Definitive radiotherapy for cutaneous epithelioid hemangioendothelioma: a case report and literature review

Epithelioid hemangioendothelioma (EHE) is a rare tumor of the vascular endothelium and the most common involved sites are liver, lung and bone. Approximately one-third are also known to occur in other sites, such as the skin or large vessels. Although a number of treatment modalities have been tried, treatment responses after definitive radiotherapy (RT) have not been well described. Here, we report the case of multiple cutaneous EHE on both feet in an 81-year-old woman successfully treated by definitive RT. She underwent definitive RT of 60 Gy using a volumetric modulated arc therapy and all involved lesions were completely resolved with a small residual discoloration. At 20 months of follow-up after completion of RT, no progressive or recurrent lesions on either foot were observed.