HSP90 inhibitors for high-grade glioma treatment

Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. This highly aggressive tumor is difficult to treat and virtually all GBM patients succumb to the disease despite maximal surgical resection, radiotherapy and chemotherapy (1). Many chemotherapeutic agents have been tested against GBM; however the genetic heterogeneity and the diverse molecular pathology create difficulties to treat and virtually all tumors recur.