KRAS mutations: efficacy and sensitivity of early predictive screening of cancer progression require other gene mutations in addition to KRAS

The KRAS gene, also known as Kristen rat sarcoma viral oncogene homolog, is a member of the Ras family of cell proliferation regulators and plays an important role in cancer progression upon the mutation induced activation of this gene (1). A significant role that they play is in a cell proliferation signaling cascade that involves receptor to nucleus signal transduction and therefore the activation of this pathway is under tight control (1,2).