Identification of protein lysine lactylation and potential targets in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies with high morbidity and mortality. Exploring the molecular pathogenesis of ESCC is of pivotal importance to improve patients’ prognosis. Lactate-mediated lysine lactylation (Kla) is a novel post-translational modification and critical for cancer progression. However, the role and mechanism of Kla in ESCC metastasis are poorly defined.