Elucidating alternative pathways triggering small cell lung carcinoma tumor biology

In their recent perspective Ito et al. comprehensively reviewed the carcinogenesis of pure and combined small cell lung carcinoma (SCLC) (1) and we appreciate the explicit discussion of our article Meder et al. “NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas.” (2).