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New Impact Factor for Translational Cancer Research: 1.7

We are pleased to announce that Translational Cancer Research (TCR) has attained its latest impact factor update for the 2024 citation year: 1.7. More >>

Translational Cancer Research 2024 CiteScore Released: 2.5

We are pleased to announce that the Translational Cancer Research (TCR) has achieved its 2024 CiteScore: 2.5. TCR ranks as follows across various categories: 261 out of 415 in Onco... More >>

Join us at the 33rd Annual Meeting of the European Society of Thoracic Surgery (ESTS)

Join us at the 33rd Annual Meeting of the European Society of Thoracic Surgery (ESTS) More >>

Original Article

Prognostic factor analysis and nomogram construction for elderly patients with stages III and IV epithelial ovarian cancer: a study based on the SEER database
Ye Jin, Zhu Cao, Shizhou Yang
Hepatitis B virus core/capsid protein induces hepatocellular carcinoma progression via long non-coding RNA KCNQ1OT1/miR-335-5p/CDC7 axis
Yang Liu, Xinyi Kong, Xin Yu, Jie Qiao, Kaming Yang, Zhenlin Li, Yiling Wu, Wanwen Lao, Yuetong Li, Yiqi Lin, Yanping Zhang, Changlong Bi, Aixia Zhai
Construction of a novel disulfidptosis-associated lncRNAs signature for risk features and immunotherapy in breast cancer
Jun Zhou, Yongfei Li, Jiangtao Wang, Ming Feng, Chang Yao
Carfilzomib plus pomalidomide and dexamethasone as salvage therapy in patients with relapsed or refractory multiple myeloma in China: a retrospective study
Xibin Xiao, Yanping Shao, Xian Li, Huawei Jiang, Wei Jiang, Panpan Chen, Jing Xie, Wenbin Qian
Fusobacterium nucleatum and IL-32 co-predict nodal metastasis preoperatively in head and neck cancer
Zhenwei Wang, Huiying Huang, Xiaohui Yuan, Chiyao Hsueh, Ming Zhang
Efficacy and safety of neoadjuvant immunotherapy combined with chemotherapy in patients with resectable esophageal squamous cell carcinoma: a systematic review and meta-analysis
Chong-Rui Li, Ming-Zhi Lin, Bin Li, Hai-Tian Li, Yu-Zhen Chen, Zhi-Zhong Zheng, Yi-Ming Hui
Predictive value of CT-based imaging model for BRAF gene mutation in patients with colorectal cancer: a retrospective study
Wenyan Kang, Xiaoqin Ye, Wenming Deng, Yihong Zhong, Xiaojun Li, Dehong Luo
Ramifications of lymph node metastasis in patients with pT1 colorectal cancer
Liming Wang, Pengchen Long, Yinggang Chen, Yasumitsu Hirano
Construction of a prognostic model for lung adenocarcinoma based on disulfidptosis-related lncRNAs
Man Sun, Dan Zang, Chen-Guang Liu, Huan Zhou, Jun Chen
Blocking of CDC25B suppresses sarcoma progression via arresting cell cycle
Renqin Lin, Jianhua Lin
Construction of molecular subtypes and prognostic model for breast cancer based on sulfur metabolism-related genes
Jie Lu, Qiongyan Fang, Xiaofeng Liu, Huaiyu Zheng
Guanine monophosphate synthase-mediated nuclear and mitochondrial communication in the progression of gastric cancer
Xiaoshu Guo, Keyuan Xiao, Jiping Gong, Yu Wang, Liang Zong, Jiaoping Pan, Fan Yang, Hui Mi, Yiqiang Zhang, Baolian Ma, Lei Sun, Qilong Li, Wenqing Hu
Outcomes of radiotherapy combined with immune checkpoint inhibitors in locally advanced unresectable esophageal squamous cell carcinoma: a retrospective analysis
Qingren Lin, Ning Zhou, Yaping Wang, Xiang Zhu, Feiying Gu, Juan Lin, Xiaojiang Sun
Retrospective prognostic evaluation and single-cell transcriptomic analyses of non-small cell lung carcinoma with malignant pleural effusion
Peizhu Wu, Ran Gao, Kaikai Zhao, Xiangjiao Meng
FBXO32 promotes gastric cancer progression by regulating NME1
Xiong-Hui Rao, Huaiyu Qiu, Weifei Zhang, Nuoqing Weng, Xiaobin Wu
Determining the optimal surgical margin using whole scene pathology and molecular surgical margin analysis in colorectal cancer radical surgery—a cross-sectional study
Shuhan Lin, Hao Lai, Yazhen Zhu, Xianwei Mo, Yan Feng, Yuan Lin
Development and validation of an MBD3/UHRF1 methylation-regulator-based prognostic model for pancreatic cancer survival
Xue Cheng, Yangmei Zhang, Chunbin Wang, Kai Chen
Potential biomarker for screening nasopharyngeal carcinoma: three-microRNA panel in serum
Xutai Li, Zhenjian Ge, Wenkang Chen, Yingqi Li, Shengjie Lin, Yutong Wu, Pengwu Zhang, Huimei Zhou, Yongqing Lai
Competing risk analysis of surgical resection vs. radiofrequency ablation in early-stage small hepatocellular carcinoma: a SEER-based study
Zhenpeng Zeng, Ying Wu, Xiaosong Tan, Yumin Wu, Chunlin Liu, Duanming Du
Risk factors analysis for percutaneous endoscopic gastrostomy in patients with oral cancer: a retrospective study
Bohan Long, Lidan Hou, Hang Yin, Bin Xu, Wei Cao, Xiangjun Meng, Lei Wang
Knockdown of MIR205HG prevents cell proliferation, migration and invasion through autophagy and ferroptosis pathways in lung adenocarcinoma
Zhong Huang, Yongyang Chen, Yuliu Xie, Xiaobi Huang, Yudong Guo, Yuexin Zheng, Miao Yin, Yanfeng Liang, Yuetong Jiang, Xiao Lei, Wenmei Su, Haiqing Luo
Transarterial chemoembolization in combination with lenvatinib and sintilimab for the treatment of unresectable hepatocellular carcinoma with arterioportal shunts: a retrospective analysis
Hui Yang, Guangping Qiu
A predictive model based on immune related genes for diffuse large B cell lymphoma (DLBCL)
Ruixin Sun, Pengcheng Liu, Zizhen Xu
Effects of radiotherapy, chemotherapy, and chemoradiotherapy on survival outcomes in patients with gallbladder carcinoma: a real population-based study
Feng Liu, Yanchao Qin, Linjie Li, Baoping Jiao
Pre-radiotherapy frailty and associated determinants in elderly patients with thoracic tumors
Xiaoying Shen, Xiaofang Qi, Xiaowei Fu
Proteomics-based prognostic signature in colon adenocarcinoma patients with familial adenomatous polyposis
Shi-Qin Li, Wei Jiang, Yu-Cheng Zhu
A retrospective study using the Surveillance Epidemiology and End Results (SEER) database to predict risk and prognostic factors for lung metastasis in cervical carcinoma: nomogram development and validation
Hao Jin, Hairong Wang, Junting Guo, Nan Gong, Zhengchao Jin
CNTN1 promotes cell proliferation and metastasis in ovarian cancer through PSEN1
Zhiying Qi, Yuqing Ji, Yanying Xu, Ruimeng Guo, Xuewang Guo, Yu Dou, Yingying Yue, Fang Wang
Vitamin D-regulated miRNA expression in tumoral and normal adjacent tissue of localized gastric cancer patients: the impact on survival and time to relapse
Antía Cousillas Castiñeiras, Elena Gallardo Martín, Ana Fernández Montes, Marta Carmona Campos, Marta Covela Rúa, Mercedes Salgado Fernández, María Luz Pellón Augusto, José Carlos Méndez Méndez, Elena Brozos Vázquez, Nieves Martínez Lago
Polyamine metabolism and immune related genes as prognostic features in breast cancer: a novel risk model approach
Weimiao Li, Changyou Shan, Liang Liang, Guoxu Zheng, Shuqun Zhang
Integrated single-cell and bulk RNA sequencing reveals prognostic and immunotherapy-associated myofibroblastic cancer-associated fibroblast subtypes in head and neck squamous cell carcinoma
Xiufang Qiu, Yuhao Lin, Qian Li, Ameya A. Asarkar, Zhiheng Ke, Yiying Xu, Lisha Chen
Systemic immune response induced by radiofrequency ablation versus microwave ablation at varying powers in murine models of hepatocellular carcinoma
Xudong Qi, Zewen Zhu, Frank Tacke, Ming Yin
Theaflavin inhibits the malignant phenotype of human anaplastic thyroid cancer 8305C cells by regulating lipid metabolism via PI3K/AKT signaling
Shaojun Cai, Liyong Zhang, Tenghong Liu, Bo Wang, Shouyi Yan, Sisi Wang, Jiafan Yu, Sibin Wu, Siying Lin, Wenxin Zhao
The effect and related mechanisms of RAC1 GTP on radiotherapy for hepatocellular carcinoma
Xiaoyu Xu, Zhengxuying Fang, Wei Jiang, Jianbo Chou, Yi Lu
Silencing PPA1 promotes the survival of non-small cell lung cancer A549 cells under glucose-starved conditions
Shuying Wang, Meijiang Wang, Tianshu Jin, Xianglin Wang, Yuyin Luo, Dehong Luo, Yurui Liu
Identification of glycolysis-related genes and analysis of potential prognostic clinical application in oral squamous cell carcinoma
Rongxi Chen, Yuhui Li, Wenhao Sun, Junhui Wang, Tianjun Lan, Jinsong Li, Fan Wu, Zijing Huang
Development of a KRP-based pH-responsive drug delivery system for solid tumors
Yu Wu, Jiahong Pei, Hanzhuo Wang, Mei Yu, Dandan Wang

Review Article

Diagnosis and multimodality treatment of primary malignant tracheal tumors
Benoit Jacques Bibas, Mariana Rodrigues Cremonese, Paula Duarte D’Ambrosio, Ana Carolina de Rezende, Sergio Leonardo Favareto, Anna Carolina Pap-Rubi, Paulo Francisco G. Cardoso, Helio Minamoto, Paulo Manuel Pêgo-Fernandes, Ricardo Mingarini Terra
Development and clinical applications of liquid biopsy assays in cancer screening
Ying Han, Peiying Zhang, Yuan Gong, Lele Song
Current and evolving practices of carbohydrate antigens in gastric cancer: a narrative review
Shujing Zhao, Kaixu Li, Haiyu Wang, Yumin Ding, Dehong Li
Review Article 
The management of brain necrosis as a result of SRS treatment for intra-cranial tumors
Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen
Published online: 28 August 2014
Meta-Analysis 
Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu
Published online: 05 March 2013
Review Article 
Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai
Published online: 05 March 2013
Biological basis of IORT 
Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects
Ithaisa Sologuren, Carlos Rodríguez-Gallego, Pedro Carlos Lara
Published online: 25 February 2014
Original Article 
Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review
Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi
Published online: 28 April 2017
Review Article 
EGFR first- and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients
Niki Karachaliou, Manuel Fernandez-Bruno, Jillian Wilhelmina Paulina Bracht, Rafael Rosell
Published online: 19 January 2019
Review Article 
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
Published online: 18 June 2015
Review Articles 
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Published online: 26 September 2013
Biological basis of IORT 
Cell and molecular response to IORT treatment
Luigi Minafra, Valentina Bravatà
Published online: 25 February 2014
Review Article 
Multiple keratoacanthoma centrifugum marginatum—a case report and systematic review
Yiman Wang, Wenling Zhao, Yueping Zeng, Li Li, Hongzhong Jin
Published online: 30 December 2018
Review Article 
EGFR and HER2: is there a role in ovarian cancer?
Eleonora Teplinsky, Franco Muggia
Published online: 13 February 2015
Review Articles 
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Published online: 01 August 2012

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park
How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis
Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao
Alcohol intake patterns for cancer and non-cancer individuals: a population study
Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng
Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial
Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu
Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management
Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas
Exosomal lncRNAs as new players in cell-to-cell communication
Mihnea Dragomir, Baoqing Chen, George A. Calin
Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy
Souparno Bhattacharya, Aroumougame Asaithamby
Translational research in radiation-induced DNA damage signaling and repair
Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue
Genetically engineered mouse models for studying radiation biology
Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Advances on immunotherapy in genitourinary and renal cell carcinoma
Gregory P. Botta, Eric Granowicz, Carrie Costantini
The role of novel immunotherapies in non-Hodgkin lymphoma
Allyson Pishko, Sunita D. Nasta
MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan
Do p53 stress responses impact organismal aging?
Paul Hasty, Judith Campisi, Z. Dave Sharp
Pharmacological targeting of mutant p53
Samuel Kogan, Darren Carpizo
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Michael I. Carr, Stephen N. Jones
Regulation of cytotoxic T-cell responses by p53 in cancer
Mitchell W. Braun, Tomoo Iwakuma
The IGF-1R/AKT pathway determines cell fate in response to p53
Lei Duan, Carl G. Maki
Intra molecular interactions in the regulation of p53 pathway
Jiandong Chen
TP53 mutations in epithelial ovarian cancer
Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu
Modulation of the p53 family network by RNA-binding proteins
Chris Lucchesi, Jin Zhang, Xinbin Chen
Radiomics in head and neck cancer: from exploration to application
Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller
Prostate cancer radiomics and the promise of radiogenomics
Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack
Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies
Wei Lu, Wengen Chen
The emerging field of radiomics in esophageal cancer: current evidence and future potential
Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin
Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
Jung H. Suh, Julie D. Saba
Computational methods and opportunities for phosphorylation network medicine
Yian Ann Chen, Steven A. Eschrich

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
New light on the pancreatic cyst conundrum
Nathan A. Berger
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?
Andrew J. Scott, John C. Wilkinson
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
Nan Ding, Qianzheng Zhu
Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?
Apar Gupta, Nisha Ohri, Bruce G. Haffty
Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents
Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi
CRISPR-based genetic interaction maps inform therapeutic strategies in cancer
Poornima Ramkumar, Martin Kampmann
Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study
Melin J. Khandekar, Rakesh Jain
The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin
Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed
Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer
Joanne P. Young, Timothy J. Price, Susan Parry
Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response
R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang
Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes
Theresa L. Whiteside
TIC10/ONC201—a potential therapeutic in glioblastoma
Georg Karpel-Massler, Markus D. Siegelin
IDH mutational status and the immune system in gliomas: a tale of two tumors?
Bryan D. Choi, William T. Curry
ONC201: a new treatment option being tested clinically for recurrent glioblastoma
Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry
When better still might not be good enough
Waldemar Debinski
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy
Vincent C. O. Njar
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28
Leonardo Chicaybam, Prasad S. Adusumilli
Exosome mediated phenotypic changes in lung cancer pathophysiology
Yoshihisa Shimada, John D. Minna
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aaron D. DeWard, Rebecca J. Critchley-Thorne
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein
Felicia L. Lenzo, William G. Cance
New incriminating evidence against IGF2
Wen Ding, Lina A. Shehadeh
Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect
Paul Grippo, Ajay V. Maker
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger
RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver
Satomi Yamamoto, Tomoo Iwakuma
Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy
Michael J. Baine, Chi Lin
Rogue one: another faction of the Wnt empire implicated in assisting GBM progression
Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed
Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway
Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems
Li Tian, Ashley Chang, Marites P. Melancon
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
James P. White
Low-frequency ultrasound may improve drug penetration in colonic mucosa
Qiubing Chen, Bo Xiao, Didier Merlin
Dividing and conquering the variation among variants in EML4-ALK lung cancer
Trever G. Bivona
Unlocking the epigenetic code of T cell exhaustion
Jiazhu Wu, Huidong Shi
KDM1 links nuclear GSK3β to epigenetic alterations
Weijie Guo, Binhua P. Zhou
Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease
Deepa Rangachari, Daniel B. Costa
Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy
Bhagelu R. Achyut, Ali S. Arbab
Neuroendocrine differentiation in prostate cancer: key epigenetic players
Karishma Gupta, Sanjay Gupta
PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression
Kim A. Brogden, Shireen Vali, Taher Abbasi
Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy
Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias
The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies
Keith T. Schmidt, William D. Figg
Information-dense analysis for information-dense understanding
Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
Fabiana Perna, Michel Sadelain
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells
Alex J. Gooding, William P. Schiemann
Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?
Nathan A. Berger
Microtubule targeting agents in glioma
Anda-Alexandra Calinescu, Maria G. Castro
Moving molecular subtypes to the clinic in gastric cancer
Joseph Chao, Jeeyun Lee, Samuel J. Klempner
Intraoperative subtyping of lung adenocarcinoma: an unmet need
Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli
Emerging roles of FGF signaling in hepatocellular carcinoma
Nana Zheng, Wenyi Wei, Zhiwei Wang
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
Brandon J. Manley, James J. Hsieh
Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer
Salma Kaochar, Nicholas Mitsiades

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike
Jeffrey J. Tosoian, Emmanuel S. Antonarakis
A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer
Sawsan Rashdan, David E. Gerber
MOAP-1, UBR5 and cisplatin resistance in ovarian cancer
Scott T. Eblen, Amber Bradley
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer
Weimin Gao
The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)
Theresa L. Whiteside
[18F]-choline PET/CT as an imaging biomarker for primary liver cancers
Zhenghong Lee
Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best
Yoshio Yamaoka, David Y. Graham
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function
Theodoros Karantanos, Vassiliki A. Boussiotis
Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer
Angel Qin, Gregory P. Kalemkerian
Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered
Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham
Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells
Praveen Kumar Vemula, Venkatakrishna Rao Jala
Helios—controller of Treg stability and function
Claire Chougnet, David Hildeman
Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation
Jon K. Obst, Marianne D. Sadar
Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird
Fat lure: adipocytes attract cancer cells out of the prostate
Alexandra M. Blee, Haojie Huang
Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers
Guoli Chen, Ming-Tseh Lin

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
The STAMPEDE trial: paradigm-changing data through innovative trial design
Bradley C. Carthon, Emmanuel S. Antonarakis
Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway
Derek B. Oien, Jeremy Chien, Nikki Cheng
Feed your gut with caution!
Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar
Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma
Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma
Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
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Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
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Molecular mechanisms involved in tumor repopulation after radiotherapy
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Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
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Original Articles

Third generation gold nanoplatform optimized for radiation therapy
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Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Below are the latest Translational Cancer Research articles published online ahead of print publication.