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Welcome to the 2026 Clinical Research Innovation Forum & Editors-in-Chief Meet-and-Greet

We are pleased to invite you to join the 2026 Clinical Research Innovation Forum & Editors-in-Chief Meet-and-Greet co-organized by AME Publishing Company and Wolters Kluwer.The eve... More >>

Join us at the 41st Annual EAU Congress (EAU26)

The 41st Annual EAU Congress (EAU26), Europe’s biggest urological event, is going to be held in London, UK from March 13 to 16, 2026 More >>

TCR 2025 Annual Report

Greetings from the Editorial Office of TCR! More >>

Editorial Commentary

Cancer of unknown primary in the neck—challenging in diagnosis and treatment
Gunnar Wichmann, Theresa Wald, Andreas Dietz
Translational Cancer Research  
2026;
15
(5)
:360
.
Induced pluripotent stem cell-derived natural killer cells: poised for the clinic as an off-the-shelf allogeneic cell therapy
Tianchen Xiong, Jianhua Yu
Translational Cancer Research  
2026;
15
(5)
:361
.
Computed tomography monitoring of small lung nodules: finding the right balance
Brane Grambozov, Josef Karner, Elvis Ruznic, Franz Zehentmayr
Translational Cancer Research  
2026;
15
(5)
:362
.
Antiviral therapy and the risk of extrahepatic malignancies in chronic hepatitis C: insights from recent evidence
Tatsuo Kanda, Reina Sasaki-Tanaka, Shuji Terai
Translational Cancer Research  
2026;
15
(5)
:363
.
Translation is not exportation: why European Prospective Investigation into Cancer and Nutrition rewrites the 4Kscore story
Whi-An Kwon
Translational Cancer Research  
2026;
15
(5)
:364
.
Fully human BCMA CAR-T therapy in multiple myeloma: lessons from long-term follow-up
Ahad Moulvi, Ata Abbas, Lara Soueid, Louis Williams, Faiz Anwer, Shahzad Raza
Translational Cancer Research  
2026;
15
(5)
:365
.
Quality of life with EV-302 in advanced urothelial carcinoma: lessons and implications
David J. Benjamin, Arash Rezazadeh Kalebasty
Translational Cancer Research  
2026;
15
(5)
:366
.
Reconsidering dual BCR::ABL1 inhibition in Philadelphia chromosome-positive acute lymphoblastic leukemia: is sequential better than concurrent?
Hiroto Ishii, Shoko Ishii, Yasuhiro Arakawa, Shingo Yano
Translational Cancer Research  
2026;
15
(5)
:367
.
Defining the biological boundaries of daratumumab monotherapy: long-term insights from the CENTAURUS trial in high-risk smoldering multiple myeloma
Katsuhiro Miura
Translational Cancer Research  
2026;
15
(5)
:368
.
Epcoritamab plus gemcitabine and oxaliplatin in transplant-ineligible relapsed/refractory diffuse large B-cell lymphoma: how should this regimen be positioned in current treatment algorithms?
Mariko Tsuda, Junichi Kiyasu
Translational Cancer Research  
2026;
15
(5)
:369
.

Original Article

The anti-migratory effect of curcumin in colorectal cancer involves IKKβ/NF-κB/Snail-mediated EMT inhibition
Bei Liu, Lu Xiao, Jing Shi, Jun Zhang, Min Chen
Translational Cancer Research  
2026;
15
(5)
:370
.
Comparative efficacy and safety of systemic therapies in transplant-eligible and ineligible relapsed/refractory large B-cell lymphoma: a Bayesian network meta-analysis
Liling Huang, Kai Chen, Min Wang, Chao Guo, Yang Li, Qiu Yu, Zixian Liu, Zhenling Li
Translational Cancer Research  
2026;
15
(5)
:371
.
Advancing the understanding of tumor microenvironment through medical imaging based on bibliometric analysis
Keling Huang, Ziqing Han, Yufei Xia, Xinjing Lou, Xinyu Wu, Ruizhi Fu, Linyu Wu, Chen Gao
Translational Cancer Research  
2026;
15
(5)
:372
.
TRIM37 interacts with PTEN to promote progression of hepatocellular carcinoma cells by modulating AKT/GSK-3β/β-Catenin pathway
Qingqing Wang, Xiaojian Zhang, Jie Zhang
Translational Cancer Research  
2026;
15
(5)
:373
.
Immune-driven induction of miR-501-5p by IL-17A enhances colorectal cancer progression
Yi Zhang, Ping Wang, Junchao Zhang, Wenxin Shen, Dandan Ma, Chonghao Yang, Bin Feng, Hongbin Liu, Yingnan Huang, Haibin Wu, Haohao Huang
Translational Cancer Research  
2026;
15
(5)
:374
.
A prognostic model for head and neck squamous cell carcinoma based on eosinophil extracellular trap related genes
Chuyu Han, Xuecheng Luo, Shouyin Xiao, Jiaou Lv, Bin Wang, Zhilin Li
Translational Cancer Research  
2026;
15
(5)
:375
.
Targeting EHMT2 inhibition in glioblastoma: effects on tumor progression and STAT3 signaling
Chengning Xu, Wenhao Yin, Hengzhu Zhang, Liguo Zhang
Translational Cancer Research  
2026;
15
(5)
:376
.
Individual and combined effects of marital status, household income, and residence on cancer management and survival in primary bone cancer: a SEER-based retrospective cohort study
Fang Lin, Leilei Tian, Chuang Li, Rui Shi, Jinling Liu, Shizhou Wu
Translational Cancer Research  
2026;
15
(5)
:377
.
A network pharmacology and molecular docking approach to investigate the anticancer mechanism of baicalin against melanoma through induction of apoptosis via EGFR-mediated PI3K/AKT pathway
Zhongshun He, Aiping Huang, Jing Lv, Jing Zhou, Wenrong Lou, Biao Xu, Xuesong Wu
Translational Cancer Research  
2026;
15
(5)
:378
.
The prognostic predictive value of monocyte to high-density lipoprotein cholesterol ratio in HR+/HER− breast cancer patients
Jie-Yu Zhou, Bin-Hao Jiang, Zhao-Jun Wang, Hai-Guang Ma, Yang Ye, Zhi-Wei Li
Translational Cancer Research  
2026;
15
(5)
:379
.
Identification of chondroitin polymerizing factor as a biomarker for predicting immunotherapy response in breast cancer: a bioinformatics analysis of tumor microenvironment
Zimeng He, Yunsheng Xu, Chunyan Wu
Translational Cancer Research  
2026;
15
(5)
:380
.
Comprehensive genomics and functional analyses identify SMARCAL1 as a key oncogenic regulator in lung adenocarcinoma
Zehao Huang, Yue Li, Jundao He, Zhanyu Xu, Huajian Peng, Nuo Yang
Translational Cancer Research  
2026;
15
(5)
:381
.
The flavonoid astragalin induces apoptosis in lung adenocarcinoma and correlates with a prognostic cell cycle gene signature associated with PANoptosis
Juncheng Bai, Yuxin Chen, Lan Bao, Caiying Zhou, Jintao Zhang
Translational Cancer Research  
2026;
15
(5)
:382
.
T4bN0 colon cancer shows worse survival than T1–2N1 disease: a multicenter real-world study in China
Xin Li, Lei Liang, Zhen-Ya Yang, Jun-Nan Li, Ning Xu, Jun Yang
Translational Cancer Research  
2026;
15
(5)
:383
.
Development of a prognostic nomogram for colorectal cancer with peritoneal metastasis: a SEER database analysis
Rouyan Zhong, Xiaoyan Wang, Dandan Gong, Changfeng Man, Yu Fan
Translational Cancer Research  
2026;
15
(5)
:384
.
Construction and testing of a nomogram for patients with pancreatic signet-ring cell carcinoma and analysis of treatment-related survival differences: a study based on the Surveillance, Epidemiology, and End Results (SEER) database
Ping Lin, Jihuang Wang, Linxiang Zhang, Siyi Xiu, Xiaoping Huang
Translational Cancer Research  
2026;
15
(5)
:385
.
WT1-AS acts as a tumor suppressor in cervical cancer via OSR2-mediated transcriptional activation
Gulimire Buranjiang, Li Xie, Yang Wang, Shiying Jin, Yina Wang
Translational Cancer Research  
2026;
15
(5)
:386
.
Prognostic significance and pathological correlation analysis of DKK4 in colorectal cancer
Xiaoxiong Wang, Minghai Shan, Xia Qiao, Lu Ding, Jiali Yang, Fang He, Yushen Mian, Xu Zhang, Shaoqi Yang
Translational Cancer Research  
2026;
15
(5)
:387
.
Comparison of 5-year survival rates and prognostic factors between adenoid cystic carcinoma and squamous cell carcinoma of the maxillary sinus: a SEER database analysis
Chenguang Zhang, Yicong Wang, Chunlong Zhao, Wanru Chen, Manman Cheng, Guanghao Yue, Bin Guo
Translational Cancer Research  
2026;
15
(5)
:388
.
An bibliometric analysis of global research in cervical cancer radiotherapy (2015–2024): trends, hotspots, and future directions
Yue Hou, Yu Gao, Wen-Ming Yan
Translational Cancer Research  
2026;
15
(5)
:389
.
Identifying and validating of prognostic genes associated with myeloid cell differentiation in cervical cancer: development of a risk model based on single-cell RNA sequencing combined with bulk RNA sequencing data
Xiaomin Wen, Wenlan Zheng, Tingting Zhai, Qi Wang, Yong Liang, Xin Zhang
Translational Cancer Research  
2026;
15
(5)
:390
.
Efficacy and safety of National Centralized Drug Procurement-procured versus non-National Centralized Drug Procurement oxaliplatin in unresectable or metastatic pancreatic cancer: a retrospective cohort study
Ziqi Ye, Linlin Yang, Yanfang Zhang, Xiaoting Wang, Yuefeng Rao
Translational Cancer Research  
2026;
15
(5)
:391
.
COL10A1 overexpression potentially contributes to poor outcomes in breast cancer via autophagy and vasculogenic mimicry
Liu Gao, Jingrui Yang, Xinru Fan, Yu Ling, Xu Jiang, Xin Jin, Hui Xu, Yunzhi Ling, Li Yu
Translational Cancer Research  
2026;
15
(5)
:392
.
Development and validation of prognostic nomograms for patients with cervical cancer and liver metastasis: a SEER-based study
Lihong Guo, Lingling Song, Xueqin Liu, Bohao Zhang, Yang Sun, Dandan Cui, Jie Zhang
Translational Cancer Research  
2026;
15
(5)
:393
.
Micropeptide colorectal neoplasia differentially expressed (CRNDE) 84aa encoded by CRNDE elicits a T-cell immune response to breast cancer
Lili Zeng, Peng Hu, Changsong Bai, Yujia Luo, Xinyu Fang, Xinyu Liu, Qingyi Yuan, Xiaofeng Zhu
Translational Cancer Research  
2026;
15
(5)
:394
.
SPDEF downregulation promotes tumor aggressiveness and poor prognosis in triple-negative breast cancer
Changsheng Wei, Qingqing Liu, Haitao Wang, Xiaofeng Liu
Translational Cancer Research  
2026;
15
(5)
:395
.
Identification of prognostic immune-related genes and evaluation of chemotherapy and immunotherapy responses in pancreatic cancer
Yang Yang, Haodong Tang, Jiahua Zhou
Translational Cancer Research  
2026;
15
(5)
:396
.
LncRNA SOX21-AS1 is associated with poor prognosis and immunomodulation in glioblastoma
Yanyan Yang, Jiayao Sun, Yan Fang, Wei Shan, Pengfei Li, Yaxuan Ma, Weimin Ni
Translational Cancer Research  
2026;
15
(5)
:397
.
Hyperplasia suppressor gene inhibits the progression of malignant meningioma via the Wnt/β-catenin signaling pathway
Yuhua Guan, Minmin Guo, Lai Jiang, Gang Zheng, Xin Huang, Hua Tang
Translational Cancer Research  
2026;
15
(5)
:398
.
Predictive modelling of duodenal stump leakage after gastric cancer and long-term oncological outcomes
Xufeng Shu, Ahao Wu, Xiaoqiang Wang, Chendong Yuan, Guoyang Zhang, Jianbo Xiong, Wenzheng Chen, Guosen Wang, Zhengrong Li, Zhigang Jie
Translational Cancer Research  
2026;
15
(5)
:399
.
A disulfidptosis-related lncRNA prognostic model identifies MALINC1 as a regulator of platinum drug sensitivity in colon adenocarcinoma
Yungui Li, Shijun Cao, Mingwu Duan, Menghao Qiao, Zijing Wu, Yan Cheng
Translational Cancer Research  
2026;
15
(5)
:400
.
Periostin promotes papillary thyroid carcinoma progression by modulating mTOR/AKT pathway
Song Wang, Yuanchun Li, Hong Li, Fan Yang, Xinjian Li, Dianliang Jia, Xin Wang
Translational Cancer Research  
2026;
15
(5)
:401
.
Association of serum vitamins and carotenoids with breast cancer status among adult women in NHANES 2017–2018: a cross-sectional study
Bohan Hu, Ji Liang
Translational Cancer Research  
2026;
15
(5)
:402
.
Efficacy and safety of antibody-drug conjugates for HR+/HER2-low advanced breast cancer: a systematic review with Bayesian network meta-analysis and real-world study
Linbing Duan, Hu Chen, Yan Kong, Qian Dong
Translational Cancer Research  
2026;
15
(5)
:403
.
Identification of protein lysine lactylation and potential targets in esophageal squamous cell carcinoma
Hanlu Zhang, Xiuji Yan, Lucheng Xi, Sicheng Chen, Qixin Shang, Long-Qi Chen, Wen-Ping Wang
Translational Cancer Research  
2026;
15
(5)
:404
.
Beyond traditional survival estimates: conditional survival and individualized prognosis in primary breast lymphoma
Huijuan Zhang, Guanghua Wu, Chunxu Liao
Translational Cancer Research  
2026;
15
(5)
:405
.
Unveiling LAIR1: a prognostic biomarker associated with gastric cancer progression and metastasis
Xufeng Shu, Chendong Yuan, Xiaoqiang Wang, Jianbo Xiong, Wenzheng Chen, Guoyang Zhang, Zhigang Jie
Translational Cancer Research  
2026;
15
(5)
:406
.
Comprehensive analysis to develop a stromal senescence-associated gene signature for predicting hepatocellular carcinoma
Jin Lu, Zhenhua Zhang, Wei Yuan, Yingjian Zhang
Translational Cancer Research  
2026;
15
(5)
:407
.
Epidemiology and prognostic factors of acute erythroid leukemia
Shan Liu, Yaobin Lin
Translational Cancer Research  
2026;
15
(5)
:408
.
Multi-algorithm machine learning combined with in silico gene knockout reveals the diagnostic value and functional regulatory networks of ferroptosis-related genes in gastric cancer
Wen Ma, Ke Liu, Lei Wang
Translational Cancer Research  
2026;
15
(5)
:409
.
Parimifasor elicits broad-spectrum antitumor effects by suppressing the expression of oncogenic genes
Kai Li, Minshan Sun, Ruijuan Du, Qian Wang, Bo Bian, Yutian Zhang, Hua Bian
Translational Cancer Research  
2026;
15
(5)
:410
.
YTHDF1 enhances ACSL3 translation in an m6A-dependent manner to regulate lipid metabolism and colorectal cancer progression
Yabo Chen, Zhiming Wang, Lisha Cheng, Hexia Gan, Yufu Lin
Translational Cancer Research  
2026;
15
(5)
:411
.
NCOA4-driven ferritinophagy and GSH reprogramming underlie maslinic acid-induced ferroptosis and autophagy in breast cancer
Yifei Li, Shugong Zhou, Ruobing Li, Yingshuo Liu, Xiaohui Guo, Linying Peng, Yan Liu, Mi Li, Lina Zhao, Yunfeng Zhang, Haifeng Cai, Fen Hu
Translational Cancer Research  
2026;
15
(5)
:412
.
Liquid-liquid phase separation-related gene signature characterizes prognostic subtypes and therapeutic sensitivities in gastric cancer
Bing Yan, Qiying Lao, Lijuan Lin
Translational Cancer Research  
2026;
15
(5)
:413
.
Role of PDGFA expression in the prognosis of head and neck squamous cell carcinoma: construction of prognostic nomogram and functional mechanism exploration
Ying Li, Shengfei Zhou
Translational Cancer Research  
2026;
15
(5)
:414
.
Fusobacterium nucleatum promotes colorectal cancer metastasis by modulating the NF-κB-MMP-2/MMP-9 signaling pathway
Cheng Peng, Xingxing Liu, Qibin He, Mengcheng Hu, Guangxuan Tie, Zhiqiang Dong, Chengcan Lu, Jinquan Shuang
Translational Cancer Research  
2026;
15
(5)
:415
.
Personalized survival prediction in pediatric glioblastoma using a machine learning-powered web tool
Shaohuai Chen, Regina Chizi Tunje, Anjie Lu, Xinyu Ji, Hansong Sheng, Xiangjie Kong
Translational Cancer Research  
2026;
15
(5)
:416
.
Single-cell analysis identifies a tumor-specific T-cell metabolic signature: prognostic model and association with immunosuppressive microenvironment in ovarian cancer
Huadong Tian, Xiaotong Liu, Guojiao Wang, Zimo Wang, Yuexi Luo
Translational Cancer Research  
2026;
15
(5)
:417
.
Carcinogenic role of ESCO2 in cholangiocarcinoma: integration of bioinformatics analysis and experimental validation
Le Fan, Yong Jiang, Jing Hu, Feng Xiao, Yunxia Chai, Bin Yi, Yinghe Qiu
Translational Cancer Research  
2026;
15
(5)
:418
.
A P-body-related risk score predicts prognosis and immune microenvironment in lung adenocarcinoma
Ting Lei, Jun-Ling Hou
Translational Cancer Research  
2026;
15
(5)
:419
.
Development and validation of nomograms for predicting overall survival and cancer-specific survival in female gastric signet-ring cell carcinoma: a SEER database analysis
Zhihan Zhou, Chen Zhu, Yong Diao, Xunxun Wu, Xiaoyun You, Huiyong Yang
Translational Cancer Research  
2026;
15
(5)
:420
.
Integrative single-cell and bulk transcriptomics identify an ALK-associated three-gene signature predicting neuroblastoma outcomes
Aiguo Zhu, Yuren Xia, Xin Li, Zhengchao Jin, Jian Wang, Yi Pan
Translational Cancer Research  
2026;
15
(5)
:421
.
Utidelone exhibits favorable responses in refractory patients with advanced breast cancer
Xue Bai, Qiuyi Zhang, Xiaofeng Xie, Xuelian Chen, Jiayi Huang, Liping Chen, Lin Song, Xiaofeng Lan, Meidi Liu, Rongmei Lei, Caiwen Du
Translational Cancer Research  
2026;
15
(5)
:422
.
Phagocytic remodeling in CD74High tumor-associated macrophages during brain metastasis of lung adenocarcinoma
Junming Jia, Jiaxin Cao, Zeren Chen, Huichao Lin, Hongqian Cao, Ke He, Ziyan Li, Mingzhu Yin, Yang Li
Translational Cancer Research  
2026;
15
(5)
:423
.
Risk factors for cerebrospinal fluid leakage after spinal tumor surgery: a systematic review and meta-analysis
Meng Yang, Junhao Huang, Yonggang Yang, Guoyi Luo, Xiangqin Wang, Bingbing Hou
Translational Cancer Research  
2026;
15
(5)
:424
.
Cation homeostasis-related prognostic genes uncovered by transcriptomic analysis in breast cancer
Mingxing Xu, Zhihao Ye, Weimin Hong, Liquan Zhu, Chaoqi He, Zhuotao Yang, Junsi Hu, Da Qian, Xuli Meng, Zhuozhuo Ren
Translational Cancer Research  
2026;
15
(5)
:425
.
Integrated transcriptomics identifies HIF1A and GSTP1 as biomarkers for cutaneous squamous cell carcinoma
Wenting Li, Tao Xu, Yu Ding, Jianghan Chen, Guotai Yao, Siyu Wu, Jianhua Wu
Translational Cancer Research  
2026;
15
(5)
:426
.
Integrating innovative multiomics and machine learning strategies for prognostic biomarker discovery in hepatocellular carcinoma: guiding personalized treatment strategies with single-cell analysis
Yi Cheng, Ru Luo, Xianfei Zhong
Translational Cancer Research  
2026;
15
(5)
:427
.
Identification and validation of tumor microenvironment remodeling markers associated with prognosis in differentiated thyroid cancer
Xiaokang Liu, Qiang Ma, Dai Su, Yu Li, Xiangting Zeng, Liang Guo
Translational Cancer Research  
2026;
15
(5)
:428
.
Prognostic value and potential upstream regulator of Schwann cells in esophageal squamous cell carcinoma
Yiming Lei, Xingbo Zhang, Weiran Hou, Xiumin Zhang, Zirui Zhou, Qinchen Liu, Jiantao Zhang, Feiyu Liu, Wei Wang, Zhen Wang
Translational Cancer Research  
2026;
15
(5)
:429
.
Development and internal validation of a nomogram based on HER2 status for predicting pathological complete response to neoadjuvant chemotherapy in triple-negative breast cancer
Xiaoke Chai, Chongyi Wei, Tao Yang, Haicun Zhou, Xiaoyan Du, Qiandan Wang, Tao Zhang, Jianping Long
Translational Cancer Research  
2026;
15
(5)
:430
.
Circadian-immune-related gene signature for lung squamous cell carcinoma: machine learning and multi-omics analysis
Yiheng Lu, Hui Li, Siyao Wang, Fan Yang, Shuyan Xiao, Yining Liu, Qiaowei Liu, Xiao Han, Yi Hu
Translational Cancer Research  
2026;
15
(5)
:431
.
Comprehensive analysis of prognostic biomarkers for immunotherapy response in patients with advanced malignant melanoma
Luqiao Li, Yueling Yang, Rong Huang, Mengke Zhao, Fufeng Wang, Yu Ren, Lianjun Zhao
Translational Cancer Research  
2026;
15
(5)
:432
.

Review Article

Mogamulizumab for adult T-cell leukemia/lymphoma: a literature review
Can Jones, Jun Chih Wang, Hayder Saeed
Translational Cancer Research  
2026;
15
(5)
:433
.
Artificial intelligence in radiation treatment planning: a narrative review from automation to clinical decision support
James C. L. Chow
Translational Cancer Research  
2026;
15
(5)
:434
.
Apoptosis signaling and cancer targeted therapy: from bench to bespoke
Xin Huang, Chunyan Zhu, Jiahui Liu, Jingwen Ye, Jiatao Lou, Lin Wang
Translational Cancer Research  
2026;
15
(5)
:435
.
The research progress of gastric cancer vaccines: a narrative review
Haoran Wu, Fan Zhang, Qiangzu Shao, Zeping Huang
Translational Cancer Research  
2026;
15
(5)
:436
.
Neuro-glioma activity-dependent growth mechanisms: an actionable circuit from NLGN3-ADAM10 to AMPA synapses
Ya-Fei Tian, Jun-Yue Fan, Qiong Wu, Jun Pu
Translational Cancer Research  
2026;
15
(5)
:437
.
Exosomal miRNA as a biomarker for diagnosis and prognosis, and a new target for regulating treatment resistance in DLBCL: a research progress narrative review
Huifang He, Xia Wang, Li Yang, Chan Rong, Xin Zheng, Qingxiu Zhong, Qingshan Li, Xin Xu
Translational Cancer Research  
2026;
15
(5)
:438
.
Review Article 
The management of brain necrosis as a result of SRS treatment for intra-cranial tumors
Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen
Published online: 28 August 2014
Meta-Analysis 
Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu
Published online: 05 March 2013
Review Article 
Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai
Published online: 05 March 2013
Original Article 
Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review
Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi
Published online: 28 April 2017
Biological basis of IORT 
Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects
Ithaisa Sologuren, Carlos Rodríguez-Gallego, Pedro Carlos Lara
Published online: 25 February 2014
Review Articles 
Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer
Deep Kwatra, Anand Venugopal, Shrikant Anant
Published online: 26 September 2013
Review Article 
EGFR first- and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients
Niki Karachaliou, Manuel Fernandez-Bruno, Jillian Wilhelmina Paulina Bracht, Rafael Rosell
Published online: 19 January 2019
Review Article 
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
Published online: 18 June 2015
Review Articles 
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Published online: 26 September 2013
Biological basis of IORT 
Cell and molecular response to IORT treatment
Luigi Minafra, Valentina Bravatà
Published online: 25 February 2014
Review Articles 
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
Published online: 19 June 2013
Review Articles 
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Published online: 19 June 2013
Review Article 
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Published online: 30 June 2017
Review Article 
EGFR and HER2: is there a role in ovarian cancer?
Eleonora Teplinsky, Franco Muggia
Published online: 13 February 2015
Review Article 
Multiple keratoacanthoma centrifugum marginatum—a case report and systematic review
Yiman Wang, Wenling Zhao, Yueping Zeng, Li Li, Hongzhong Jin
Published online: 30 December 2018
Review Article 
Urological complications after radiation therapy—nothing ventured, nothing gained: a Narrative Review
Joanna Chorbińska, Wojciech Krajewski, Romuald Zdrojowy
Published online: 26 February 2021

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park
How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis
Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao
Alcohol intake patterns for cancer and non-cancer individuals: a population study
Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng
Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial
Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu
Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management
Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas
Exosomal lncRNAs as new players in cell-to-cell communication
Mihnea Dragomir, Baoqing Chen, George A. Calin
Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy
Souparno Bhattacharya, Aroumougame Asaithamby
Translational research in radiation-induced DNA damage signaling and repair
Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue
Genetically engineered mouse models for studying radiation biology
Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Advances on immunotherapy in genitourinary and renal cell carcinoma
Gregory P. Botta, Eric Granowicz, Carrie Costantini
The role of novel immunotherapies in non-Hodgkin lymphoma
Allyson Pishko, Sunita D. Nasta
MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan
Do p53 stress responses impact organismal aging?
Paul Hasty, Judith Campisi, Z. Dave Sharp
Pharmacological targeting of mutant p53
Samuel Kogan, Darren Carpizo
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Michael I. Carr, Stephen N. Jones
Regulation of cytotoxic T-cell responses by p53 in cancer
Mitchell W. Braun, Tomoo Iwakuma
The IGF-1R/AKT pathway determines cell fate in response to p53
Lei Duan, Carl G. Maki
Intra molecular interactions in the regulation of p53 pathway
Jiandong Chen
TP53 mutations in epithelial ovarian cancer
Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu
Modulation of the p53 family network by RNA-binding proteins
Chris Lucchesi, Jin Zhang, Xinbin Chen
Radiomics in head and neck cancer: from exploration to application
Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller
Prostate cancer radiomics and the promise of radiogenomics
Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack
Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies
Wei Lu, Wengen Chen
The emerging field of radiomics in esophageal cancer: current evidence and future potential
Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin
Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
Jung H. Suh, Julie D. Saba
Computational methods and opportunities for phosphorylation network medicine
Yian Ann Chen, Steven A. Eschrich

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
New light on the pancreatic cyst conundrum
Nathan A. Berger
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?
Andrew J. Scott, John C. Wilkinson
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
Nan Ding, Qianzheng Zhu
Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?
Apar Gupta, Nisha Ohri, Bruce G. Haffty
Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents
Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi
CRISPR-based genetic interaction maps inform therapeutic strategies in cancer
Poornima Ramkumar, Martin Kampmann
Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study
Melin J. Khandekar, Rakesh Jain
The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin
Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed
Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer
Joanne P. Young, Timothy J. Price, Susan Parry
Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response
R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang
Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes
Theresa L. Whiteside
TIC10/ONC201—a potential therapeutic in glioblastoma
Georg Karpel-Massler, Markus D. Siegelin
IDH mutational status and the immune system in gliomas: a tale of two tumors?
Bryan D. Choi, William T. Curry
ONC201: a new treatment option being tested clinically for recurrent glioblastoma
Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry
When better still might not be good enough
Waldemar Debinski
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy
Vincent C. O. Njar
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28
Leonardo Chicaybam, Prasad S. Adusumilli
Exosome mediated phenotypic changes in lung cancer pathophysiology
Yoshihisa Shimada, John D. Minna
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aaron D. DeWard, Rebecca J. Critchley-Thorne
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein
Felicia L. Lenzo, William G. Cance
New incriminating evidence against IGF2
Wen Ding, Lina A. Shehadeh
Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect
Paul Grippo, Ajay V. Maker
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger
RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver
Satomi Yamamoto, Tomoo Iwakuma
Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy
Michael J. Baine, Chi Lin
Rogue one: another faction of the Wnt empire implicated in assisting GBM progression
Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed
Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway
Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems
Li Tian, Ashley Chang, Marites P. Melancon
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
James P. White
Low-frequency ultrasound may improve drug penetration in colonic mucosa
Qiubing Chen, Bo Xiao, Didier Merlin
Dividing and conquering the variation among variants in EML4-ALK lung cancer
Trever G. Bivona
Unlocking the epigenetic code of T cell exhaustion
Jiazhu Wu, Huidong Shi
KDM1 links nuclear GSK3β to epigenetic alterations
Weijie Guo, Binhua P. Zhou
Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease
Deepa Rangachari, Daniel B. Costa
Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy
Bhagelu R. Achyut, Ali S. Arbab
Neuroendocrine differentiation in prostate cancer: key epigenetic players
Karishma Gupta, Sanjay Gupta
PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression
Kim A. Brogden, Shireen Vali, Taher Abbasi
Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy
Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias
The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies
Keith T. Schmidt, William D. Figg
Information-dense analysis for information-dense understanding
Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
Fabiana Perna, Michel Sadelain
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells
Alex J. Gooding, William P. Schiemann
Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?
Nathan A. Berger
Microtubule targeting agents in glioma
Anda-Alexandra Calinescu, Maria G. Castro
Moving molecular subtypes to the clinic in gastric cancer
Joseph Chao, Jeeyun Lee, Samuel J. Klempner
Intraoperative subtyping of lung adenocarcinoma: an unmet need
Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli
Emerging roles of FGF signaling in hepatocellular carcinoma
Nana Zheng, Wenyi Wei, Zhiwei Wang
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
Brandon J. Manley, James J. Hsieh
Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer
Salma Kaochar, Nicholas Mitsiades

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike
Jeffrey J. Tosoian, Emmanuel S. Antonarakis
A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer
Sawsan Rashdan, David E. Gerber
MOAP-1, UBR5 and cisplatin resistance in ovarian cancer
Scott T. Eblen, Amber Bradley
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer
Weimin Gao
The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)
Theresa L. Whiteside
[18F]-choline PET/CT as an imaging biomarker for primary liver cancers
Zhenghong Lee
Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best
Yoshio Yamaoka, David Y. Graham
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function
Theodoros Karantanos, Vassiliki A. Boussiotis
Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer
Angel Qin, Gregory P. Kalemkerian
Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered
Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham
Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells
Praveen Kumar Vemula, Venkatakrishna Rao Jala
Helios—controller of Treg stability and function
Claire Chougnet, David Hildeman
Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation
Jon K. Obst, Marianne D. Sadar
Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird
Fat lure: adipocytes attract cancer cells out of the prostate
Alexandra M. Blee, Haojie Huang
Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers
Guoli Chen, Ming-Tseh Lin

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
The STAMPEDE trial: paradigm-changing data through innovative trial design
Bradley C. Carthon, Emmanuel S. Antonarakis
Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway
Derek B. Oien, Jeremy Chien, Nikki Cheng
Feed your gut with caution!
Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar
Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma
Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma
Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Below are the latest Translational Cancer Research articles published online ahead of print publication.