Integrated transcriptomic analysis and machine learning identify immunogenic cell death genes as prognostic markers and therapeutic targets in non-small cell lung cancer

Immunogenic cell death (ICD) is a regulated cell death that activates antitumor immunity, yet its prognostic role in non-small cell lung cancer (NSCLC) remains unclear. This study aimed to develop and validate a robust ICD-related gene (ICDRG) signature for predicting survival and characterizing the tumor immune microenvironment in NSCLC.