This issue focusing on breast cancer is guest-edited by Dr. Gianluca Franceschini, Dr. Alejandro Martín Sánchez and Dr. Riccardo Masetti from Multidisciplinary Breast Center, Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy. It is specifically thought to provide the reader an insight of most recent evidences regarding radiology and molecular imaging, oncoplastic and reconstructive surgery, axillary staging and treatment, BRCA mutation carriers and HER2 positive management, novel integrated therapies results and other topics whose results are constantly debated in literature ant that are key elements in everyday multidisciplinary breast cancer management.