MET exon 14 mutation: another actionable genomic variation in patients with advanced NSCLC

In their recent work published in the Journal of Clinical Oncology, Awad and colleagues presented the interesting results of next-generation sequencing analysis conducted on tissue from 6,376 cancer patients, with a special focus on the description of MET exon 14 mutations in patients with non-squamous non-small cell lung cancer (NSCLC) (1). Nowadays, using the molecular platforms that have been developed, detailed information about the presence or absence of a very high number of different molecular alterations can be acquired simultaneously and in a very short time. Thanks to the availability of targeted drugs, much of this information is not only useful to increase our knowledge about molecular characteristics of different tumors, but it can be also useful to select patients as candidates for the treatment with specific agents.