Vol 15, No 2 (February 28, 2026): Translational Cancer Research

Editorial Commentary

Bridging histopathology, inferred transcriptomics, and immunotherapy response prediction in head and neck cancer
Adriana Torres da Silva
Translational Cancer Research  
2026;
15
(2)
:71
.
Integrating tumor regression and nodal status for refined prognostication after neoadjuvant therapy in esophageal cancer: where does TRG-N fit in the evolving global landscape?
Eisuke Booka, Hiroya Takeuchi
Translational Cancer Research  
2026;
15
(2)
:72
.
Improving stratification in HPV-negative head and neck squamous cell carcinoma (HNSCC) using emerging immune-based biomarkers
Justin M. Hintze, Siqi Chen, Luc G. T. Morris
Translational Cancer Research  
2026;
15
(2)
:73
.
Timing matters: concurrent vs. sequential immunotherapy in combination with chemoradiation in head and neck cancer
Lindsey M. Bachmann, Dalia El-Gamal, Trisha M. Wise-Draper
Translational Cancer Research  
2026;
15
(2)
:74
.
Early clearance of circulating tumor DNA as a determinant of induction therapy response in human papillomavirus-associated oropharyngeal squamous cell carcinoma
Kento Kawakita, Yukinori Takenaka
Translational Cancer Research  
2026;
15
(2)
:75
.

Original Article

Single-cell analysis of UNC13D-mediated immune and dedifferentiation heterogeneity in acute myeloid leukemia and development of a prognostic model
Ziqian Wang, Daobin Zhou
Translational Cancer Research  
2026;
15
(2)
:76
.
Multi-omics analysis of BTF3L4 as a prognostic and immune biomarker in hepatocellular carcinoma
Chengfeng Guo, Pingping Sun, Kai Gao, Jiawei An, Huien Xie, Mingyan Zhu, Yicheng Xiong, Yao Wang
Translational Cancer Research  
2026;
15
(2)
:77
.
A novel prognostic model based on vasculogenic mimicry in ovarian cancer
Yunjing Song, Sijing Cai, Jing Ma, Yue Yang, Yue Chen, Runrong Li, Fanliang Meng
Translational Cancer Research  
2026;
15
(2)
:78
.
Ability of lactylation-related genes to stratify patients with ovarian cancer and predict immunotherapy response
Zhijian Tang, Wei Li, Ruiqiong Ma, Panjian Wei, Jinghong Huang, Ruijun Wang, Yuanming Pan, Jianliu Wang
Translational Cancer Research  
2026;
15
(2)
:79
.
Cuprotosis-related gene subtypes, prognostic modeling, and tumor microenvironment remodeling in breast cancer
Tian-Wei Sun, Min-Yuan Li, Jie Ma, Jin-Wei Wu
Translational Cancer Research  
2026;
15
(2)
:80
.
Enhanced CT-based deep learning radiomics and biological correlations for predicting immunotherapy efficacy in advanced non-small cell lung cancer
Jianbin Zhu, Huaxian Shi, Zhuofeng Liang, Ting Lin, Caihong Li, Chunxiu Jiang, Qiuxian Wang, Jianhua Mo, Dong Zeng, Zhibo Wen
Translational Cancer Research  
2026;
15
(2)
:81
.
Bioinformatics analysis of the expression and prognostic significance of depression-related genes in lung adenocarcinoma
Yu Lu, Rui Wang, Tingting Fan, Jialin Zhang, Yiming Xu
Translational Cancer Research  
2026;
15
(2)
:82
.
HOXB8 promotes invasion and metastasis of high-grade serous ovarian cancer via suppression of the KDM6B/C/EBPα signaling axis
Li Xiang, Yanqin Lou, Ping Wang, Yajun Hu, Donghua Wang
Translational Cancer Research  
2026;
15
(2)
:83
.
Metastatic patterns, prognostic factors, and deep learning model development in primary gastrointestinal melanoma: a retrospective cohort analysis
Chao Li, Wenjing Yu, Yuanming Pan, Wei Li, Guibin Yang, Wei Li
Translational Cancer Research  
2026;
15
(2)
:84
.
Development and internal validation of a prognostic model for hepatocellular carcinoma after liver resection based on the albumin-bilirubin score and triglyceride-glucose index
Yibo Wang, Yubo Zhao, Linhai Wei, Zhening Yan, Xiang Li, Yinghan Wang, Yue Sun, Yanbo Ma
Translational Cancer Research  
2026;
15
(2)
:85
.
Prediction of overall survival in patients with hepatocellular carcinoma and second primary malignancies: a prognostic model based on the SEER database
Peng Pan, Zhanjin Wang, Weiwei Xue, Kaihao Du, Yuandong Li, Haoman Shi, Zhan Wang
Translational Cancer Research  
2026;
15
(2)
:86
.
Prognostic significance of lymph node-related indices and a novel nomogram for rectal cancer patients with synchronous liver metastases after the preoperative chemoradiotherapy: a population-based study
Kexing Xi, Youbo Wu, Xiaowen Sun, Changzheng Du, Feng Wang, Jialiang Liu, Yanjiang Yin, Yutong Wang, Jiaxiang Liu, Guoxin Li
Translational Cancer Research  
2026;
15
(2)
:87
.
Bioinformatics identification of adenosylhomocysteinase (AHCY) as a regulator of ferroptosis in nasopharyngeal carcinoma cells via the Hippo-Yes-associated protein (Hippo-YAP) pathway
Huizhen Zheng, Xiaodan Wang, Qin Chen
Translational Cancer Research  
2026;
15
(2)
:88
.
Pan-cancer analysis identifies FAM111B as a biomarker for immune suppression microenvironment in low-grade gliomas
Zhihai Wang, Longji Li, Bingcheng Wang, Zihao Liu, Xianyong Yin, Dong He, Yuming Li, Qian Liu, Tao Xin
Translational Cancer Research  
2026;
15
(2)
:89
.
Identification of immune-related targets of N6-methyladenosine regulators in hepatocellular carcinoma via RNA-seq analysis
Yubo Zhao, Digun Zhang, Hongqun Zheng, Xuejian Chen, Lishan Xu
Translational Cancer Research  
2026;
15
(2)
:90
.
A multimodal fusion model for bone tumor benign and malignant diagnosis: development and validation with clinical text and radiographs
Ju Zeng, Qiuchi Chen, Tao Zhang, Decui Liang, Dongming Li
Translational Cancer Research  
2026;
15
(2)
:91
.
Expression analyses of fatty acid binding proteins (FABPs) in breast cancer subtypes: implications for immune modulation and clinical outcomes
Eman Taha Osman Ali, Eun-Ji Min, Wonkyoung Cho, Young Mi Park
Translational Cancer Research  
2026;
15
(2)
:92
.
Mechanistic study of the role of emodin in targeting and inhibiting the Rap1 signaling pathway to regulate epithelial-mesenchymal transition and reverse cisplatin resistance in hepatocellular carcinoma
Rui Zhang, Yue Jiao, Song Wang, Ling Wang, Yan Leng, Zhuang Xiong, Ming Yang
Translational Cancer Research  
2026;
15
(2)
:93
.
Comprehensive analysis of liquid-liquid phase separation-related genes in osteosarcoma: implications for prognosis, immune infiltration and drug sensitivity
Cao Han, Zhuo Zhao, Xinghan Zhao, Jiyong Jiang, Tao Zhong, Yi Fang, Haidong Liang, Wenji Song
Translational Cancer Research  
2026;
15
(2)
:94
.
Single-cell RNA sequencing identifies cancer-associated fibroblast marker genes for determining cancer subtypes in oral squamous cell carcinoma and predicting patient prognosis
Feng Wang, Jianrong Li, Jun Zhou, Yuntao Lin, Yuling Chen, Lin Yang, Yufan Wang, Huijun Yang, Hongyu Yang
Translational Cancer Research  
2026;
15
(2)
:95
.
Interpretable machine learning-based survival prediction and key gene identification in cancer using gene expression and clinical data
Shicai Liu, Han Zhang
Translational Cancer Research  
2026;
15
(2)
:96
.
Combinatorial treatment with donafenib and quercetin suppresses lipid metabolism in HepG2 cells by targeting the CREB1/DRP1/SREBP1 axis
Lei Xiang, Jinjie Shi, Xueqing Huang, Shi Zhou
Translational Cancer Research  
2026;
15
(2)
:97
.
Construction and validation of a palmitoylation-related prognostic model for lung adenocarcinoma based on integrated bioinformatics and machine learning
Zhilan Huang, Tingyi Xie, Mingwen Tang, Anqi Su, Zhujin Jin, Zhuni Chen, Dan Jia, Wei Xie
Translational Cancer Research  
2026;
15
(2)
:98
.
Tumor habitat characteristics derived from intravoxel incoherent motion for early response assessment in soft tissue sarcoma undergoing neoadjuvant radiotherapy and targeted therapy: a phase II study
Xin Wen, Jiuming Jiang, Lei Miao, Zhaoyang Yang, Fan Liu, Sicong Wang, Yueluan Jiang, Yang Song, Meng Li, Ningning Lu
Translational Cancer Research  
2026;
15
(2)
:99
.
Prognostic prediction and immune correlation analysis of anoikis- and epithelial-mesenchymal transition-related genes in lung adenocarcinoma
Tianjia Liu, Xueting Dong, Yuling Liang, Jingyun Liu, Yi Xiong, Longxiong Liao, Qibiao Wu, Xian-Ming Fan, Dan Luo
Translational Cancer Research  
2026;
15
(2)
:100
.
Efficacy and safety of programmed cell death protein 1/programmed death-ligand 1 inhibitors combined with chemotherapy for breast cancer: a systematic review and meta-analysis
Geqiong Xiao, Chenchen Bi, Zhidong Cai, Junwei Yan, Tingting Lv, Xiang Wang, Haigang Ding, Zhinan Ding, Yuying Xuan, Junxia Chen, Zheng Liu
Translational Cancer Research  
2026;
15
(2)
:101
.
Comprehensive analysis identifies PKMYT1 as an oncogene and potential prognostic and immunological biomarker in lung adenocarcinoma
Yuanze Cai, Kexin Luo, Meihan Liu, Haiyang Zhao, Guoyi Li, Yumeng Lei, Daiyuan Ma, Yongsheng Zhao, Hongpan Zhang
Translational Cancer Research  
2026;
15
(2)
:102
.
Brain tumor detection based on transcription regulation features identified from public cerebrospinal fluid cell-free DNA sequencing data
Sixian Xia, Wei Dai, Jian Wu
Translational Cancer Research  
2026;
15
(2)
:103
.
Multiomics study on the tertiary lymphatic structure signature of colon cancer
Jing Wang, Yuguo Sun, Yan Guo, Yanni Ren, Xueting Tu, Lei Zhang
Translational Cancer Research  
2026;
15
(2)
:104
.
Development and validation of a ferroptosis-related gene signature for prognostic prediction and therapeutic target identification in invasive lobular carcinoma
Junjie Liu, Xiaoqian Li, Ziyan Li, Rui Zhang, Xiaoduo Li, Kexuan Feng, Wei Zhang, Jianjun He, Huimin Zhang
Translational Cancer Research  
2026;
15
(2)
:105
.
Investigating the material basis and molecular mechanisms of Oldenlandia diffusa in the treatment of papillary thyroid carcinoma: a network pharmacology and experimental study
Chao Ding, Tie-Feng Shi, Xiang-Jun Kong, Jia-Yu Dong, Ying-Ming Liu, Yong-Hou Zhao
Translational Cancer Research  
2026;
15
(2)
:106
.
Identification and validation of a novel estrogen-related model for breast cancer to predict the prognosis
Manzhi Xia, Shufeng Dong, Jie Cao, Jia Wang, Chunlei Wang
Translational Cancer Research  
2026;
15
(2)
:107
.
COL10A1 transcriptional regulation of ANXA5-mediated ferroptosis is involved in malignant progression of head and neck squamous cell carcinoma
Tingchen Mou, Lina Cai, Liyuan Zhou, Yukang Ying, Xuhui Xu, Zhenxing Zhang
Translational Cancer Research  
2026;
15
(2)
:108
.
Tumor-intrinsic B4GALNT3 expression drives a protective immune microenvironment in endometriosis-associated ovarian cancer
Li Luo, Zirui Zhu, Weiwei Dai, Na Cao, Mingzhu Ye
Translational Cancer Research  
2026;
15
(2)
:109
.
Exploring the lactate-metabolism related characteristics during the development of medulloblastoma through single-cell and bulk RNA-seq
Ce Wang, Rong Zhang, Shenglan Li, Zhuang Kang, Shaohuai Xia, Wenbin Li
Translational Cancer Research  
2026;
15
(2)
:110
.
Multi-parameter magnetic resonance imaging (MRI) deep learning radiomics predicts complete response after induction immunochemotherapy in locally advanced nasopharyngeal carcinoma
Bifa Zhu, Liru Zhu, Kaihua Chen, Ling Li, Xiaodong Zhu
Translational Cancer Research  
2026;
15
(2)
:111
.
BACE2 facilitates lung adenocarcinoma progression by enhancing mTORC1 signalling
Zhixin You, Wei He, Yanfei Zhou, Huijiao Li
Translational Cancer Research  
2026;
15
(2)
:112
.
A novel gene signature based on Like-Smith family members-related genes for predicting the prognosis of hepatocellular carcinoma
Sijun Chen, Xujian Chen, Xiaofang Sun, Shaohan Wu
Translational Cancer Research  
2026;
15
(2)
:113
.
Efficacy and potential mechanism of main active ingredients of Astragalus membranaceus in animals with hepatocellular carcinoma: a systematic review and meta-analysis
Huanhuan Li, Linhua Xuan, Yuehang Fan, Hua Li, Xing Jin, Ping Jiang, Ning Chen
Translational Cancer Research  
2026;
15
(2)
:114
.
Prognostic impact of cancer-directed surgery in primary pulmonary lymphoma: a population-based, propensity score-matched analysis
Yue Zhang, Wenming Chen, Ying Tian
Translational Cancer Research  
2026;
15
(2)
:115
.
Transmembrane protein 9 as a novel biomarker promotes oral squamous cell carcinoma growth via IL1RN and serves as an immune therapeutic target
Jian-Hao Li, Si-Da Dong, Yuan-Dong Zuo, Ji-Chen Li
Translational Cancer Research  
2026;
15
(2)
:116
.
Development and validation of an 11-CpG methylation signature-based nomogram for predicting prognosis in early-onset breast cancer
Jingyi Tang, Yan Li, Xiaofan Han
Translational Cancer Research  
2026;
15
(2)
:117
.
CNN3 promotes angiogenesis in osteosarcoma, associated with upregulating VEGF-A and enhancing endothelial cell activity
Dong Sun, Fei Dai, Binqing Xiang, Heng Wang, Haiyan Tao, Shuai Zhang, Xiaoliang Tao, Xianjie Zhu, Fei Luo, Lei Song
Translational Cancer Research  
2026;
15
(2)
:118
.
Efficacy of transarterial chemoembolization combined with PD-1 versus PD-L1 inhibitors in mass-forming intrahepatic cholangiocarcinoma: a multicenter retrospective study
Yuefeng Hu, Jiang Guo, Dong Liu, Jian Wei, Guang Chen, Tianhao Su, Xu Lu, Long Jin
Translational Cancer Research  
2026;
15
(2)
:119
.
Causal relationship between metabolic syndrome and gastric cancer: insights from comprehensive analysis and biomarker identification
Chendong Yuan, Zhenzhen Hu, Xufeng Shu, Xiaoqiang Wang, Zhigang Jie
Translational Cancer Research  
2026;
15
(2)
:120
.
Rosa roxburghii Tratt fruit polysaccharides inhibit proliferation and induce apoptosis in human cervical cancer cell line
Huiqiong Liang, Qianqian Li, Yuxing Liao, Hongmei Huang, Wenjie Yang, Xueying Li, Guiyuan Chen, Cuixiang Zhang
Translational Cancer Research  
2026;
15
(2)
:121
.
Pathological features and biomarkers of hepatocellular carcinoma: a bibliometric analysis from 2005 to 2025
Xiaguang Duan, Kang Wu, Ke Chai
Translational Cancer Research  
2026;
15
(2)
:122
.
A panel of machine learning approaches for diagnostic model development and validation in ovarian cancer
Shengyan Shen, Lingling Zhang, Qiran Sun, Yating Huang, Ying Yang, Ningning Hu, Susu Jiang, Liwen Zhang, Xiaoqin Wang, Rujun Chen
Translational Cancer Research  
2026;
15
(2)
:123
.
Construction of a postoperative disease-free survival prediction model for non-small cell lung cancer patients based on dual-energy computed tomography parameters and blood inflammatory indicators
Weiming Zhao, Tingting Li, Xilong Zhou, Wenjing Fan, Shuhua Li, Ying Meng, Yihong Gu, Jingcheng Huang, Zongyu Xie, Fang Su
Translational Cancer Research  
2026;
15
(2)
:124
.
ITPG: an immune-related transcriptomic predictive model for gastric cancer prognosis
Musu Li, Yue Sun, Liaowei Zhang, Zixuan Lu, Hongmei Wo, Fang Shao, Shaowen Tang, Yang Zhao, Juncheng Dai, Honggang Yi
Translational Cancer Research  
2026;
15
(2)
:125
.
A risk score model based on glycosylation-related genes for predicting radioresistance and prognosis of lung adenocarcinoma
Yihong Chen, Baixia Yang, Xiaogang Zhai, Weidong Shi, Hongyan Qian, Qin Ge
Translational Cancer Research  
2026;
15
(2)
:126
.
The value of an integrated multi-omics model in the diagnosis of benign and malignant pulmonary nodules
Wucui Huang, Xiaoli Zhu
Translational Cancer Research  
2026;
15
(2)
:127
.
Mature tertiary lymphoid structures tumor microenvironment-based risk model to assess patients with pancreatic ductal adenocarcinoma
Zheng Gu, Chaoran He, Sheng Cheng, Qiang Su, Junxian Yu
Translational Cancer Research  
2026;
15
(2)
:128
.
Construction and validation of a prognostic model associated with chromatin remodeling in hepatocellular carcinoma
Chuang Zhou, Ding Li, Lin Sun
Translational Cancer Research  
2026;
15
(2)
:129
.
Greater susceptibility of patients with idiopathic pulmonary fibrosis to basal cell carcinoma: a combined genomics and Mendelian randomization analysis
Shuang Sun, Sibo Wang, Linghao Shi, Guojing Han, Chaojun Sheng, Wei Zhao
Translational Cancer Research  
2026;
15
(2)
:130
.
Neoadjuvant androgen deprivation therapy with bicalutamide compared to hormonal agents in treating high-risk prostate cancer: a real-world cohort study
Jia Liu, Yushuang Cui, Xingxing Tang, Jinchao Ma, Peng Du
Translational Cancer Research  
2026;
15
(2)
:131
.
Salvia miltiorrhiza-derived microRNA58 inhibits tumor growth by targeting Krüppel-like factor 3 in human endothelial cells
Yan Qin, Minghui Zhao, Jingxin Zhang, Yuhe Pei, Siyuan Suo, Min Wu, Yan Shi, Feixiang Wu, Zhou Shen, Hao Li, Hao Zhang, Lan Zhang
Translational Cancer Research  
2026;
15
(2)
:132
.

Review Article

Current status and advances in research on the impact and mechanisms of atmospheric pollutants on gastric cancer: a narrative review
Chunbo Zhang, Qiangzu Shao, Jie Liu, Fan Zhang, Yumin Li, Zeping Huang
Translational Cancer Research  
2026;
15
(2)
:133
.

Case Report

A case report of idiopathic pulmonary fibrosis concurrent with EGFR 19 deletion lung adenocarcinoma
Zhiyi Li, Kai Xu, Ruxuan Chen, Yujie Shi, Mengqi Wang, Qi Chen, Ji Li, Chi Shao, Hui Huang
Translational Cancer Research  
2026;
15
(2)
:134
.
B-cell lymphoma initially presenting as isolated pleural effusion: a challenging diagnostic case report
Yan Chen, Yunjing Hao, Wei Zhao, Nan Zhang, Yi Zhou
Translational Cancer Research  
2026;
15
(2)
:135
.

Letter to the Editor

Does coordinated targeting of metabolism and autophagy, modulated by microtubule dynamics, influence therapeutic vulnerability to eribulin in glioblastoma?
Guilherme Augusto Sousa Alcântara, João Agostinho Machado-Neto
Translational Cancer Research  
2026;
15
(2)
:136
.