Concurrent or sequential letrozole with adjuvant breast radiotherapy

Bourgier et al. (1,2) performed a thoughtful randomized clinical trial in the hopes that it would shed light on a clinically relevant topic, that lacks good evidence—what is the ideal sequence of endocrine therapy (ET) and radiation (RT) in women who receive breast conserving therapy for early stage hormone-receptor positive breast cancer? Moreover, the investigators also sought to identify a biomarker for radiation-induced subcutaneous fibrosis (RISF), using cutting edge for a translational science.