Original Articles
Surgical organ displacement for proton radiotherapy
Abstract
Background: Although proton radiotherapy can provide more precision in dose delivery, the acute and chronic toxicity of radiation to adjacent normal tissues may cause greater collateral damage. To study this issue, we performed adequately and safely proton radiotherapy after surgical organ displacements to patients with primary or recurrent pelvic and abdominal cancer.
Methods: All the charts, pathologic categories, diagnostic images (CT, MRI, and PET), treatment plans and outcomes of patients treated at IUHPTC who had undergone surgical organ displacement with the intention for treatment with proton radiotherapy were reviewed.
Results: 15 patients without distant metastasis ranged from 16 to 82 years of age were included in the study. They received proton radiotherapy after the laparotomy and displacement of organs using omentum and/ or saline breast prostheses, anterior oophoropexy, colopexy, or diverting colostomy if required. All patients completed protons radiotherapy except for one recurrent pancreatic cancer patient developed a perforation of a marginal ulcer at a previous gastrojejunostomy. There were no radiation-related complications greater than Grade 2 radiation dermatitis and enteritis. Most of patients with recurrent pelvic tumors have shown good responses to treatment thus far.
Conclusions: It’s shown that the combination of surgical organ displacement and proton radiotherapy is technically feasible and safe for effectively treating a difficult cancer and also diminishing or eliminating the costly and disabling effects often seen with conventional radiation.
Methods: All the charts, pathologic categories, diagnostic images (CT, MRI, and PET), treatment plans and outcomes of patients treated at IUHPTC who had undergone surgical organ displacement with the intention for treatment with proton radiotherapy were reviewed.
Results: 15 patients without distant metastasis ranged from 16 to 82 years of age were included in the study. They received proton radiotherapy after the laparotomy and displacement of organs using omentum and/ or saline breast prostheses, anterior oophoropexy, colopexy, or diverting colostomy if required. All patients completed protons radiotherapy except for one recurrent pancreatic cancer patient developed a perforation of a marginal ulcer at a previous gastrojejunostomy. There were no radiation-related complications greater than Grade 2 radiation dermatitis and enteritis. Most of patients with recurrent pelvic tumors have shown good responses to treatment thus far.
Conclusions: It’s shown that the combination of surgical organ displacement and proton radiotherapy is technically feasible and safe for effectively treating a difficult cancer and also diminishing or eliminating the costly and disabling effects often seen with conventional radiation.
