Online First

The articles on this page have not yet been scheduled for a specific issue. For published content, please visit Archive.

Original Article

Multi‑cohort validation of BRAF-PTPRT co-mutation as a predictor of favorable immunotherapy response in melanoma

Dongmei Han, Caihong Wu, Dan Wang, Hao Jin, Weishuai Liu

Published online: 02 September 2026

PDF Open Access

Original Article

A Nomogram for Suicide-Specific Mortality Risk Stratification in Patients with Tongue Cancer: A SEER-Based Study, 2004–2017

Sha-Sha Du, Hai-Ping You, Yu-Ling Zhang, Nan-Jun Chen, Chen Ren, Heng-Wen Sun, Fei Xu, Xin Hua

Published online: 31 August 2026

PDF Open Access

Review Article

Barrier-Matched Engineering of Macrophages for Solid Tumor Immunotherapy: Design Logic, Translational Barriers and Clinical Outlook

Jian Wu, Jiabao Dong, Yi Shen, Haoyun Yu, Miyang Xu, Jiangfeng Zhang, Wei Wei, Xiongfeng Li

Published online: 31 August 2026

PDF Open Access

Original Article

Multi-omics integration identifies PON2 as a prognostic biomarker and mediator of tumor microenvironment remodeling in gallbladder cancer

Jian Yang, Lingbo Hu, Chao Yang, Haoyang Bei, Yulian Wu

Published online: 31 August 2026

PDF Open Access

Review Article

Cellular Immunotherapy for Lung Cancer: Current Clinical Evidence, Translational Challenges, and Future Perspectives

Ma Nannan, Shang Chunxiang

Published online: 31 August 2026

PDF Open Access

Review Article

Engineering an Arginine-Nitric Oxide Circuit in Escherichia coli Nissle 1917 to Remodel the Tumor Microenvironment for Enhanced Immunotherapy: A Review

Sujuan Li, Yuanhang Zhang, Peng fei Sun

Published online: 28 August 2026

PDF Open Access

Original Article

Lnc-TIM3 Promotes Acute Lymphoblastic Leukemia Progression through miR-5094-Mediated Regulation of TIM3

Jing Sun, Jiou Zhao, Wenfeng Fu, Huimin Li, Meiyun Kang, Yongjun Fang, Yaping Wang

Published online: 28 August 2026

PDF Open Access

Case report

Two elderly female cases of gastric signet ring cell carcinoma with pulmonary metastasis manifesting as diffuse ground-glass opacities and pleural involvement: an atypical imaging pattern mimicking lung infection

Yike Wang, Yingbo Xie, Xuan Yao, Pei Ma, Fengnan Wang, Xinqing Lin, Xiaohong Xie, Ming Liu, Chengzhi Zhou, Zhanhong Xie

Published online: 28 August 2026

PDF Open Access

Original Article

Efficacy and safety of antibody-drug conjugates in advanced small-cell lung cancer: a systematic review and single-arm meta-analysis of prospective clinical trials

Peipei Zhang, Weixing Zhao, Jiayun Ma, Yuan Li, Huiyuan Peng, Jun Jiang

Published online: 28 August 2026

PDF Open Access

Original Article

Expression, Prognostic Association, and Immune Microenvironment Correlates of C4orf50 in Breast Cancer: A TCGA-BRCA Bioinformatics Study

Sihang Lin, Lixia Liu, Jiayu Guan, Jie Wang, Chuanrong Cen, La Wei, Huawei Yang

Published online: 28 August 2026

PDF Open Access

Review Article

Kinase-Based Molecular Subtyping and a Prognostic Risk Model in Colorectal Cancer with Functional Validation of PLK4

Chao Shen, Changmin Ding, Xiaofeng Han, Yanzhao Wang

Published online: 28 August 2026

PDF Open Access

Original Article

AMOT mediates YAP1 activation and promotes the cell progression and glycolysis in non-small cell lung cancer by modulating the Hippo signaling pathway

Yihao Guo, Wendong Wang, Jinsong Li, Jun Zhang

Published online: 28 August 2026

PDF Open Access

Original Article

FBXO17 regulates the malignant progression of colorectal cancer via the Wnt/β-catenin pathway

Enyan Tang, Yijie Xiao, Xiaohong Qian, Shufei Li, and Bin Chen

Published online: 28 August 2026

PDF Open Access

Original Article

Identification of HBV-Associated Membrane Proteins as Prognostic Biomarkers for Hepatocellular Carcinoma based on Retrospective Analysis of Integrated Membrane Proteomics

Zichen Liu, Jiaming Wan, Guoli Deng, Mingzhu Zhang, Shaohua Zhang, Qizhi Liu, Liu Ouyang, Shupeng Liu

Published online: 28 August 2026

PDF Open Access

Original Article

Personalized Prediction of Sequential Therapeutic Responses in HR+/HER2-low Breast Cancer Using Patient‐derived Organoids

Wei Zhao, Zhongni Wu, Chengpan Li, Hongbo Zhang, Dabing Huang, Lijuan Wang, Xiaodan Zhang, Juanjuan Zhang, Xinyu Ma, Yifan Wen, Joseph Benjamin Holman, Xudong Yuan, Tingting Wang, Wei Wang, Weiping Ding, and Yueyin Pan

Published online: 26 August 2026

PDF Open Access

Original Article

Development and Internal Validation of Machine Learning Models for Predicting Lymph Node Metastasis in Cutaneous Head and Neck Melanoma

Bingyu Cheng, Jianqun Ji

Published online: 26 August 2026

PDF Open Access

Original Article

Analysis and validation of prognostic markers for thyroid cancer by single-cell and bulk RNA sequencing

Yang Yang, Liufei Yang, Xianfeng Jiang

Published online: 24 August 2026

PDF Open Access

Original Article

MIF-mediated intercellular crosstalk drives antigen-presenting-like cancer-associated fibroblast differentiation in triple-negative breast cancer via TGF-β signaling

Jun Wang, Yeru Li, Jia Zhu, Dan Ruan, Xinchang Xu, Wei Wang

Published online: 24 August 2026

PDF Open Access

Original Article

URGCP promotes osteosarcoma progression by regulating the ESCRT-III subunit CHMP4B

Yue Wang, Yuhuai Wu, Bin Zhou, Jianping Liu

Published online: 20 August 2026

PDF Open Access

Original Article

LncRNA FGD5-AS1 promotes M2 polarization of tumor-associated macrophages to facilitate the malignant phenotype of non-small cell lung cancer cells

Jing Wang, Hangui Wang, Zheng Song, Lijie Yang, Ning Wang

Published online: 20 August 2026

PDF Open Access

Original Article

Survival and treatment selection in NUT Carcinoma: a population-based study and propensity score-matched comparison with poorly differentiated head and neck squamous cell carcinoma

Guoliang Yang, Tingyao Ma, Yixin Jing, Yiming Ding, Xiaohong Chen, Zhigang Huang

Published online: 20 August 2026

PDF Open Access

Original Article

Development and external validation of an XGBoost-based prognostic model for small cell lung cancer with brain metastases

Pei Jiao, Chen Chen, Koudong Zhang, Qian Sun, Can Wang

Published online: 20 August 2026

PDF Open Access

Original Article

The m6A/METTL3 modifies USP11 to promote Warburg Effect Progression of Colon cancer undifferentiated by HIF-1α/ YAP signaling pathway

Yingying Wang, Feifei Zhu, Xiaolei Chen, Lei Feng, Zhichen Pu

Published online: 18 August 2026

PDF Open Access

Original Article

A clinicopathological and hematological biomarker-based nomogram for overall survival in early-onset colorectal cancer: development, external validation, and translational implications

Mingming Su, Changhe Xia, Zhihan Li, Bo Gao, Juan Zhang, Guanglin Wang, Guangquan An, Xiaoling Duan, Jitao Hu, Jiaxu Han, Chenhui Li

Published online: 18 August 2026

PDF Open Access

Original Article

Multi-omics analysis of GBP2 as a prognostic and immune-associated biomarker in papillary thyroid carcinoma

Zhanwei Du, Liu Wang, Yixiao Zhang, Jing Han, Zhijun Ma

Published online: 17 August 2026

PDF Open Access

Original Article

Selenium metabolism-related gene TXNRD1 drives tumor progression and microenvironment remodeling in oral squamous cell carcinoma

Jun Zhan, Qixiang Sun, Wenyuan Zhu, Xiao Lu, Yao He

Published online: 17 August 2026

PDF Open Access

Original Article

A pathomics model for predicting lactate-related prognostic risk groups and their biological mechanisms in lung adenocarcinoma

Lingling Zhou, Wen Liu, Ye Pan, Wan Lei, Lingfei Yan, Jingfang Zou, Kejian Qian, Fei Wang

Published online: 17 August 2026

PDF Open Access

Original Article

MRI-derived habitat radiomics integrated with transformer deep learning for preoperative prediction of high CD9 expression: a novel prognostic marker in adult-type Diffuse Gliomas

Bingxin Pang, Mengyuan Yuan, Ying Yan, Jie Li, Jing Xue, Lina Jing, Bo Jiang, Shengjun Sun

Published online: 17 August 2026

PDF Open Access

Original Article

PM2.5 Promotes Migration of Hepatocellular Carcinoma by Targeting miR-25

Qiaoxin Li, Yuxuan Lu, Quanyu Guo, Tianle Jin, Le Lu, Hao Shang, Meng Fan, Jiantao Mo, Hua Zhang, Wanying Feng, Xuanbo Da, Hongwei Lu

Published online: 17 August 2026

PDF Open Access

Original Article

Development and temporal validation of nomograms and machine learning models for predicting overall and cancer-specific survival in primary distal cholangiocarcinoma: a SEER-based study

Wentao Shang, Xibin Duan

Published online: 14 August 2026

PDF Open Access

Original Article

Glaucocalyxin A sensitizes ovarian cancer cells to PARP inhibitors by inducing DNA damage

Lingling Zhuang, Lanyan Hu, Qi Chen

Published online: 14 August 2026

PDF Open Access

Original Article

Telmisartan enhances anti-PD-1 efficacy in MSS colorectal cancer via modulation of PD-L1 and STAT3 signaling

Xin Lin, Jingying Li, Wei Lin

Published online: 14 August 2026

PDF Open Access

Original Article

Metabolic signature of phosphoethanolamine and arginine pathways predicts prognosis and immunotherapy resistance in lung adenocarcinoma

Tao Wang, Hongwei Li, Fei Ding

Published online: 13 August 2026

PDF Open Access

Original Article

MRI-Based Radiomics for Predicting P53-Mutated Hepatocellular Carcinoma: Intratumoral and Peritumoral Analysis

Jingfei Weng, Dinghua Yao, Qihu Zeng, Yuqing He, Chun Yang, Bin Yang

Published online: 13 August 2026

PDF Open Access

Original Article

Association Between Primary-Site Surgery and Overall Survival in Non-Metastatic and Metastatic Colorectal Cancer: A Population-Based Study Using the SEER Database

Fan Xueru, luo Tianzi, li Zelun, Wang Xiaoge, Xu Erping

Published online: 13 August 2026

PDF Open Access

Original Article

Integrating Multimodal Data for Precise Subtyping and Prognostication in Patients with Pulmonary Mucinous Adenocarcinoma

Weiwei Yang, Chen Chen, Lue Li, Zehao Chen, Ziyi Chen, Hanbo Le, Yongkui Zhang, Wangyu Zhu

Published online: 13 August 2026

PDF Open Access

Original Article

Prognostic value of neutrophil-to-lymphocyte ratio in nasopharyngeal carcinoma: a systematic review and meta-analysis of 30 cohorts through June 30, 2026

Yunliang Lu, Biaoyou Chen, Jingfeng Ye, Xinyi Hu, Tingting Jiang, Zhe Zhang, Tingting Huang

Published online: 11 August 2026

PDF Open Access

Original Article

Radiomics-based machine learning models decipher heterogeneity of anoikis-related molecular subtypes for prognostic stratification in head and neck squamous cell carcinoma

Linyong Wu, Dayou Wei, Wubiao Chen, Songhua Li, Zhendong Lu, Youwen Fu, Wenci Liu

Published online: 11 August 2026

PDF Open Access

Original Article

The DNA Mismatch Repair Landscape in Pancreatic Adenocarcinoma: A Novel Prognostic Signature with Implications for Immune Microenvironment and Chemotherapy Response

Hui Tang, Xuping Yang, Xiao Duan, Jia Feng, Changjing Xu, Yilan Huang, Longyang Jiang

Published online: 18 May 2026

PDF Open Access