Exosomes in lymph and cancer

A primary tumor can spread locally through direct extension, regionally through lymphatic vessels, and distantly through lymphatic and blood vessels. The lymphatic and circulatory systems are interconnected at sites such as the thoracic and right lymphatic ducts, where they empty into the left and right subclavian veins, respectively. In this article we review how normal and tumor exosomes influence the lymph system, with special emphasis on tumor related exosomes.