Vol 15, No 1 (January 31, 2026): Translational Cancer Research

Editorial Commentary

Radiomics of soft tissue sarcoma metastases to assess prognostic factors related to intrapatient intertumor heterogeneity
George R. Matcuk Jr, Brandon K. K. Fields
Translational Cancer Research  
2026;
15
(1)
:1
.
Leveraging cell’s endogenous regulatory network: towards safer and more effective CAR T cell therapies for solid tumors
Huong Nguyen, Fu-Sen Liang
Translational Cancer Research  
2026;
15
(1)
:2
.
The use of stereotactic ablative body radiotherapy (SABR) for oligoprogressive cancers
Jenna Bhimani, Ankit Chadha, Neal Navani, Crispin T. Hiley
Translational Cancer Research  
2026;
15
(1)
:3
.
Precision targeting of CCNE1-amplified tumors—lessons from BLU-222 and beyond
Frida Rantanen, Daniela Ungureanu
Translational Cancer Research  
2026;
15
(1)
:4
.
Tertiary lymphoid structures: prognostic insights and implications for immunotherapy in HPV-negative head and neck cancer
Tobias Andermatt, Christoph Schultheiss, Mascha Binder
Translational Cancer Research  
2026;
15
(1)
:5
.

Original Article

A Cori cycle-related gene signature predicts prognosis, immune microenvironment, and drug response in breast cancer
Xiang Fang, Hongchang Tang, Kewang Sun, Zhenye Lv, Xiaozhen Liu, Xuli Meng, Yongfeng Li
Translational Cancer Research  
2026;
15
(1)
:6
.
Development and validation of a clinical-radiomics nomogram for the differential diagnosis of focal pancreatic solid lesions: a retrospective cohort study
Qinmei Wang, Yiyang Wang, Jing Wang, Xiangde Min, Qinghai Tan, Bo Wang
Translational Cancer Research  
2026;
15
(1)
:7
.
IL20RB as a prognostic and immune-related biomarker in lung cancer: association with immune infiltration, tumor progression, and potential therapeutic targeting
Hefei Li, Jiajia Tan, Hongjun Chu, Hongfei Zhang, Lihua Zhang, Jiayan Ji, Shuai Lu, Dongyue Wang, Zhen Zhang, Rujian Lu
Translational Cancer Research  
2026;
15
(1)
:8
.
METTL16 antagonizes astaxanthin-induced ferroptosis in colorectal cancer cells
Xianzhen Zeng, Xinyu Wang, Jiao Wang, Rui Zheng, Yingjie Zhang, Tonggang Li, Jia Ma, Xueshan Pan
Translational Cancer Research  
2026;
15
(1)
:9
.
F-box protein 28 serves as a prognostic and predictive biomarker for gastric cancer
Wanting Song, Minmin Chen, Chenyan Li, Yiling Li, Xuren Sun
Translational Cancer Research  
2026;
15
(1)
:10
.
Total flavonoids extracted from Penthorum chinense Pursh inhibits oxidative stress and inflammation in liver cancer cells through the JAK2/STAT3 pathway
Xiaoyan Li, Xiaoqiang Zhang, Junchao Xue
Translational Cancer Research  
2026;
15
(1)
:11
.
Effect of folic acid-targeted triptolide-loaded microbubbles combined with ultrasound on apoptosis of human MCF-7 breast cancer xenografts in nude mice
Chunxin Huang, Lianjie Bai, Weiyang Lyu, Xing Li, Rui Zhang, Zihe Chen, Dandan Zhou, Huilin Liu
Translational Cancer Research  
2026;
15
(1)
:12
.
Hsa_circ_0001756, a novel biomarker, promotes breast cancer progression via miR-584-5p/TRAF6 signaling axis
Jun-Ying Wu, Xi-Xi Wu, Li-Yan Shi, Ling-Xia Wang, Ying Cao, Xue-Jun Shao, Bo Wang, Huan Yang
Translational Cancer Research  
2026;
15
(1)
:13
.
Therapeutic efficacy evaluation of the injection mucosa knife in endoscopic submucosal dissection for rectal neuroendocrine tumors
Jie Xu, Bin He, Yunfu Feng, Luojie Liu, Ying Shi
Translational Cancer Research  
2026;
15
(1)
:14
.
CREM regulates the tumor immune microenvironment and predicts prognosis in thyroid carcinoma
Hao Ling, Guangmei Wu, Long Tang, Yanzhu Hu
Translational Cancer Research  
2026;
15
(1)
:15
.
Prognostic nomograms for overall and cancer-specific survival in individuals with large cell neuroendocrine carcinoma: a population-based study
Yanmin Pei, Yefeng Chen
Translational Cancer Research  
2026;
15
(1)
:16
.
Efficacy and safety of neoadjuvant chemotherapy combined with concurrent chemoradiotherapy and concurrent chemoradiotherapy alone in locally advanced cervical cancer: a systematic review and meta-analysis
Yaqiong Lu, Jing Zhao, Zhihong Jia, Chunlin Zhang
Translational Cancer Research  
2026;
15
(1)
:17
.
The WT 1-AS/miR-206 axis regulates the proliferation and migration of breast cancer through the cuproptosis related gene BCL11A
Jiasi Li, Huiliang Yang, Renwu Liu
Translational Cancer Research  
2026;
15
(1)
:18
.
CD36 as a potential prognostic biomarker and modulator of the tumor microenvironment in glioma
Linzong Xu, Pengfei Sun
Translational Cancer Research  
2026;
15
(1)
:19
.
Toward individualized prognosis in primary breast diffuse large B-cell lymphoma: incidence trends and a predictive model
Zhiwei Li, Zhaojun Wang, Jieyu Zhou, Yang Ye
Translational Cancer Research  
2026;
15
(1)
:20
.
Multi-omics analysis links FERMT1 expression to patient survival, immunotherapy response, and metastasis across cancers
Pei Chen, Lu Xiao, Chaoxiang Lv, Qiqi Zhang, Yunchuan Wu, Min Chen
Translational Cancer Research  
2026;
15
(1)
:21
.
Preoperative peripheral blood lymphocyte subsets integrated with geriatric nutritional risk index for prognostic assessment in elderly colorectal carcinoma patients
Yuxin Wang, Yizhe Hao, Houjun Jia
Translational Cancer Research  
2026;
15
(1)
:22
.
PHGDH knockdown activates autophagic flux to suppress migration and invasion of gastric cancer cells
Shaowei Li, Yue Cao, Wenzhuo Xu, Xin Wang, Ruomei Li, Jing Huang, Hailong Zhang
Translational Cancer Research  
2026;
15
(1)
:23
.
GNAL-driven calcium signaling reshapes the spatiotemporal immune landscape in ER+ breast cancer: causal insights and prognostic implications
Jing Zeng, Dongchen Tian, Jiahui Zhang, Guixin Wang, Yingxi Li, Yue Yu, Yao Tian, Jinxian He, Weiyu Shen, Zhaohui Chen
Translational Cancer Research  
2026;
15
(1)
:24
.
Establishment of a model to predict the recurrence time of hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer
Mengyu Hu, Huajie Xing, Huiping Li, Yaxin Liu, Jiayang Zhang
Translational Cancer Research  
2026;
15
(1)
:25
.
Single-cell analysis reveals the prognostic role of immune escape in the colorectal cancer microenvironment
Qixin Gan, Xuan Xu, Haifen Liu, Yuejun Li
Translational Cancer Research  
2026;
15
(1)
:26
.
Prognostic value of palmitoylation-regulated mechanisms in glioblastoma: integrated multi-omics analysis via least absolute shrinkage and selection operator (LASSO) regression and single-cell sequencing
Yujie Ji, Xiangyu Dai, Lei Jiang, Haixin Zeng, Zheng Cai, Bing Li
Translational Cancer Research  
2026;
15
(1)
:27
.
Establishment and validation of a prognostic model based on liquid-liquid phase separation-related genes in gastric cancer
Yueli Tian, Ruifeng Duan, Jianwen Li, Ying Song
Translational Cancer Research  
2026;
15
(1)
:28
.
Novel fatty acid metabolism-related molecular subtyping and prognostic signature for breast cancer
Jiaqi Du, Xianglin Liu, Zixin Jin, Qingliang Jiang, Yangyang Li, Chen Liu, Bin Wang, Yandong Liu
Translational Cancer Research  
2026;
15
(1)
:29
.
Macrophage-associated SLAMF9 is a potential therapeutic target for glioma
Kailin Yin, Xingzhi Han, Zhihao Liu, Xueying Bai, Juemin Gao, Qun Zhang
Translational Cancer Research  
2026;
15
(1)
:30
.
Development and verification of a competing risk model for forecasting cancer-specific survival in malignant bone tumor patients: an analysis of SEER database
Yun Wang, Lang Chen, Xue Yi, Ruo-Yu Wang, Wen-Li Du
Translational Cancer Research  
2026;
15
(1)
:31
.
Temporal-spatial evolution of tumor habitat analysis: a bibliometric study on research hotspots and trends in medical imaging (2014–2025)
Xuanle Li, Yongde Guo, Shichen Xu, Huixin Ouyang, Ye Li, Dong Liang, Xin Liu, Hairong Zheng, Zhanli Hu, Bo Yuan, Na Zhang
Translational Cancer Research  
2026;
15
(1)
:32
.
SanHuang decoction may suppress breast cancer by regulating M1 macrophage polarization via NF-κB signaling pathway: in vitro and in vivo studies
Yu Ying, Mengmeng Guo, Qingyun Ning, Yuyan Wei, Jiajia Qian, Ren Cai
Translational Cancer Research  
2026;
15
(1)
:33
.
Risk factors and nomogram for early mortality in young patients with non-metastatic gastric cancer
Chao Peng, Tianhong Xia, Ting Li, Dengwen Wei
Translational Cancer Research  
2026;
15
(1)
:34
.
Key genes and pathway differences between serrated polyps and conventional adenomas: insights from multi-omics
Youtao Zhou, Cuiyan Yang, Yuan Gao, Sihua Ye, Hongdan Zhou, Zikai Lin, Yuewu Fu, Xinci Ning, Chuanfeng Ke
Translational Cancer Research  
2026;
15
(1)
:35
.
Sodium selenite promotes apoptosis and augments autophagic flux in cervical cancer cells by activating the YAP-Hippo signaling pathway
Changhai Wang, Ke Zhu, Long Bai, Xiaoxiao Zhu
Translational Cancer Research  
2026;
15
(1)
:36
.
Evaluating differentiation grade as a guide for decision-making in elective neck dissection for early-stage oral squamous cell carcinoma: a population-based cohort study
Junxu Chen, Derong Zou, Hao Zan, Xiangyu Li, Hyung Jun Kim
Translational Cancer Research  
2026;
15
(1)
:37
.
VDAC1 and VDAC2 as prognostic biomarkers and therapeutic targets in hepatocellular carcinoma
Yujie Deng, Runmin Long, Meng Tang, Haiyang Song, Lei Liu
Translational Cancer Research  
2026;
15
(1)
:38
.
Secretogranin II serves as a potential prognostic biomarker and correlates with the immune microenvironment in pancreatic neuroendocrine tumors
Wuhan Yang, Linghuan Xu, Hui Li, Shubin Wang, Hao Guo, Jiaqi Zhang, Li Peng
Translational Cancer Research  
2026;
15
(1)
:39
.
Integrative machine learning of hypoxia and centrosome-related gene signatures enables prognostic stratification and therapeutic insights in lung adenocarcinoma
Zexia Zhao, Hui Du, Chaoyi Jia, Wenhao Zhao, Hua Huang, Sensen Hou, Chen Ding, Zixuan Hu, Yanan Wang, Yongwen Li, Hongyu Liu, Jun Chen
Translational Cancer Research  
2026;
15
(1)
:40
.
Integrated single-cell and transcriptomic analysis of CD8+CD101+TIM3+ T cells in hepatocellular carcinoma: implications for tumor microenvironment and prognostic modeling
Feifeng Ran, Zhang Jiang, Lilin Que, Lan Luo, Li Liang, Mei Gan, Rensheng Wang, Leifeng Liang
Translational Cancer Research  
2026;
15
(1)
:41
.
Orphan G protein-coupled receptor GPR137 regulates ferroptosis by targeting the Wnt/β-catenin pathway in sonic hedgehog-medulloblastoma
Jianbin Ying, Taotao Zhang, Yuyan He, Fan Chen, Qingshuang Zhao, Junjie Jing
Translational Cancer Research  
2026;
15
(1)
:42
.
Clinical utility of OGN in pan-cancer: diagnostic biomarker and immune microenvironment regulator
Xiaoyan Chen, Xue Wang, Jian Peng
Translational Cancer Research  
2026;
15
(1)
:43
.
Multiplex droplet digital polymerase chain reaction for rapid diagnosing suspected bloodstream infections in patients with hematologic malignancies
Fangyi Dong, Shishuang Wu, Xiaoqiang Fan, Ge Jiang, Ran Li, Liping Zhu, Jing Wang, Jiang Xia, Yu Zheng, Junmin Li, Kai Qing, Kai Xue
Translational Cancer Research  
2026;
15
(1)
:44
.
Association of METTL14 expression with prognosis and immunotherapy in breast cancer
Junbo Hu, Zhen Wang, Yanju Lu, Zhen Wei, Lindan Dong, Yuxia Li, Honglin Yan, Na Tang
Translational Cancer Research  
2026;
15
(1)
:45
.
Single-patient single-cell RNA sequencing reveals neuroendocrine predominance and immunosuppression in small-cell lung cancer
Yiru Wang, Siyi He, Rensheng Wang, Weimei Huang
Translational Cancer Research  
2026;
15
(1)
:46
.
The atypical kinase right open reading frame kinase 1 suppresses glioma cell growth through mammalian target of rapamycin inhibition and apoptotic signaling activation
Daofei Ji, Jicheng Li, Peng Wang, Shangfeng Gao, Wen Li
Translational Cancer Research  
2026;
15
(1)
:47
.
Development and validation of a herb-related gene signature for prognosis prediction and therapeutic response assessment in breast cancer
Jihan Qiu, Hanzhi Li, Lingfeng Tang, Haochen Yu
Translational Cancer Research  
2026;
15
(1)
:48
.
A novel prognostic model for colon adenocarcinoma based on cofactor and vitamin metabolism-related genes
Qinglin Yang, Zhouyuan Du, Haixin Yu, Tao Liu
Translational Cancer Research  
2026;
15
(1)
:49
.
SUMOylation of UBE2C facilitates hepatocellular carcinoma proliferation and invasion via the MAPK pathway
Yongli Kang, Jiayi Wang, Yongjian Li, Jie Yang
Translational Cancer Research  
2026;
15
(1)
:50
.
Role of TRAIL in mediating the effect of lipidome on breast cancer: a Mendelian randomization study
Xinmin Wang, Tiantian Yang, Xin Wang, Kaixuan Hu, Jianping Hu, Hubing Shi, Jing Jing, Ting Luo
Translational Cancer Research  
2026;
15
(1)
:51
.
Integrating WGCNA and machine learning algorithm to identify ACSM5 as a prognostic biomarker and therapeutic target for predicting immunotherapy efficacy in non-small cell lung cancer
Xiaofei Ma, Weijiao Du, Ming Bai, Zhenbo Dai
Translational Cancer Research  
2026;
15
(1)
:52
.
Development and validation of a machine learning model for predicting early death in metastatic pancreatic ductal adenocarcinoma: a study based on the SEER database
Leiming Zhang, Jikai He
Translational Cancer Research  
2026;
15
(1)
:53
.
Identification of necrosis-related signature for predicting prognosis and immunotherapy response in gastric cancer
Yao Zhang, Jinghao Cao, Feifan Jin, Yajuan Lu, Yingchao Liu, Aoli Deng, Feiyan Pan, Chen Yang
Translational Cancer Research  
2026;
15
(1)
:54
.
Evaluation of parietal pleural invasion in subpleural lung cancer by VEGFR2 targeted microbubble-based ultrasound molecular imaging
Shiyu Zhang, Yuxin Zhang, Dian Tao, Jiaxin Tang, Liantu He, Yu Hong, Wuxi Chen, Dongjun Wei, Guosheng Liang, Dazhi Zhou, Haixing Liao, Qing Tang, Hongwei Yang
Translational Cancer Research  
2026;
15
(1)
:55
.
A nomogram to predict disease-free survival in patients with residual triple-negative breast cancer after neoadjuvant chemotherapy based on clinicopathological and sonographic features
Qiuyi Zheng, Zhe Jin, Jingjing You, Yingyu Wang, Hui Zhu, Jielan Xu, Ting Liang, Shufang Pei
Translational Cancer Research  
2026;
15
(1)
:56
.
Prognostic characteristics, recurrence patterns and survival outcomes of uterine papillary serous carcinoma: a single-centre retrospective cohort study
Jacopo Conforti, Alisha Sattar, Andreas Zouridis, Sarah Smyth, Ahmed Darwish, Negin Sadeghi, Mostafa Abdalla, Loryn Caulfield, Sally Trent, Federico Ferrari, Christina Pappa, Sean Kehoe, Susan Addley, Hooman Soleymani majd
Translational Cancer Research  
2026;
15
(1)
:57
.
MicroRNA-374b-5p suppresses osteosarcoma progression via the PDPK1-mediated AKT pathway
Yong Xi, Zhengyi Sun, Jingbin Wu, Yongxin Ren, Dong Zhou
Translational Cancer Research  
2026;
15
(1)
:58
.
ARHGAP11A affects lung adenocarcinoma (LUAD) and pancreatic adenocarcinoma (PAAD) progression by regulating FAM83A
Kang Sun, Li-Jie Song, Ren-Quan Lu, Qing-Zhong Liu
Translational Cancer Research  
2026;
15
(1)
:59
.
A circulating microRNA-based diagnostic model for breast cancer, in which the miR-139-3p/RPA2 axis regulates the sensitivity to DNA-damaging agents
Jingjing Liu, Yuyun Wang, Xiaotong Xu, Yuchen Zhang, Xinyu Liu, Xu Liu, Shunan Wang, Shaorong Zhao, Jin Zhang
Translational Cancer Research  
2026;
15
(1)
:60
.
EGCG promotes apoptosis in BT-549 triple-negative breast cancer cells by targeting STAT3
Ke Zhang, Xinghua Tan, Xufeng Zhou, Lushan Yu, Zhihua Tang
Translational Cancer Research  
2026;
15
(1)
:61
.
Inhibition of radiotherapy sensitivity in nasopharyngeal carcinoma via the long non-coding RNA RHPN1-AS1
Jun Jiang, Dong Wang, Mei Kang, Yaqin Qian, Tianqi Zha, Chang-Sheng Shao
Translational Cancer Research  
2026;
15
(1)
:62
.

Brief Report

Survival and response outcomes in patients with recurrent/metastatic head and neck cancer treated with opioids and statins: an exploratory pilot study
Elihu Igbinadolor, Tyler J. Kristoff, Dong M. Shin, Conor E. Steuer, Nabil F. Saba, Nicole C. Schmitt
Translational Cancer Research  
2026;
15
(1)
:63
.

Review Article

Modern radiotherapy in inoperable locally advanced non-small cell lung cancer: a review of techniques, dose fractionation, and immuno-synergistic strategies
Xiaoyin Zhang, Liping Deng, Yunxue Zheng, Wen Yang, Min Wu, Yuan Huang, Yingqi Gu, Jingbo Wu
Translational Cancer Research  
2026;
15
(1)
:64
.
Tumor microenvironment-guided targeted and immunotherapy in anaplastic thyroid cancer: a literature review from preclinical models to clinical translation
Hong Kang, Shizhen Wu, Hao Gong, Fei Li
Translational Cancer Research  
2026;
15
(1)
:65
.
Introduction to animal modelling: factors and tools for choosing the optimal model for sarcoma research—a comprehensive literature review
Piotr Remiszewski, Anna M. Czarnecka, Eryk Siedlecki, Michał Mikula, Piotr Rutkowski
Translational Cancer Research  
2026;
15
(1)
:66
.
Therapeutic application of IL-12 for cancer therapy
Zhiqing Qi, John Maher
Translational Cancer Research  
2026;
15
(1)
:67
.
Optimizing the therapeutic ratio: a narrative review of de-escalation and response-adapted strategies in series including human papillomavirus negative head and neck cancer
Icaro Thiago de Carvalho, Sérgio Leonardo Favareto, Renata Jane Chaves Bernardo, Ana Carolina Pires de Rezende
Translational Cancer Research  
2026;
15
(1)
:68
.

Case Report: iMDT Corner

A case report of hemophagocytic lymphohistiocytosis secondary to tislelizumab and bevacizumab combination therapy for renal cell carcinoma
Linli Shi, Xiaobing Li, Rong Xie, Xianmin Zhu, Qing Huang, Hui Jiang, Taigo Kato, Jing Tang
Translational Cancer Research  
2026;
15
(1)
:69
.