Vol 14, No 2 (February 28, 2025): Translational Cancer Research

Editorial Commentary

The TROP2 paradox: enhancing precision in immunotherapy for advanced non-small cell lung cancer patients—a commentary
Saqib Raza Khan, Saurav Verma, Daniel Breadner, Jacques Raphael
Translational Cancer Research  
2025;
14
(2)
:660-666
.
To be or low TMB (tumor mutational burden)
Markus Falk, Markus Tiemann, Joachim H. Ficker, Wolfgang M. Brueckl
Translational Cancer Research  
2025;
14
(2)
:667-669
.
Osimertinib for uncommon EGFR mutations: herding UNICORNs in a field of horses
Sean C. Dougherty, Ryan D. Gentzler
Translational Cancer Research  
2025;
14
(2)
:670-675
.
Accelerated hypofractionated chemoradiation followed by stereotactic ablative radiotherapy boost for locally advanced, unresectable non-small cell lung cancer
Urs M. Weber, Alexander S. Watson, Brian D. Kavanagh, Paul A. Bunn
Translational Cancer Research  
2025;
14
(2)
:676-678
.
Deciding where Trop-2 directed antibody drug conjugates work in non-small cell lung cancer: the not so straightforward road
Robert Hsu
Translational Cancer Research  
2025;
14
(2)
:679-684
.

Original Article

Prognostic significance of alterations in peripheral cellular and humoral immune biomarkers during radiochemotherapy in head and neck cancer patients
Chunmei Zhu, Shuyuan Zhang, Qiuji Wu
Translational Cancer Research  
2025;
14
(2)
:685-705
.
Construction and validation of machine learning models for predicting lymph node metastasis in cutaneous malignant melanoma: a large population-based study
Ling-Feng Lan, Yi-Long Kai, Xiao-Ling Xu, Jun-Kun Zhang, Guang-Bo Xu, Yan-Bi Dai, Yan Shen, Hua-Ya Lu, Ben Wang
Translational Cancer Research  
2025;
14
(2)
:706-716
.
Expression profile, regulatory mechanism and prognostic potential of MBNL2 in esophageal squamous cell carcinoma
Shenglai Zhang, Xiaoqin Chu, Yan Zhang, Jianwei Qiu, Liuhong Pan, Liugen Gu, Haifeng Kang, Lin Wang
Translational Cancer Research  
2025;
14
(2)
:717-730
.
Radiomics models using machine learning algorithms to differentiate the primary focus of brain metastasis
Yuping Xie, Xuanzi Li, Shuai Yang, Fujie Jia, Yuanyuan Han, Mingsheng Huang, Lei Chen, Wei Zou, Chuntao Deng, Zibin Liang
Translational Cancer Research  
2025;
14
(2)
:731-742
.
Development and validation of a prognosis prediction model for overall survival in correlation between butyrate metabolism and gastric cancer prognosis: Mendelian randomization and transcriptomics analysis
Renjun Gu, Kun Mei, Zilu Chen, Yan Huang, Fangyu Wang
Translational Cancer Research  
2025;
14
(2)
:743-760
.
Construction and validation of a prognostic model of lncRNAs associated with RNA methylation in lung adenocarcinoma
Liren Zhang, Lei Yang, Xiaobo Chen, Qiubo Huang, Zhiqiang Ouyang, Ran Wang, Bingquan Xiang, Hong Lu, Wenjun Ren, Ping Wang
Translational Cancer Research  
2025;
14
(2)
:761-777
.
Specific effects of hypoxia-immune core gene ARHGAP11A on lung adenocarcinoma
Kang Sun, Luyao Wang, Xueying Zhang, Huili Chen, Ziqiang Wang, Jing Zhang, Xiaojing Wang, Chaoqun Lian
Translational Cancer Research  
2025;
14
(2)
:778-795
.
Talin1 Ser425 phosphorylation promotes colorectal cancer progression and metastasis
Zhengxiu He, Jian Sun, Mengmeng Wang, Shanshan Chen, Guoxin Mao, Li Yang
Translational Cancer Research  
2025;
14
(2)
:796-807
.
Nomogram for predicting survival in breast cancer with lung metastasis based on SEER data
Cheng-Liang Chen, Ni-Ya Chen, Shuo Wu, Xiao Lin, Xin-Wei He, Ying Qiu, Di-Xin Xue, Jie Li, Meng-Die He, Xi-Xi Dong, Wei-Ya Zhuang, Mei-Zhen Liang
Translational Cancer Research  
2025;
14
(2)
:808-826
.
FUT10 is related to the poor prognosis and immune infiltration in clear cell renal cell carcinoma
Yuqi Zhang, Ke Cui, Rong Qiang, Lin Wang
Translational Cancer Research  
2025;
14
(2)
:827-842
.
Identification of Fanconi anemia pathway genes as novel prognostic biomarkers and therapeutic targets for breast cancer
Yunyong Wang, Xiaohang Lu, Hongsheng Lin, Yangling Zeng, Jiaqian He, Jinna Tan, Mingfen Li
Translational Cancer Research  
2025;
14
(2)
:843-864
.
CD69 predicts prognosis through immune cell infiltration and decitabine treatment response in acute myeloid leukemia
Jie Zhou, Hao Wu, Bing Li, Lixin Lv, Shunli Zhu, Aibin Liang, Jianfei Fu
Translational Cancer Research  
2025;
14
(2)
:865-880
.
Diagnostics and immunological function of CENPN in human tumors: from pan-cancer analysis to validation in breast cancer
Yubo Jing, Yiyang Wang, Yongxiang Li, Xinzhu Huang, Junyi Wang, Dlraba Yelihamu, Chenming Guo
Translational Cancer Research  
2025;
14
(2)
:881-906
.
Characterization of immune landscape and prognostic value of IL-17-related signature in invasive breast cancer
Wenge Dong, Xiaojie Gu, Jiejing Li, Zhigang Zhuang
Translational Cancer Research  
2025;
14
(2)
:907-929
.
Construction of a prognostic model and analysis of related mechanisms in breast cancer based on multiple datasets
Xiaofeng Wan, Jianmin Zhan, Shuke Ye, Chuanrong Chen, Runsheng Li, Ming Shen
Translational Cancer Research  
2025;
14
(2)
:930-948
.
A novel necroptosis-related miRNA signature for predicting the prognosis of esophageal cancer and immune infiltration analysis
Miao Zhang, Shaoran Song, Bo Wang, Yangyang Shang, Peijun Liu, Juan Li
Translational Cancer Research  
2025;
14
(2)
:949-965
.
A prognostic model for laryngeal squamous cell carcinoma based on the mitochondrial metabolism-related genes
Wei-Ming Hu, Wen-Jing Jiang
Translational Cancer Research  
2025;
14
(2)
:966-979
.
The prognostic significance of fragile X mental retardation syndrome-related protein 1 (FXR1) in breast cancer
Ohud A. Alsalmi, Abrar I. Aljohani, Afaf A. Alharthi, Amal F. Gharib, Abdulrahman R. Alrubayee, Ramy M. Abbas, Meshari A. Alsuwat, Khalid J. Alzahrani, Batool S. Alsaleh
Translational Cancer Research  
2025;
14
(2)
:980-989
.
Analysis of risk and prognostic factors for pulmonary metastasis in gastric cancer: a study based on the Surveillance, Epidemiology, and End Results database
Wei Kong, Su Yan
Translational Cancer Research  
2025;
14
(2)
:990-1007
.
The prognostic and immune significance of SNHG3 in clear cell renal cell carcinoma
Cheng Li, Pengnan Hu, Chenglong Fan, Hua Mi
Translational Cancer Research  
2025;
14
(2)
:1008-1023
.
The screening of optimal primary tumor resection candidates in patients with small cell lung cancer: a population-based predictive model
Zhidong Wang, Cheng Gong, Youpu Zhang, Yongxiang Qian, Yang Liu, Ce Chao
Translational Cancer Research  
2025;
14
(2)
:1024-1036
.
Mitochondrial permeability transition drives the expression, identification and validation of necrosis-related genes in prognostic risk models of hepatocellular carcinoma
Jiaxuan Jin, Mengyuan Wang, Yinuo Liu, Wei Li, Xuemei Zhang, Zhuoxin Cheng
Translational Cancer Research  
2025;
14
(2)
:1037-1052
.
Constructing and validating a novel prognostic risk score model for rectal cancer based on four immune-related genes
Ruyun Cai, Zhonghua Hong, Hezhai Yin, Huilin Chen, Mengting Qin, Yihong Huang
Translational Cancer Research  
2025;
14
(2)
:1053-1069
.
Oncogenic role and prognostic significance of PIMREG in melanoma
Xiao Wei, Yujia Jiang, Tianxiang Xia, Jun Du
Translational Cancer Research  
2025;
14
(2)
:1070-1084
.
Comprehensive analysis of the immunological implication and prognostic value of MEAK7 in non-small cell lung cancer
Jing-Yu Miao, Zhen Lin
Translational Cancer Research  
2025;
14
(2)
:1085-1100
.
The causal effects of 2,821 protein level ratios on non-small cell lung cancer: a two-sample Mendelian randomization study
Xinyun Zou, Jinlan Shen, Xiaokai Li, Yong Diao, Ling Zhang
Translational Cancer Research  
2025;
14
(2)
:1101-1110
.
Clinical characterization and prognostic modeling of bladder cancer patients with a history of prior tumors: a SEER database analysis
Zhengli Liu, Haojie Zhang, Rongtuan Luo, Bin Wang, Tengfei Li, Baoshou Zheng
Translational Cancer Research  
2025;
14
(2)
:1111-1123
.
PRSS3 is a potential prognostic biomarker for lung adenocarcinoma
Lu Nie, Xueqing Zhang, Jie Wu
Translational Cancer Research  
2025;
14
(2)
:1124-1140
.
OPN3 enhances the proliferation, migration, and invasion of triple-negative breast cancer cells via the regulation of the TGF-β signaling pathway
Yameng Liu, Yue Zhao, Jingjing Zhang, Xiao Wu, Yumei Li, Ke Tang, Zhengquan Han
Translational Cancer Research  
2025;
14
(2)
:1141-1156
.
Construction and validation of a cell death-related genes prognosis signature of hepatocellular carcinoma
Yue Ma, Che Ismail Che Noh, Rahmawati Pare
Translational Cancer Research  
2025;
14
(2)
:1157-1170
.
FAM60A promotes proliferation and invasion of colorectal cancer cells by regulating the Wnt/β-catenin signaling pathway
Zhikun Dong, Shuwen Jin, Kan Tang, Xiaomei Li, Yonglin Chen
Translational Cancer Research  
2025;
14
(2)
:1171-1189
.
Construction of a prognostic signature for breast cancer based on genes involved in unsaturated fatty acid biosynthesis
Hua Meng, Shuangyi Zhang, Min Ling, Yuanyuan Hu, Xiaohong Xie
Translational Cancer Research  
2025;
14
(2)
:1190-1204
.
Circulating white blood cell traits, chemokines and small cell lung cancer risk: a Mendelian randomization study
Huizhong Zhu, Chenyang Wang, Teng Ma
Translational Cancer Research  
2025;
14
(2)
:1205-1213
.
Establishment of a prognosis-related predictive model for hepatocellular carcinoma patients with macrovascular invasion treated with transcatheter arterial chemoembolization combined with intensity modulated radiotherapy
Dan Yang, Wanting Tian, Wei Wang, Xuan Zhao, Chaozhi Wang, Zhufang Ma
Translational Cancer Research  
2025;
14
(2)
:1214-1222
.
Vanillic acid inhibits TGF-β type I receptor to protect bone marrow mesenchymal stem cells from radiation-induced bystander effects
Ting Zhou, Yi-Ming Zhang, Gu-Cheng Zhou, Fu-Xian Liu, Zhi-Ming Miao, Li-Ying Zhang, Yang-Yang Li, Zhi-Wei Liu, Shang-Zu Zhang, Jing Li, Fan Niu, Yan Chen, Yong-Qi Liu
Translational Cancer Research  
2025;
14
(2)
:1223-1236
.
Diagnostic accuracy of pleural fluid carbohydrate antigen 72-4 for malignant pleural effusion: a systematic review and meta-analysis
Xi-Shan Cao, Chang-Mei Feng, Li Yan, Lei Zhang, Wei Jiao, Mei-Ying Wang, Wen-Qi Zheng, Zhi-De Hu
Translational Cancer Research  
2025;
14
(2)
:1237-1245
.
ATP5A1 as a potential prognostic biomarker in clear-cell renal cell carcinoma
Wei Zhou, Qianli Tang, Jun Wu, Minyu Huang, Qun Huang, Tianzi Qin, Ning Tang, Shasha Gai
Translational Cancer Research  
2025;
14
(2)
:1246-1264
.
Role of cancer stem cell heterogeneity in intrahepatic cholangiocarcinoma
Yiwang Zhang, Juping Xie, Xiangqi Huang, Jintian Gao, Zhiyong Xiong
Translational Cancer Research  
2025;
14
(2)
:1265-1281
.
Comprehensive bioinformatics analysis of co-mutation of FLG2 and TP53 reveals prognostic effect and influences on the immune infiltration in ovarian serous cystadenocarcinoma
Meng Li, Dongmei Han, Hao Jin
Translational Cancer Research  
2025;
14
(2)
:1282-1296
.
High-sensitivity modified Glasgow prognostic score (HS-mGPS) is a prognostic biomarker for small duct-type intrahepatic cholangiocarcinoma—a retrospective cohort study
Xintao He, Zixin Liang, Shuo Zhang, Youxiang Ding, Xiaoping Qian, Hongyan Wu, Jun Chen
Translational Cancer Research  
2025;
14
(2)
:1297-1310
.
Total Astragalus saponins promote ferroptosis in gastric cancer cells by upregulating SIRT3
Yue Zou, Jingling Zhao, Chengyin Li, Rui Wang, Xiaocui Jiang, Zhongyi Zhu, Qiyuan Wang, Min Xiao
Translational Cancer Research  
2025;
14
(2)
:1311-1322
.
CALD1 inhibits invasion of human ovarian cancer cells by affecting cytoskeletal structure and the number of focal adhesion
Yongchao Li, Zhao Yang, Menglong Xu, Haocheng Guan, Zhenhui Wu, Shuwei Li
Translational Cancer Research  
2025;
14
(2)
:1323-1335
.
Enhancing prognostic accuracy in invasive breast cancer by combining contrast-enhanced ultrasound and clinical data: a multicenter retrospective study
Shiyu Li, Yueming Li, Yongqi Fang, Zhiying Jin, Sisi Huang, Wei Wang, Kefah Mokbel, Yongjie Xu, Hua Yang, Zhili Wang
Translational Cancer Research  
2025;
14
(2)
:1336-1358
.
A novel machine learning-driven immunogenic cell death signature for predicting ovarian cancer prognosis
Yali Wang, Peng Zhao, Xude Sun, Felipe Batalini, Gabriel Levin, Hooman Soleymani majd, Hao Chen, Tingting Gao
Translational Cancer Research  
2025;
14
(2)
:1359-1374
.
The miR-155-5p/FBXO11 axis inhibits the progression of gastric cancer via the mTOR pathway
Tao Yuan, Haiyan Liu, Fangfang Li, Qingyue Meng, Yajuan Wang, Mei Yuan
Translational Cancer Research  
2025;
14
(2)
:1375-1387
.
Androgen receptor expression distribution characteristics in young female breast cancer patients in China: a study of clinicopathological features
Jianhong Tu, Xiyan Li, Yuexia Chen, Wei Qu, Dan Gong, Adam Ofri, Rainer J. Klement, Swarna Lakshmi Arumugam, Yao Zhou
Translational Cancer Research  
2025;
14
(2)
:1388-1400
.
The efficacy and safety of the addition of programmed cell death protein 1 inhibitor to preoperative chemotherapy in locoregionally advanced oropharyngeal carcinoma
Guan-Zhong Lu, Zhi-Cong Hong, Yi-Feng Yu, Lin-Feng Guo, Daniel T. Ginat, San-Gang Wu, Li-Mei Guan
Translational Cancer Research  
2025;
14
(2)
:1401-1414
.
Low expression of PRTN3 regulates the progression of gastric cancer by inhibition of cell cycle and promotion of apoptosis
Haoyu Zhu, Fei Wang, Xinran Lu, Hao Wu, Chao Shi, Silvio Matsas, Renata D’Alpino Peixoto, Marcelo Porfirio Sunagua Aruquipa, Chong Tang, Shichun Feng
Translational Cancer Research  
2025;
14
(2)
:1415-1427
.
Genome-wide profiling of a prognostic RNA-binding protein signature in esophageal cancer
Shaowu Sun, Junya Wang, Yujie Zhang, Yuetong Li, Yanan Guo, Chunyao Huang, Alfredo Tartarone, Pierlorenzo Pallante, Kaiyuan Li, Guoqing Zhang, Xue Pan, Xiangnan Li
Translational Cancer Research  
2025;
14
(2)
:1428-1446
.

Review Article

The emerging role of transmembrane proteins in tumorigenesis and therapy
Chenlu Shen, Xiao Han, Qi Liu, Tao Lu, Weiwei Wang, Xinyi Wang, Zhimin Ou, Shengjie Zhang, Xiangdong Cheng
Translational Cancer Research  
2025;
14
(2)
:1447-1466
.
Cryoablation for breast cancer: a narrative review of advances, clinical applications, and future challenges
Manchen Yang, Baosan Han, Ping Ye
Translational Cancer Research  
2025;
14
(2)
:1467-1478
.
Narrative review of 3D bioprinting for the construction of in vitro tumor models: present and prospects
Jia-Yu Tao, Jun Zhu, Yu-Qiong Gao, Min Jiang, Hong Yin
Translational Cancer Research  
2025;
14
(2)
:1479-1491
.

Case Report: iMDT Corner

A rare case report of colon metastasis from primary oropharyngeal squamous cell carcinoma treated with a combination of surgery, radiotherapy and immunotargeted therapy
Zhijian Xu, Jianjian Lv, Daniel T. Ginat, Yuvnik Trada, Mi Zhou
Translational Cancer Research  
2025;
14
(2)
:1492-1499
.
Amyopathic dermatomyositis associated with immune checkpoint inhibitor therapy in lung adenocarcinoma: a case report
Zhang Zhang, Takehiro Uemura, Pengyi Guo
Translational Cancer Research  
2025;
14
(2)
:1500-1505
.