Divergent Roles of PRR11 and HEPACAM in Pleural Mesothelioma: PRR11 as a Prognostic Biomarker and HEPACAM as a Stage-Associated Gene with Paradoxical Expression

Pleural mesothelioma (PM) is an aggressive malignancy with poor prognosis. While identifying drivers of tumor progression is critical, the molecular alterations specifically associated with T-stage advancement remain poorly understood. This study aimed to investigate genes linked to T-stage progression in PM using The Cancer Genome Atlas (TCGA) data, with a focus on the previously unreported roles of PRR11 and HEPACAM in this disease.