Low-frequency ultrasound may improve drug penetration in colonic mucosa

Ulcerative colitis (UC) is a chronic relapsing inflammatory disease that is characterized by disruption of the mucosal barrier and excessive inflammatory reactions in the colon and rectum (1). The common symptoms of UC include diarrhea, hemafecia, abdominal pain, and malnutrition (2). Although immense progress has been made in developing efficient therapeutic strategies, there is still no fully effective cure for UC. Given the lack of treatment options, UC patients currently suffer from a compromised quality of life and an increased risk of developing colorectal cancer (3,4).