Multimodality imaging for early assessment of head and neck patients during induction chemotherapy: a reliable future option?

Wong and coauthors recently published on Journal of Nuclear Medicine (1) an interesting article regarding how 18-F-FDG-PET/CT and DW-MRI seem to be useful for early response assessment to radical chemo-radiotherapy (RT-CT) in head and neck squamous cell carcinoma (HNC) after one cycle of induction chemotherapy (IC). This paper faces several well recognized uncertainties regarding the optimal treatment strategy for locally advanced HNC.