Vol 14, No 11 (November 30, 2025): Translational Cancer Research

Editorial Commentary

Combining anti-metabolic treatments with the repurposing of eribulin for glioblastoma: a clinical opportunity?
Étienne Audet-Walsh, Lucas Galey, Samuele Renzi, Nadine Morin, Samer M. I. Hussein, Maxime Richer, Marc-Étienne Huot
Translational Cancer Research  
2025;
14
(11)
:7463-7466
.
 (30 November 2025) 
PDF Full Text (227) Peer Review File COI Form Open Access Get Permission
Chemotherapy-free combination strategies in recurrent platinum-resistant ovarian cancer: promise, evidence and perspectives
Pauline Corbaux, Gilles Freyer
Translational Cancer Research  
2025;
14
(11)
:7467-7471
.
 (30 November 2025) 
PDF Full Text (285) COI Form Open Access Get Permission
Translating NSABP B-51 findings into practice: rethinking regional nodal irradiation in breast cancer
Kefah Mokbel, Muharrem Oner
Translational Cancer Research  
2025;
14
(11)
:7472-7477
.
 (30 November 2025) 
PDF Full Text (1193) Peer Review File COI Form Open Access Get Permission
Racial disparities in ovarian cancer survival transcend the somatic mutational landscape
Robert D. Morgan, George J. Burghel
Translational Cancer Research  
2025;
14
(11)
:7478-7479
.
 (30 November 2025) 
PDF Full Text (157) COI Form Open Access Get Permission

Original Article

Sorting nexin 9 expression and prognostic implications in lung adenocarcinoma: integrative bioinformatic and in vitro validation
Weidi Liu, Yichen Yin, Baozhen Wang, Tao Li, Jing Chen
Translational Cancer Research  
2025;
14
(11)
:7480-7493
.
 (30 November 2025) 
PDF Full Text (322) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Machine learning prediction of overall survival in patients with primary gastrointestinal melanoma
Fuli Gao, Xiaodan Xu
Translational Cancer Research  
2025;
14
(11)
:7494-7506
.
 (30 November 2025) 
PDF Full Text (248) Reporting Checklist Peer Review File COI Form Open Access Get Permission
LINC02081 as an oncogene promotes cell proliferation and G2/M cycle through p53 signaling pathway in lung adenocarcinoma
Lizhong Zeng, Haimei Wen, Tong Jiao, Ting Jiao, Qiuhong Zhang, Meijuan Han, Yang Chen, Shuanying Yang
Translational Cancer Research  
2025;
14
(11)
:7507-7520
.
 (30 November 2025) 
PDF Full Text (251) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
A novel pyridazinone and thiophene compound IMB5043 activated apoptosis and autophagy in cisplatin-resistant non-small cell lung cancer cells
Yingzheng Hou, Xueting Cao, Rui Cao, Hongmei Tang, Jing Chen
Translational Cancer Research  
2025;
14
(11)
:7521-7535
.
 (30 November 2025) 
PDF Full Text (181) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Ubiquitin-conjugating enzyme E2S serves as a prognostic marker for skin cutaneous melanoma
Guojun Du, Lei Li, Yunhui Jiang, Peipei Yang, Ganglin Xu
Translational Cancer Research  
2025;
14
(11)
:7536-7549
.
 (30 November 2025) 
PDF Full Text (202) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Clinical characteristics and prognosis of elderly patients with gastric gastrointestinal stromal tumors: a population-based study
Qian Xu, Mingxia Xia, Yiling Ni, Xiao Xu, Zhenguo Qiao, Li Zhou
Translational Cancer Research  
2025;
14
(11)
:7550-7562
.
 (30 November 2025) 
PDF Full Text (187) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Thermal ablation versus surgical resection for colorectal liver metastases: a Grading of Recommendations, Assessment, Development, and Evaluation (GRADE)-assessed systematic review, survival meta-analysis, and meta-regression
Muhammad Ansab, Sepideh Razi, Shree Rath, Umama Alam, Noor Ul Huda Ramzan, Muhammad Burhan, Asad Iqbal, Anwaar Saeed
Translational Cancer Research  
2025;
14
(11)
:7563-7579
.
 (30 November 2025) 
PDF Full Text (422) Reporting Checklist Peer Review File COI Form Open Access Get Permission
PM2.5 promotes non-small cell lung cancer tumorigenesis by miR-21-5p targeting PDE4DIP accumulated
Yan-Jun Lin, Yuan-Hao Wu, Jingqing Ma, Lu Fang, Bo Liu, Shu Meng
Translational Cancer Research  
2025;
14
(11)
:7580-7597
.
 (30 November 2025) 
PDF Full Text (210) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
ZBTB7B modulates the androgen receptor as an upstream regulator via colocalization and direct binding in LNCaP prostate cancer cells
Eunji Im, Su-Yeon Park, Deok-Yong Sim, Ah Reum Cho, Bum Ju Kil, Bonglee Kim, Bum-Sang Shim, Sung-Hoon Kim
Translational Cancer Research  
2025;
14
(11)
:7598-7610
.
 (30 November 2025) 
PDF Full Text (277) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Prognostic characteristics and recurrence patterns of grade 1 endometrial carcinoma: a large retrospective analysis of a tertiary center
Negin Sadeghi, Jacopo Conforti, Andreas Zouridis, Ammara Kashif, Ahmed Darwish, Sarah Louise Smyth, Alisha Sattar, Susan Addley, Christina Pappa, Stephen Damato, Mostafa Abdalla, Sean Kehoe, Federico Ferrari, Hooman Soleymani majd
Translational Cancer Research  
2025;
14
(11)
:7611-7620
.
 (30 November 2025) 
PDF Full Text (291) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Neutrophil depletion dampens inflammation and enhances CD8+ T cell effect on tumor control but undermines anti-PD-1 therapy
Maike Zheng, He Chang, Shuqin Li, Chaohong Wang, Sibo Long, Yongqiang Wang, Tongmei Zhang, Guirong Wang, Yu Wang, Yan Zhao
Translational Cancer Research  
2025;
14
(11)
:7621-7640
.
 (30 November 2025) 
PDF Full Text (232) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Curcumin induces ferroptosis in hepatocellular carcinoma by regulating PERK/Nrf2/HO-1 signaling pathway
Cheng Yuan, Ruiwen Liu, Xinming Xu, Jun Sun, Yi Zhu, Rongzhu Lu, Yueyu Liu, Jian Chen
Translational Cancer Research  
2025;
14
(11)
:7641-7653
.
 (30 November 2025) 
PDF Full Text (272) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Clinical characteristics and long-term prognosis of primary mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma in the small intestine
Jiayi Ding, Luojie Liu, Ye Ye
Translational Cancer Research  
2025;
14
(11)
:7654-7668
.
 (30 November 2025) 
PDF Full Text (176) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Genetic insights into colorectal cancer pathogenesis: a multi-omics and immunity perspective
Shengyi Zhou, Xinyi Zhang, Shiwen Wang, Yunfan Zhou, Yizhou Sun
Translational Cancer Research  
2025;
14
(11)
:7669-7685
.
 (30 November 2025) 
PDF Full Text (200) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Development and validation of a pathomics model to predict SOX11 expression and prognosis in hepatocellular carcinoma
Shuna Liu, Yuhui Cai, Boping Zhou
Translational Cancer Research  
2025;
14
(11)
:7686-7699
.
 (30 November 2025) 
PDF Full Text (191) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Causal relationship between hypertension and cancer: a two‐sample bidirectional Mendelian randomization study
Chenggong Zeng, Juanhua Zhu, Yan Mao, Xi Zhen, Zhiqing Wei, Zijun Zhen
Translational Cancer Research  
2025;
14
(11)
:7700-7711
.
 (30 November 2025) 
PDF Full Text (215) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Risk factors for refractory malignant pleural effusion and the impact on prognosis in non-small cell lung cancer patients with advanced EGFR mutations: a retrospective cohort study using propensity score matching
Heng-Ning Lian, Guang-Qing Shi, Huan Wang, Zhen-Yan Wu, Li-Jie Ma, Zhen-Liang Xiao, Jing Zhou
Translational Cancer Research  
2025;
14
(11)
:7712-7724
.
 (30 November 2025) 
PDF Full Text (190) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
A new combined prognostic model involving SLC44A4 improves the predictive ability for colorectal cancer patients
Panyuan Li, Xiaoqing Cheng, Yanchuang Wu, Guoxiang Fu, Jia Zhu, Caixia Sheng, Xiaotong Hu, Zhinong Jiang
Translational Cancer Research  
2025;
14
(11)
:7725-7740
.
 (30 November 2025) 
PDF Full Text (255) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Impact of single-site distant metastases on prognosis in advanced ovarian cancer: a Surveillance, Epidemiology, and End Results population-based study
Zhanna Yuan, Peiqin Shi, Wenwen Zhang, Pengpeng Qu
Translational Cancer Research  
2025;
14
(11)
:7741-7757
.
 (30 November 2025) 
PDF Full Text (162) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Identification and prognostic assessment of clonal and functional heterogeneity in head and neck squamous cell carcinoma
Yibo Guo, Xiuyin Wu, Yi Xu, Yu Zhang, Zheqi Liu, Tong Ji, Jie Hao, Yang Wang
Translational Cancer Research  
2025;
14
(11)
:7758-7772
.
 (30 November 2025) 
PDF Full Text (198) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Clinicopathological characteristics and long-term prognosis of duodenal signet ring cell carcinoma: a SEER-based analysis
Jiayi Ding, Ye Ye, Luojie Liu
Translational Cancer Research  
2025;
14
(11)
:7773-7789
.
 (30 November 2025) 
PDF Full Text (207) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Dietary restriction-responsive genes define prognostic subtypes and predict metastasis in colorectal cancer
Qibin Li, Zengtao Wang, Jinyi Long, Ziyang Xu, Jie Zhang
Translational Cancer Research  
2025;
14
(11)
:7790-7809
.
 (30 November 2025) 
PDF Full Text (185) Reporting Checklist Peer Review File COI Form Open Access Get Permission
ING5-mediated regulation of lung cancer progression via the OIP5-AS1/miR-381-3p/SEC24A axis
Wenxi Cui, Qihao Wang, Xin Gongsun, Junfeng Bai, Yisong Li, Yanda Zhang, Kai Cui
Translational Cancer Research  
2025;
14
(11)
:7810-7823
.
 (30 November 2025) 
PDF Full Text (160) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Bioinformatics-based multi-omics and machine learning analysis identifies stemness-associated molecular subtypes and a prognostic index in breast cancer
Yan-Yu Hou, Wen-Jia Chen, Yang-Zheng Lan, Hua-Tao Wu, Jing Liu
Translational Cancer Research  
2025;
14
(11)
:7824-7846
.
 (30 November 2025) 
PDF Full Text (295) Reporting Checklist Peer Review File COI Form Open Access Get Permission
MCRS1 is associated with immunosuppressive microenvironments in pan-cancer and promotes hepatocellular carcinoma malignant phenotypes
Qiang Wang, Yuntao Ye, Mengyu Zhang, Bo Li
Translational Cancer Research  
2025;
14
(11)
:7847-7869
.
 (30 November 2025) 
PDF Full Text (195) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Expression and role of PD-L1 and SOX10 in hepatocellular carcinoma
Byoung Chan So, Han Ju Park, Kyoung Min Kim, Ho Sung Park, Kyu Yun Jang, Myoung Ja Chung, Woo Sung Moon, Jae Do Yang, Ae Ri Ahn
Translational Cancer Research  
2025;
14
(11)
:7870-7880
.
 (30 November 2025) 
PDF Full Text (175) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Developing of potential mRNA vaccines based on tumor antigens and immune subtypes of esophageal cancer
Zewei Zhang, Jixiang Hou, Yingxue Wang, Ying Jiang, Wenjuan Wang, Juan Zhao, Gaowa Jin, Lei Zhao, Quanfu Li
Translational Cancer Research  
2025;
14
(11)
:7881-7902
.
 (30 November 2025) 
PDF Full Text (218) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
The influence of tumor location on the onset of endocrine deficits in pediatric brain tumor survivors
Giorgio Attinà, Alberto Romano, Palma Maurizi, Tommaso Verdolotti, Stefano Mastrangelo, Antonio Ruggiero
Translational Cancer Research  
2025;
14
(11)
:7903-7911
.
 (30 November 2025) 
PDF Full Text (147) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Prediction of postoperative survival in patients with head and neck acinic cell carcinoma: a population-based study
Silin Zhang, Weiping Wang, Sa Chen, Xiaowu Huang, Yu Chen, Xiangmin Zhang, Danyi Du
Translational Cancer Research  
2025;
14
(11)
:7912-7925
.
 (30 November 2025) 
PDF Full Text (167) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Evaluation of nomogram prediction model for postoperative deep vein thrombosis in patients with non-small cell lung cancer
Pengyu Ji, Zhenping Guo, Yong Wang, Hui Wang, Chun Yin
Translational Cancer Research  
2025;
14
(11)
:7926-7937
.
 (30 November 2025) 
PDF Full Text (198) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
NFATc1 activates the Ras/Raf/p38 MAPK pathway to promote the progression of lung adenocarcinoma
Aijuan Sun, Jiayu Yang, Yanhua Chang, Shudong Yang
Translational Cancer Research  
2025;
14
(11)
:7938-7953
.
 (30 November 2025) 
PDF Full Text (158) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Association between cholecystectomy and colorectal cancer: results from the National Health and Nutrition Examination Survey (NHANES) 2017–2023 and Mendelian randomization analyses
Shunchen Zhou, Bosen Zhao, Jiaying Qu, Xingyu Gao, Xiaolin Wang, Chunhui Yang, Qiangsong Tong, Liduan Zheng
Translational Cancer Research  
2025;
14
(11)
:7954-7966
.
 (30 November 2025) 
PDF Full Text (262) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Development and validation of a delta ultrasomics model for predicting treatment response to neoadjuvant chemotherapy in breast cancer
Zhenhu Lin, Meijuan Zheng, Zhiyong Li, Zhenyan Fang, Huiping Zhang, Xiaoqing Fan, Huanrong Cao, Rongxi Liang
Translational Cancer Research  
2025;
14
(11)
:7967-7979
.
 (30 November 2025) 
PDF Full Text (207) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Significance of the association between hypoxia and pyroptosis-related genes in the prognostic prediction of glioblastoma: insights from model construction and validation
Qiang Chen, Helan Yuan, Weilong Huang, Huichen Li, Yuqing Liao, Qiuhua Jiang, Dong Wang
Translational Cancer Research  
2025;
14
(11)
:7980-7994
.
 (30 November 2025) 
PDF Full Text (167) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Identification of the key gene for hepatocellular carcinoma based on bioinformatics and machine learning and experimental verification
Jin Lu, Junjie Ma, Can Yu, Shaoyang Lu, Xueying Zhao, Lei Zhang
Translational Cancer Research  
2025;
14
(11)
:7995-8011
.
 (30 November 2025) 
PDF Full Text (286) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
SAMD4B: a novel prognostic biomarker of endometrial carcinoma
Changmin Shin, Tae-Kyu Jang, Changho Song
Translational Cancer Research  
2025;
14
(11)
:8012-8021
.
 (30 November 2025) 
PDF Full Text (194) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Circulating tumor cells as a recurrence risk marker in glioma: a retrospective study
Xiangqi Huang, Jingrui Guo, Yongmei Cui, Jing Liang, Na Cheng, Yiwang Zhang, Dan He
Translational Cancer Research  
2025;
14
(11)
:8022-8031
.
 (30 November 2025) 
PDF Full Text (183) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Fatty acid metabolism-related signature suggests an oncogenic role of FASN in cervical cancer
Qinli Yang, Jing Zhang, Xiujuan Shang, Bohao Sun, Tong Wang, Yichen Wu, Chunhong Zhu, Wenqing Xiang, Hao Wang
Translational Cancer Research  
2025;
14
(11)
:8032-8054
.
 (30 November 2025) 
PDF Full Text (254) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Application value of a prognostic risk model based on lactate-related genes in non-small cell lung cancer
Jinhua Bao, Jun Gu, Tanao Ji
Translational Cancer Research  
2025;
14
(11)
:8055-8069
.
 (30 November 2025) 
PDF Full Text (202) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Uridine-cytidine kinase 2 as a novel potential prognostic and therapeutic biomarker in gastric cancer
Weilin Sun, Hui Guo, Mingzhi Cai, Gang Ma, Li Zhang, Yang Yu, Hongjie Zhan
Translational Cancer Research  
2025;
14
(11)
:8070-8085
.
 (30 November 2025) 
PDF Full Text (174) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Engineered macrophages accumulate in solid tumors and locally deliver immune-activating proteins to inhibit tumor progression
Yan Xu, Yang Zhou, Jiahe Wang
Translational Cancer Research  
2025;
14
(11)
:8086-8104
.
 (30 November 2025) 
PDF Full Text (304) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Association of the aggregate index of systemic inflammation in cancer survivors with all-cause, cardiovascular, and cancer- related mortality
Yajing Dong, Haiyi Guo, Jie Guo, Lei Sun, Sai Wen, Mingming Guo, Shanshan Fu, Linna Xiao
Translational Cancer Research  
2025;
14
(11)
:8105-8118
.
 (30 November 2025) 
PDF Full Text (185) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Clinical efficacy and safety of pyrotinib as the first-line treatment of HER2-positive advanced breast cancer in Xinjiang Uygur Autonomous Region of China
Qi Xiao, Dan Liu, Li Li, Zhenhui Zhao, Yan Li, Xiaoping Ma, Bingyu Li, Xiner Zhang, Bing Zhao
Translational Cancer Research  
2025;
14
(11)
:8119-8131
.
 (30 November 2025) 
PDF Full Text (230) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access Get Permission
Prognostic potential of N6-methyladenosine methylation-associated genes in lung adenocarcinoma
Yuhan Lei, Jian Wang
Translational Cancer Research  
2025;
14
(11)
:8132-8141
.
 (30 November 2025) 
PDF Full Text (169) Reporting Checklist Peer Review File COI Form Open Access Get Permission

Review Article

Combination immunotherapy in Japanese patients with advanced renal cell carcinoma: bridging gaps between clinical trials, real-world evidence, and the potential value of adverse events—a narrative review
Koji Iinuma, Masayuki Tomioka, Tomoki Taniguchi, Kota Kawase, Yuki Tobisawa, Keita Nakane, Takuya Koie
Translational Cancer Research  
2025;
14
(11)
:8142-8153
.
 (30 November 2025) 
PDF Full Text (273) Reporting Checklist Peer Review File COI Form Open Access Get Permission
On the translational potential of atlases in precision oncology
Lucrezia Zorzi, Lucia Casella, Marco Dominietto, Enrico Capobianco
Translational Cancer Research  
2025;
14
(11)
:8154-8165
.
 (30 November 2025) 
PDF Full Text (175) Peer Review File COI Form Open Access Get Permission
A narrative review of segmentectomy versus lobectomy in elderly patients with early-stage NSCLC: challenging the longstanding standard
Chanwoo Kim, Jae Yeon Kim, Se Eun Park, Sanghyun Han, Sujeong Kim, Dohun Kim
Translational Cancer Research  
2025;
14
(11)
:8166-8175
.
 (30 November 2025) 
PDF Full Text (304) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Advancing circular economy practices in radiography: a narrative review of sustainable medical imaging
Aanuoluwapo Clement David-Olawade, Oluwayomi B. Rotifa, James Ijiwade, Melissa McLaughlin, David B. Olawade, Stergios Boussios
Translational Cancer Research  
2025;
14
(11)
:8176-8200
.
 (30 November 2025) 
PDF Full Text (367) Reporting Checklist Peer Review File COI Form Open Access Get Permission

Case Report

Long-term survival in a patient with leptomeningeal metastases from non-small cell lung cancer treated with stereotactic radiotherapy (SRT), programmed cell death protein 1 (PD-1) inhibitor, and granulocyte-macrophage colony-stimulating factor (GM-CSF): a case report
Jiale Huan, Chanchan Shan, Huifeng Gu, Yun Li, Weixiang Qi
Translational Cancer Research  
2025;
14
(11)
:8201-8209
.
 (30 November 2025) 
PDF Full Text (281) Reporting Checklist Peer Review File COI Form Open Access Get Permission
Clinical case report on the efficacy and safety of savolitinib in elderly patients with non-small cell lung cancer harboring METex14 skipping mutations
Man Sun, Dan Zang, Huan Zhou, Jun Chen
Translational Cancer Research  
2025;
14
(11)
:8210-8217
.
 (30 November 2025) 
PDF Full Text (218) Reporting Checklist Peer Review File COI Form Open Access Get Permission