This focused issue of Translational Imaging in Cancer Patient Care highlights current topics in the field of imaging addressing many common and debilitating oncological conditions. The authors have succeeded in covering a wide range of quantitative morphometric and compositional methods, particularly DW-MRI and ultrasound (US) imaging. Among the various functional imaging techniques, diffusion weighted imaging has the particular appeal that this method is widely available and completely non-invasive (without the injection of a contrast agent or a radioisotope).