Fei Yu
Translational Cancer Research  
2026;
15
(6)
:492
.
Comprehensive bioinformatics analysis identifies DNA methylation signatures associated with immune evasion and predicts immunotherapy response in breast cancer
Yurong Cheng, Jing Wang, Dong Yan
Translational Cancer Research  
2026;
15
(6)
:493
.
Predictive value of the preoperative systemic immune-inflammation index for primary chemotherapy resistance risk in patients with advanced gastric cancer
Xu Liu, Zhen Feng, Yang Xiang, Jiemin Zhou, Wendan Jing, Hongyu He, Gang Yang
Translational Cancer Research  
2026;
15
(6)
:494
.
Venous thromboembolism risk in sarcoma patients receiving combined immune checkpoint inhibitors and VEGF pathway inhibitors: a real-world cohort study
Rahul Kumar, Rohan A. Phadke, Andrew Bouras, Harlene Kaur, Samer G. Salman, Sai Sarnala, Swapna Vaja, Dylan Riley, Samuel W. Rice, Marta Batus, Alan Blank
Translational Cancer Research  
2026;
15
(6)
:495
.
A mitochondrial function-based prognostic model for hepatocellular carcinoma uncovers MRPS15 as a key driver of tumor progression through oxidative phosphorylation
Weifei Liang, Shi Zhang, Yuyang Zhang, Donglin Sun, Fang Wang, Hong Lin, Yunhong Tian
Translational Cancer Research  
2026;
15
(6)
:496
.
Spatial immune profiling of local tissues and its correlation with peripheral blood cytokines in lung squamous cell carcinoma patients with immune-related pneumonitis
Hui He, Yuanyuan Wen, Jiale Yan, Lei Zhou, Haifeng Li
Translational Cancer Research  
2026;
15
(6)
:497
.
A pneumolysin mutant (ΔA146 ply) induces pyroptosis in triple-negative and HER2-positive breast cancer cells via the Caspase-1/GSDME pathway: a potential antibody-drug conjugate payload
Xiaochun Tan, Jing Chen, Qinlong Yu, Junhua Tian, Jiayuan Wang, Weifeng Shen
Translational Cancer Research  
2026;
15
(6)
:498
.
Single-cell mitophagy patterns dictate intercellular crosstalk in the tumor microenvironment to promote osteosarcoma progression
Wei Shi, Lei Zhang, Liying Mei, Chengqi Zhang, Lei Liu, Nan Zhao, Qingyu Liu
Translational Cancer Research  
2026;
15
(6)
:499
.
Tumor-derived CCL20 activates tumor-associated neutrophils, predicting good prognosis in endometrial cancer
Linyan Zhu, Wenwu Luo, Siyu Li, Chengkang Wu, Zhi Wang, Qiang Wu, Keshuo Ding
Translational Cancer Research  
2026;
15
(6)
:500
.
Accuracy of machine learning in detecting lymph node metastasis of esophageal cancer: a systematic review and meta-analysis
Jing Chen, Jiren Weng, Xuefeng Lin
Translational Cancer Research  
2026;
15
(6)
:501
.
Exosome-mediated regulation of the immune microenvironment via JAK/STAT signaling promotes pancreatic cancer progression
Shunxin Hao, Zhi Yao, Can Li, Tao Xiong, Jingxi Song, Yifeng Liu
Translational Cancer Research  
2026;
15
(6)
:502
.
CNTN-1 regulates malignant biological behaviors of lung squamous cell carcinoma (LUSC) via the endoplasmic reticulum stress (ERS)/epithelial-mesenchymal transition (EMT) axis
Kaimei Zhou, Weijie Dong, Shengjin Li, Depeng Jiang, Qi Wu, Zimo Wang, Minchao Li, Ruijie Zhang
Translational Cancer Research  
2026;
15
(6)
:503
.
Low-dose radiotherapy combined with immune checkpoint inhibitors in advanced malignancies: a real-world exploratory study
Kai Xin, Liping Deng, Meiqing Ding, Mengmeng Feng, Xiahui Wu, Lijing Zhu
Translational Cancer Research  
2026;
15
(6)
:504
.
Expression profiling, molecular subtyping and prognostic signature construction of chemokines and chemokine receptors in gastric cancer
Tianshu Feng, Yaoqi Li, Jieyu Hu, Liang Zhao, Xiaobin Yao
Translational Cancer Research  
2026;
15
(6)
:505
.
A nomogram based on systemic inflammatory markers: development and validation for predicting postoperative overall survival in gastric cancer
Liuyi Yang, Xuexian Cao, Yulan Gu, Jinghua Ye
Translational Cancer Research  
2026;
15
(6)
:506
.

Review Article

Mitochondrial dynamics imbalance in hepatocellular carcinoma: from molecular mechanisms to new strategies for targeted therapy
Fuxiang Chen, Chunyang Ma, Xitong Bo, Yilong Zhou, Suqing Zhang
Translational Cancer Research  
2026;
15
(6)
:507
.
Association between the Prognostic Nutritional Index and survival outcomes in hepatocellular carcinoma patients receiving immune checkpoint inhibitors: a systematic review and meta-analysis
Jiajia Qian, Shang Gao, Yunhao Zhu, Jingxia Wu
Translational Cancer Research  
2026;
15
(6)
:508
.
Micro- and nanoplastic exposure and cancer: current evidence, mechanistic pathways, and translational challenges
Yuxin Han, Zihan Chen, Zizhou Zhang, Xiaolan Lv, Yue Han, Liubing Hou, Xiaoying Xue, Huandi Zhou
Translational Cancer Research  
2026;
15
(6)
:509
.

Letter to the Editor

Toward precision immunotherapy in recurrent/metastatic head and neck squamous cell carcinoma: lessons from the FOCUS trial
Christoph Schultheiss, Tobias Andermatt, Anna Brandt, Mascha Binder
Translational Cancer Research  
2026;
15
(6)
:510
.
Review Article 
The management of brain necrosis as a result of SRS treatment for intra-cranial tumors
Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen
Published online: 28 August 2014
Meta-Analysis 
Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu
Published online: 05 March 2013
Review Article 
Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai
Published online: 05 March 2013
Original Article 
Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review
Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi
Published online: 28 April 2017
Biological basis of IORT 
Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects
Ithaisa Sologuren, Carlos Rodríguez-Gallego, Pedro Carlos Lara
Published online: 25 February 2014
Review Articles 
Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer
Deep Kwatra, Anand Venugopal, Shrikant Anant
Published online: 26 September 2013
Review Article 
EGFR first- and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients
Niki Karachaliou, Manuel Fernandez-Bruno, Jillian Wilhelmina Paulina Bracht, Rafael Rosell
Published online: 19 January 2019
Review Article 
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
Published online: 18 June 2015
Review Articles 
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Published online: 26 September 2013
Biological basis of IORT 
Cell and molecular response to IORT treatment
Luigi Minafra, Valentina Bravatà
Published online: 25 February 2014
Review Articles 
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
Published online: 19 June 2013
Review Articles 
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Published online: 19 June 2013
Review Article 
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Published online: 30 June 2017
Review Article 
EGFR and HER2: is there a role in ovarian cancer?
Eleonora Teplinsky, Franco Muggia
Published online: 13 February 2015
Review Article 
Urological complications after radiation therapy—nothing ventured, nothing gained: a Narrative Review
Joanna Chorbińska, Wojciech Krajewski, Romuald Zdrojowy
Published online: 26 February 2021
Review Article 
Multiple keratoacanthoma centrifugum marginatum—a case report and systematic review
Yiman Wang, Wenling Zhao, Yueping Zeng, Li Li, Hongzhong Jin
Published online: 30 December 2018

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park
How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis
Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao
Alcohol intake patterns for cancer and non-cancer individuals: a population study
Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng
Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial
Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu
Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management
Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas
Exosomal lncRNAs as new players in cell-to-cell communication
Mihnea Dragomir, Baoqing Chen, George A. Calin
Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy
Souparno Bhattacharya, Aroumougame Asaithamby
Translational research in radiation-induced DNA damage signaling and repair
Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue
Genetically engineered mouse models for studying radiation biology
Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Advances on immunotherapy in genitourinary and renal cell carcinoma
Gregory P. Botta, Eric Granowicz, Carrie Costantini
The role of novel immunotherapies in non-Hodgkin lymphoma
Allyson Pishko, Sunita D. Nasta
MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan
Do p53 stress responses impact organismal aging?
Paul Hasty, Judith Campisi, Z. Dave Sharp
Pharmacological targeting of mutant p53
Samuel Kogan, Darren Carpizo
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Michael I. Carr, Stephen N. Jones
Regulation of cytotoxic T-cell responses by p53 in cancer
Mitchell W. Braun, Tomoo Iwakuma
The IGF-1R/AKT pathway determines cell fate in response to p53
Lei Duan, Carl G. Maki
Intra molecular interactions in the regulation of p53 pathway
Jiandong Chen
TP53 mutations in epithelial ovarian cancer
Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu
Modulation of the p53 family network by RNA-binding proteins
Chris Lucchesi, Jin Zhang, Xinbin Chen
Radiomics in head and neck cancer: from exploration to application
Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller
Prostate cancer radiomics and the promise of radiogenomics
Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack
Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies
Wei Lu, Wengen Chen
The emerging field of radiomics in esophageal cancer: current evidence and future potential
Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin
Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
Jung H. Suh, Julie D. Saba
Computational methods and opportunities for phosphorylation network medicine
Yian Ann Chen, Steven A. Eschrich

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
New light on the pancreatic cyst conundrum
Nathan A. Berger
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?
Andrew J. Scott, John C. Wilkinson
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
Nan Ding, Qianzheng Zhu
Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?
Apar Gupta, Nisha Ohri, Bruce G. Haffty
Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents
Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi
CRISPR-based genetic interaction maps inform therapeutic strategies in cancer
Poornima Ramkumar, Martin Kampmann
Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study
Melin J. Khandekar, Rakesh Jain
The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin
Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed
Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer
Joanne P. Young, Timothy J. Price, Susan Parry
Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response
R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang
Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes
Theresa L. Whiteside
TIC10/ONC201—a potential therapeutic in glioblastoma
Georg Karpel-Massler, Markus D. Siegelin
IDH mutational status and the immune system in gliomas: a tale of two tumors?
Bryan D. Choi, William T. Curry
ONC201: a new treatment option being tested clinically for recurrent glioblastoma
Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry
When better still might not be good enough
Waldemar Debinski
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy
Vincent C. O. Njar
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28
Leonardo Chicaybam, Prasad S. Adusumilli
Exosome mediated phenotypic changes in lung cancer pathophysiology
Yoshihisa Shimada, John D. Minna
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aaron D. DeWard, Rebecca J. Critchley-Thorne
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein
Felicia L. Lenzo, William G. Cance
New incriminating evidence against IGF2
Wen Ding, Lina A. Shehadeh
Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect
Paul Grippo, Ajay V. Maker
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger
RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver
Satomi Yamamoto, Tomoo Iwakuma
Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy
Michael J. Baine, Chi Lin
Rogue one: another faction of the Wnt empire implicated in assisting GBM progression
Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed
Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway
Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems
Li Tian, Ashley Chang, Marites P. Melancon
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
James P. White
Low-frequency ultrasound may improve drug penetration in colonic mucosa
Qiubing Chen, Bo Xiao, Didier Merlin
Dividing and conquering the variation among variants in EML4-ALK lung cancer
Trever G. Bivona
Unlocking the epigenetic code of T cell exhaustion
Jiazhu Wu, Huidong Shi
KDM1 links nuclear GSK3β to epigenetic alterations
Weijie Guo, Binhua P. Zhou
Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease
Deepa Rangachari, Daniel B. Costa
Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy
Bhagelu R. Achyut, Ali S. Arbab
Neuroendocrine differentiation in prostate cancer: key epigenetic players
Karishma Gupta, Sanjay Gupta
PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression
Kim A. Brogden, Shireen Vali, Taher Abbasi
Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy
Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias
The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies
Keith T. Schmidt, William D. Figg
Information-dense analysis for information-dense understanding
Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
Fabiana Perna, Michel Sadelain
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells
Alex J. Gooding, William P. Schiemann
Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?
Nathan A. Berger
Microtubule targeting agents in glioma
Anda-Alexandra Calinescu, Maria G. Castro
Moving molecular subtypes to the clinic in gastric cancer
Joseph Chao, Jeeyun Lee, Samuel J. Klempner
Intraoperative subtyping of lung adenocarcinoma: an unmet need
Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli
Emerging roles of FGF signaling in hepatocellular carcinoma
Nana Zheng, Wenyi Wei, Zhiwei Wang
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
Brandon J. Manley, James J. Hsieh
Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer
Salma Kaochar, Nicholas Mitsiades

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike
Jeffrey J. Tosoian, Emmanuel S. Antonarakis
A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer
Sawsan Rashdan, David E. Gerber
MOAP-1, UBR5 and cisplatin resistance in ovarian cancer
Scott T. Eblen, Amber Bradley
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer
Weimin Gao
The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)
Theresa L. Whiteside
[18F]-choline PET/CT as an imaging biomarker for primary liver cancers
Zhenghong Lee
Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best
Yoshio Yamaoka, David Y. Graham
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function
Theodoros Karantanos, Vassiliki A. Boussiotis
Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer
Angel Qin, Gregory P. Kalemkerian
Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered
Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham
Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells
Praveen Kumar Vemula, Venkatakrishna Rao Jala
Helios—controller of Treg stability and function
Claire Chougnet, David Hildeman
Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation
Jon K. Obst, Marianne D. Sadar
Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird
Fat lure: adipocytes attract cancer cells out of the prostate
Alexandra M. Blee, Haojie Huang
Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers
Guoli Chen, Ming-Tseh Lin

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
The STAMPEDE trial: paradigm-changing data through innovative trial design
Bradley C. Carthon, Emmanuel S. Antonarakis
Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway
Derek B. Oien, Jeremy Chien, Nikki Cheng
Feed your gut with caution!
Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar
Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma
Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma
Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen