Efficacy and safety of liposome-paclitaxel/liposome-paclitaxel combined with S-1 in 17 advanced gastric cancer patients with poor performance status
Introduction
Gastric cancer is the fifth most common cancer and the third leading cause of cancer deaths worldwide (1). Gastric cancer is one of the most common tumors in China. For patients with gastric cancer, operation is the main treatment to obtain a chance for cure. Chemotherapy is one of the main treatments for prolonging survival and improving quality of life for advanced gastric cancer who are not suitable for surgery or who have undergone postoperative recurrence and metastasis (2,3). However, advanced gastric cancer patients with poor performance status (PS) due to multiple organ metastases or celiac metastases, intestinal obstruction, severe anemia, and advanced age are often unable to tolerate high-intensity chemotherapy. The conventional supportive treatment is the best treatment option. The average overall survival (OS) of the best supportive care is about 3 months. For these patients, whether some highly effective and low-toxic chemotherapy regimens may prolong survival and improve quality of life is worthy of clinical exploration.
Paclitaxel is a new anti-microtubule drug that is commonly used for breast cancer, non-small cell lung cancer, gastric cancer, head and neck cancer and other cancers. According to the United States National Comprehensive Cancer Network (NCCN) guidelines (4), taxanes single-agent or in combination with other drugs are recommended as first-line treatment options for advanced gastric cancer. Liposome-paclitaxel (L-PTX) is a liposomal form of paclitaxel with improved efficacy and less side-effects as compared to common paclitaxel. It is considered relatively safe for advanced gastric cancer patients with poor PS.
Phase I clinical studies of liposomal-paclitaxel have been completed. The main pharmacokinetic parameters of L-PTX and conventional paclitaxel (C-PTX) after a single intravenous infusion of 175 mg/m2 were as follows: peak plasma concentrations (Cmax) were 6,455±2,247 and 7,400±1,542 µg/L; the areas under the plasma concentration-time curve (AUC0-∞) were 14,812±2,846 and 21,693±2,657 µg·h·L-1; the plasma elimination half-life (t1/2z) were 30.5±7.3 and 13.7±3.2 h; the apparent volumes of distribution (Vz) were 526.8±112.1 and 162.9±49.1 L/m2; the plasma clearance rates (CLz) were 12.3±2.7 and 8.2±1.0 L·h-1·m-2, respectively. The statistical analysis showed that there was a significant difference in major pharmacokinetic parameters between L-PTX and C-PTX (P<0.05) (5).
Fluorouracil is widely used in the treatment of gastric cancer. S-1, an orally administered fluorouracil, is used clinically to treat gastric and head and neck cancers. It is a compound containing tegafur, 5-chloro-2,4-dihydroxypyridine, and potassium oxonate with a molar ratio of 1:0.4:1 (6,7). Some studies have shown that S-1 has lower gastrointestinal toxicity than 5-Fu, but their anti-tumor effects are not significantly higher (5). S-1 has good efficacy in the treatment of advanced gastric cancer. The combination of S-1 and other chemotherapeutic agents can achieve better chemotherapeutic effect than S-1 alone (8). A multicenter phase II clinical trial showed that weekly treatment with paclitaxel and S-1 in advanced gastric cancer can achieve a considerable survival time and low toxicity (9).
L-PTX has fewer adverse reactions than paclitaxel in patients with advanced gastric cancer (10). The short-term efficacy of L-PTX plus S-1 compared with oxaliplatin plus S-1 was similar, but the L-PTX group had lower toxicity and could be used to treat elderly patients with advanced gastric cancer (11). Therefore, we used L-PTX single-agent or L-PTX plus S-1 to treat advanced gastric cancer patients PS scores ≥2.
Methods
Patients selection
This study included a retrospective collection of 17 advanced gastric cancer patients with poor PS who were treated in our hospital from July 2015 to March 2018. The diagnosis of gastric cancer was confirmed by endoscopic biopsy or postoperative pathology. Gastric cancer was in an advanced stage or had recurred and metastasized at the time of diagnosis. The patients are required to meet at least one of the following conditions: (I) patients older than 70 years, (II) patients having intestinal obstruction or celiac metastasis, and (III) patients with multiple organ metastases. All patients had poor PS due to the above characteristics. Their PS was rated as ≥2 according to the Eastern Cooperative Oncology Group (ECOG) scale, and the patients could not tolerate routine high-intensity chemotherapy. This study was approved by the Research Ethics Committee at the Second Affiliated Hospital of Soochow University. All patients signed the informed consent before enrolling into this study and also released the use of their clinical data in this study.
Treatment methods
L-PTX single-agent referred to 60–80 mg/m2 given on days 1 and 8, in a 21-day cycle. Some patients were in extremely poor condition, the total amount of L-PTX was divided into three doses (days 1, 8, and 15). If the general condition of the patient was extremely poor, the total amount of L-PTX was divided into three doses (days 1, 8, and 15). Timed sequential (TS) regimen: L-PTX 60–80 mg/m2 given on days 1 and 8. S-1, 40–60 mg/m2 twice a day on days 1–14, in a 21-day cycle. The dose of L-PTX or S-1 was based on the patient’s body surface area and PS. The course of treatment was 3 weeks and continued until six sessions or patient’s disease progression, intolerable toxicity, and death. Disease progression was indicated by computed tomography (CT) showing disease progression, significant increase in ascites, significant increase in intestinal obstruction. Toxic reactions that were difficult to tolerate include hematological toxicity (grade 4 leukopenia or neutropenia, grade 3 febrile neutropenia, grade 3 thrombocytopenia). Some patients initially could not tolerate the 2-drug combination chemotherapy regimen, only L-PTX single-agent chemotherapy was given or low-dose chemotherapy was given first. After the patient's physical condition improves, plus S-1 was also given other dose of L-PTX was increased.
Efficacy and toxicity evaluation
The patients were followed up every 3 months until the patient died or March 2018, whichever came first. All patients were evaluated for tumor response, including complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD), according to the response evaluation criteria in solid tumors guidelines (version 1.1). The evaluation criteria for the remission of lesions that could not be assessed by imaging were: (I) Significant reduction in ascites; (II) improvement in digestive tract obstruction; (III) anemia improved. Adverse events were graded according to the National Cancer Institute (NCI) common toxicity criteria (CIC) (version 4.0). Detection of adverse events continues throughout the course of treatment.
Result analysis
Progression-free survival (PFS) was recorded as the time from the date of entry into the study to the time of disease progression or death without evidence of progression occurred. OS was recorded from the time of diagnosed with gastric cancer to the time of death or last follow-up visit. The objective response rate (ORR) was the sum of CR and PR, and the disease control rate was the sum of CR, PR, and SD. Median OS and PFS were calculated using the Kaplan–Meier method.
Results
Patients characteristics
From July 2015 to March 2018, we observed a total of 17 patients. The median age was 64 years (age distribution: 23–81 years; 7 females and 10 males). The pathological types were poorly differentiated adenocarcinoma in 8 cases and adenocarcinoma in 7 cases. Four patients were older than 75 years old, 3 patients had intestinal obstruction, and 12 had celiac metastases.
Ten patients had an advanced stage of cancer at the time of diagnosis and were unable to undergo surgery. Four patients had undergone radical surgery. One patient had undergone adjuvant chemotherapy with oxaliplatin + S-1 (SOX) after surgery, two patients had received adjuvant chemotherapy with oxaliplatin + capecitabine (XELOX), and one patient had received adjuvant chemotherapy with oxaliplatin + raltitrexed. All patients had a PS score ≥2.
Of the 17 patients, 15 were advanced first-line chemotherapy. Three patients had recurrence after radical gastrectomy. Two of the 17 patients were advanced second-line chemotherapy. Three patients were given L-PTX monotherapy first, and after general improvement, they were given L-PTX + S-1. The remaining patients were treated with L-PTX + S-1 chemotherapy directly.
Among the 17 patients, four were given irinotecan, leucovorin and 5-FU (FOLFIRI) regimen as second-line chemotherapy after disease progression, two of whom also received cisplatin intraperitoneal chemotherapy (Table 1).
Table 1
Included patients | n=17 (%) |
---|---|
Age (years) | |
Median (min–max) | 64 [23–81] |
Sex | |
Male | 10 (58.82) |
Female | 7 (41.18) |
ECOG | |
2 | 3 (17.65) |
3 | 10 (58.82) |
4 | 4 (23.53) |
Histology | |
Low-middle differentiated | 1 (5.82) |
Poorly differentiated | 7 (41.18) |
Adenocarcinoma | 7 (41.18) |
Unknown | 1 (5.82) |
Surgery | |
Yes | |
Radical | 4 (23.53) |
Palliative | 3 (17.65) |
No | 10 (58.82) |
Patients’ condition | |
Digestive tract obstruction | 8 |
Age greater than 75 years old | 4 |
Moderate to severe anemia | 6 |
Metastasis sites | |
Liver | 4 |
Lymph node | 4 |
Peritoneal | 13 |
Lung | 1 |
Bone | 1 |
Total | 23 |
Second line | |
FOLFIRI | 4 |
Cisplatin intraperitoneal | 2 |
Best supportive care | 11 |
ECOG, Eastern Cooperative Oncology Group; FOLFIRI, irinotecan, leucovorin and 5-FU.
ORR and survival time
In all patients, there was no CR. PR was observed in 6 cases, accounting for 35.29% (6/17); SD in 5 cases, accounting for 29.41% (5/17); and PD in 6 cases, accounting for 35.29% (6/17). The ORR and disease control rate were 35.29% (6/17) and 64.71% (11/17), respectively (Table 2). The median PFS was 6.50 months [95% confidence interval (CI): 4.81–8.20], and the median OS was 13.00 months (95% CI: 0.00–33.65) (Figure 1A,B). The median PFS for PS groups 2, 3 and 4 was 4, 5.75 and 6.5 months, respectively. The median OS for PS groups 2, 3 and 4 was 9, 8.5 and 29 months, respectively. The PFS rates in 3, 6, and 9 months were 76.47% (13/17), 47.06% (8/17), and 29.41% (5/17), respectively. The OS rates in 3, 6, and 9 months were 100% (17/17), 82.35% (14/17), and 70.59% (12/17), respectively.
Table 2
Recent efficacy | Patient number |
---|---|
CR | 0 |
PR | 6 |
SD | 5 |
PD | 6 |
ORR (%) | 6/17 (35.29%) |
Disease control rate (%) | 11/17 (64.71%) |
CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; ORR, objective response rate.
![Click on image to zoom](http://cdn.amegroups.cn/journals/pbpc/files/journals/3/articles/31903/public/31903-PB3-9915-R1.png/w300)
Typical case 1
The patient was a 50-year-old man. He received XELOX (capecitabine and oxaliplatin) regimen for half a year after radical total gastrectomy. Approximately 1.5 years after the end of chemotherapy, the patient developed celiac metastasis with intestinal obstruction (Figure 2A) and hypokalemia. After the best supportive care, the patient was given L-PTX single-drug (60 mg d1 + 90 mg d8, 15) chemotherapy. After one cycle of chemotherapy, the patient’s bowel movements gradually became unobstructed. He was then given four regimens of TS (L-PTX 120 mg given on days 1 and 8 combined with S-1 80 mg twice a day on days 1–14, 3 weeks as one cycle). After 4 times of TS regimens, the intestinal obstruction was eliminated (Figure 2B). The patient’s blood potassium level returned to normal, and weight increased by 20 kg.
![Click on image to zoom](http://cdn.amegroups.cn/journals/pbpc/files/journals/3/articles/31903/public/31903-PB4-2503-R1.png/w300)
Typical case 2
The patient was a 56-year-old man who had stomach and cardiac cancer involving the lower esophagus. He underwent an operation in the lower esophagus due to eating obstruction. Postoperatively, he was given six regimens of chemotherapy with “docetaxel + cisplatin” and was maintained on docetaxel single-agent 2 times. However, several changes were made in the chemotherapy regimen due to disease progression. He had an esophageal stenosis in December 2015 (Figure 3A). After receiving L-PTX single-agent treatment (L-PTX 120 mg given on days 1 and 8), his esophageal stenosis was significantly improved (Figure 3B). Afterward, he was given five regimens of TS (L-PTX 120 mg given on days 1 and 8 combined with S-1 120 mg twice a day on days 1–14, 3 weeks as one cycle).
![Click on image to zoom](http://cdn.amegroups.cn/journals/pbpc/files/journals/3/articles/31903/public/31903-PB5-8119-R1.png/w300)
Toxicity
Hematological and non-hematological toxicities are listed in Table 3. The most common hematological toxicities were neutropenia and anemia with incidence rates of 35.29% (6/17) and 88.24% (15/17), respectively. One patient (5.88%) had grade 2 neutropenia, and no patient had grade 3 or grade 4 neutropenia. Five patients (29.41%) had grade 3 anemia. Non-hematologic toxicity was mild. Nausea accounted for 41.18% (7/17), and other non-hematologic toxicities included fatigue (4/17, 23.53%), vomiting (7/17, 41.48%), elevated transaminases (1/17, 5.88%), and diarrhea (5/17, 29.41%). No patient experienced grade 4 non-hematologic toxicity. These toxic reactions improved after symptomatic treatment, and no treatment-related deaths occurred.
Table 3
Toxicity NCI CTC term | All grades, n (%) | Grade 3–4, n (%) |
---|---|---|
Hematological | ||
Neutropenia | 6 (35.29) | 0 (0.00) |
Anemia | 15 (88.24) | 5 (29.41) |
Non-hematological | ||
Nausea | 7 (41.18) | 0 (0.00) |
Fatigue | 4 (23.53) | 0 (0.00) |
Vomiting | 7 (41.48) | 0 (0.00) |
Transaminases increased | 1 (5.88) | 0 (0.00) |
Diarrhea | 5 (29.41) | 0 (0.00) |
All | 45 | 5 |
NCI, National Cancer Institute; CTC, common toxicity criteria.
Discussion
The incidence of gastric cancer is much higher in China compared with other countries. In China, due to economic conditions and inadequate attention to the disease, some patients are already in advanced stages at the time of initial diagnosis. Several studies suggest that systemic chemotherapy is superior to best supportive care for advanced gastric cancer (12-14). Compared with best supportive care alone, chemotherapy plus best supportive care can extend OS of advanced gastric cancer by 2 months (12). A recent meta-analysis showed a median OS of 3.2 months for best supportive care in advanced gastric cancer patients with PS scores of 0–1 points (15). The US NCCN guidelines (4) recommend chemotherapy with best supportive care for advanced gastric cancer patients with a PS score of ≤2 and best supportive care for those with a PS score of >2. However, the guidelines also indicate that the recommendations are applicable to the general status of most patients and may not be applicable to all patients (4). Specifically, each patient should be given individualized treatment options according to specific conditions. Our clinical experience shows that not all patients with PS scores ≥2 can receive active antitumor therapy. In gastric cancer patients with a PS score ≥2, poor PS usually results from two causes. One is that there are other diseases combined with gastric cancer, and the other is due to digestive tract obstruction and anemia caused by the tumor itself. In the latter case, if the tumor load can be reduced by active antitumor therapy, the patient’s physical condition can be improved, and he/she can receive follow-up treatment, providing an opportunity to extend the life span and improve the quality of life. However, these patients have difficulty tolerating conventional regimens and doses of chemotherapy; therefore, a highly effective and low-toxicity chemotherapy regimen must be explored.
Current chemotherapy drugs used for the treatment of advanced gastric cancer include taxanes, fluorouracils (5-Fu, S-1, capecitabine), irinotecan, platinum drugs (cisplatin, carboplatin, oxaliplatin), etc. However, there is no standard advanced first-line chemotherapy regimen (16). Multiple phase I and phase II clinical trials have shown that weekly treatment of advanced gastric cancer with paclitaxel combined with S-1 demonstrated tolerable toxicity and efficacy (17-19). A phase II multicenter prospective randomized clinical trial concluded that S-1 plus paclitaxel and S-1 plus cisplatin are both effective in patients with advanced gastric cancer (20). However, S-1 plus paclitaxel has better efficacy and tolerability in gastric cancer patients with abdominal metastasis (21). The patients we have observed for gastric cancer, the poor PS of the patients was due to tumors rather than comorbidities. The chemotherapy regimen used was L-PTX or L-PTX plus S-1 chemotherapy. L-PTX is a paclitaxel liposome that was successfully developed in China in 2003. The use of liposomes instead of polyoxyethylene castor oil and absolute ethanol compound media can reduce paclitaxel toxicity and solvent-induced allergic reactions (22,23). Clinical pharmacokinetic tests showed that the elimination half-life of paclitaxel liposomes is significantly longer than that of paclitaxel injection, which allows tumor cells to be exposed to an effective killing concentration of paclitaxel for a longer period of time. In addition, the liposome preparation has a passive targeting property, which is better than that of paclitaxel in tumor tissues and is significantly poorer than that of C-PTX in normal tissue and blood (24). Therefore, liposomal-paclitaxel has advantages over traditional paclitaxel in enhancing drug targeting, reducing adverse drug reactions, and improving body tolerance. In our previous study on the use of liposomal-paclitaxel in advanced gastric cancer patients with better physical status, we found that liposomal-paclitaxel has a comparable efficacy to that of paclitaxel, and it is well tolerated. Therefore, we observed the efficacy and safety of L-PTX/L-PTX combined with S-1 in advanced gastric cancer patients with poor PS. The results showed that the chemotherapy regimen can prolong the survival of the patients and improve their quality of life.
Of the 17 patients, five had cardia or pyloric obstruction due to tumors, and three developed intestinal obstruction due to peritoneal metastasis. As these patients are unable to eat, they are generally in poor PS. On the basis of active parenteral nutrition, L-PTX single-agent was given. After 1–2 cycles of treatment, the obstruction in the digestive tract gradually disappeared, and the patients’ diet gradually returned to normal. Then with or without S-1, the patients’ survival time was extended, and their quality of life improved. This finding shows that for advanced gastric cancer patients with tumor-induced digestive tract obstruction, L-PTX single-drug chemotherapy can be given on the basis of adequate parenteral nutrition. If the treatment is effective, patients can receive further treatment, and their quality of life can be improved, extending their survival time.
Among the patients that we treated, six had poor physical condition due to moderate to severe anemia caused by tumor hemorrhage. For patients with hemoglobin below 60 g/L, chemotherapy is given concurrently with transfusion therapy. In the treatment of patients with hemoglobin of more than 60 g/L, because of non-compliance with Chinese blood transfusion regulations, the above regimen will be given on the basis of adequate parenteral nutrition support treatment. The results showed that after treatment, four patients had reduced tumor burden and hemorrhage, gradually increased hemoglobin, and improved physical status. These patients also had the opportunity to continue follow-up treatment, improve their quality of life, and prolong survival.
In the treatment of malignant tumors, age is also a factor to be considered. Among the 17 patients, four were older than 75 years. Combined with digestive tract obstruction or anemia, these patients had poor PS, but we still administered liposomal-paclitaxel or liposomal-paclitaxel combined with S-1. The results showed that an 80-year-old patient had obstruction due to stomach cancer, and her obstruction disappeared after one cycle of L-PTX single-agent chemotherapy. After the administration of liposomal-paclitaxel combined with S-1 for six cycles, the patient’s OS reached 28 months.
Besides the therapeutic effect, we also observed the side effects of treatment. The results showed that the side effects of liposomal paclitaxel single-agent or liposomal paclitaxel plus S-1 were mild, and the common toxicity was 1–2 grade neutropenia and anemia. And patients can be well tolerated after symptomatic and supportive treatment. Therefore, advanced gastric cancer patients with a PS score ≥2 should be distinguished. If the patient’s poor physical status is caused by the tumor itself, systemic chemotherapy can be given on the basis of adequate supportive care. The choice of chemotherapy regimen and chemotherapy drug needs to be individualized according to the patient’s physical status. Because L-PTX has high efficacy and low toxicity, it can be considered for advanced gastric cancer with poor physical status, especially those with digestive tract obstruction and who are unable to eat. When the treatment is effective and the obstruction is relieved, S1 can be added to increase the therapeutic effect. Patients who do not have digestive tract obstruction and are able to eat can be directly given a combination chemotherapy based on his/her physical status to obtain rapid improvement of his/her condition.
Because the proportion of advanced gastric cancer patients with PS score ≥2 is very low among patients with gastric cancer, the proportion of patients with poor physical status caused by the tumor itself is even smaller. As of now, we only observed 17 patients. There are still several deficiencies in the data, and a large phase III clinical trial is needed to verify our results.
In summary, if the poor physical status of advanced gastric cancer patients is caused by tumor-induced digestive tract obstruction, anemia, etc., systemic chemotherapy can be considered. The chemotherapy program requires drugs with high efficiency and low toxicity. Our results show that L-PTX single-agent or L-PTX plus S-1 has a potential to be used for the treatment of advanced gastric cancer patients.
Acknowledgments
Funding: The current study was supported by grants from
Footnote
Conflict of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tcr.2019.08.17). The authors have no conflicts of interest to declare.
Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). This study was approved by the Research Ethics Committee at the Second Affiliated Hospital of Soochow University (JD-LK-2019-089-01). All patients signed the informed consent before enrolling into this study and also released the use of their clinical data in this study.
Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
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