Original Article
Dietary vitamin D intake and risk of non-small cell lung cancer: a matched case-control study
Abstract
Background: Several studies indicated that serum vitamin D (Vit D) level was associated with lung cancer development and prognosis. To investigate the association between dietary Vit D and the risk of non-small cell lung cancer (NSCLC), a case-control study was conducted.
Methods: Dietary Vit D intake was ascertained in 200 NSCLC cases and 200 controls in the 1:1 matched case-control study. Face-to-face interviews were conducted to collect dietary information using a food frequency questionnaire (FFQ). Logistic regression was use to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI) between dietary Vit D intake and the risk of NSCLC.
Results: Dietary Vit D intake was associated with a risk reduction relative to NSCLC. The adjusted OR for NSCLC of the second to fourth quartile levels of Vit D were 0.63 (range, 0.41–0.89), 0.48 (range, 0.25–0.67), and 0.37 (range, 0.14–0.53) according to the first quartile levels respectively.
Conclusions: This study indicated that dietary Vit D intake insufficiency might be a risk factor for NSCLC.
Methods: Dietary Vit D intake was ascertained in 200 NSCLC cases and 200 controls in the 1:1 matched case-control study. Face-to-face interviews were conducted to collect dietary information using a food frequency questionnaire (FFQ). Logistic regression was use to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI) between dietary Vit D intake and the risk of NSCLC.
Results: Dietary Vit D intake was associated with a risk reduction relative to NSCLC. The adjusted OR for NSCLC of the second to fourth quartile levels of Vit D were 0.63 (range, 0.41–0.89), 0.48 (range, 0.25–0.67), and 0.37 (range, 0.14–0.53) according to the first quartile levels respectively.
Conclusions: This study indicated that dietary Vit D intake insufficiency might be a risk factor for NSCLC.
