Vol 15, No 4 (April 30, 2026): Translational Cancer Research

Editorial

Axillary surgery after neoadjuvant therapy: rethinking completion axillary dissection for residual micrometastatic disease
Mariam Rizk, Kinan Mokbel, Kefah Mokbel
Translational Cancer Research  
2026;
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:225
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 (30 April 2026) 
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Original Article

Establishing the role of the neurotransmitter receptor-related gene GABRD in the diagnosis, prognosis and immune infiltrates of colorectal cancer by bioinformatics analysis and experimental validation
Leiyan Wei, Wu Zhu, Zhiqin Guo, Hong Zhang, Linna Yuan, Lin Zhang, Bohao Sun, Shaoqing Hu, Jing Zhang, Wanxin Wu, Xiangyi Chen
Translational Cancer Research  
2026;
15
(4)
:226
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 (30 April 2026) 
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Serum amyloid A1 promote progression of breast cancer and is associated with epithelial-mesenchymal transition
Jiali Lin, Xiaozhi Huang, Liuxian Pan, Mingli Li, Langhuan Lei, Xing Yang, Wei Shi, Yanping Ding, Ziqiong Jiang, Wei Li, Qiuyu Liang
Translational Cancer Research  
2026;
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:227
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 (30 April 2026) 
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Association of primary lesion surgery and surgical modality with overall survival in patients with stage IV cutaneous melanoma: a population-based study
Dun-Chang Mo, Long Chen, Yong-Jun Du, Peng-Hui Luo, Shang-Xiao Huang, Han-Lei Wang, Xiu-Juan Liang, Peng Lin, Jian-Feng Huang
Translational Cancer Research  
2026;
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:228
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 (30 April 2026) 
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Impact of the immuno-oncology era on cerebrovascular disease and cancer-specific mortality in older adults with advanced non-small cell lung cancer: a competing-risks cohort study
Meijun Zhou, Yujuan Huang, Cheng Yu, Guang Yao, You Li, Gai Xiao, Yana Chen, Huiyun Yu
Translational Cancer Research  
2026;
15
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:229
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 (30 April 2026) 
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Development and validation of a multi-task deep learning model integrating PET-CT radiomics, clinical variables, and EBV DNA for prognostic prediction in locally advanced nasopharyngeal carcinoma
Jian Zhang, Yi Luo, Shuting Lai, Yunlong Lou, Haidong Yu, Lang Peng
Translational Cancer Research  
2026;
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:230
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 (30 April 2026) 
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Investigation of immunohistochemical marker expression in breast cancer of varying severity and construction of a predictive model
Zhihao Zhai, Jiuqing Chi, Caixia Li, Qingjun Li, Xin Du, Yanuo Li, Xiaowu Wang
Translational Cancer Research  
2026;
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:231
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 (30 April 2026) 
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Identifying research gaps in PIK3CA-mutant breast cancer: a bibliometric analysis of evolving trends and clinical applications
Min Yan, Xinyu Li, Fanfan Li
Translational Cancer Research  
2026;
15
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:232
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 (30 April 2026) 
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PD-1-targeted therapeutic strategies for advanced or recurrent gastric and gastroesophageal junction cancer: a systematic review and network meta-analysis
Yuxin Liu, Manling Zhou, Junjie Xi, Gege Sun, Zeyu Wang
Translational Cancer Research  
2026;
15
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:233
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 (30 April 2026) 
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Analyses of single-cell and bulk RNA-sequencing datasets identify biomarker-based molecular subtypes and a prognostic signature in lung adenocarcinoma
Minshan Fang, Xiuxia Zheng
Translational Cancer Research  
2026;
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:234
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 (30 April 2026) 
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PTTG1-DLX2 axis drives malignant progression of lung adenocarcinoma by activating the WNT/β-catenin signaling pathway
Huili Chen, Xinyu Zhang, Xiaofu Lian, Ziqiang Wang, Feiyue Zhang, Jing Zhang, Shengping Min, Shasha Yang, Xiaojing Wang, Chaoqun Lian
Translational Cancer Research  
2026;
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:235
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 (30 April 2026) 
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Dairy product consumption and thyroid cancer risk: a systematic review and meta-analysis of observational studies
Xin Song, Jiarui Li, Mingxiu Sun, Ming Tang, Kaize Zheng, Siyu Li, Likun Du
Translational Cancer Research  
2026;
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:236
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 (30 April 2026) 
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Integrating multiple omics and machine learning to reveal the prognostic value of endoplasmic reticulum stress gene FKBP10 in gastric cancer
Xuanyu Chen, Chenchen Liu, Yuqin Wang, Aoyang Yu, Zichen Pei, Zhiyuan Yao, Gengchen Li, Lin Yan, Xitai Zhang, Zhengxiang Han
Translational Cancer Research  
2026;
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:237
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 (30 April 2026) 
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The role of the CDCA gene family in tumor stemness maintenance and drug sensitivity
Lin Xiang, Tian Peng, Guo-Bin Song, Hou-Qun Ying, Xue-Xin Cheng
Translational Cancer Research  
2026;
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:238
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 (30 April 2026) 
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Identification of a novel ion channel-related gene signature to predict prognosis and immune response of gastric cancer
Xixian Zhao, Liuye Huang
Translational Cancer Research  
2026;
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:239
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 (30 April 2026) 
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Single-cell and bulk transcriptomic analyses identify B-cell senescence-associated biomarkers in papillary thyroid carcinoma
Tenghong Liu, Zhijun Chen, Hongyi Wu, Wenxin Zhao
Translational Cancer Research  
2026;
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:240
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 (30 April 2026) 
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Establishment and evaluation of a prognostic model for sodium overload necrosis in acute myeloid leukemia
Kunying Xie, Jin Wei
Translational Cancer Research  
2026;
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:241
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 (30 April 2026) 
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Molecular mechanism of miR-27a-3p targeting FBXW7 regulating the malignant behavior of osteosarcoma cells
Huaibin Zhang, Rongxuan Liu, Xiaorong Liu, Wenqiang Liang, Wenji Wang, Yongping Wang
Translational Cancer Research  
2026;
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:242
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 (30 April 2026) 
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Black ginseng extract suppresses lung cancer growth in a xenograft mouse model
Hye Jin Park, Ha Rin Namkung, Su Bin Jung, Kwang-Tae Choi, Seung Tae Lee
Translational Cancer Research  
2026;
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:243
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 (30 April 2026) 
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Multiomic characterization of response and resistance to neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma
Yue Li, Jun Liu, Wen Yu, Xin-Yun Song, Xu-Wei Cai, Guang-Zhong Wang, Xiao-Long Fu
Translational Cancer Research  
2026;
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:244
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 (30 April 2026) 
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Overexpression of FOXO1 may suppress proliferation and migration and correlate with tumor immune cells in nasopharyngeal carcinoma
Peng Yu, Wenyang Wei, Guoqing Wu, Xuexiang Liu, Shini Qin, Han Ma, Leru Feng, Yonglin Cai, Limin Liu
Translational Cancer Research  
2026;
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:245
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 (30 April 2026) 
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The obesity paradox effect of triglyceride-glucose-body mass index (TyG-BMI) on all-cause mortality in patients with malignant tumors: a machine learning-driven cohort study
Mingxing Wang, Yahao Li, Jian Chen, Wanhui Dong, Yuru Wang, Siyi Bo, Pantong Wu, Zhiying Wang, Zhixian Zhong, Yi Zhong
Translational Cancer Research  
2026;
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:246
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 (30 April 2026) 
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Plasma fatty acid associated with risk of gastrointestinal cancer: a prospective cohort study from UK Biobank
Tianyu Song, Sien Hu, Yongji Sun, Jian Wu, Yulian Wu, Xiawei Li
Translational Cancer Research  
2026;
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:247
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 (30 April 2026) 
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Knockdown of TRIM35 suppresses cell proliferation and metastasis by modulating the PPAR signalling pathway in papillary thyroid cancer cells
Liubing Zhang, Aiping Peng, Yue Qin
Translational Cancer Research  
2026;
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:248
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 (30 April 2026) 
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Lipid metabolism-related gene expression predicts prognostic outcomes in lung adenocarcinoma
Xianyong Li, Qianqian Tang, Xuankai Wang, Na Liu, Jianjun Xu
Translational Cancer Research  
2026;
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:249
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 (30 April 2026) 
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Translational progress and bottlenecks in neurotransmitter-cancer research [2000–2025]: an integrated bibliometric and interventional trial analysis
Ming Zhang, Weihao Sun, Yizhao Ma, Jialin C. Zheng, Qihui Wu, Ge Gao
Translational Cancer Research  
2026;
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:250
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 (30 April 2026) 
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Construction of an actin cytoskeleton-related gene signature for predicting prognosis and therapeutic response in glioblastoma: based on machine learning
Mengda Li, Juntao Li, Zhixiao Li, Guanzheng Liu, Yuanhang Zhou, Mayuan Meng, Zikuan Chai, Ye Yuan, Chao Wang, Xudong Fu, Chunxiao Ma
Translational Cancer Research  
2026;
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:251
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 (30 April 2026) 
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Overexpression of ACTL6A is associated with poor prognosis in gastric cancer, and nuclear level is an independent predictor
Qiqi Wang, Haihong He, Yiwen Zhou, Peng Li, Tingting Huang
Translational Cancer Research  
2026;
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:252
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 (30 April 2026) 
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A novel risk model of cholesterol metabolism-related mRNAs for predicting overall survival and immune signature in glioma based on machine learning and multi-omics data
Danlei Yu, Kecheng Shen, Jun Wang, Fan Jiang, Pengfei Xia, Zhengquan Yu
Translational Cancer Research  
2026;
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:253
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 (30 April 2026) 
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Non-coding RNAs (ncRNAs)-mediated high expression of Ras-related C3 botulinum toxin substrate 1 (RAC1) correlates with poor prognosis and tumor immune infiltration of liver hepatocellular carcinoma
Tao Zhang, Tao Jiang, Yuting Jiang, Ren Lang, Qiang He
Translational Cancer Research  
2026;
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:254
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 (30 April 2026) 
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Results of the feasibility study of clinical trials of the new cancer treatment technology Karanahan for patients with advanced breast cancer
Anastasia S. Proskurina, Veronika A. Markina, Vera S. Ruzanova, Genrikh S. Ritter, Evgeniya V. Dolgova, Svetlana S. Kirikovich, Evgeniy V. Levites, Yaroslav R. Efremov, Eugene I. Vereschagin, Olga Y. Leplina, Alexandr A. Ostanin, Elena R. Chernykh, Nikolay A. Kolchanov, Sergey V. Sidorov, Sergey S. Bogachev
Translational Cancer Research  
2026;
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:255
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 (30 April 2026) 
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Long non-coding RNA (lncRNA) CDKN2A-DT promotes proliferation, migration, and invasion of oral squamous cell carcinoma via the PI3K/AKT/mTOR axis
Ke Liao, Wei Lv, Binghua Feng, Xiaoping Su, Xuanping Huang
Translational Cancer Research  
2026;
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:256
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 (30 April 2026) 
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CLIP2 is a potential biomarker for platinum resistance and prognosis in ovarian cancer: a bioinformatics analysis
Minghui Qiu, Mengxing Zhao, Jiani Zhao, Haoyun Zhao, Weiqi Jiang, Lu Yang, Lindong Yang
Translational Cancer Research  
2026;
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:257
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 (30 April 2026) 
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OSBPL3 promotes colorectal cancer progression through modulation of TGF-β signaling and immune cell infiltration
Weijun Liang, Chengxing Wang, Jianchang Wei, Chaorong Zhou, Canxiu He, Yaoming He, Jinglin Zhao, Shangren Li, Jie Cao
Translational Cancer Research  
2026;
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:258
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 (30 April 2026) 
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A2M promotes the progression of STAD by upregulating vimentin expression and epithelial-mesenchymal transition: boinformatics analysis and experimental verification
Wenyan Jiang, Guowen Ma, Huakai Zeng, Xinyue Xu, Junyi Liu, Xiaoke Wang, Yuyao Li, Xindi Huang, Wenjie Xu, Chunyan Fang, Wenqi Sun, Xuejian Wang
Translational Cancer Research  
2026;
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:259
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 (30 April 2026) 
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Nomogram prediction for breast cancer-specific survival in patients with ER−/PR−/HER2+ breast cancer: an analysis based on the SEER population
Li You, Yiman Ge, Jiangyan Yong, Yuye Li, Lingling Zhang, Qiongying Hu
Translational Cancer Research  
2026;
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:260
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 (30 April 2026) 
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Integrated transcriptomic analysis and machine learning identify immunogenic cell death genes as prognostic markers and therapeutic targets in non-small cell lung cancer
Xiaodong Chen, Tongtong Zhang, Zhe Yang, Fang Zhang
Translational Cancer Research  
2026;
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:261
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 (30 April 2026) 
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Optimization of temporal phase in multi-phase contrast-enhanced MRI for gross tumor volume determination in pancreatic cancer radiotherapy
Kangning Meng, Yujie Guo, Yong Yin, Ya Su, Lizhen Wang, Ruozheng Wang, Guanzhong Gong
Translational Cancer Research  
2026;
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:262
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 (30 April 2026) 
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Development and multicenter validation of an immunoinflammatory marker-MRI model for pathological complete response after neoadjuvant chemotherapy in invasive breast cancer
Fan Meng, Yanfang Deng, Junhui Yuan, Shaobo Fang, Hongkai Zhang, Tiandong Chen, Renzhi Zhang, Yunjing Xue, Xuejun Chen, Jinrong Qu
Translational Cancer Research  
2026;
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:263
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Integrating single-cell and spatial transcriptomics to decipher the neuro-immune microenvironment of breast cancer brain metastasis: a key regulatory axis, prognostic model, and drug discovery
Jing Li, Weiyi Wu, Jingkang Lu, Huan Yang, Yongling Leng, Bingxi Lei
Translational Cancer Research  
2026;
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:264
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 (30 April 2026) 
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Construction of a prognostic risk model based on colorectal cancer-specific ferroptosis genes and preliminary validation of FGFR4
Aduo Gao, Lina Tang, Xiangyan Meng, Minghui Zhang, Shengjie Yin
Translational Cancer Research  
2026;
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:265
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 (30 April 2026) 
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Ferroptosis-related lncRNA signature predicts prognosis and treatment response in colon cancer
Ting Wang, Chengyi Wang, Yubing Lu, Yanfeng Zhong, Yangyang Xue, Xin Liu, Erbao Chen, Guoqing Lv
Translational Cancer Research  
2026;
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:266
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 (30 April 2026) 
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UBA6 serves as a prognostic biomarker and promotes tumor progression in pancreatic ductal adenocarcinoma
Zesha Xu, Yinghua Zhang, Ying Wang
Translational Cancer Research  
2026;
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:267
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 (30 April 2026) 
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Metaxins regulate cancer stem cell-like properties in H1299 cells
Heabin Kim, Seung-Hyun Jung, Seonmi Jo, Jeong Moo Han, Jei Ha Lee
Translational Cancer Research  
2026;
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:268
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 (30 April 2026) 
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Multi-omics analysis identifies RARRES1 as a potential biomarker linked to immunosuppressive microenvironment and its radiomics prediction in ovarian cancer
Tao Yang, Mao Hua, Deguo Xu
Translational Cancer Research  
2026;
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:269
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 (30 April 2026) 
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Tertiary lymphoid structure-related genes drive tumor microenvironment heterogeneity and prognostic disparities in left- vs. right-sided colon cancer
Hongyi Zhou, Xiaohong Qian, Qiujun Dai, Qiqi Zhu, Peiyuan Li, Wei Cui, Yibin Zhao
Translational Cancer Research  
2026;
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:270
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 (30 April 2026) 
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A novel programmed-cell-death-related prognostic risk model for cervical cancer based on mitochondrial genes
Liping Cao, Chi Zhang
Translational Cancer Research  
2026;
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:271
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 (30 April 2026) 
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Asporin promotes gastric cancer progression by regulating NRF2 ubiquitination and competitively binding to KEAP1
Lei Yin, Mingming Du, Jieping Ying, Xiang Zhong, Feiran Wang, Nannan Zhang, Zhong Chen
Translational Cancer Research  
2026;
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:272
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 (30 April 2026) 
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Multi-omics clustering combined with multiple machine learning to identify epigenetic features in low-grade glioma patients
Lixuan Qiu, Xiaofu Lian, Xiaoyu Qiang, Chaoqun Lian, Jing Zhang
Translational Cancer Research  
2026;
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:273
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 (30 April 2026) 
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Chromatin remodeling-driven stratification and a five-gene RiskScore define proliferative aggressiveness and therapeutic vulnerabilities in neuroblastoma
Aiguo Zhu, Xin Li, Zhengchao Jin, Yi Pan, Jian Wang
Translational Cancer Research  
2026;
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:274
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 (30 April 2026) 
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Exploring the significance of IgM expression in the lymphatic system during breast cancer progression
Dingyuan Cui, Jie Li, Guangfei Yang, Wen Wang, Chengrong Mi
Translational Cancer Research  
2026;
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:275
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 (30 April 2026) 
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Construction and external validation of a nomogram for predicting 10-year recurrence risk after radical resection in Chinese patients with stage III colorectal cancer
Qingliang Wu, Liangxiao Wu, Yongjin He, Guoqing Yu, Dandan Chen
Translational Cancer Research  
2026;
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:276
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 (30 April 2026) 
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Integrated analysis of the prognostic and immunotherapeutic significance of ZEB1-AS1 in hepatocellular carcinoma
Xiangdong Niu, Yifeng Chen, Jing Yu, Xue Chen, Xuyun Wang, Guogan Ding, Liangyin Fu, Xiangyong Hao
Translational Cancer Research  
2026;
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:277
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 (30 April 2026) 
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Radiation-activated astrocytes promote tumor progression through CXCL12 secretion and induce resistance to anti-PD-1 immunotherapy
Xinlong Li, Haotian Wei, Yufeng Zhu, Peng Feng, Juncheng Wang, Guoqiang Yuan, Yawen Pan
Translational Cancer Research  
2026;
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:278
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 (30 April 2026) 
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Deciphering the molecular crosstalk between pancreatic ductal adenocarcinoma and type 2 diabetes through multi-dataset integration
Fan-Jie Jin, Jian-Fang Li, Hong-Yong Fu, Liang-Jun Xie, Lu-Ping Qin, Mu-Hua Cheng
Translational Cancer Research  
2026;
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:279
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 (30 April 2026) 
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Lysine crotonylation-related long non-coding RNAs: a novel prognostic framework for gastric carcinoma
Hao Hu, Hegui Zhao, Daiyi Yao, Qulai Tang, Chenghong Mou, Yang Deng
Translational Cancer Research  
2026;
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:280
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 (30 April 2026) 
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Development and validation of a non-invasive nomogram for predicting bone metastasis in newly diagnosed breast cancer
Li Wang, Xin Zhang, Simin Lu, Shourong Liu
Translational Cancer Research  
2026;
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:281
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 (30 April 2026) 
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Magnetic resonance imaging-based radiomics analysis: predicting vascular invasion in breast invasive ductal carcinoma using different machine learning models
Hongen Li, Li Zhang, Yihui Zeng, Yan Zhang, Zhiqiu Ye
Translational Cancer Research  
2026;
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:282
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 (30 April 2026) 
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Bioinformatics analysis of PBLD as a potential biomarker in pan-cancer and colon adenocarcinoma
Jiayue Chen, Xiaoqiong Chen, Yuanhao Wei, Jinyuan Ou, Lanxi Yue, Xuanle Li, Bing Huang, Fachao Zhi, Xinmei Zhao
Translational Cancer Research  
2026;
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:283
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 (30 April 2026) 
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Establishment and validation of a novel anoikis-related prognostic signature of lung squamous cell carcinoma
Zhengpan Wei, Kaishang Zhang, Kaiyuan Li, Shaowu Sun, Xu Liu, Wenbo Fan, Zelong Wang, Tianliang Zhao, Tongfa Yan, Bin Yan, Zhiqian Zhao, Qihang Zhao, Guoqing Zhang, Xue Pan, Xiangnan Li
Translational Cancer Research  
2026;
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:284
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 (30 April 2026) 
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Identification of EFNA family as new potential prognostic biomarkers correlated with immune cell infiltration in hepatocellular carcinoma
Junjun Wang, Xiaorui Li, Biyun Zheng, Zhixin Chen, Fenglin Chen, Xuefen Fang
Translational Cancer Research  
2026;
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:285
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 (30 April 2026) 
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Dexamethasone and N-acetylcysteine for the prevention of post-embolization syndrome following transarterial chemoembolization in hepatocellular carcinoma: a systematic review and network meta-analysis
Meihui Cao, Zhiqian Li, Chao Xue
Translational Cancer Research  
2026;
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:286
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 (30 April 2026) 
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Baseline neutrophil-to-lymphocyte ratio as a prognostic biomarker in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis
Yanli Liu, Chengyan Xu, Shuang Zhao, Yun Chen
Translational Cancer Research  
2026;
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:287
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 (30 April 2026) 
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DNPEP promotes the growth, metastasis, and cisplatin resistance of tongue squamous cell carcinoma through RACK1/ERK signaling pathway
Jianwei Liu, Zichen Xu, Yuqi Xin, Qingkun Jiang, Zhiliang Nie, Jiaxuan Qiu
Translational Cancer Research  
2026;
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:288
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 (30 April 2026) 
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Identification of immune-related gene signature for predicting prognosis of glioblastoma patients
Lu Ye, Weichao Ma, Jiaoming Li, Yuhan Ming, Fengjuan Zhou, Juan Liu
Translational Cancer Research  
2026;
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:289
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 (30 April 2026) 
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Construction of a diagnostic model for colorectal cancer based on exosome-related genes: integration of immune cell differentials and molecular docking
Yulai Yin, Li Li, Shuang Liu, Yixuan Xie, Yuwei Li, Yuan Gao, Chen Xu, Yan Wang
Translational Cancer Research  
2026;
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:290
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 (30 April 2026) 
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Identification of shared diagnostic biomarkers and molecular pathways between chronic kidney disease and renal cell carcinoma using transcriptomics and machine learning
Xiaocheng Peng, Ziyi Wang, Jia Si, Hongsheng Ji, Geyang Xu, Yuanfang Chen, Mulong Du, Ming Xu
Translational Cancer Research  
2026;
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:291
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 (30 April 2026) 
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An exploratory study on whole-lung radiomics features from computed tomography for prognostic prediction in non-small cell lung cancer with concurrent chemoradiotherapy
Zhongjun Huang, Benlan Li, Yong Hu, Youlong Mo, Tianchu He, Mingdan Zhao, Ya Li, Min Zhang, Ji Xia, Minfang Wang, Xian Liu, Yaping Quan, Hongyan Luo, Lingyun Wang, Weiwei Ouyang, Jie Peng
Translational Cancer Research  
2026;
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:292
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 (30 April 2026) 
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Digitoxin inhibits the growth of HSC-3 cells by inducing G2/M cell cycle arrest and apoptosis
Ying Rui, Yan Wang, Hongfei Gong, Xuanyu Zhu, Qing Xu, Jing Lin, Jingchen Wei
Translational Cancer Research  
2026;
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:293
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 (30 April 2026) 
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Mitochondrial gene APOO reprograms lipid metabolism to influence the prognosis of breast cancer
Yupeng Sha, Yi Du, Ming Niu, Quan Yuan, Jiguang Han
Translational Cancer Research  
2026;
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:294
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 (30 April 2026) 
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Prognostic value and therapeutic implications of HMGA2 in EGFR-mutant non-small cell lung cancer
Yichen Yang, Shixuan Yan, Zitao Liu, Zhibing Luo, Jie Wang, Ganxiu Deng, Jianjun Zhou, Li Xu, Changwen Deng
Translational Cancer Research  
2026;
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(4)
:295
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 (30 April 2026) 
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Lipid metabolism-related molecular typing and prognostic characteristics of cutaneous melanoma
Linxue Li, Lezhen Xu, Wen Shi, Jingyu Zhao, Julin Gu
Translational Cancer Research  
2026;
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:296
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 (30 April 2026) 
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Diagnostic performances of skin cancers using intensity- and gradient-based features with optical coherence tomography: a pilot study
Wei Gao, Lingyi Lu, Bingjiang Lin, Suling Xu, Alexander A. Moryatov, Sergey V. Kozlov, Valery P. Zakharov, Dmitry V. Kornilin, Ivan A. Bratchenko
Translational Cancer Research  
2026;
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(4)
:297
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 (30 April 2026) 
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Lysosome-dependent cell death reveals a prognostic signature in colorectal cancer via integrated analysis of scRNA-seq and bulk RNA-seq data
Cuihua Li, Dan Cui, Hui Wang, Wentong Yu, Xiaohui Qiu
Translational Cancer Research  
2026;
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(4)
:298
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 (30 April 2026) 
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A prognostic model based on Scissor+ cancer-associated macrophages identified from bulk and single cell RNA sequencing data in ovarian cancer
Yijie Mao, Sulong Xu, Xiaoyan Bao, Biqiong Pan, Hong Chen, Jiefang Lu
Translational Cancer Research  
2026;
15
(4)
:299
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 (30 April 2026) 
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Development and internal validation of a multivariable prognostic prediction model in advanced breast cancer patients based on the SEER database
Yuhan Dong, Lizhi Teng, Juntong Du, Shuai Yan, Wenxi Zhao, Hongyue Wang, Weiyang Tao
Translational Cancer Research  
2026;
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:300
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 (30 April 2026) 
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Prediction of distant metastasis and survival of appendiceal cancer patients: a SEER population-based study
Yanan Guo, Yike Ji, Yuanjia Ren, Linhua Yao, Jing Yu
Translational Cancer Research  
2026;
15
(4)
:301
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 (30 April 2026) 
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Preoperative prediction of HER2 expression in gastric cancer based on an enhanced CT radiomics model
Han Feng, Zhi Yang, Mingguo Xie
Translational Cancer Research  
2026;
15
(4)
:302
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 (30 April 2026) 
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Metformin suppressed epithelial-mesenchymal transition, cisplatin resistance and metastatic potential of ovarian cancer via inhibiting TGF-β1/Smads
Hualong Tang, Zhengyu Han, Wanglong Zhu, Xinyue Lin, Ji Chen, Jiaofeng Li, Xingqiang He, Mei Chen, Yuhan Yang, Zhiling Yang, Fengtian Li, Jingyi Wang, Xia Meng, Kun Zhang
Translational Cancer Research  
2026;
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(4)
:303
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 (30 April 2026) 
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Tirzepatide attenuates doxorubicin-induced cardiotoxicity via mitochondrial function improvement
Zhong Li, Conghui Li, Han Zhan, Dingqin Cai, Yangyu Ou, Yan Long, Xiaoping Li, Limin Liu
Translational Cancer Research  
2026;
15
(4)
:304
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 (30 April 2026) 
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IGF2BP3 promotes immune evasion and predicts poor prognosis in head and neck squamous cell carcinoma
Wenfu Lu, Guochao Zhang, Yin Ding, Fangyuan Liao, Yaxin Luo, Yan Sui, Xiaowen Zhang, Pingan Wu
Translational Cancer Research  
2026;
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(4)
:305
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 (30 April 2026) 
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Clinical and prognostic implications of KRT19 expression in pancreatic ductal adenocarcinoma
Hyung Jun An, Kwang Bum Cho, Kyung In Shin
Translational Cancer Research  
2026;
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(4)
:306
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 (30 April 2026) 
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Identification and analysis of endoplasmic reticulum stress- related genes in neuroblastoma and construction of a prognostic gene signature
Wenting Lu, Ruixi Zhou, Yan Yue, Junjie Ying, Tao Xiong, Jun Tang, Jing Shi, Hua Wang, Li Zhang, Tiechao Ruan
Translational Cancer Research  
2026;
15
(4)
:307
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 (30 April 2026) 
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A distinct form of colorectal cancer: signet ring cell carcinoma
Dong Li, Chuanhua Yang, Feiwu Long, Lili Xiang
Translational Cancer Research  
2026;
15
(4)
:308
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 (30 April 2026) 
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Explainable machine-learning prediction of overall and cancer-specific survival in adult triple-negative breast cancer using SEER: a comparative study of nomograms and random survival forests
Yinfang Zhang, Yuanyuan Dou, Chaoxia An, Tongtong Liu, Tingting Shao, Weijie Yang, Wenjing Guo, Peng Song
Translational Cancer Research  
2026;
15
(4)
:309
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 (30 April 2026) 
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Machine learning-based early survival prediction in early-onset hepatocellular carcinoma: a SEER-based multi-model comparative study
Huan Ma, Zhenpeng Zeng, Chenjie Xiao, Chunyan Li, Xiaosong Tan, Duanming Du, Ying Wu
Translational Cancer Research  
2026;
15
(4)
:310
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 (30 April 2026) 
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Nomogram for predicting cancer-specific mortality risk in endometrial cancer after postoperative radiotherapy
Qingyi Wang, Ailin Tao, Yinfeng Tuo, Jiali Li, Fanglei Liu, Zhihui Deng, Guona Li
Translational Cancer Research  
2026;
15
(4)
:311
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 (30 April 2026) 
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Identification and validation of ZAP70 as a potential biomarker associated with T cell infiltration in lung adenocarcinoma
Lunqiang Zhang, Xiuying Li, Fang Jin
Translational Cancer Research  
2026;
15
(4)
:312
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 (30 April 2026) 
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Clinical features, central nervous system risk, and therapeutic outcomes in primary sinonasal diffuse large B-cell lymphoma: a retrospective cohort study of 94 patients
Na Yao, Chengji Wang, Monan Niu, Lei Yang, Jia Cong, Jin Ye, Xin Li, Jing Yang, Liqiang Wei, Liang Wang
Translational Cancer Research  
2026;
15
(4)
:313
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 (30 April 2026) 
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Integrated single-cell and bulk RNA sequencing reveals novel biomarkers of invasive adenocarcinoma subtypes in lung adenocarcinoma
Xiaoming Wu, Xuxia Ye, Bo Wang, Zhoule Li, Chengnan Fang, Jian Xu, Mengli Wu
Translational Cancer Research  
2026;
15
(4)
:314
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 (30 April 2026) 
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Clinical outcomes and prognostic factors of systemic therapy combined with interventional treatment in hepatocellular carcinoma: a multicenter retrospective case series
Shilong Yu, Tongguo Si, Chu Wang, Donghui Liu, Gang Jin, Xudong Zhang, Huikai Li, Mao Yang, Weihao Zhang, Yongfei Guo, Rentao Li, Huiwen Wang, Shijie Li, Miao Xu, Dongfeng He, Haifeng Liu
Translational Cancer Research  
2026;
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(4)
:315
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 (30 April 2026) 
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The effects of adjuvant radiotherapy on survival outcomes in polymorphous adenocarcinoma: a retrospective cohort study
Makayla R. Matthews, Victoria I. Fonseca, Samuel Auger, Christopher A. Pede, Ramez Phillips, Jason Tasoulas, Christopher Blake Sullivan
Translational Cancer Research  
2026;
15
(4)
:316
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 (30 April 2026) 
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RNF112 mediates immunosuppression to inhibit the proliferation of cervical cancer by Foxm1
Huiying Pan, Lei Bao, Wei Shi, Jing Wan
Translational Cancer Research  
2026;
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(4)
:317
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 (30 April 2026) 
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MTFR2 regulated the proliferation, apoptosis, migration, and invasion of endometrial cancer cells through the Drp1/MFN1 signaling pathway mediated mitochondrial fission
Xuefei Bai, Min Wei, Qi Wang, Yongxiu Yang
Translational Cancer Research  
2026;
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(4)
:318
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 (30 April 2026) 
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Survival benefit of adjuvant radiotherapy for gallbladder cancer patients with stage IIIA: a population based, propensity score-matched study
Xin Zhao, Yunfeng Qiao, Long He, Congdun Ran
Translational Cancer Research  
2026;
15
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:319
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 (30 April 2026) 
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Exosomal P4HA3: a promising biomarker for diagnosis and prognosis in gastric cancer
Jinquan Lin, Chunyu Wang, Qingli Fang, Zhi Zhao
Translational Cancer Research  
2026;
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(4)
:320
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 (30 April 2026) 
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The effect of astragaloside IV on doxorubicin-induced cardiotoxicity in young mice: exploring its cardioprotective effect during childhood tumor chemotherapy
Huai-Yang Liu, Jing-Jing Yang, Jin-Sheng Gao, Dan Tang, Ya-Jing Tian, Jia-Cheng Wang, Jin-Hu Yang, Shao-Fang Gao
Translational Cancer Research  
2026;
15
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:321
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 (30 April 2026) 
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Loss of GGT6 promotes colorectal cancer progression and correlates with poor prognosis: a study based on multi-database mining and functional validation
Yu Yang, Jiamin Li, Shangzhiyu Gong, Chenyi Zhao, Lulu He, Feng Guo
Translational Cancer Research  
2026;
15
(4)
:322
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 (30 April 2026) 
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Comprehensive analysis and validation of the prognostic value of glycosylation- and mitophagy-related genes for head and neck squamous cell carcinoma
Qiaoling Lu, Li Ying, Lang Ling, Wu Hui, Xinbin Wang
Translational Cancer Research  
2026;
15
(4)
:323
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 (30 April 2026) 
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LncRNA ELFN1-AS1 promotes colon cancer occurrence and progression by regulating the miR-191-5p/ZBTB34 axis
Yue Jiang, Yanmei Hou, Yongjun Du, Xiangdong Yang
Translational Cancer Research  
2026;
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:324
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 (30 April 2026) 
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Clinical value and cost-effectiveness analysis of conditionally approved anticancer drugs in China from 2015 to 2023
Zhiming Huang, Xuanzhuang Lu, Haoyang Wang, Jinlian Li, Rong Shao, Jinping Xie
Translational Cancer Research  
2026;
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:325
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 (30 April 2026) 
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The potential of ATF5 as a prognostic marker and therapeutic target in cancer: insights from bioinformatics analysis and experimental validation
Yanrong Zhao, Hongyu Yang, Tingting Cai, Zhizhong Hao, Qingju Sun, Dongmeng Qian, Ming Hu
Translational Cancer Research  
2026;
15
(4)
:326
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 (30 April 2026) 
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Clinical significance of circulating tumor DNA monitoring based on TP53 mutation in high-grade serous ovarian cancer patients
Heejung Jung, Ok-Ju Kang, Young-Jae Lee, Sung Wan Kang, Min-Seo Lee, Shin-Wha Lee, Yong Man Kim
Translational Cancer Research  
2026;
15
(4)
:327
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 (30 April 2026) 
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Tree-based model for diffuse-type gastric cancer prognostication: a population study based on the Surveillance, Epidemiology, and End Results database
Lei Cai, Yeqi Sun, Beibei Lv, Wenjing Su, Jia Li
Translational Cancer Research  
2026;
15
(4)
:328
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 (30 April 2026) 
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Network pharmacology approach and experimental verification of Danzhi Xiaoyao Powder for breast cancer treatment based on UHPLC-Q-Orbitrap HRMS
Kan Ni, Nan Xu, Xun Lu, Changjiang Gu, Cheng Lu
Translational Cancer Research  
2026;
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(4)
:329
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 (30 April 2026) 
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Development and validation of a macrophage-related prognostic model for overall survival in ovarian cancer via integrated RNA sequencing analysis
Tao Yu, Guangji Yang, Dongyan Ren, Yantao Li, Chong Yue, Qin Yang, Jie Zhang
Translational Cancer Research  
2026;
15
(4)
:330
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 (30 April 2026) 
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A machine learning-based basement membrane gene signature model for predicting ovarian cancer survival
Qian Hu, Yuan-Yue Li, Jing Ge
Translational Cancer Research  
2026;
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(4)
:331
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 (30 April 2026) 
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Adaptive radiotherapy based on nodal response to induction chemotherapy in nasopharyngeal carcinoma: a retrospective dose de-escalation analysis
Wenxuan Huang, Weisi Wang, Yizhi Ge, Dan Zong, Lanfang Zhang, Lijun Wang, Shengfu Huang, Xia He
Translational Cancer Research  
2026;
15
(4)
:332
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 (30 April 2026) 
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Physical activity and cancer survival: the role of peripheral blood immune and inflammatory markers in reducing mortality—a retrospective cohort study based on NHANES 1999–2018
Xin Liu, Xuefei Fan, Chenggong Li, Xinquan Liang, Pingping Hu, Jiandong Zhang
Translational Cancer Research  
2026;
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(4)
:333
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 (30 April 2026) 
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Characterizing immune heterogeneity in gastric cancer by high-throughput T-cell receptor sequencing: predictive clonotypes and functional signatures
Tianhua Liu, Zhengrong Chen, Guilian Cheng, Liming Xu, Lei Gan, Zhenyu Ye, Xudong Shen
Translational Cancer Research  
2026;
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(4)
:334
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 (30 April 2026) 
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Fibulin-5 (FBLN5) as a context-dependent pan-cancer regulator: integrated multi-omics analysis reveals dual roles in tumor progression and therapeutic resistance
Jingtao Tong, Kaitai Liu, Yajie Shi, Yanggang Dan, Bingchuan Hu, Hui Zhang
Translational Cancer Research  
2026;
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:335
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 (30 April 2026) 
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Review Article

Targeting “undruggable” cancer proteins: pharmacological challenges and emerging strategies
Juan Luiz Coelho-Silva, Natália Sudan Parducci, Maria Fernanda Lopes Carvalho, Vahid Vahedian, Keli Lima, Bruna Oliveira de Almeida, João Agostinho Machado-Neto
Translational Cancer Research  
2026;
15
(4)
:336
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 (30 April 2026) 
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A narrative review of cinobufacini for endometrial cancer: mechanisms and therapeutic implications
Liying Xu
Translational Cancer Research  
2026;
15
(4)
:337
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 (30 April 2026) 
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Tumor cell plasticity in non-small cell lung cancer: the role of microRNA and implications for diagnosis, prognosis and treatment
Iyare Izevbaye
Translational Cancer Research  
2026;
15
(4)
:338
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 (30 April 2026) 
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The double-edged sword of tumor-targeted treatment: the influence of targeted therapy on the heart
Yexuan Huang, Liwen Chen, Cheng Ding, Cheng Zou, Zhaoliang Su, Xiaozheng Shu, Yan Wu
Translational Cancer Research  
2026;
15
(4)
:339
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 (30 April 2026) 
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CRISPR technology in ovarian cancer research: advances from gene editing to precision diagnosis and therapy
Yuanling Zhang, Yinhua Tan, Yuanyuan Du, Rui Xiang, Yi Liu
Translational Cancer Research  
2026;
15
(4)
:340
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 (30 April 2026) 
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Metronomic chemotherapy combined with immunotherapy in solid tumor: a systematic review
Shaoxing Li, Zongxi Li, Xiangjie Liu, Hua Yu
Translational Cancer Research  
2026;
15
(4)
:341
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 (30 April 2026) 
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Targeting the MICA/B-NKG2D axis in cancer: from molecular structure to immunotherapeutic strategies—a narrative review
Yuwei Zheng, Wanyi Ding, Bingbing Chen, Caizheng Geng, Xiaowei Li
Translational Cancer Research  
2026;
15
(4)
:342
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 (30 April 2026) 
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Precision, prevention and progress: charting two decades of change in gynaecological oncology—a narrative review
Sabina Ioana Nistor, Ruyu Shao, Jacopo Conforti, Francis Gardner, Federico Ferrari, Lamiese Ismail, Xiaoyu Niu, Desheng Yao, Hooman Soleymani majd
Translational Cancer Research  
2026;
15
(4)
:343
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 (30 April 2026) 
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PARP inhibitors in the treatment of ovarian cancer: a narrative review
Yan Wang, Xiaoli Li, Yudan Yang, Xiufang Lv, Kang Wang, Haochen Li, Xiaohao Liu, Ke Jin, Ming Gao
Translational Cancer Research  
2026;
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:344
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 (30 April 2026) 
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Editorial Commentary

Starving leukemia: nicotinamide phosphoribosyltransferase-dependent nicotinamide adenine dinucleotide salvage links metabolic vulnerability to therapeutic sensitivity in acute myeloid leukemia
Juan Luiz Coelho-Silva, Diego Antonio Pereira-Martins, João Agostinho Machado-Neto
Translational Cancer Research  
2026;
15
(4)
:345
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 (30 April 2026) 
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Postoperative proton therapy in uterine and cervical cancer: promising evidence but remaining questions
Lars Wessel, Nathalie Arians
Translational Cancer Research  
2026;
15
(4)
:346
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 (30 April 2026) 
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From prognosis to precision: interpreting HER2DX assay in early HER2-positive breast cancer
Yuhei Yamaguchi, Yuki Kojima, Kan Yonemori
Translational Cancer Research  
2026;
15
(4)
:347
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 (30 April 2026) 
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Can whole genome data analysis be used to personalize breast cancer care?
Wanping Xu, Edward R. Sauter
Translational Cancer Research  
2026;
15
(4)
:348
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 (30 April 2026) 
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Post-transplant oral decitabine and cedazuridine maintenance in high-risk acute myeloid leukemia or myelodysplastic syndrome
Thura Win Htut, Farhad Ravandi
Translational Cancer Research  
2026;
15
(4)
:349
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 (30 April 2026) 
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Do ethnic differences influence the response to immunotherapy in advanced cervical cancer?
Giovanna Vieira Giannecchini, Ana Beatriz Tavares Filgueiras, Diocésio Alves Pinto de Andrade, Andreia Cristina de Melo
Translational Cancer Research  
2026;
15
(4)
:350
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 (30 April 2026) 
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Anti-HCV treatment and risk for extrahepatic cancers: evidence of benefits with questions remaining
Hanyang Liu, Frank Tacke
Translational Cancer Research  
2026;
15
(4)
:351
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 (30 April 2026) 
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Risk-reducing surgery, risk-reducing medication, and surveillance in young BRCA carriers with breast cancer: considering all the options
Nicola Flaum, Ashu Gandhi, Sacha J. Howell, D. Gareth Evans
Translational Cancer Research  
2026;
15
(4)
:352
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 (30 April 2026) 
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Iodine seed-marking protocol for response-guided axillary de-escalation after neoadjuvant therapy in node-positive breast cancer
Sergi Vidal-Sicart, Renato A. Valdés Olmos
Translational Cancer Research  
2026;
15
(4)
:353
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 (30 April 2026) 
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Too much, too soon?—trastuzumab deruxtecan in the first line metastatic setting
Ashley P. Davenport, Margaret E. Gatti-Mays
Translational Cancer Research  
2026;
15
(4)
:354
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 (30 April 2026) 
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Residual disease after neoadjuvant therapy in HER2-positive breast cancer: biology, burden, or both?
Élise Di Lena, Kazuaki Takabe
Translational Cancer Research  
2026;
15
(4)
:355
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 (30 April 2026) 
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Refining breast cancer risk estimation in carriers of pathogenic BRCA2 variants
Délio Marques Conde, Renata Lazari Sandoval
Translational Cancer Research  
2026;
15
(4)
:356
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 (30 April 2026) 
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Sentinel lymph node biopsy in early-stage oral squamous cell carcinoma: reassessing its role in contemporary practice
Chin Shien Lin, Leandro Luongo Matos
Translational Cancer Research  
2026;
15
(4)
:357
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 (30 April 2026) 
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Moderately hypofractionated IMPT with pelvic nodal irradiation for high-risk prostate cancer: an emerging standard or an incremental step?
Elías Gomis Sellés, Antonio J. Conde, Fernando López Campos, Felipe Couñago
Translational Cancer Research  
2026;
15
(4)
:358
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 (30 April 2026) 
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Small device, big impact: how a simple chairside 3D-printed retractor reshapes dose and patient experience in head and neck radiotherapy
Paulo Sérgio da Silva Santos, Vinícius Rizzo-Marques
Translational Cancer Research  
2026;
15
(4)
:359
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 (30 April 2026) 
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