Original Article
Contrast enhanced ultrasound guided biopsy shows higher positive sampling rate than conventional ultrasound guided biopsy for gastrointestinal stromal tumors diagnosis
Abstract
Background: With the development of tyrosine kinase receptor inhibitor target therapy for gastrointestinal stromal tumors (GISTs), pre-treatment histopathological and immunocytochemical diagnosis of GISTs becomes important for clinical management. The purpose of this study was to compare the diagnostic accuracy of conventional ultrasound (US) guided vs. contrast-enhanced ultrasound (CEUS)-guided core needle biopsy for GISTs.
Materials and methods: Between September 2011 and July 2015, 53 GIST patients underwent 61 conventional US guided or CEUS guided core needle biopsy at the Cancer Hospital & Institute, Peking Union Medical College & Chinese Academy of Medical Sciences. The outcomes of the biopsies were analyzed.
Results: The diagnostic yield of CEUS guided biopsy group (96.2%, 27/28) was higher than conventional US guided biopsy group (78.8%, 26/33; P=0.042). The risk of undeterminable biopsy specimens in CEUS group (7.2%, 2/28) was lower than conventional US group (27.3%, 9/33; P=0.042). In both groups none patients had significant complications such as bleeding, pain, perforation or peritonitis after the biopsy.
Conclusions: CEUS guided core needle biopsy for the diagnosis of GIST improved the diagnostic yield and therefore the pre-treatment risk assessment for GIST. The inclusion of CEUS guided biopsy in the diagnostic work-up of advanced or metastatic GIST is recommended.
Materials and methods: Between September 2011 and July 2015, 53 GIST patients underwent 61 conventional US guided or CEUS guided core needle biopsy at the Cancer Hospital & Institute, Peking Union Medical College & Chinese Academy of Medical Sciences. The outcomes of the biopsies were analyzed.
Results: The diagnostic yield of CEUS guided biopsy group (96.2%, 27/28) was higher than conventional US guided biopsy group (78.8%, 26/33; P=0.042). The risk of undeterminable biopsy specimens in CEUS group (7.2%, 2/28) was lower than conventional US group (27.3%, 9/33; P=0.042). In both groups none patients had significant complications such as bleeding, pain, perforation or peritonitis after the biopsy.
Conclusions: CEUS guided core needle biopsy for the diagnosis of GIST improved the diagnostic yield and therefore the pre-treatment risk assessment for GIST. The inclusion of CEUS guided biopsy in the diagnostic work-up of advanced or metastatic GIST is recommended.
