Vol 14, No 8 (August 31, 2025): Translational Cancer Research

Editorial Commentary

Balancing evidence and individualization in adjuvant CDK4/6 therapy
Humaid O. Al-Shamsi, Muharrem Oner, Kefah Mokbel
Translational Cancer Research  
2025;
14
(8)
:4479-4481
.
Liquid biopsy for the detection of non-viral head and neck squamous cell carcinoma
Yukinori Takenaka, Masashi Mori, Hidenori Inohara
Translational Cancer Research  
2025;
14
(8)
:4482-4485
.
Advancing RET-targeted therapy in thyroid cancer: insights and implications from the LIBRETTO-001 study
Han-Sang Baek, Dong-Jun Lim
Translational Cancer Research  
2025;
14
(8)
:4486-4490
.

Original Article

Identification of disulfidptosis-related long non-coding RNA signature to predict the prognosis, immunotherapy, and chemotherapy options in acute myeloid leukemia
Minglei Huang, Longze Zhang, Ye Liu, Shuangmin Wang, Sikan Jin, Zhixu He, Xianyao Wang
Translational Cancer Research  
2025;
14
(8)
:4491-4506
.
Exploration of the mechanism of curcumin in the regulation of apoptosis for the treatment of colorectal cancer
Yu Wu, Da-Zhi Gao, Ning-Ning Zhao, Yu Han, Xue-Feng Zhao
Translational Cancer Research  
2025;
14
(8)
:4507-4519
.
Development and validation of an immune-related gene signature for the prognostic and immune landscape prediction in head and neck squamous cell carcinoma by integrated analysis of machine learning and Mendelian randomization
Zhengyu Wei, Guoli Wang, Yanghao Hu, Chongchang Zhou, Yuna Zhang, Yaowen Wang
Translational Cancer Research  
2025;
14
(8)
:4520-4538
.
A novel prognostic model based on endoplasmic reticulum stress-associated E3 ligases and deubiquitinating enzymes in hepatocellular carcinoma
Caixia Zhong, Yurui Liu, Kaishun Hu, Dong Yin
Translational Cancer Research  
2025;
14
(8)
:4539-4548
.
Overexpression of miR-1283 inhibits cell proliferation and migration of colorectal cancer cells by targeting PDZD8
Zhen Wang, Xiang Li, Huan Zhou, Enda Yu, Xiaohong Yang
Translational Cancer Research  
2025;
14
(8)
:4549-4560
.
METTL11A serves as a novel therapeutic target for acute myeloid leukemia through regulation of the p38-MAPK pathway
Ju Li, Jiasi Zhang, Pei Zhang
Translational Cancer Research  
2025;
14
(8)
:4561-4573
.
Evaluating the efficacy of combined modality therapy versus chemotherapy alone in unresectable primary pulmonary diffuse large b-cell lymphoma: a retrospective cohort study
Yuchen Liu, Ruonan An, Ping Cheng, Guofeng Sun
Translational Cancer Research  
2025;
14
(8)
:4574-4585
.
Enhanced antitumor efficacy of sorafenib and everolimus combination in pancreatic neuroendocrine neoplasms through mTOR inhibition
Hongxia Zheng, Yue Gao, Mujie Ye, Jianan Bai, Min Liu, Qin Long, Jinhao Chen, Xinyun Qiang, Qiyun Tang
Translational Cancer Research  
2025;
14
(8)
:4586-4597
.
Harnessing natural killer cell-related genes for prognostic and therapeutic advances in lung adenocarcinoma: a predictive model for survival and immunotherapy outcomes
Minqi Zhu, Likang Wang, Fang Chen
Translational Cancer Research  
2025;
14
(8)
:4598-4620
.
Untargeted metabolomics integrated with SHAP analysis identifies novel biomarkers of oxaliplatin induced peripheral neurotoxicity in gastric cancer
Yujiao Hua, Xinlei Liu, Juan Lv, Yan Zhang, Yongjuan Ding, Jinghua Chen
Translational Cancer Research  
2025;
14
(8)
:4621-4637
.
Development and validation of a prognosis model for patients with brain-metastasis non-small cell lung cancer by machine-learning
Jingxin Liu, Yibing Wang, Xianwei Zhou, Meijin Reng, Ziyue Xiang, Ruimin Chang, Wen Hao, Xitai Sun, Yang Yang
Translational Cancer Research  
2025;
14
(8)
:4638-4648
.
Unveiling prognostic factors and predictive modeling in lung adenocarcinoma with neuroendocrine differentiation
Wei Li, Yuanming Pan, Siyu Cai, Shenglong Xie, Bin He
Translational Cancer Research  
2025;
14
(8)
:4649-4661
.
Thyroid differentiation score-related genes and prognostic model for thyroid cancer
Shang Lin, Di Chen, Chen-Wei Pan, Xiang-Chou Yang
Translational Cancer Research  
2025;
14
(8)
:4662-4678
.
Clinical immunotherapeutic significance of RAS gene mutations in melanoma
Yixin Xu, Xueying Wang, Yulei Guo, Danyu Qian, Qinghua Wang, Zhenpeng Li
Translational Cancer Research  
2025;
14
(8)
:4679-4690
.
A novel risk score model incorporating six co-stimulatory molecules for accurate prognosis prediction of laryngeal cancer
Tianyi Liu, Shan Gao, Jie Jiang, Yan Shi
Translational Cancer Research  
2025;
14
(8)
:4691-4702
.
Machine learning-based prognosis prediction for serous ovarian cancer using the SEER database and data from a single center in China
Huan Chen, Yuexing Zhao, Qian Sun, Pei Jiao
Translational Cancer Research  
2025;
14
(8)
:4703-4719
.
Exploration of signature-related FAM genes and correlation between FAM50A expression and the pathogenesis and prognosis of hepatocellular carcinoma
Shaohan Wu, Sijun Chen, Xiaofang Sun, Xujian Chen
Translational Cancer Research  
2025;
14
(8)
:4720-4747
.
Risk factors and treatment strategies for female reproductive system carcinosarcoma with metastasis
Huijie Wu, Peiqiong Huo, Miao Dong, Ying Xiao, Lewei Tu
Translational Cancer Research  
2025;
14
(8)
:4748-4758
.
Identification of hub genes related to radiosensitivity and prognosis in rectal cancer
Hui Yang, Yin Liu, Mengdi Hao, Huimin Li, Dajin Yuan, Lei Ding
Translational Cancer Research  
2025;
14
(8)
:4759-4773
.
Identification of metabolic driver genes and targeted drug screening for lung adenocarcinoma metastasis at the single-cell resolution
Liang Wu, Wenjuan Zhao, Xin Guo, Zuquan Hu, Sen Chen, Wenzhu Huang
Translational Cancer Research  
2025;
14
(8)
:4774-4790
.
Diagnostic value of circulating tumor cells in gastric cancer: a systematic review and meta-analysis
Kang Yang, Peiwen Ouyang, Ke Gao, Zhaohui Duan
Translational Cancer Research  
2025;
14
(8)
:4791-4803
.
Analysis of clinicopathological characteristics and prognosis of appendiceal neuroendocrine tumors: a retrospective cohort study based on the SEER database
Xia Ren, Ganhong Wang, Jian Chen, Luojie Liu, Dan Li
Translational Cancer Research  
2025;
14
(8)
:4804-4821
.
RHOJ enhances adhesion and proliferation capabilities and suppresses apoptosis of melanoma cells by activating the Rap1 signaling pathway
Xi He, Jie Ma, Jiali Xia, Zhiqiang Guan, Guan Jiang
Translational Cancer Research  
2025;
14
(8)
:4822-4836
.
Influential factors affecting the survival benefit of combined neoadjuvant therapy and esophagectomy in patients with esophageal cancer: an analysis based on the SEER database
Mi Chen, Li Jia, Zhou Su
Translational Cancer Research  
2025;
14
(8)
:4837-4850
.
Prognostic implication of endoplasmic reticulum stress-related gene signature in lung adenocarcinoma and its effect on tumor immunity
Yangyang Xu, Tingting Cai, Jun Xie, Qian He, Chong Li
Translational Cancer Research  
2025;
14
(8)
:4851-4866
.
Pulmonary metastasis risk and overall survival score in choriocarcinoma: a novel nomogram-based risk assessment system
Wenqiang Li, Qian He, Qian Huang, Zhiping Deng
Translational Cancer Research  
2025;
14
(8)
:4867-4881
.
Role of the transcription factor SOX8 in hepatocellular carcinoma development and lymph node metastasis
Xiong Teng, Tian-Man Li, Kai Peng, Yu-Hua Li, Han-Jing Zhang, Bin Ge, Hai-Xiang Xie, Ke-Jian Yang, Chong-Jiu Qin, Xi-Wen Liao, Guang-Zhi Zhu, Xin Zhou, Tao Peng
Translational Cancer Research  
2025;
14
(8)
:4882-4905
.
Effects of different cancer-directed therapies on mortality of patients with stage I pulmonary large cell neuroendocrine carcinoma: a retrospective cohort study based on the SEER database
Shijun Chen, Mohan Weng, Yanru Jiang, Tingting Li, Qicai Li, Chengling Zhao
Translational Cancer Research  
2025;
14
(8)
:4906-4919
.
miR-378a-5p targets FGR to suppress proliferation, invasion and migration in lung adenocarcinoma cells
Yali Zhang, Tingting Bian, Runfeng Yang, Qi Zheng, Jianguo Zhang, Yifei Liu, Lihua Gao
Translational Cancer Research  
2025;
14
(8)
:4920-4938
.
Inhibition of SLC25A10 promotes cellular senescence and impedes hepatocellular carcinoma progression
Yi-Hong Ding, Tian-Yi Huang, Shi-Meng Xu, Min Li, Xiang Shi, Wen-Yan Sun, Cui-Hua Lu, Zhao-Xiu Liu, Wei Huang
Translational Cancer Research  
2025;
14
(8)
:4939-4954
.
Diagnostic accuracy of SHOX-2 methylation for malignant pleural effusion: a systematic review and meta-analysis
Hao-Jie Wang, Jian-Ying Cui, Wen-Jie Hou, Xu-Lei Hao, Wen-Qi Zheng, Zhi-De Hu, Xi-Shan Cao, Li Yan
Translational Cancer Research  
2025;
14
(8)
:4955-4964
.
Development and validation of a preoperative nomogram for predicting residual tumor risk in breast cancer patients undergoing excisional biopsy
Yangfan Fan, Yiwei Wu, Fangfang Chen, Fang Wan, Dianlei Liu, Jingpei Long, Tao Zhang
Translational Cancer Research  
2025;
14
(8)
:4965-4975
.
Transarterial chemoembolization combined with tyrosine kinase inhibitors and programmed death receptor-1 inhibitors for unresectable hepatocellular carcinoma: a systematic review and meta-analysis
Yonghong He, Yuexi Liu, Jie Xu, Yanan He
Translational Cancer Research  
2025;
14
(8)
:4976-4988
.
An efficient epithelial-mesenchymal transition-related gene signature for predicting the survival of patients with lung adenocarcinoma
Pengkai Han, Chittibabu Guda, Qiping Liu
Translational Cancer Research  
2025;
14
(8)
:4989-5001
.
Acute radiation-induced brain injury in patients with glioma and the construction of a clinical prediction model: a cohort study
Liang Liang, Qiangfeng Pi, Shuo Jiang, Jie Zhou, Lauren Singer, Li Cao
Translational Cancer Research  
2025;
14
(8)
:5002-5011
.
The functional role of exosomal miRNA-675-3p derived from patients with hepatocellular carcinoma
Chi Liang, Xiang Ji, Shan Liu, Liancheng Xu, Yicheng Xiong, Guanyi Cao
Translational Cancer Research  
2025;
14
(8)
:5012-5027
.
ISG20L2 as a driver in the proliferation and invasion of lung adenocarcinoma via NKX2-1 regulation
Xiaoming Fang, Xinyu Zhang, Ping Liu, Dan Yu, Andrzej Swierniak, Carl G. Maki, Ruichen Gao, Ming Liu
Translational Cancer Research  
2025;
14
(8)
:5028-5044
.
Facilitation of natural killer T-cell cytotoxic activity in uterine sarcoma via the CKS2-PI3K-AKT-MICA axis
Yali Du, Ting Lan, Mengyuan Liu, Weiyan Wu, Jinqi Ma
Translational Cancer Research  
2025;
14
(8)
:5045-5058
.
Comparisons of the efficacy of different Chinese medicine injections on immune function in patients with nasopharyngeal carcinoma during combined therapy: a systematic review and network meta-analysis
Zhaohui Gu, Tian Zhang, Xinyue Chen
Translational Cancer Research  
2025;
14
(8)
:5059-5076
.
Value of ZSCAN9 in the treatment and survival prediction of hepatocellular carcinoma: a bioinformatics study
Suwei Jing, Wenlei Dong, Chao Zhan
Translational Cancer Research  
2025;
14
(8)
:5077-5092
.
Microbial community profiles in breast cancer and normal adjacent tissues: associations with clinicopathological characteristics
Dengfeng Xue, Chunhui Wu, Ruihong Hou, Huijuan Xu, Xinzheng Li
Translational Cancer Research  
2025;
14
(8)
:5093-5108
.
Investigation into the sensitivity of adipocytes mediated by the major vault protein (MVP) to chemotherapy for triple-negative breast cancer
Lianjin Qin, Ruofan Fei, Wenjuan Wang, Qingjian He
Translational Cancer Research  
2025;
14
(8)
:5109-5126
.
Elevated suicide risk in thyroid cancer patients: determining mortality rates and identifying predictive factors using Surveillance, Epidemiology, and End Results (SEER) data
Jiaojiao Ma, Xi Wang, Shanshan Wang, Xuejiao Yu, Yang Li, Zhe Sun, Huilin Li, Yong Cheng, Bo Zhang
Translational Cancer Research  
2025;
14
(8)
:5127-5141
.
Classification of chemoradiotherapy sensitivity in hypopharyngeal squamous cell carcinoma based on deep-learning and radiomics feature fusion
Hengmin Tao, Xinbo Yang, Meihui Chen, Baosheng Li
Translational Cancer Research  
2025;
14
(8)
:5142-5154
.
A development and validation of predictive model based on novel immune-related gene-based subtypes for the risk assessment of cutaneous melanoma
Fei Li, Xinji Li, Tianhui Niu, Xiaoxin Li, Ling Guan, Zhiyong Wang, Bin Liang, Yuanyuan Li, Zhiwei Hao, Chengyu Sui
Translational Cancer Research  
2025;
14
(8)
:5155-5165
.
Identification of mechanosensitive ion channel-related molecular subtypes and key genes for ovarian cancer
Lu Zhang, Li Wang, Min Wang, Kefei Peng, Huihui Chen, Xin Wang, Ling Zhou
Translational Cancer Research  
2025;
14
(8)
:5166-5175
.

Retraction

Retraction: Expression of centrosomal protein 55 in glioma tissue and the influence on glioma cell functions
Yifan Xu, Tianyu Lu, Wu Xu, Weitao Chen, Weibang Liang, Wei Jin
Translational Cancer Research  
2025;
14
(8)
:5176
.
Retraction: MicroRNA-494 represses osteosarcoma development by modulating ASK-1 related apoptosis complexes
Gan Gao, Yuekui Jian
Translational Cancer Research  
2025;
14
(8)
:5177
.