Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer

Serrated polyposis (SPS) is a syndrome characterised by multiple serrated polyps (MSP) in the large bowel and an increased personal and familial risk of colorectal cancer (CRC). To date efforts to estimate the level of risk associated with SPS have been carried out in the setting of an arbitrary set of clinical criteria. A recent report has presented evidence that the boundary used for meeting these criteria may need to be reconsidered.