As the Professor of Pathology, Immunology and Otolaryngology at the University of Pittsburgh School of Medicine, UPMC Hillman Cancer Center, Pittsburgh, USA, Prof. Theresa L. Whiteside has been studying cellular and molecular cancer immunology for many years, with a special interest in tumor-mediated escape mechanisms and surrogate immunologic markers of prognosis and response to therapy in patients with cancer. Translational Cancer Research (TCR) is pleased to interview her this time with a focus on the current understanding about the tumor-escape mechanisms, her recent NIH-funded research, the NIH Career Development Program (CDP) that she is involved in, and some special moments throughout her research.