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19th Asian Society for Neuro-Oncology (ASNO) Annual Meeting

The 19th Asian Society for Neuro-Oncology (ASNO) Annual Meeting will be held at the One Farrer Hotel, Singapore from 16 – 18 August 2024. More >>

New Impact Factor for Translational Cancer Research: 1.5

We are pleased to announce that Translational Cancer Research (TCR) has attained its latest impact factor update for the 2023 citation year: 1.5. More >>

Translational Cancer Research 2023 CiteScore Released: 2.1

We are pleased to announce that the Translational Cancer Research (TCR) has received its 2023 CiteScore: 2.1, ranking 209 out of 333 journals in the Radiology, Nuclear Medicine and... More >>

Original Article

Elucidating the molecular and immune interplay between head and neck squamous cell carcinoma and diffuse large B-cell lymphoma through bioinformatics and machine learning
Jing Zheng, Xinxin Li, Xun Gong, Yuan Hu, Min Tang
Construction of ferroptosis and pyroptosis model to assess the prognosis of gastric cancer patients based on bioinformatics
Hanlu Shi, Hongfeng Yao, Yi Zhou, Gaoping Wu, Keyi Li, Lusheng Tang, Chen Yang, Dong Wang, Weidong Jin
Prognostic significance of B cell senescence-associated genes as risk markers in prostate adenocarcinoma
Huaiying Zheng, Wei Jiang, Shaoxing Zhu, Xiaobao Chen
Copper metabolism-related lncRNAs predict prognosis and immune landscape in liver cancer patients
Rui Luo, Shu Huang, Xiaomin Shi, Huan Xu, Jieyu Peng, Wenjie Lei, Shiqi Li, Wei Zhang, Lei Shi, Yan Peng, Xiaowei Tang
Immunogenic cell death-related signature predicts prognosis and immunotherapy efficacy in bladder cancer
Long Guo, Na Chen, Mei Qiu, Juliang Yang, Min Zhou, Fei Liu
Determining new disulfidptosis-associated lncRNA signatures pertinent to breast cancer prognosis and immunological microenvironment
Yifan Zheng, Yufeng Lin, Yongcheng Zhang, Shangjie Liu, Yongxia Yang, Wenbin Huang
Pan-cancer analysis combined with experimental validation revealed that KTN1 is an immunological and prognostic biomarker
Yan Ouyang, Yu Shen, Shengming Lai, Haiyan Huang, Yongsheng Huang, Shuwei Ren
Nomogram for predicting the early death of patients with stage IV ovarian cancer: a retrospective analysis of the SEER database
Pan Chen, Shunjie Zheng, Lin Zhang
Identification of the CD8+ T-cell exhaustion signature of hepatocellular carcinoma for the prediction of prognosis and immune microenvironment by integrated analysis of bulk- and single-cell RNA sequencing data
Jianhui Fan, Qinghua Zhang, Tiancong Huang, Haitao Li, Guoxu Fang
Development of a risk prediction model for personalized assessment of postoperative recurrence risk in colon cancer patients
Jing-Jing Zhang, Ya-Meng Liu, Ya-Wei Li, Zheng-Quan Han
Prognostic signature detects homologous recombination deficient in glioblastoma
Dongdong Luo, Aiping Luo, Su Hu, Hailin Zhao, Xuefeng Yao, Dan Li, Biao Peng
The relationship between marital status and survival in primary bone cancer: a population-based study
Xiaoxia Huang, Leilei Tian, Chuang Li, Jinling Liu, Rui Shi, Fang Lin, Yi Luo
Construction of a disulfidptosis-related lncRNAs signature of the subtype, prognostic, and immunotherapy in neuroblastoma
Yongcheng Fu, Nan Zhang, Jingyue Wang, Yuanyuan Wang, Da Zhang
Alpha-fetoprotein-to-PIVKA-II ratio as a potential biomarker for hepatocellular carcinoma differentiation, imaging characteristics, and patient survival
Menene Nkonika Dieu-Merci, Jihong Hu, Xinyi Fang, Renjie Zhao, Xiaojie Xie, Wenqiu Pan, Thapa Aayush, Fang Yin, Hu Xingyue, Dan Han
Development of prediction models for liver metastasis in colorectal cancer based on machine learning: a population-level study
Yuncan Xing, Guanhua Yu, Zheng Jiang, Zheng Wang
Bioinformatics analysis reveals VEGFC’s prognostic significance in head and neck squamous cell carcinoma and its association with immune cell infiltration
Yulian Tang, Ting Hu, Wenli Yin, Changqiao Huang, Dewen Liu, Fengming Lai, Chengliang Yang, Lizhu Tang
Exploring potential causal genetic variants and genes for endometrial cancer: Open Targets Genetics, Mendelian randomization, and multi-tissue transcriptome-wide association analysis
Guorui Zhang, Su Mao, Guangwei Yuan, Yang Wang, Jingyun Yang, Yuxin Dai
Dephosphorylation-related signature predicts the prognosis of papillary renal cell carcinoma
Jia Feng, Longyang Jiang, Hui Tang, Yuankai Si, Li Luo, Jing Liu, Dengmin Hu, Yilan Huang
Prognostic analysis of SYTL4 in acute myeloid leukemia
Kun-Ying Xie, Jin Wei
The prognosis and treatment consideration for non-small cell lung carcinoma patients with tumor size of >2.0–3.0 cm and visceral pleural invasion: a SEER-based study
Xirui Lin, Haijie Xu, Jianrong Chen, Jiaying Wu, Jiong Lin, Hansheng Wu
Therapy-related myeloid neoplasms in Korean patients with ovarian or primary peritoneal cancer treated with poly(ADP-ribose) polymerase inhibitors
Yoon Jung Jang, Heyjin Kim, Sang-Young Ryu, Moon-Hong Kim, Beob-Jong Kim, Hee Jung Jung, Jisik Kang, Sung Hyun Yang, Im Il Na, Hyo-Rak Lee, Hye Jin Kang
Multi-omics decipher the immune microenvironment and unveil therapeutic strategies for postoperative ovarian cancer patients
Zhibing Liu, Fei Wang, Weiwei Chen, Yujie Zhai, Jinbo Jian, Xiaole Wang, Yingjiang Xu, Jiajia An, Lei Han
Comparison of postoperative radiotherapy and definitive radiotherapy for non-metastatic adenoid cystic carcinoma of the head and neck, a propensity score matching based on the SEER database
Mingyu Tan, Yanliang Chen, Tianqi Du, Qian Wang, Xun Wu, Xiaohu Wang, Hongtao Luo, Shilong Sun, Qiuning Zhang, Wenzhen Yuan
SKA1/2/3 link to poor prognosis and immune infiltration of head and neck squamous cell carcinomas
Churen Zhang, Jianguo Ke, Jia Li, Qiaoling Cai
Potential role of TWIST1 and its methylation in bladder urothelial carcinoma
Meixuan Wan, Hongxue Meng, Huining Li
Neuroepithelial cell transforming 1 as a key regulator in non-small cell lung cancer: unveiling causal links and therapeutic potentials
Xiaoqing Shangguan, Xinping Zhang, Xiwu Chen, Zheng Zhang, Lei Wang
Emerging functions of FMNL1 in myeloid neoplasms: insights from bioinformatics to biological and pharmacological landscapes
João Agostinho Machado-Neto, Hugo Passos Vicari, Jean Carlos Lipreri da Silva, Maria Fernanda Lopes Carvalho, Keli Lima
Construction and validation of a novel prognostic model with palmitoylation-related genes for glioblastoma
Guowen Qin, Gang Pang, Shuaishuai Wu, Shuiqing Bi, Shengyong Lan, Xiuwen Tang, Beiquan Hu, Junlin Zhou, Fengning Shi, Chengjian Qin
A novel immune-related gene prognostic signature combining immune cell infiltration and immune checkpoint for glioblastoma patients
Xu Liu, Xiaomei Liu
Epidemiological characteristics of myxopapillary ependymoma and factors affecting overall survival: a SEER-based analysis
Ge Huang, Zhengyuan Xie, Jinhong Li
A lncRNA signature associated with endoplasmic reticulum stress supports prognostication and prediction of drug resistance in acute myelogenous leukemia
Yu Fu, Shupeng Wang, Lingyu Meng, Yahui Liu
Integrative multi-omics and machine learning approach reveals tumor microenvironment-associated prognostic biomarkers in ovarian cancer
Wenzhi Jiao, Shasha Yang, Yue Li, Yu Li, Shanshan Liu, Jianwei Shi, Minmin Yu
ABALON regulates mitophagy and 5-FU sensitivity in colorectal cancer via PINK1-Parkin pathway
Huimin Liu, Ying Huang, Chunmei Zhao, Guihua Wang, Xudong Wang
The expression and prognostic value of IFIT3 in esophageal squamous cell carcinoma
Jiawang Cao, Qipeng Zhang, Yiwen Xuan, Zhuan Ou, Qinghua Yu, Daoqi Zhu, Enwu Xu
Landscape and prognostic significance of oncogene drivers in metastatic castration sensitive prostate cancer
Theodore Wang, Jongmyung Kim, Ritesh Kumar, Rebecca A. Deek, Ryan Stephenson, Tina Mayer, Biren Saraiya, Saum Ghodoussipour, Thomas Jang, David Golombos, Vignesh Packiam, Ronald Ennis, Lara Hathout, Salma K Jabbour, Ozan Guler, Cem Onal, Matthew P. Deek
Integrating artificial intelligence in renal cell carcinoma: evaluating ChatGPT’s performance in educating patients and trainees
J. Patrick Mershon, Tasha Posid, Keyan Salari, Richard S. Matulewicz, Eric A. Singer, Shawn Dason
FLT3 mutation-related immune checkpoint molecule absent in melanoma 2 (AIM2) contributes to immune infiltration in pediatric and adult acute myeloid leukemia: evidence from bioinformatics analysis
Jing Zhao, Yue Cui, Hua Zhou, Dongming Zhou, Zhiping Che, Ning Zhang, Qi Yun, João Agostinho Machado-Neto, Daniela Damiani, Lika’a Fasih Y. Al-Kzayer, Rohan Kulkarni, Meng Gu
PARP1 promotes tumor proliferation in lenalidomide-resistant multiple myeloma via the downregulation of microRNA-192-5p-AKT signaling
Yuqing Luo, Yalu Chen, Cheng Ai, Xiaguang Huang, Fabiana Perna, Brandon J. Kale, Say Min Lim, Meier Gu, Panpan Gao, Chunmeng Rong, Zefeng Zhou, Yiqin Weng, Yinyan Jiang, Fang Yang, Yongming Xia
Novel cuprotosis-related gene signature: a prognostic indicator and regulator of the glioma immune microenvironment
Dongming Gao, Lin Zhou, Youyuan Bao, Wenyin Shi, Lei Li, Liang Gao
Increased expression of HBXIP (LAMTOR5) predicts poor prognosis and is correlated with immune-cell infiltration in glioma
Linyang Shi, Hui Chen, Junmin Chen, Joshua D. Palmer, Lin Wang, Li Sheng
SLC1A3 knockdown in inhibiting the proliferation, apoptosis resistance, and migration of ovarian cancer cells
Wu Zhou, Yanqiang Xiong, Liangping Zhao, Gabriel Levin, Felipe Batalini, Zhihui Liu, Yuanxue Ma
Postexercise downregulation of NUP155 in regulating non-small cell lung cancer progression via the PTEN/AKT signaling pathway
Jiangang Xu, Liyin Zhang, Menghui Feng, Weijun Hong, Xinming Ye
The efficacy of plasma exosomal miRNAs as predictive biomarkers for PD-1 blockade plus chemotherapy in gastric cancer
Yunqi Hua, Shuang Luo, Qian Li, Ge Song, Xiaoling Tian, Peng Wang, Hongwei Zhu, Shuang Lv, Xinyi Zhang, Zixuan Yang, Geoffrey Ku, Guo Shao
CTNND2 gene expression in melanoma tissues and its effects on the malignant biological functions of melanoma cells
Jiaojiao Qu, Xianfeng Cheng, Mingyan Liu, Qiang Zhang
N-acetyltransferase 10 as a novel prognostic biomarker in papillary renal cell carcinoma: a machine learning and experimental validation study
Liyang Li, Fan Li, Chenghao Zhou, Kangxin Ni, Haiyi Hu, Mingchao Wang, Huan Wang, Lei Gao
GCNT3 promotes the proliferation, apoptosis, invasion, and migration of breast cancer through the PI3K/AKT pathway
Yifan Li, Zhen Ren, Teng Wu, Nannan Zhang, Zhixian He

Brief Report

Sex-based differences in CEACAM5 expression in lung cancer
Gavitt A. Woodard, Emma R. Kane, Nicholas Todorovic, Samantha Prince, Sanja Dacic, Lieping Chen

Review Article

Non-clear cell renal cell carcinoma narrative review: where we are in 2024
Michael J. Pierro, Alexander Gallan, Deepak Kilari
Bladder sparing management for muscle-invasive bladder cancer after a complete clinical response: ready for prime time?—a narrative review
Mann Patel, Kyle Moore, Benjamin L. Lichtbroun, Ryan D. Stephenson, Tina Mayer, Biren Saraiya, David Golombos, Thomas Jang, Vignesh T. Packiam, Saum Ghodoussipour
Winning hearts & minds: prostate cancer outreach and clinical trial enrollment in minority men
Rebecca Anderson, Aleksander Popovic, Matthew Davis, Evan Kovac
Management of translocation carcinomas of the kidney
Yasser Ged, Ardit Feinaj, Ezra Baraban, Nirmish Singla
Adjuvant therapy in renal cell carcinoma (RCC): progress, at last
Andrew N. Bueno, Mark N. Stein, Karie Runcie
Contemporary surgical management of testicular seminoma
Rachel Passarelli, John L. Pfail, Thomas L. Jang
Management strategies for radio-recurrent prostate cancer: a comprehensive review
Syed N. Rahman, Hyung Suk Kim, Lindsey T. Webb, Gabriela M. Diaz, Michael S. Leapman, Preston C. Sprenkle, Joseph M. Brito, Joseph Renzulli, Thomas V. Martin, Patrick Kenney, Isaac Yi Kim
Predicting response to bacillus Calmette-Guerin in high-risk non-muscle invasive bladder cancer
Amir M. Soltani-Tehrani, Aman Kumar, Kamal S. Pohar
Treatment approaches for prostate cancer in sub-Saharan Africa
Brooke Kania, Kirthana Sharma, Pleasure Ramatlho, Peter Vuylsteke, Andrew Ndlovu, Tina Mayer
Perioperative systemic therapy in high-risk renal cell carcinoma following nephrectomy: a narrative review
Adam Khorasanchi, Taylor Goodstein, Shawn Dason, Eric A. Singer, Danielle Zimmerman, Yuanquan Yang
A narrative clinical trials review in the realm of focal therapy for localized prostate cancer
Alon Lazarovich, Vijay Viswanath, Aaron S. Dahmen, Abhinav Sidana
Targeting C797S mutations and beyond in non-small cell lung cancer—a mini-review
Wolfram C. M. Dempke, Klaus Fenchel
Targeting breast cancer resistance protein (BCRP/ABCG2) in cancer
Rouan Chen, Yue Yu, Ruixin Liu, Qian Chen
Immunotherapy for locally advanced and metastatic basal cell carcinoma: a narrative review
Xiaoqing Li, Hongru Wang, Qingli Lu
Review Article 
The management of brain necrosis as a result of SRS treatment for intra-cranial tumors
Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen
Published online: 28 August 2014
Meta-Analysis 
Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu
Published online: 05 March 2013
Review Article 
Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai
Published online: 05 March 2013
Biological basis of IORT 
Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects
Ithaisa Sologuren, Carlos Rodríguez-Gallego, Pedro Carlos Lara
Published online: 25 February 2014
Original Article 
Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review
Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi
Published online: 28 April 2017
Review Article 
EGFR first- and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients
Niki Karachaliou, Manuel Fernandez-Bruno, Jillian Wilhelmina Paulina Bracht, Rafael Rosell
Published online: 19 January 2019
Review Articles 
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Published online: 26 September 2013
Review Article 
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
Published online: 18 June 2015
Biological basis of IORT 
Cell and molecular response to IORT treatment
Luigi Minafra, Valentina Bravatà
Published online: 25 February 2014
Review Article 
Multiple keratoacanthoma centrifugum marginatum—a case report and systematic review
Yiman Wang, Wenling Zhao, Yueping Zeng, Li Li, Hongzhong Jin
Published online: 30 December 2018
Review Article 
EGFR and HER2: is there a role in ovarian cancer?
Eleonora Teplinsky, Franco Muggia
Published online: 13 February 2015
Review Article on Endometrial Cancer 
Current role of Pipelle endometrial sampling in early diagnosis of endometrial cancer
Milan Milosav Terzic, Gulzhanat Aimagambetova, Sanja Terzic, Melanie Norton, Gauri Bapayeva, Simone Garzon
Published online: 23 December 2020
Review Articles 
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Published online: 01 August 2012

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park
How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis
Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao
Alcohol intake patterns for cancer and non-cancer individuals: a population study
Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng
Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial
Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu
Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management
Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas
Exosomal lncRNAs as new players in cell-to-cell communication
Mihnea Dragomir, Baoqing Chen, George A. Calin
Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy
Souparno Bhattacharya, Aroumougame Asaithamby
Translational research in radiation-induced DNA damage signaling and repair
Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue
Genetically engineered mouse models for studying radiation biology
Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Advances on immunotherapy in genitourinary and renal cell carcinoma
Gregory P. Botta, Eric Granowicz, Carrie Costantini
The role of novel immunotherapies in non-Hodgkin lymphoma
Allyson Pishko, Sunita D. Nasta
MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan
Do p53 stress responses impact organismal aging?
Paul Hasty, Judith Campisi, Z. Dave Sharp
Pharmacological targeting of mutant p53
Samuel Kogan, Darren Carpizo
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Michael I. Carr, Stephen N. Jones
Regulation of cytotoxic T-cell responses by p53 in cancer
Mitchell W. Braun, Tomoo Iwakuma
The IGF-1R/AKT pathway determines cell fate in response to p53
Lei Duan, Carl G. Maki
Intra molecular interactions in the regulation of p53 pathway
Jiandong Chen
TP53 mutations in epithelial ovarian cancer
Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu
Modulation of the p53 family network by RNA-binding proteins
Chris Lucchesi, Jin Zhang, Xinbin Chen
Radiomics in head and neck cancer: from exploration to application
Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller
Prostate cancer radiomics and the promise of radiogenomics
Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack
Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies
Wei Lu, Wengen Chen
The emerging field of radiomics in esophageal cancer: current evidence and future potential
Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin
Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
Jung H. Suh, Julie D. Saba
Computational methods and opportunities for phosphorylation network medicine
Yian Ann Chen, Steven A. Eschrich

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
New light on the pancreatic cyst conundrum
Nathan A. Berger
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?
Andrew J. Scott, John C. Wilkinson
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
Nan Ding, Qianzheng Zhu
Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?
Apar Gupta, Nisha Ohri, Bruce G. Haffty
Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents
Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi
CRISPR-based genetic interaction maps inform therapeutic strategies in cancer
Poornima Ramkumar, Martin Kampmann
Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study
Melin J. Khandekar, Rakesh Jain
The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin
Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed
Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer
Joanne P. Young, Timothy J. Price, Susan Parry
Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response
R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang
Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes
Theresa L. Whiteside
TIC10/ONC201—a potential therapeutic in glioblastoma
Georg Karpel-Massler, Markus D. Siegelin
IDH mutational status and the immune system in gliomas: a tale of two tumors?
Bryan D. Choi, William T. Curry
ONC201: a new treatment option being tested clinically for recurrent glioblastoma
Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry
When better still might not be good enough
Waldemar Debinski
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy
Vincent C. O. Njar
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28
Leonardo Chicaybam, Prasad S. Adusumilli
Exosome mediated phenotypic changes in lung cancer pathophysiology
Yoshihisa Shimada, John D. Minna
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aaron D. DeWard, Rebecca J. Critchley-Thorne
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein
Felicia L. Lenzo, William G. Cance
New incriminating evidence against IGF2
Wen Ding, Lina A. Shehadeh
Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect
Paul Grippo, Ajay V. Maker
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger
RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver
Satomi Yamamoto, Tomoo Iwakuma
Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy
Michael J. Baine, Chi Lin
Rogue one: another faction of the Wnt empire implicated in assisting GBM progression
Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed
Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway
Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems
Li Tian, Ashley Chang, Marites P. Melancon
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
James P. White
Low-frequency ultrasound may improve drug penetration in colonic mucosa
Qiubing Chen, Bo Xiao, Didier Merlin
Dividing and conquering the variation among variants in EML4-ALK lung cancer
Trever G. Bivona
Unlocking the epigenetic code of T cell exhaustion
Jiazhu Wu, Huidong Shi
KDM1 links nuclear GSK3β to epigenetic alterations
Weijie Guo, Binhua P. Zhou
Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease
Deepa Rangachari, Daniel B. Costa
Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy
Bhagelu R. Achyut, Ali S. Arbab
Neuroendocrine differentiation in prostate cancer: key epigenetic players
Karishma Gupta, Sanjay Gupta
PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression
Kim A. Brogden, Shireen Vali, Taher Abbasi
Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy
Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias
The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies
Keith T. Schmidt, William D. Figg
Information-dense analysis for information-dense understanding
Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
Fabiana Perna, Michel Sadelain
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells
Alex J. Gooding, William P. Schiemann
Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?
Nathan A. Berger
Microtubule targeting agents in glioma
Anda-Alexandra Calinescu, Maria G. Castro
Moving molecular subtypes to the clinic in gastric cancer
Joseph Chao, Jeeyun Lee, Samuel J. Klempner
Intraoperative subtyping of lung adenocarcinoma: an unmet need
Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli
Emerging roles of FGF signaling in hepatocellular carcinoma
Nana Zheng, Wenyi Wei, Zhiwei Wang
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
Brandon J. Manley, James J. Hsieh
Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer
Salma Kaochar, Nicholas Mitsiades

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike
Jeffrey J. Tosoian, Emmanuel S. Antonarakis
A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer
Sawsan Rashdan, David E. Gerber
MOAP-1, UBR5 and cisplatin resistance in ovarian cancer
Scott T. Eblen, Amber Bradley
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer
Weimin Gao
The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)
Theresa L. Whiteside
[18F]-choline PET/CT as an imaging biomarker for primary liver cancers
Zhenghong Lee
Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best
Yoshio Yamaoka, David Y. Graham
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function
Theodoros Karantanos, Vassiliki A. Boussiotis
Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer
Angel Qin, Gregory P. Kalemkerian
Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered
Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham
Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells
Praveen Kumar Vemula, Venkatakrishna Rao Jala
Helios—controller of Treg stability and function
Claire Chougnet, David Hildeman
Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation
Jon K. Obst, Marianne D. Sadar
Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird
Fat lure: adipocytes attract cancer cells out of the prostate
Alexandra M. Blee, Haojie Huang
Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers
Guoli Chen, Ming-Tseh Lin

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
The STAMPEDE trial: paradigm-changing data through innovative trial design
Bradley C. Carthon, Emmanuel S. Antonarakis
Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway
Derek B. Oien, Jeremy Chien, Nikki Cheng
Feed your gut with caution!
Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar
Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma
Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma
Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

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