Vol 15, No 5 (May 30, 2026): Translational Cancer Research

Editorial Commentary

Cancer of unknown primary in the neck—challenging in diagnosis and treatment
Gunnar Wichmann, Theresa Wald, Andreas Dietz
Translational Cancer Research  
2026;
15
(5)
:360
.
Induced pluripotent stem cell-derived natural killer cells: poised for the clinic as an off-the-shelf allogeneic cell therapy
Tianchen Xiong, Jianhua Yu
Translational Cancer Research  
2026;
15
(5)
:361
.
Computed tomography monitoring of small lung nodules: finding the right balance
Brane Grambozov, Josef Karner, Elvis Ruznic, Franz Zehentmayr
Translational Cancer Research  
2026;
15
(5)
:362
.
Antiviral therapy and the risk of extrahepatic malignancies in chronic hepatitis C: insights from recent evidence
Tatsuo Kanda, Reina Sasaki-Tanaka, Shuji Terai
Translational Cancer Research  
2026;
15
(5)
:363
.
Translation is not exportation: why European Prospective Investigation into Cancer and Nutrition rewrites the 4Kscore story
Whi-An Kwon
Translational Cancer Research  
2026;
15
(5)
:364
.
Fully human BCMA CAR-T therapy in multiple myeloma: lessons from long-term follow-up
Ahad Moulvi, Ata Abbas, Lara Soueid, Louis Williams, Faiz Anwer, Shahzad Raza
Translational Cancer Research  
2026;
15
(5)
:365
.
Quality of life with EV-302 in advanced urothelial carcinoma: lessons and implications
David J. Benjamin, Arash Rezazadeh Kalebasty
Translational Cancer Research  
2026;
15
(5)
:366
.
Reconsidering dual BCR::ABL1 inhibition in Philadelphia chromosome-positive acute lymphoblastic leukemia: is sequential better than concurrent?
Hiroto Ishii, Shoko Ishii, Yasuhiro Arakawa, Shingo Yano
Translational Cancer Research  
2026;
15
(5)
:367
.
Defining the biological boundaries of daratumumab monotherapy: long-term insights from the CENTAURUS trial in high-risk smoldering multiple myeloma
Katsuhiro Miura
Translational Cancer Research  
2026;
15
(5)
:368
.
Epcoritamab plus gemcitabine and oxaliplatin in transplant-ineligible relapsed/refractory diffuse large B-cell lymphoma: how should this regimen be positioned in current treatment algorithms?
Mariko Tsuda, Junichi Kiyasu
Translational Cancer Research  
2026;
15
(5)
:369
.

Original Article

The anti-migratory effect of curcumin in colorectal cancer involves IKKβ/NF-κB/Snail-mediated EMT inhibition
Bei Liu, Lu Xiao, Jing Shi, Jun Zhang, Min Chen
Translational Cancer Research  
2026;
15
(5)
:370
.
Comparative efficacy and safety of systemic therapies in transplant-eligible and ineligible relapsed/refractory large B-cell lymphoma: a Bayesian network meta-analysis
Liling Huang, Kai Chen, Min Wang, Chao Guo, Yang Li, Qiu Yu, Zixian Liu, Zhenling Li
Translational Cancer Research  
2026;
15
(5)
:371
.
Advancing the understanding of tumor microenvironment through medical imaging based on bibliometric analysis
Keling Huang, Ziqing Han, Yufei Xia, Xinjing Lou, Xinyu Wu, Ruizhi Fu, Linyu Wu, Chen Gao
Translational Cancer Research  
2026;
15
(5)
:372
.
TRIM37 interacts with PTEN to promote progression of hepatocellular carcinoma cells by modulating AKT/GSK-3β/β-Catenin pathway
Qingqing Wang, Xiaojian Zhang, Jie Zhang
Translational Cancer Research  
2026;
15
(5)
:373
.
Immune-driven induction of miR-501-5p by IL-17A enhances colorectal cancer progression
Yi Zhang, Ping Wang, Junchao Zhang, Wenxin Shen, Dandan Ma, Chonghao Yang, Bin Feng, Hongbin Liu, Yingnan Huang, Haibin Wu, Haohao Huang
Translational Cancer Research  
2026;
15
(5)
:374
.
A prognostic model for head and neck squamous cell carcinoma based on eosinophil extracellular trap related genes
Chuyu Han, Xuecheng Luo, Shouyin Xiao, Jiaou Lv, Bin Wang, Zhilin Li
Translational Cancer Research  
2026;
15
(5)
:375
.
Targeting EHMT2 inhibition in glioblastoma: effects on tumor progression and STAT3 signaling
Chengning Xu, Wenhao Yin, Hengzhu Zhang, Liguo Zhang
Translational Cancer Research  
2026;
15
(5)
:376
.
Individual and combined effects of marital status, household income, and residence on cancer management and survival in primary bone cancer: a SEER-based retrospective cohort study
Fang Lin, Leilei Tian, Chuang Li, Rui Shi, Jinling Liu, Shizhou Wu
Translational Cancer Research  
2026;
15
(5)
:377
.
A network pharmacology and molecular docking approach to investigate the anticancer mechanism of baicalin against melanoma through induction of apoptosis via EGFR-mediated PI3K/AKT pathway
Zhongshun He, Aiping Huang, Jing Lv, Jing Zhou, Wenrong Lou, Biao Xu, Xuesong Wu
Translational Cancer Research  
2026;
15
(5)
:378
.
The prognostic predictive value of monocyte to high-density lipoprotein cholesterol ratio in HR+/HER− breast cancer patients
Jie-Yu Zhou, Bin-Hao Jiang, Zhao-Jun Wang, Hai-Guang Ma, Yang Ye, Zhi-Wei Li
Translational Cancer Research  
2026;
15
(5)
:379
.
Identification of chondroitin polymerizing factor as a biomarker for predicting immunotherapy response in breast cancer: a bioinformatics analysis of tumor microenvironment
Zimeng He, Yunsheng Xu, Chunyan Wu
Translational Cancer Research  
2026;
15
(5)
:380
.
Comprehensive genomics and functional analyses identify SMARCAL1 as a key oncogenic regulator in lung adenocarcinoma
Zehao Huang, Yue Li, Jundao He, Zhanyu Xu, Huajian Peng, Nuo Yang
Translational Cancer Research  
2026;
15
(5)
:381
.
The flavonoid astragalin induces apoptosis in lung adenocarcinoma and correlates with a prognostic cell cycle gene signature associated with PANoptosis
Juncheng Bai, Yuxin Chen, Lan Bao, Caiying Zhou, Jintao Zhang
Translational Cancer Research  
2026;
15
(5)
:382
.
T4bN0 colon cancer shows worse survival than T1–2N1 disease: a multicenter real-world study in China
Xin Li, Lei Liang, Zhen-Ya Yang, Jun-Nan Li, Ning Xu, Jun Yang
Translational Cancer Research  
2026;
15
(5)
:383
.
Development of a prognostic nomogram for colorectal cancer with peritoneal metastasis: a SEER database analysis
Rouyan Zhong, Xiaoyan Wang, Dandan Gong, Changfeng Man, Yu Fan
Translational Cancer Research  
2026;
15
(5)
:384
.
Construction and testing of a nomogram for patients with pancreatic signet-ring cell carcinoma and analysis of treatment-related survival differences: a study based on the Surveillance, Epidemiology, and End Results (SEER) database
Ping Lin, Jihuang Wang, Linxiang Zhang, Siyi Xiu, Xiaoping Huang
Translational Cancer Research  
2026;
15
(5)
:385
.
WT1-AS acts as a tumor suppressor in cervical cancer via OSR2-mediated transcriptional activation
Gulimire Buranjiang, Li Xie, Yang Wang, Shiying Jin, Yina Wang
Translational Cancer Research  
2026;
15
(5)
:386
.
Prognostic significance and pathological correlation analysis of DKK4 in colorectal cancer
Xiaoxiong Wang, Minghai Shan, Xia Qiao, Lu Ding, Jiali Yang, Fang He, Yushen Mian, Xu Zhang, Shaoqi Yang
Translational Cancer Research  
2026;
15
(5)
:387
.
Comparison of 5-year survival rates and prognostic factors between adenoid cystic carcinoma and squamous cell carcinoma of the maxillary sinus: a SEER database analysis
Chenguang Zhang, Yicong Wang, Chunlong Zhao, Wanru Chen, Manman Cheng, Guanghao Yue, Bin Guo
Translational Cancer Research  
2026;
15
(5)
:388
.
A bibliometric analysis of global research in cervical cancer radiotherapy (2015–2024): trends, hotspots, and future directions
Yue Hou, Yu Gao, Wen-Ming Yan
Translational Cancer Research  
2026;
15
(5)
:389
.
Identifying and validating of prognostic genes associated with myeloid cell differentiation in cervical cancer: development of a risk model based on single-cell RNA sequencing combined with bulk RNA sequencing data
Xiaomin Wen, Wenlan Zheng, Tingting Zhai, Qi Wang, Yong Liang, Xin Zhang
Translational Cancer Research  
2026;
15
(5)
:390
.
Efficacy and safety of National Centralized Drug Procurement-procured versus non-National Centralized Drug Procurement oxaliplatin in unresectable or metastatic pancreatic cancer: a retrospective cohort study
Ziqi Ye, Linlin Yang, Yanfang Zhang, Xiaoting Wang, Yuefeng Rao
Translational Cancer Research  
2026;
15
(5)
:391
.
COL10A1 overexpression potentially contributes to poor outcomes in breast cancer via autophagy and vasculogenic mimicry
Liu Gao, Jingrui Yang, Xinru Fan, Yu Ling, Xu Jiang, Xin Jin, Hui Xu, Yunzhi Ling, Li Yu
Translational Cancer Research  
2026;
15
(5)
:392
.
Development and validation of prognostic nomograms for patients with cervical cancer and liver metastasis: a SEER-based study
Lihong Guo, Lingling Song, Xueqin Liu, Bohao Zhang, Yang Sun, Dandan Cui, Jie Zhang
Translational Cancer Research  
2026;
15
(5)
:393
.
Micropeptide colorectal neoplasia differentially expressed (CRNDE) 84aa encoded by CRNDE elicits a T-cell immune response to breast cancer
Lili Zeng, Peng Hu, Changsong Bai, Yujia Luo, Xinyu Fang, Xinyu Liu, Qingyi Yuan, Xiaofeng Zhu
Translational Cancer Research  
2026;
15
(5)
:394
.
SPDEF downregulation promotes tumor aggressiveness and poor prognosis in triple-negative breast cancer
Changsheng Wei, Qingqing Liu, Haitao Wang, Xiaofeng Liu
Translational Cancer Research  
2026;
15
(5)
:395
.
Identification of prognostic immune-related genes and evaluation of chemotherapy and immunotherapy responses in pancreatic cancer
Yang Yang, Haodong Tang, Jiahua Zhou
Translational Cancer Research  
2026;
15
(5)
:396
.
LncRNA SOX21-AS1 is associated with poor prognosis and immunomodulation in glioblastoma
Yanyan Yang, Jiayao Sun, Yan Fang, Wei Shan, Pengfei Li, Yaxuan Ma, Weimin Ni
Translational Cancer Research  
2026;
15
(5)
:397
.
Hyperplasia suppressor gene inhibits the progression of malignant meningioma via the Wnt/β-catenin signaling pathway
Yuhua Guan, Minmin Guo, Lai Jiang, Gang Zheng, Xin Huang, Hua Tang
Translational Cancer Research  
2026;
15
(5)
:398
.
Predictive modelling of duodenal stump leakage after gastric cancer and long-term oncological outcomes
Xufeng Shu, Ahao Wu, Xiaoqiang Wang, Chendong Yuan, Guoyang Zhang, Jianbo Xiong, Wenzheng Chen, Guosen Wang, Zhengrong Li, Zhigang Jie
Translational Cancer Research  
2026;
15
(5)
:399
.
A disulfidptosis-related lncRNA prognostic model identifies MALINC1 as a regulator of platinum drug sensitivity in colon adenocarcinoma
Yungui Li, Shijun Cao, Mingwu Duan, Menghao Qiao, Zijing Wu, Yan Cheng
Translational Cancer Research  
2026;
15
(5)
:400
.
Periostin promotes papillary thyroid carcinoma progression by modulating mTOR/AKT pathway
Song Wang, Yuanchun Li, Hong Li, Fan Yang, Xinjian Li, Dianliang Jia, Xin Wang
Translational Cancer Research  
2026;
15
(5)
:401
.
Association of serum vitamins and carotenoids with breast cancer status among adult women in NHANES 2017–2018: a cross-sectional study
Bohan Hu, Ji Liang
Translational Cancer Research  
2026;
15
(5)
:402
.
Efficacy and safety of antibody-drug conjugates for HR+/HER2-low advanced breast cancer: a systematic review with Bayesian network meta-analysis and real-world study
Linbing Duan, Hu Chen, Yan Kong, Qian Dong
Translational Cancer Research  
2026;
15
(5)
:403
.
Identification of protein lysine lactylation and potential targets in esophageal squamous cell carcinoma
Hanlu Zhang, Xiuji Yan, Lucheng Xi, Sicheng Chen, Qixin Shang, Long-Qi Chen, Wen-Ping Wang
Translational Cancer Research  
2026;
15
(5)
:404
.
Beyond traditional survival estimates: conditional survival and individualized prognosis in primary breast lymphoma
Huijuan Zhang, Guanghua Wu, Chunxu Liao
Translational Cancer Research  
2026;
15
(5)
:405
.
Unveiling LAIR1: a prognostic biomarker associated with gastric cancer progression and metastasis
Xufeng Shu, Chendong Yuan, Xiaoqiang Wang, Jianbo Xiong, Wenzheng Chen, Guoyang Zhang, Zhigang Jie
Translational Cancer Research  
2026;
15
(5)
:406
.
Comprehensive analysis to develop a stromal senescence-associated gene signature for predicting hepatocellular carcinoma
Jin Lu, Zhenhua Zhang, Wei Yuan, Yingjian Zhang
Translational Cancer Research  
2026;
15
(5)
:407
.
Epidemiology and prognostic factors of acute erythroid leukemia
Shan Liu, Yaobin Lin
Translational Cancer Research  
2026;
15
(5)
:408
.
Multi-algorithm machine learning combined with in silico gene knockout reveals the diagnostic value and functional regulatory networks of ferroptosis-related genes in gastric cancer
Wen Ma, Ke Liu, Lei Wang
Translational Cancer Research  
2026;
15
(5)
:409
.
Parimifasor elicits broad-spectrum antitumor effects by suppressing the expression of oncogenic genes
Kai Li, Minshan Sun, Ruijuan Du, Qian Wang, Bo Bian, Yutian Zhang, Hua Bian
Translational Cancer Research  
2026;
15
(5)
:410
.
YTHDF1 enhances ACSL3 translation in an m6A-dependent manner to regulate lipid metabolism and colorectal cancer progression
Yabo Chen, Zhiming Wang, Lisha Cheng, Hexia Gan, Yufu Lin
Translational Cancer Research  
2026;
15
(5)
:411
.
NCOA4-driven ferritinophagy and GSH reprogramming underlie maslinic acid-induced ferroptosis and autophagy in breast cancer
Yifei Li, Shugong Zhou, Ruobing Li, Yingshuo Liu, Xiaohui Guo, Linying Peng, Yan Liu, Mi Li, Lina Zhao, Yunfeng Zhang, Haifeng Cai, Fen Hu
Translational Cancer Research  
2026;
15
(5)
:412
.
Liquid-liquid phase separation-related gene signature characterizes prognostic subtypes and therapeutic sensitivities in gastric cancer
Bing Yan, Qiying Lao, Lijuan Lin
Translational Cancer Research  
2026;
15
(5)
:413
.
Role of PDGFA expression in the prognosis of head and neck squamous cell carcinoma: construction of prognostic nomogram and functional mechanism exploration
Ying Li, Shengfei Zhou
Translational Cancer Research  
2026;
15
(5)
:414
.
Fusobacterium nucleatum promotes colorectal cancer metastasis by modulating the NF-κB-MMP-2/MMP-9 signaling pathway
Cheng Peng, Xingxing Liu, Qibin He, Mengcheng Hu, Guangxuan Tie, Zhiqiang Dong, Chengcan Lu, Jinquan Shuang
Translational Cancer Research  
2026;
15
(5)
:415
.
Personalized survival prediction in pediatric glioblastoma using a machine learning-powered web tool
Shaohuai Chen, Regina Chizi Tunje, Anjie Lu, Xinyu Ji, Hansong Sheng, Xiangjie Kong
Translational Cancer Research  
2026;
15
(5)
:416
.
Single-cell analysis identifies a tumor-specific T-cell metabolic signature: prognostic model and association with immunosuppressive microenvironment in ovarian cancer
Huadong Tian, Xiaotong Liu, Guojiao Wang, Zimo Wang, Yuexi Luo
Translational Cancer Research  
2026;
15
(5)
:417
.
Carcinogenic role of ESCO2 in cholangiocarcinoma: integration of bioinformatics analysis and experimental validation
Le Fan, Yong Jiang, Jing Hu, Feng Xiao, Yunxia Chai, Bin Yi, Yinghe Qiu
Translational Cancer Research  
2026;
15
(5)
:418
.
A P-body-related risk score predicts prognosis and immune microenvironment in lung adenocarcinoma
Ting Lei, Jun-Ling Hou
Translational Cancer Research  
2026;
15
(5)
:419
.
Development and validation of nomograms for predicting overall survival and cancer-specific survival in female gastric signet-ring cell carcinoma: a SEER database analysis
Zhihan Zhou, Chen Zhu, Yong Diao, Xunxun Wu, Xiaoyun You, Huiyong Yang
Translational Cancer Research  
2026;
15
(5)
:420
.
Integrative single-cell and bulk transcriptomics identify an ALK-associated three-gene signature predicting neuroblastoma outcomes
Aiguo Zhu, Yuren Xia, Xin Li, Zhengchao Jin, Jian Wang, Yi Pan
Translational Cancer Research  
2026;
15
(5)
:421
.
Utidelone exhibits favorable responses in refractory patients with advanced breast cancer
Xue Bai, Qiuyi Zhang, Xiaofeng Xie, Xuelian Chen, Jiayi Huang, Liping Chen, Lin Song, Xiaofeng Lan, Meidi Liu, Rongmei Lei, Caiwen Du
Translational Cancer Research  
2026;
15
(5)
:422
.
Phagocytic remodeling in CD74High tumor-associated macrophages during brain metastasis of lung adenocarcinoma
Junming Jia, Jiaxin Cao, Zeren Chen, Huichao Lin, Hongqian Cao, Ke He, Ziyan Li, Mingzhu Yin, Yang Li
Translational Cancer Research  
2026;
15
(5)
:423
.
Risk factors for cerebrospinal fluid leakage after spinal tumor surgery: a systematic review and meta-analysis
Meng Yang, Junhao Huang, Yonggang Yang, Guoyi Luo, Xiangqin Wang, Bingbing Hou
Translational Cancer Research  
2026;
15
(5)
:424
.
Cation homeostasis-related prognostic genes uncovered by transcriptomic analysis in breast cancer
Mingxing Xu, Zhihao Ye, Weimin Hong, Liquan Zhu, Chaoqi He, Zhuotao Yang, Junsi Hu, Da Qian, Xuli Meng, Zhuozhuo Ren
Translational Cancer Research  
2026;
15
(5)
:425
.
Integrated transcriptomics identifies HIF1A and GSTP1 as biomarkers for cutaneous squamous cell carcinoma
Wenting Li, Tao Xu, Yu Ding, Jianghan Chen, Guotai Yao, Siyu Wu, Jianhua Wu
Translational Cancer Research  
2026;
15
(5)
:426
.
Integrating innovative multiomics and machine learning strategies for prognostic biomarker discovery in hepatocellular carcinoma: guiding personalized treatment strategies with single-cell analysis
Yi Cheng, Ru Luo, Xianfei Zhong
Translational Cancer Research  
2026;
15
(5)
:427
.
Identification and validation of tumor microenvironment remodeling markers associated with prognosis in differentiated thyroid cancer
Xiaokang Liu, Qiang Ma, Dai Su, Yu Li, Xiangting Zeng, Liang Guo
Translational Cancer Research  
2026;
15
(5)
:428
.
Prognostic value and potential upstream regulator of Schwann cells in esophageal squamous cell carcinoma
Yiming Lei, Xingbo Zhang, Weiran Hou, Xiumin Zhang, Zirui Zhou, Qinchen Liu, Jiantao Zhang, Feiyu Liu, Wei Wang, Zhen Wang
Translational Cancer Research  
2026;
15
(5)
:429
.
Development and internal validation of a nomogram based on HER2 status for predicting pathological complete response to neoadjuvant chemotherapy in triple-negative breast cancer
Xiaoke Chai, Chongyi Wei, Tao Yang, Haicun Zhou, Xiaoyan Du, Qiandan Wang, Tao Zhang, Jianping Long
Translational Cancer Research  
2026;
15
(5)
:430
.
Circadian-immune-related gene signature for lung squamous cell carcinoma: machine learning and multi-omics analysis
Yiheng Lu, Hui Li, Siyao Wang, Fan Yang, Shuyan Xiao, Yining Liu, Qiaowei Liu, Xiao Han, Yi Hu
Translational Cancer Research  
2026;
15
(5)
:431
.
Comprehensive analysis of prognostic biomarkers for immunotherapy response in patients with advanced malignant melanoma
Luqiao Li, Yueling Yang, Rong Huang, Mengke Zhao, Fufeng Wang, Yu Ren, Lianjun Zhao
Translational Cancer Research  
2026;
15
(5)
:432
.

Review Article

Mogamulizumab for adult T-cell leukemia/lymphoma: a literature review
Can Jones, Jun Chih Wang, Hayder Saeed
Translational Cancer Research  
2026;
15
(5)
:433
.
Artificial intelligence in radiation treatment planning: a narrative review from automation to clinical decision support
James C. L. Chow
Translational Cancer Research  
2026;
15
(5)
:434
.
Apoptosis signaling and cancer targeted therapy: from bench to bespoke
Xin Huang, Chunyan Zhu, Jiahui Liu, Jingwen Ye, Jiatao Lou, Lin Wang
Translational Cancer Research  
2026;
15
(5)
:435
.
The research progress of gastric cancer vaccines: a narrative review
Haoran Wu, Fan Zhang, Qiangzu Shao, Zeping Huang
Translational Cancer Research  
2026;
15
(5)
:436
.
Neuro-glioma activity-dependent growth mechanisms: an actionable circuit from NLGN3-ADAM10 to AMPA synapses
Ya-Fei Tian, Jun-Yue Fan, Qiong Wu, Jun Pu
Translational Cancer Research  
2026;
15
(5)
:437
.
Exosomal miRNA as a biomarker for diagnosis and prognosis, and a new target for regulating treatment resistance in DLBCL: a research progress narrative review
Huifang He, Xia Wang, Li Yang, Chan Rong, Xin Zheng, Qingxiu Zhong, Qingshan Li, Xin Xu
Translational Cancer Research  
2026;
15
(5)
:438
.