Vol 15, No 7 (July 31, 2026): Translational Cancer Research

Editorial Commentary

Transdermal estradiol (tE2) as an alternative androgen deprivation therapy (ADT) in locally advanced prostate cancer
Ame Stephanie Ayemere, Jeanny B. Aragon-Ching
Translational Cancer Research  
2026;
15
(7)
:513
.
The evolution of cancer therapeutics: from “undruggable” to “drugged”
Daniel Neureiter, Matthias Ocker
Translational Cancer Research  
2026;
15
(7)
:514
.
The significance of the 4Kscore in predicting medium- to long-term prostate cancer risk: insights from the European prospective investigation into cancer and nutrition
Yozo Mitsui, Koichi Nakajima
Translational Cancer Research  
2026;
15
(7)
:515
.
Next-generation sequencing-based high-risk genomic stratification in multiple myeloma
Zhou Zhang, Wei Zhang
Translational Cancer Research  
2026;
15
(7)
:516
.
Dual target combination therapy demonstrates promise in extramedullary myeloma
James Behrmann, Faith E. Davies
Translational Cancer Research  
2026;
15
(7)
:517
.
Hepatitis C virus and extrahepatic malignancies: where we stand and how we can advance the field
Ken Sato
Translational Cancer Research  
2026;
15
(7)
:518
.

Original Article

Development and external validation of a machine learning-based multimodal radiomics nomogram for predicting progression-free survival in triple-negative breast cancer
Yanhui Lu, Zhuolin Li, Weiyuan Zhang, Weiming Mao, Fanxin Fu, Wanting Wang, Chunyan Luo, Rongyan Zhou, Yu Guan, Bo He, Jun Li
Translational Cancer Research  
2026;
15
(7)
:519
.
Garcinoic acid promotes ferroptosis-associated growth inhibition in esophageal squamous cell carcinoma through an MDM2-associated mechanism
Li-Ying Sun, Peng Huang, Yan-Hua Su
Translational Cancer Research  
2026;
15
(7)
:520
.
Development and validation of a nomogram for predicting chemotherapy-induced liver injury in breast cancer patients
Meizhen Liang, Dixin Xue, Rusi Su, Weili Wu, Chengliang Chen
Translational Cancer Research  
2026;
15
(7)
:521
.
Prognostic value of gut microbiota-derived metabolites in non-small cell lung cancer: a retrospective cohort study of overall survival
Haitao Pan, Xiangfei Chen, Wan Wu, Meiqin Wang, Yanqing Wang
Translational Cancer Research  
2026;
15
(7)
:522
.
High SRD5A2 expression is associated with poor prognosis and promotes tumor cell progression in colorectal cancer
Meng-Fan Jia, Meng-Nan Dai, Kai-Ye Hua, Si-Yuan Du, Jian Lu, Ying-Wei Zhu
Translational Cancer Research  
2026;
15
(7)
:523
.
An externally validated lactylation-associated prognostic signature for overall survival prediction in lung adenocarcinoma identifies TUBA1C as a candidate gene
Zhi Wang, Nuo Yan, Taohui Ding, Wenxun Xiong, Weiqiang Feng, Yunzhe Wang, Yiping Wei
Translational Cancer Research  
2026;
15
(7)
:524
.
Efficacy of nab-paclitaxel combined with immune checkpoint inhibitors in solid tumors: a systematic review and meta-analysis of randomized controlled trials
Xiao Li, Yaqiong Song, Jianhua Li
Translational Cancer Research  
2026;
15
(7)
:525
.
Development and validation of a multivariable CT-based Delta-radiomics model for predicting efficacy to bevacizumab therapy in patients with colorectal liver metastases
Long Yuan, Shenglin Li, Yuntai Cao, Ming Xu, Huaze Xi, Jingjing Yang, Junlin Zhou
Translational Cancer Research  
2026;
15
(7)
:526
.
In vitro characterization of a novel anti-GD2/ROR1 bispecific antibody exhibiting tumor cell killing efficacy in neuroblastoma cross-cancer activity in ROR1-positive triple-negative breast cancer
Tian Lin, Xinghe Chen, He Huang, Jianxing Zhang, Yali Xu, Junshan Lin
Translational Cancer Research  
2026;
15
(7)
:527
.
The role of apparent diffusion coefficient histogram analysis in improving O-RADS magnetic resonance imaging classification of adnexal lesions: a retrospective diagnostic accuracy study
Yibei Yu, Hongliang Zhao, Yakui Wang, Jing Li, Zhuozhao Zheng
Translational Cancer Research  
2026;
15
(7)
:528
.
The impact of age on survival in stage II colon cancer: a SEER database analysis stratified by chemotherapy status
Zhengrong Zou, Xin Tang, Xinping Hong, Lingting Zou
Translational Cancer Research  
2026;
15
(7)
:529
.
CKMT2 functions as a novel oncogenic gene in osteosarcoma, revealed by bioinformatics and experimental approaches
Xuefei Wu, Fei Ding, Weijie Wu, Honghua Dong
Translational Cancer Research  
2026;
15
(7)
:530
.
A weakly supervised deep learning model for OSCC diagnosis and lesion highlighting in histopathology images
Jun Yan, Lijun Sun, Song Wang
Translational Cancer Research  
2026;
15
(7)
:531
.
PLAU accelerates extracellular matrix remodeling through partial epithelial-mesenchymal transition in head and neck squamous cell carcinoma
Zhichang Liu, Qiaojing Jia, Zhichao Yang, Haizhong Zhang, Jingmiao Wang, Lisha Liu, Dan Lou, Jianxing Wang
Translational Cancer Research  
2026;
15
(7)
:532
.
Elevated TARDBP expression correlates with an unfavorable prognosis, immune evasion, and poor immune efficacy in hepatocellular carcinoma
Jungang Tan, Jiazuo Cai, Zhimin Zhou, Ziqing Sun, Ronghui Zheng, Chengcong Chen
Translational Cancer Research  
2026;
15
(7)
:533
.
METTL17 promotes gastric cancer progression via inhibiting glycogen synthase kinase-3β to activate Wnt/β-catenin signaling
Man Gao, Yixun Zhang, Wenjing Bao, Yilin Shi, Weiyi Chen, Yang Liu, Rumeng Wang, Ning Zhang, Lingli Zhang, Lizhou Jia
Translational Cancer Research  
2026;
15
(7)
:534
.
miR-506-5p targets MAPK7 to impede glioma growth and invasion through suppressing epithelial-mesenchymal transition and matrix metalloproteinases
Tingting Sun, Guojin Wang, Ye Chen, Xin Geng, Xiaofeng Zhu, Houjun Zhou
Translational Cancer Research  
2026;
15
(7)
:535
.
Integrative analysis of HMGB3 in esophageal carcinoma: expression profile, prognostic significance, and immune microenvironment associations
Shen-Bo Fu, Long Jin, Jia Liu, Rong Yang, Jing Liang, Jun-Jun Guo, Li Chen, Bin Zhao
Translational Cancer Research  
2026;
15
(7)
:536
.
Clinicopathological characteristics and prognosis of pulmonary spindle cell carcinoma: a population-based retrospective study using SEER data
Linwei Zhuang, Jianli Gao, Yi Zhang, Jiangbo Lin
Translational Cancer Research  
2026;
15
(7)
:537
.
A comparative analysis of clinical and sonographic features: cutaneous melanoma and melanocytic nevi
Wanli Ye, Yongrui Wang, Hongyan Liu, Yong Jiang, Xingheng Wang, Li Qiu, Yuanjiao Tang
Translational Cancer Research  
2026;
15
(7)
:538
.
Clinical overall survival prediction and disease characteristics of locally advanced non-small cell lung cancer: an integrated analysis based on the SEER and TCGA databases
Yuanhui Tian, Yan Deng, Xiaoli Liao, Shutao Yuan, Ke Li
Translational Cancer Research  
2026;
15
(7)
:539
.
Feasibility study on the application of Raman spectroscopy in the diagnosis of glioma
Zilong Wei, Jincheng Yang, Guanzhong Qiu, Yaodong Zhao
Translational Cancer Research  
2026;
15
(7)
:540
.
HOXD9 prioritization within developmental regulator-related genes suggests stage-adjusted prognostic relevance in hepatocellular carcinoma
Junling Zhu, Xujie Tang, Qianru Zhu, Sen Jiang
Translational Cancer Research  
2026;
15
(7)
:541
.
Interpretable machine learning prediction of 1-year overall survival in pancreatic cancer patients aged 65 years and older
Bo Zeng, Hongyi Liu, Qi Huang
Translational Cancer Research  
2026;
15
(7)
:542
.
TRIM47 promotes cell viability, cell cycle progression, metabolic reprogramming, and inhibits apoptosis of glioma via the NF-κB signaling pathway
Xin Lai, Jin Zhu, Haocheng Jia, Ping Zhang, Bin Wang, Yuping Tang, Qishan Ran
Translational Cancer Research  
2026;
15
(7)
:543
.
A radiotherapy resistance-related prognostic signature predicts survival and the immune landscape in rectal cancer
Tingting Jiang, Liyuan Zhu, Rujin Jiang, Hongchuan Jin, Shijin Yuan
Translational Cancer Research  
2026;
15
(7)
:544
.
PRSS1 promotes gastric cancer invasion and metastasis by induction of the epithelial-mesenchymal transition and activation of the MAPK/ERK pathway
Xiang Bai, Haoyu Zhu, Huiwen Lin, Chao Shi, Chong Tang, Shichun Feng, Fei Wang
Translational Cancer Research  
2026;
15
(7)
:545
.
Clinicopathological characteristics and prognosis of breast carcinoma with apocrine differentiation: a propensity score-matched analysis of the SEER database
Manxiu Li, Liting Jin, Jun Shao, Tiejun Wang, Xinhong Wu
Translational Cancer Research  
2026;
15
(7)
:546
.
Bergamottin demonstrates preclinical effectiveness against pancreatic cancer by modulating PPAR-γ to induce apoptosis
Cheng Wang, Linxiao Sun, Kaixian Deng, Qiangqiang Li
Translational Cancer Research  
2026;
15
(7)
:547
.
Hepatotoxicity of immune checkpoint inhibitor plus targeted therapy versus tyrosine kinase inhibitor monotherapy in unresectable hepatocellular carcinoma: a systematic review and meta-analysis
Shuangyue Wang, Yajuan He, Yingfei Wei, Feng Chen, Min Luo
Translational Cancer Research  
2026;
15
(7)
:548
.
TRIM32 drives head and neck squamous cell carcinoma progression via TP53 suppression and lysosomal/autophagy dysregulation
Langxiong Chen, Yuyang Zhang, Huaying Liao, Weiyan Liang, Weihan Luo, Baiyao Wang, Lei Wang, Hongwei Yu, Ling Cheng, Jingjing Song, Yawei Yuan, Yunhong Tian, Yuchao Wu
Translational Cancer Research  
2026;
15
(7)
:549
.
Differentiating breast cancer lung metastasis from primary lung cancer using clinical and computed tomography radiomics features
Jinhua Huang, Tinglei Shao, Caihong Zheng, Liantao Guo, Chuan Wang, Chunsen Xu, Lili Wang, Zhonghua Han
Translational Cancer Research  
2026;
15
(7)
:550
.
A multi-omics integration of bulk and single-cell transcriptomics identifies and validates a 16-gene epithelial-mesenchymal transition prognostic signature in tongue squamous cell carcinoma
Kai Fu, Lin Li, Ruyv Wang, Juan Li, Weiyi Wang
Translational Cancer Research  
2026;
15
(7)
:551
.
A real-world cohort study reveals the treatment paradox of radiotherapy underuse despite its association with survival advantage
Zhuo Song, Lei Wang, Qianhao Zang, Mingli Ding, Yingjie Wang, Gang Ren, Yupeng Di, Zijie He
Translational Cancer Research  
2026;
15
(7)
:552
.
Bioinformatics-based identification of ferroptosis-related biomarkers and immune infiltration in retinoblastoma
Xingxin Fu, Chengzhen Gong, Jun Zhang, Mingxing Wu, Xuhui Li, Xueshan Dai, Yan Xu
Translational Cancer Research  
2026;
15
(7)
:553
.
Palmitoylation-related gene signature for immune subtyping, prognostic stratification, and immunotherapy guidance in hepatocellular carcinoma
Xiang Gao, Fangzhou Wang, Yuanxu Qu, Yingao Liu, Yamin Zheng
Translational Cancer Research  
2026;
15
(7)
:554
.
ALOX12 suppresses colon cancer progression by promoting p53-mediated ferroptosis through upregulating ROS-induced stress
Junjie Wu, Congxing Liu, Yaya Sun, Guangqing Jiang, Yupeng Zhao, Yihong Zhang, Yiping Yin, Xin Shi
Translational Cancer Research  
2026;
15
(7)
:555
.
Construction of lactate-myeloid-related prognostic risk model and prediction of immune-excluded microenvironment in gastric cancer via integrated scRNA-Seq and bulk RNA-Seq
Xiaying Han, Qimiao Chen, Xijian Huang, Zhixing Hao, Yaxuan Han, Yewei Xu, Jing Chen, Jia Qi, Jian Chen
Translational Cancer Research  
2026;
15
(7)
:556
.
Osteoblast-specific factor 2 reduces glutathione by downregulating PRKRA expression in oral squamous cell carcinoma
Binbin Yu, Shimin Zhao, Jun Wang
Translational Cancer Research  
2026;
15
(7)
:557
.
Real-world retrospective cohort study of three conversion therapy regimens for unresectable locally advanced pancreatic cancer: a single-center 5-year analysis focused on conversion resection rate and survival outcomes
Rui-Zhi He, Min Zhou, Yong-Jun Chen, Xing-Jun Guo
Translational Cancer Research  
2026;
15
(7)
:558
.
Adenylate cyclase 4 suppresses malignant progression of lung adenocarcinoma through interaction with protein kinase C beta
Jieyang Wang, Chaojing Zheng, Wei Shen, Qianshun Chen, Yuyu Lin, Shuwei Huang, Lei Gao, Chen Huang
Translational Cancer Research  
2026;
15
(7)
:559
.
Elevated TMC8 expression correlates with CD8+ T cell infiltration and favorable survival in oral squamous cell carcinoma
Bingyan Zhu, Yuling Chen, Tao Zhou, Yuntao Lin, Bo Lin
Translational Cancer Research  
2026;
15
(7)
:560
.
Cysteine suppresses the progression of oral squamous cell carcinoma via regulating GLDC
Haoran Wang, Le Xu, Mengqi Zhang, Ning Zhang, Dongsheng Zhang, Xiaoqing Zhou
Translational Cancer Research  
2026;
15
(7)
:561
.
Transcriptomic and experimental validation identify biomarkers and regulatory mechanisms associated with the aryl hydrocarbon receptor in nasopharyngeal carcinoma
Qiulin Liang, Changxing Cao, Ziling Zou, Yulan Peng, Chao Feng
Translational Cancer Research  
2026;
15
(7)
:562
.
Identification of prognostic risk factors and construction of nomograms for elderly patients with stage III–IV endometrioid endometrial carcinoma: a study based on the SEER database
Shaohan Zou, Sitian Wei, Guanghui Song, Songying Zhang
Translational Cancer Research  
2026;
15
(7)
:563
.
KLF15-POU3F4 axis activates PI3K/AKT signaling to promote glioma progression
Dong Wang, Wan Yu, Ran Wang, Ning Liu
Translational Cancer Research  
2026;
15
(7)
:564
.
Matching-adjusted indirect comparison between asciminib and flumatinib as first-line treatment for chronic myeloid leukemia in China
Ying Wang, Yan Hui, Li Zhang, Yan Li, Meng Tang, Xue Gao, Bihong Zhen, Abhay Choubey, Soni Gupta, Hui Wei, Bingcheng Liu
Translational Cancer Research  
2026;
15
(7)
:565
.

Review Article

SLC16A3 links tumor metabolism to therapeutic opportunities in hepatocellular carcinoma
Zhiyan Li, Zeyu Zhou, Shuwei Liang, Hao Liu, Qiyu Sun, Jian Li
Translational Cancer Research  
2026;
15
(7)
:566
.
Emerging role of human epidermal growth factor 2-low status in the prognosis and management of triple-negative breast cancer: a narrative review
Nathan Oelschlagel, Hamid Mithoowani, Emily A. Goebel, Farhad Ghasemi, Sarah Knowles, Allison Maciver, Muriel Brackstone, Armen Parsyan
Translational Cancer Research  
2026;
15
(7)
:567
.

Case report

Sequential HER2-targeted antibody-drug conjugate therapy for acquired resistance in a 55-year-old male kidney transplant recipient with metastatic urothelial carcinoma: a case report
Tianying Li, Yinuo Zhang, Genkun Liu, Jun Chen, Sheng Zhang, Mingjuan Sun
Translational Cancer Research  
2026;
15
(7)
:568
.
Precision de-escalation of immunotherapy in extensive-stage small cell lung cancer: a case report on ctDNA-guided management in a long-term survivor
Qiuyi Zhang, Jiesheng Su, Suni Huang, Lihong Guo, Die Dai, Meng Zhang, Shiqi Lyu, Zesong Chen, Jianhua Chang
Translational Cancer Research  
2026;
15
(7)
:569
.

Erratum

Erratum: Pathological features and biomarkers of hepatocellular carcinoma: a bibliometric analysis from 2005 to 2025
Editorial Office
Translational Cancer Research  
2026;
15
(7)
:570
.