Perspective towards the clinical application of eribulin in soft tissue sarcomas

Eribulin mesilate (trade name Halaven^®) is a synthetic macrocyclic analogue of the marine halichondrin B. This anticancer drug was approved both by the U.S. Food and Drug Administration and the European Medicines Agency in 2010, for treatment of patients with metastatic breast cancer who have received at least two prior chemotherapy regimens for late-stage disease, including both anthracycline- and taxane-based chemotherapies (1), and recently, for the treatment of unresectable or metastatic liposarcoma in patients who received prior at least one line of systemic therapy including chemotherapy based on anthracyclines (2).