Vol 14, No 6 (June 30, 2025): Translational Cancer Research

Editorial Commentary

ROS1 fusion-positive non-small cell lung cancer—repotrectinib as a new treatment option
Sacha I. Rothschild, Laetitia A. Mauti
Translational Cancer Research  
2025;
14
(6)
:3272-3276
.
How to treat systemic recurrences following adjuvant immunotherapy
Piotr Rutkowski, Hanna Koseła-Paterczyk
Translational Cancer Research  
2025;
14
(6)
:3277-3280
.
Advances in genomic biomarkers for lethal metastatic castration-resistant prostate cancer
Sandra A. Frimpong, Benjamin A. Teply
Translational Cancer Research  
2025;
14
(6)
:3281-3285
.
Trastuzumab deruxtecan: expanding the role of HER2-targeted therapy in solid tumors
Hazem Aboaid, Yin Mon Myat, Daniel Thomas Jones, Kyaw Zin Thein
Translational Cancer Research  
2025;
14
(6)
:3286-3291
.
Key considerations for interpreting patient-reported outcomes in deep inferior epigastric artery perforator flap reconstruction with post-mastectomy radiotherapy
Janhavi Venkataraman, Kefah Mokbel
Translational Cancer Research  
2025;
14
(6)
:3292-3294
.
FLAURA2: evidence for escalated first-line therapy in EGFR-mutated non-small cell lung cancer with central nervous system metastases
Fangdi Sun, Joel W. Neal, Nathaniel J. Myall
Translational Cancer Research  
2025;
14
(6)
:3295-3301
.

Original Article

Prognostic factor analysis and nomogram construction for elderly patients with stages III and IV epithelial ovarian cancer: a study based on the SEER database
Ye Jin, Zhu Cao, Shizhou Yang
Translational Cancer Research  
2025;
14
(6)
:3302-3318
.
Hepatitis B virus core/capsid protein induces hepatocellular carcinoma progression via long non-coding RNA KCNQ1OT1/miR-335-5p/CDC7 axis
Yang Liu, Xinyi Kong, Xin Yu, Jie Qiao, Kaming Yang, Zhenlin Li, Yiling Wu, Wanwen Lao, Yuetong Li, Yiqi Lin, Yanping Zhang, Changlong Bi, Aixia Zhai
Translational Cancer Research  
2025;
14
(6)
:3319-3335
.
Construction of a novel disulfidptosis-associated lncRNAs signature for risk features and immunotherapy in breast cancer
Jun Zhou, Yongfei Li, Jiangtao Wang, Ming Feng, Chang Yao
Translational Cancer Research  
2025;
14
(6)
:3336-3350
.
Carfilzomib plus pomalidomide and dexamethasone as salvage therapy in patients with relapsed or refractory multiple myeloma in China: a retrospective study
Xibin Xiao, Yanping Shao, Xian Li, Huawei Jiang, Wei Jiang, Panpan Chen, Jing Xie, Wenbin Qian
Translational Cancer Research  
2025;
14
(6)
:3351-3358
.
Fusobacterium nucleatum and IL-32 co-predict nodal metastasis preoperatively in head and neck cancer
Zhenwei Wang, Huiying Huang, Xiaohui Yuan, Chiyao Hsueh, Ming Zhang
Translational Cancer Research  
2025;
14
(6)
:3359-3372
.
Efficacy and safety of neoadjuvant immunotherapy combined with chemotherapy in patients with resectable esophageal squamous cell carcinoma: a systematic review and meta-analysis
Chong-Rui Li, Ming-Zhi Lin, Bin Li, Hai-Tian Li, Yu-Zhen Chen, Zhi-Zhong Zheng, Yi-Ming Hui
Translational Cancer Research  
2025;
14
(6)
:3373-3399
.
Predictive value of CT-based imaging model for BRAF gene mutation in patients with colorectal cancer: a retrospective study
Wenyan Kang, Xiaoqin Ye, Wenming Deng, Yihong Zhong, Xiaojun Li, Dehong Luo
Translational Cancer Research  
2025;
14
(6)
:3400-3409
.
Ramifications of lymph node metastasis in patients with pT1 colorectal cancer
Liming Wang, Pengchen Long, Yinggang Chen, Yasumitsu Hirano
Translational Cancer Research  
2025;
14
(6)
:3410-3419
.
Construction of a prognostic model for lung adenocarcinoma based on disulfidptosis-related lncRNAs
Man Sun, Dan Zang, Chen-Guang Liu, Huan Zhou, Jun Chen
Translational Cancer Research  
2025;
14
(6)
:3420-3437
.
Blocking of CDC25B suppresses sarcoma progression via arresting cell cycle
Renqin Lin, Jianhua Lin
Translational Cancer Research  
2025;
14
(6)
:3438-3451
.
Construction of molecular subtypes and prognostic model for breast cancer based on sulfur metabolism-related genes
Jie Lu, Qiongyan Fang, Xiaofeng Liu, Huaiyu Zheng
Translational Cancer Research  
2025;
14
(6)
:3452-3470
.
Guanine monophosphate synthase-mediated nuclear and mitochondrial communication in the progression of gastric cancer
Xiaoshu Guo, Keyuan Xiao, Jiping Gong, Yu Wang, Liang Zong, Jiaoping Pan, Fan Yang, Hui Mi, Yiqiang Zhang, Baolian Ma, Lei Sun, Qilong Li, Wenqing Hu
Translational Cancer Research  
2025;
14
(6)
:3471-3489
.
Outcomes of radiotherapy combined with immune checkpoint inhibitors in locally advanced unresectable esophageal squamous cell carcinoma: a retrospective analysis
Qingren Lin, Ning Zhou, Yaping Wang, Xiang Zhu, Feiying Gu, Juan Lin, Xiaojiang Sun
Translational Cancer Research  
2025;
14
(6)
:3490-3499
.
Retrospective prognostic evaluation and single-cell transcriptomic analyses of non-small cell lung carcinoma with malignant pleural effusion
Peizhu Wu, Ran Gao, Kaikai Zhao, Xiangjiao Meng
Translational Cancer Research  
2025;
14
(6)
:3500-3519
.
FBXO32 promotes gastric cancer progression by regulating NME1
Xiong-Hui Rao, Huaiyu Qiu, Weifei Zhang, Nuoqing Weng, Xiaobin Wu
Translational Cancer Research  
2025;
14
(6)
:3520-3531
.
Determining the optimal surgical margin using whole scene pathology and molecular surgical margin analysis in colorectal cancer radical surgery—a cross-sectional study
Shuhan Lin, Hao Lai, Yazhen Zhu, Xianwei Mo, Yan Feng, Yuan Lin
Translational Cancer Research  
2025;
14
(6)
:3532-3541
.
Development and validation of an MBD3/UHRF1 methylation-regulator-based prognostic model for pancreatic cancer survival
Xue Cheng, Yangmei Zhang, Chunbin Wang, Kai Chen
Translational Cancer Research  
2025;
14
(6)
:3542-3553
.
Potential biomarker for screening nasopharyngeal carcinoma: three-microRNA panel in serum
Xutai Li, Zhenjian Ge, Wenkang Chen, Yingqi Li, Shengjie Lin, Yutong Wu, Pengwu Zhang, Huimei Zhou, Yongqing Lai
Translational Cancer Research  
2025;
14
(6)
:3554-3564
.
Competing risk analysis of surgical resection vs. radiofrequency ablation in early-stage small hepatocellular carcinoma: a SEER-based study
Zhenpeng Zeng, Ying Wu, Xiaosong Tan, Yumin Wu, Chunlin Liu, Duanming Du
Translational Cancer Research  
2025;
14
(6)
:3565-3576
.
Risk factors analysis for percutaneous endoscopic gastrostomy in patients with oral cancer: a retrospective study
Bohan Long, Lidan Hou, Hang Yin, Bin Xu, Wei Cao, Xiangjun Meng, Lei Wang
Translational Cancer Research  
2025;
14
(6)
:3577-3586
.
Knockdown of MIR205HG prevents cell proliferation, migration and invasion through autophagy and ferroptosis pathways in lung adenocarcinoma
Zhong Huang, Yongyang Chen, Yuliu Xie, Xiaobi Huang, Yudong Guo, Yuexin Zheng, Miao Yin, Yanfeng Liang, Yuetong Jiang, Xiao Lei, Wenmei Su, Haiqing Luo
Translational Cancer Research  
2025;
14
(6)
:3587-3598
.
Transarterial chemoembolization in combination with lenvatinib and sintilimab for the treatment of unresectable hepatocellular carcinoma with arterioportal shunts: a retrospective analysis
Hui Yang, Guangping Qiu
Translational Cancer Research  
2025;
14
(6)
:3599-3610
.
A predictive model based on immune related genes for diffuse large B cell lymphoma (DLBCL)
Ruixin Sun, Pengcheng Liu, Zizhen Xu
Translational Cancer Research  
2025;
14
(6)
:3611-3626
.
Effects of radiotherapy, chemotherapy, and chemoradiotherapy on survival outcomes in patients with gallbladder carcinoma: a real population-based study
Feng Liu, Yanchao Qin, Linjie Li, Baoping Jiao
Translational Cancer Research  
2025;
14
(6)
:3627-3641
.
Pre-radiotherapy frailty and associated determinants in elderly patients with thoracic tumors
Xiaoying Shen, Xiaofang Qi, Xiaowei Fu
Translational Cancer Research  
2025;
14
(6)
:3642-3653
.
Proteomics-based prognostic signature in colon adenocarcinoma patients with familial adenomatous polyposis
Shi-Qin Li, Wei Jiang, Yu-Cheng Zhu
Translational Cancer Research  
2025;
14
(6)
:3654-3669
.
A retrospective study using the Surveillance Epidemiology and End Results (SEER) database to predict risk and prognostic factors for lung metastasis in cervical carcinoma: nomogram development and validation
Hao Jin, Hairong Wang, Junting Guo, Nan Gong, Zhengchao Jin
Translational Cancer Research  
2025;
14
(6)
:3670-3689
.
CNTN1 promotes cell proliferation and metastasis in ovarian cancer through PSEN1
Zhiying Qi, Yuqing Ji, Yanying Xu, Ruimeng Guo, Xuewang Guo, Yu Dou, Yingying Yue, Fang Wang
Translational Cancer Research  
2025;
14
(6)
:3690-3701
.
Vitamin D-regulated miRNA expression in tumoral and normal adjacent tissue of localized gastric cancer patients: the impact on survival and time to relapse
Antía Cousillas Castiñeiras, Elena Gallardo Martín, Ana Fernández Montes, Marta Carmona Campos, Marta Covela Rúa, Mercedes Salgado Fernández, María Luz Pellón Augusto, José Carlos Méndez Méndez, Elena Brozos Vázquez, Nieves Martínez Lago
Translational Cancer Research  
2025;
14
(6)
:3702-3713
.
Polyamine metabolism and immune related genes as prognostic features in breast cancer: a novel risk model approach
Weimiao Li, Changyou Shan, Liang Liang, Guoxu Zheng, Shuqun Zhang
Translational Cancer Research  
2025;
14
(6)
:3714-3729
.
Integrated single-cell and bulk RNA sequencing reveals prognostic and immunotherapy-associated myofibroblastic cancer-associated fibroblast subtypes in head and neck squamous cell carcinoma
Xiufang Qiu, Yuhao Lin, Qian Li, Ameya A. Asarkar, Zhiheng Ke, Yiying Xu, Lisha Chen
Translational Cancer Research  
2025;
14
(6)
:3730-3745
.
Systemic immune response induced by radiofrequency ablation versus microwave ablation at varying powers in murine models of hepatocellular carcinoma
Xudong Qi, Zewen Zhu, Frank Tacke, Ming Yin
Translational Cancer Research  
2025;
14
(6)
:3746-3757
.
Theaflavin inhibits the malignant phenotype of human anaplastic thyroid cancer 8305C cells by regulating lipid metabolism via PI3K/AKT signaling
Shaojun Cai, Liyong Zhang, Tenghong Liu, Bo Wang, Shouyi Yan, Sisi Wang, Jiafan Yu, Sibin Wu, Siying Lin, Wenxin Zhao
Translational Cancer Research  
2025;
14
(6)
:3758-3771
.
The effect and related mechanisms of RAC1 GTP on radiotherapy for hepatocellular carcinoma
Xiaoyu Xu, Zhengxuying Fang, Wei Jiang, Jianbo Chou, Yi Lu
Translational Cancer Research  
2025;
14
(6)
:3772-3784
.
Silencing PPA1 promotes the survival of non-small cell lung cancer A549 cells under glucose-starved conditions
Shuying Wang, Meijiang Wang, Tianshu Jin, Xianglin Wang, Yuyin Luo, Dehong Luo, Yurui Liu
Translational Cancer Research  
2025;
14
(6)
:3785-3796
.
Identification of glycolysis-related genes and analysis of potential prognostic clinical application in oral squamous cell carcinoma
Rongxi Chen, Yuhui Li, Wenhao Sun, Junhui Wang, Tianjun Lan, Jinsong Li, Fan Wu, Zijing Huang
Translational Cancer Research  
2025;
14
(6)
:3797-3811
.
Development of a KRP-based pH-responsive drug delivery system for solid tumors
Yu Wu, Jiahong Pei, Hanzhuo Wang, Mei Yu, Dandan Wang
Translational Cancer Research  
2025;
14
(6)
:3812-3821
.

Brief Report

Investigation of effects of CFI-400945 and ionizing radiation on DNA damage response in triple-negative breast cancer
Harjot Athwal, Vasudeva Bhat, Alison L. Allan, Armen Parsyan
Translational Cancer Research  
2025;
14
(6)
:3822-3832
.

Review Article

Diagnosis and multimodality treatment of primary malignant tracheal tumors
Benoit Jacques Bibas, Mariana Rodrigues Cremonese, Paula Duarte D’Ambrosio, Ana Carolina de Rezende, Sergio Leonardo Favareto, Anna Carolina Pap-Rubi, Paulo Francisco G. Cardoso, Helio Minamoto, Paulo Manuel Pêgo-Fernandes, Ricardo Mingarini Terra
Translational Cancer Research  
2025;
14
(6)
:3833-3845
.
Development and clinical applications of liquid biopsy assays in cancer screening
Ying Han, Peiying Zhang, Yuan Gong, Lele Song
Translational Cancer Research  
2025;
14
(6)
:3846-3859
.
Current and evolving practices of carbohydrate antigens in gastric cancer: a narrative review
Shujing Zhao, Kaixu Li, Haiyu Wang, Yumin Ding, Dehong Li
Translational Cancer Research  
2025;
14
(6)
:3860-3873
.