Casein kinase 1: a new tale of chronic lymphocytic leukemia (CLL) microenvironment

The biological history of chronic lymphocytic leukemia (CLL) is strictly related to the ability of leukemic cells to invade and manipulate tissue microenvironments. This evidence is unequivocal by the observation that despite an apparent long life in vivo, CLL cells undergo in spontaneous apoptosis in vitro during culture in complete medium (1).