Urachal carcinoma: towards a precision medicine

Urachal cancer is a rare and extremely aggressive malignancy deriving from an embryological remnant of the urogenital sinus and allantois. It represents <1% of all bladder cancers, with a prevalence of approximately 0.2% and a higher incidence in males than in females (1,2). About 90% of urachal cancers are adenocarcinomas and half of them share histological and molecular features with colorectal cancer (CRC); indeed, they have a common embryological origin from the cloaca (2).