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Interviews with Editorial Board Members

TCR features a distinguished editorial board, the members of which continue to instill the power of their expertise for the journal’s development. By launching this column, we are glad to introduce to you some of them in the form of interviews, in which they will share their unique career experiences and perspectives. We believe their insights will shed light on the knowledge of related fields.

Interviews with Guest Editors

Over the years, a number of TCR guest editors have made valuable contributions to the journal. This column features interviews with our guest editors, who graciously share their experience in scientific careers and provide insightful perspectives on the special series.

New Impact Factor for Translational Cancer Research: 1.5

We are pleased to announce that Translational Cancer Research (TCR) has attained its latest impact factor update for the 2023 citation year: 1.5.

Translational Cancer Research 2023 CiteScore Released: 2.1

We are pleased to announce that the Translational Cancer Research (TCR) has received its 2023 CiteScore: 2.1, ranking 209 out of 333 journals in the Radiology, Nuclear Medicine and Imaging category.

Furthermore, we are delighted to highlight the remarkable achievements made by all AME journals in the CiteScore ranking.

Interviews with Outstanding Authors (2024)

In 2024, many authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors who have been making immense efforts in their research fields, with a brief interview of their unique perspectives and insightful views as authors.

Reviewer of the Month (2024)

In 2024, TCR reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

TCR 2023 Annual Report

Greetings from the Editorial Office of TCR!

We are pleased to share the 2023 Annual Report of Translational Cancer Research. 2023 has seen much progress for TCR. We hope 2023 will bring greater things to TCR. We would like to thank you for your support and assistance in improving the journal over the past year, and we certainly look forward to your innovations and contributions in 2024.

We would especially like to express our sincere gratitude to the editorial board members, guest editors, reviewers, authors, and readers for all your support and contributions to TCR. We wish you a happy, healthy and prosperous 2024!

Ferroptosis and cuproptosis prognostic signature for prediction of prognosis, immunotherapy and drug sensitivity in hepatocellular carcinoma: development and validation based on TCGA and ICGC databases

Identification of differentially expressed genes. (A) Heatmap revealed differentially expressed genes; (B) univariate Cox regression analysis; (C) a protein-protein interaction network showing the relationship between ferroptosis-related genes and cuproptosis-related genes.

Bartholin’s gland carcinoma—the diagnostic and management challenges of a rare malignancy—a case report and review of current literature

FDG-avid right inguinal lymph node on axial CT-PET. The green arrow: FDG-avid right inguinal lymph node on axial CT-PET. FDG, fluorodeoxyglucose; CT-PET, computed tomography-positron-emission tomography.

Development of a novel angiogenesis-related lncRNA signature to predict the prognosis and immunotherapy of glioblastoma multiforme

Differences in risk scores for clinical characteristics. (A-D) The correlations between the risk score and sex, age, MGMT status, and IDH1 status were not significant (P>0.05). (E) Among the subtypes, the proneural subtypes had a significantly lower risk score than did the mesenchymal subtypes (P<0.05). **, P<0.01. IDH1, isocitrate dehydrogenase 1; MGMT, O6-methylguanine-DNA methyltransferase; ns, no significance.

Integrated analysis of single-cell and bulk transcriptome identifies a signature based on NK cell marker genes to predict prognosis and therapeutic response in clear cell renal cell carcinoma

Single-cell sequencing analysis of 20,074 cells from 7 ccRCC samples. (A) Pearson’s correlation between nFeature and nCount. (B) PCA plot colored by different samples. (C) Cells were classified into 25 clusters via UMAP algorithm. (D) Eight cell types were identified and annotated by marker genes. (E) Heatmap visualized top 5 marker genes among 8 cell clusters. (F) Visualization of gene expression in cell clusters. PC, principal component; UMAP, uniform manifold approximation and projection; NK, nature killer; ccRCC, clear cell renal cell carcinoma; PCA, principal component analysis.

Development and validation of nomograms to predict early death in non-small cell lung cancer patients with brain metastasis: a retrospective study in the SEER database

ROC curves for the nomograms of the all-cause early death and the cancer-specific early death in the training cohort (A,B) as well as in the validation cohort (C,D). ROC, receiver operating characteristic; AUC, area under the curve.

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Vol 13, No 12 (December, 2024)

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Announcement more

19th Asian Society for Neuro-Oncology (ASNO) Annual Meeting

The 19th Asian Society for Neuro-Oncology (ASNO) Annual Meeting will be held at the One Farrer Hotel, Singapore from 16 – 18 August 2024. More >>

New Impact Factor for Translational Cancer Research: 1.5

We are pleased to announce that Translational Cancer Research (TCR) has attained its latest impact factor update for the 2023 citation year: 1.5. More >>

Translational Cancer Research 2023 CiteScore Released: 2.1

We are pleased to announce that the Translational Cancer Research (TCR) has received its 2023 CiteScore: 2.1, ranking 209 out of 333 journals in the Radiology, Nuclear Medicine and... More >>

Editorial Commentary

Do germline genetic variants affect the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors?

Katsuhiro Masago, Shiro Fujita, Eiichi Sasaki, Yoshitsugu Horio

PDF Pages: 6599-6602 Full Text (155) Peer Review File COI Form Open Access

Locally advanced non-small cell lung cancer: search for the optimal radiotherapy continues

Naoko Katsurada, Motoko Tachihara

PDF Pages: 6603-6607 Full Text (135) Peer Review File COI Form Open Access

Targeting the EZH2-SLFN11 pathway—a lesson in developing molecularly-informed treatments for recurrent small cell lung cancer

Fangdi Sun, Millie S. Das

PDF Pages: 6608-6612 Full Text (189) Peer Review File COI Form Open Access

Original Article

Percentage of fat in milk consumption and risk of six cancers: a Mendelian randomization study

Tongtong Bai, Chengyu Wu

PDF Pages: 6613-6622 Full Text (243) Reporting Checklist Peer Review File COI Form Open Access

Mitochondrial cholesterol metabolism related gene model predicts prognosis and treatment response in hepatocellular carcinoma

Xuna Guo, Feng Wang, Xuejing Li, Qiuqian Luo, Bihan Liu, Jianhui Yuan

PDF Pages: 6623-6644 Full Text (244) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Machine learning-based pan-cancer study of classification and mechanism of BRAF inhibitor resistance

Yuhang Zhao, Kai Yang, Yujun Chen, Zexi Lv, Qing Wang, Yuanyuan Zhong, Xiqun Chen

PDF Pages: 6645-6660 Full Text (252) Reporting Checklist Peer Review File COI Form Open Access

A predictive model for advanced esophageal cancer involving the lower third of the esophagus

Jing Dong, Ye Jin, Zhi Zhang, Zhaohuan Yang, Xuemei Zhang

PDF Pages: 6661-6674 Full Text (124) Reporting Checklist Peer Review File COI Form Open Access

Lycorine affects tamoxifen resistance of breast cancer via m⁶A-based HAGLR

Lei Shi, Jun-Feng Jiang, Jing Zhai

PDF Pages: 6675-6687 Full Text (138) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Prediction values of different lymph nodes staging systems for survival of children with Wilms tumor

Songqiang Chen, Zhisheng Wan, Shaohua Hu, Weizhen Bu, Yiqun Lu, Zhenli Zhao

PDF Pages: 6688-6698 Full Text (138) Reporting Checklist Peer Review File COI Form Open Access

A multi-gene blood-based methylation assay for early diagnosis of colorectal cancer

Yingshuo Xu, Huaidong Qu, Rui Liang, Menglong Li, Miao Li, Xiankun Li, Zhiqiang Wang

PDF Pages: 6699-6708 Full Text (146) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Association of branched-chain amino acids and risk of three urologic cancers: a Mendelian randomization study

Haotian Huang, Jiao Qin, Zhi Wen, Chongjian Wang, Caixia Chen, Yang Liu, Hongyuan Li, Song Cao, Xuesong Yang

PDF Pages: 6709-6720 Full Text (165) Reporting Checklist Peer Review File COI Form Open Access

Genomic landscape of medulloblastoma subtypes in an Asian cohort

Dongming Han, Xin Jin, Jiankang Li

PDF Pages: 6721-6731 Full Text (135) Data Sharing Statement Peer Review File COI Form Open Access

Comprehensive analysis of tumor immune-related gene signature for predicting prognosis, immunotherapy, and drug sensitivity in bladder urothelial carcinoma

Changgang Guo, Xiling Jiang, Yinglang Zhang, Guochang Bao

PDF Pages: 6732-6752 Full Text (143) Reporting Checklist Peer Review File COI Form Open Access

The high levels of fibrinogen and platelets are associated with poor survival in nephroblastoma in children

Qian Li, Shaoguang Feng, Chen Cheng, Dongsheng Zhu, Ni Huo

PDF Pages: 6753-6765 Full Text (104) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Regulatory T cell-associated gene signature correlates with prognostic risk and immune infiltration in patients with breast cancer

Jie Wu, Gaiping Zhao, Yan Cai

PDF Pages: 6766-6781 Full Text (173) Reporting Checklist Peer Review File COI Form Open Access

Investigation of unfavorable prognostic factors for survival in Chinese patients with gastric gastrointestinal stromal tumors

Qimin Sun, Jing Wu, Guanhua Wang, Haiyan Niu, Juan Cao, Zhiqiang Chen, Wenjun Yang

PDF Pages: 6782-6792 Full Text (118) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Multi-slice computed tomography radiomics combined with serum alpha-L-fucosidase: a potential biomarker for precise identification of pleomorphic adenoma and Warthin tumor

Qinghan Yan, Lingzi Liao, Xin Wang, Xianlin Zeng, Leyang Zhang, Dengqi He

PDF Pages: 6793-6806 Full Text (125) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Construction of a cuproptosis-tricarboxylic acid cycle-associated lncRNA model to predict the prognosis of non-small cell lung cancer

Xiang Li, Yunlong Zhao, Shengjie Wei, Yuqing Dai, Chun Yi

PDF Pages: 6807-6824 Full Text (157) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Radiomic signatures of brain metastases on MRI: utility in predicting pathological subtypes of lung cancer

Linlin Sun, Shihai Luan, Liheng Yu, Huiyuan Zhu, Haiyang Dong, Xuemei Liu, Guangyu Tao, Pengbo He, Qiang Li, Weiqiang Chen, Zekuan Yu, Hong Yu, Li Zhu

PDF Pages: 6825-6836 Full Text (131) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

The clinicopathological significance of BRI3BP in women with invasive breast cancer

Abrar I. Aljohani, Ieman A. Aljahdali, Ohud A. Alsalmi, Meshari A. Alsuwat, Abdulaziz A. Alsharif, Khalid J. Alzahrani, Batool S. Alsaleh, Ameen Nadheef, Turki S. Alqurashi

PDF Pages: 6837-6849 Full Text (173) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Clinical and pathological characteristics of HR+ breast cancer with HER2 low and HER2(0) expression: exploring endocrine therapy sensitivity

Xin Jin, Yun-Fei Ma, Tong-Jun Sun, Qiang Xie, Fa-Xiang Yin, Li-Gong Zhang, Yan Zhao

PDF Pages: 6850-6861 Full Text (158) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Prognostic value of CTF1 in glioma and its role in the tumor microenvironment

Jiakai He, Jiayin Guo, Pengfei Sun

PDF Pages: 6862-6879 Full Text (174) Reporting Checklist Peer Review File COI Form Open Access

KIF18A and CDK1 as combined therapeutic targets in cervical and endometrial carcinomas: based on bioinformatics analysis and in vitro experiments

Mengjie Wang, David Lukanovic, Fabio Barra, Aoli Lei

PDF Pages: 6880-6894 Full Text (144) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Safety and efficacy of mecapegfilgrastim in preventing neutropenia in patients with head and neck cancer: a multicenter, prospective, observational, real-world study

Gang Cheng, Yong Chen, Nong Xu, Chenyu Mao, Ningling Zhang, Minbin Chen, Haijiao Yan, Zhe Yang, Jun Bie, Lifang Ding, Zhanggui Wang, Jun Yan, Paolo Cariati, Shukui Qin

PDF Pages: 6895-6904 Full Text (147) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

CSE1L in enhancing the effect of defactinib on gastric cancer cells via the inhibition of FAK phosphorylation

Xin He, Yating Wang, Yanning Zhang, Arvind Sahu, Khaldoun Almhanna, Yan Liu

PDF Pages: 6905-6918 Full Text (157) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Construction of a prognostic survival model with tumor immune-related genes for breast cancer

Shuai Guo, Liang Guo, Jiangyun Li, Jianguo Li, Qiqi Zhang, Jing Zhang, Stergios Boussios, Masakazu Toi

PDF Pages: 6919-6935 Full Text (174) Reporting Checklist Peer Review File COI Form Open Access

IRF5 as a potential immunological biomarker in lung adenocarcinoma

Simei Li, Fangling Zhou, Huahong Lan, Xiaofei Cao, Alice Mogenet, Roberto Díaz-Peña, Meiling Zhao

PDF Pages: 6936-6946 Full Text (195) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Bioinformatics-based screening of key genes associated with gemcitabine resistance in advanced pancreatic ductal adenocarcinoma

Kaifeng Hu, Kiyoshi Hasegawa, Guozhi Zhou

PDF Pages: 6947-6955 Full Text (159) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

PTPMT1 inhibition induces apoptosis and growth arrest of human SCLC cells by disrupting mitochondrial metabolism

Xiang Liu, Yang Sun, Chuancheng Gao, Huiyan Sun, Fang Tian, Fengjun Xiao, Qinqin Xu

PDF Pages: 6956-6969 Full Text (223) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

FOXF2 may inhibit esophageal squamous cell carcinoma growth and metastasis by regulating the EZR-ERBB2 axis

Zhen-Yu Hu, Wei-Hao Deng, Wei-Jie Cai, Xian-Yu Qin, Hao-Sheng Zheng, Jian Tan, Xiao-Long Jiang, Yu-Zhen Zheng, Hong-Ying Liao

PDF Pages: 6970-6981 Full Text (139) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Diagnostic accuracy of folate receptor-positive circulating tumor cells in differentiating between benign and malignant pulmonary nodules

Guo-Feng Wu, Rong-Chao Chen, Jing Luo, Ming-Tai Li, Pei Yu, Pan-Xiao Shen, Jia-Ying Luo, Yin-Yin Qin

PDF Pages: 6982-6994 Full Text (123) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Review Article

Slamming hepatocellular carcinoma: targeting immunosuppressive macrophages via SLAMF7 reprograms the tumor microenvironment

Alix Bruneau, Linda Hammerich

PDF Pages: 6995-7001 Full Text (122) Peer Review File COI Form Open Access

Treatment of immune checkpoint inhibitor-related colitis: a narrative review

Shiyang Wang, Hanping Wang

PDF Pages: 7002-7014 Full Text (150) Reporting Checklist Peer Review File COI Form Open Access

Insight into dipeptidase 1: structure, function, and mechanism in gastrointestinal cancer diseases

Lei Wang, Guangyu Tian

PDF Pages: 7015-7025 Full Text (215) Peer Review File COI Form Open Access

Case Report: iMDT Corner

Pulmonary artery choriocarcinoma mimicking pulmonary thromboembolism: a case report

Shifang Yang, Zhidan Tan, Manzhi Zhao, Xinglin Gao, Hiren J. Mehta, Kim Styrvoky, Bryan S. Benn, Sylvia S. Yong, Bin Li

PDF Pages: 7026-7037 Full Text (146) Reporting Checklist Peer Review File COI Form Open Access

Case Report

Neurofibromatosis with diffuse intestinal ganglioneuromatosis: a case report

Yangpeng Ni, Weijian Chen, Xiaowei Wu, Shuzhi Huang, Ying Fang

PDF Pages: 7038-7044 Full Text (122) Reporting Checklist Peer Review File COI Form Open Access

Review Article

The management of brain necrosis as a result of SRS treatment for intra-cranial tumors

Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen

Published online: 28 August 2014

PDF Pages: 373-382 Full Text (126864) COI Form Open Access

Meta-Analysis

Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis

Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu

Published online: 05 March 2013

PDF Pages: 25-32 Full Text (76995) COI Form Open Access

Review Article

Common applications of next-generation sequencing technologies in genomic research

Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai

Published online: 05 March 2013

PDF Pages: 33-45 Full Text (67083) COI Form Open Access

Biological basis of IORT

Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects

Ithaisa Sologuren, Carlos Rodríguez-Gallego, Pedro Carlos Lara

Published online: 25 February 2014

PDF Pages: 18-31 Full Text (48018) COI Form Open Access

Review Articles

Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer

Rositsa Dueva, George Iliakis

Published online: 19 June 2013

PDF Pages: 163-177 Full Text (46484) COI Form Open Access

Review Articles

Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer

Deep Kwatra, Anand Venugopal, Shrikant Anant

Published online: 26 September 2013

PDF Pages: 330-342 Full Text (46083) COI Form Open Access

Original Article

Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review

Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi

Published online: 28 April 2017

PDF Pages: 354-365 Full Text (44389) COI Form Open Access

Editorial

Morphine, when used for treating patients with acute pancreatitis, could be more risky than previously suspected

Juan Iovanna, Maria Cecilia Mallmann

Published online: 24 October 2017

PDF Pages: S1166-S1168 Full Text (44397) COI Form Open Access

Review Article

EGFR first- and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients

Niki Karachaliou, Manuel Fernandez-Bruno, Jillian Wilhelmina Paulina Bracht, Rafael Rosell

Published online: 19 January 2019

PDF Pages: S23-S47 Full Text (38203) COI Form Open Access

Review Articles

Tumor microenvironment and nanotherapeutics

Meenakshi Upreti, Amar Jyoti, Pallavi Sethi

Published online: 26 September 2013

PDF Pages: 309-319 Full Text (37167) COI Form Open Access

Review Article

Cancer biomarker discovery and validation

Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida

Published online: 18 June 2015

PDF Pages: 256-269 Full Text (36209) COI Form Open Access

Biological basis of IORT

Cell and molecular response to IORT treatment

Luigi Minafra, Valentina Bravatà

Published online: 25 February 2014

PDF Pages: 32-47 Full Text (35532) COI Form Open Access

Editorial

The CROSS road in neoadjuvant therapy for esophageal cancer: long-term results of CROSS trial

Ian Wong, Simon Law

Published online: 29 September 2016

PDF Pages: S415-S419 Full Text (31032) COI Form Open Access

Review Article

Do alkaline phosphatases have great potential in the diagnosis, prognosis, and treatment of tumors?

Tingting Jiang, Qun Zeng, Jun He

Published online: 20 October 2023

PDF Pages: 2932-2945 Full Text (29216) Peer Review File COI Form Open Access

Review Articles

DNA damage tolerance: a double-edged sword guarding the genome

Gargi Ghosal, Junjie Chen

Published online: 19 June 2013

PDF Pages: 107-129 Full Text (28698) COI Form Open Access

Review Article

Multiple keratoacanthoma centrifugum marginatum—a case report and systematic review

Yiman Wang, Wenling Zhao, Yueping Zeng, Li Li, Hongzhong Jin

Published online: 30 December 2018

PDF Pages: 1743-1747 Full Text (28627) COI Form Open Access

Review Articles

DNA crosslinking damage and cancer - a tale of friend and foe

Yaling Huang, Lei Li

Published online: 19 June 2013

PDF Pages: 144-154 Full Text (28673) COI Form Open Access

Original Article

Intraoperative radiotherapy in locally-advanced and recurrent rectal cancer: retrospective review of 68 cases

Sergey Potemin, Ivan Uvarov, Igor Vasilenko

Published online: 26 April 2015

PDF Pages: 189-195 Full Text (27806) COI Form Open Access

Review Article

EGFR and HER2: is there a role in ovarian cancer?

Eleonora Teplinsky, Franco Muggia

Published online: 13 February 2015

PDF Pages: 107-117 Full Text (27600) COI Form Open Access

Review Article on Endometrial Cancer

Current role of Pipelle endometrial sampling in early diagnosis of endometrial cancer

Milan Milosav Terzic, Gulzhanat Aimagambetova, Sanja Terzic, Melanie Norton, Gauri Bapayeva, Simone Garzon

Published online: 23 December 2020

PDF Pages: 7716-7724 Full Text (27343) COI Form Open Access

Full Most Read article list >>

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data

Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman

Statistical strategies for microRNAseq batch effect reduction

Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr

Defining functional changes in the brain caused by targeted stereotaxic radiosurgery

Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli

A chain reaction approach to modelling gene pathways

Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes

Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA

Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li

Identification of cancer mechanisms through computational systems modeling

Zhen Qi, Eberhard O. Voit

Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases

Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy

Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines

Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden

Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer

Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park

How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis

Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao

Alcohol intake patterns for cancer and non-cancer individuals: a population study

Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng

Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial

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Review Article

Integrative clustering methods for high-dimensional molecular data

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Sparse principal component analysis in cancer research

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An improved understanding of cancer genomics through massively parallel sequencing

Jamie K. Teer

Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications

Louis Dubeau

Cancer biomarker discovery and validation

Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida

The promise and challenge of ovarian cancer models

Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu

Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management

Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas

Exosomal lncRNAs as new players in cell-to-cell communication

Mihnea Dragomir, Baoqing Chen, George A. Calin

Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy

Souparno Bhattacharya, Aroumougame Asaithamby

Translational research in radiation-induced DNA damage signaling and repair

Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue

Genetically engineered mouse models for studying radiation biology

Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch

Renal cell carcinoma: the search for a reliable biomarker

Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer

Advances on immunotherapy in genitourinary and renal cell carcinoma

Gregory P. Botta, Eric Granowicz, Carrie Costantini

The role of novel immunotherapies in non-Hodgkin lymphoma

Allyson Pishko, Sunita D. Nasta

MDMX under stress: the MDMX-MDM2 complex as stress signals hub

Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan

Do p53 stress responses impact organismal aging?

Paul Hasty, Judith Campisi, Z. Dave Sharp

Pharmacological targeting of mutant p53

Samuel Kogan, Darren Carpizo

Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis

Michael I. Carr, Stephen N. Jones

Regulation of cytotoxic T-cell responses by p53 in cancer

Mitchell W. Braun, Tomoo Iwakuma

The IGF-1R/AKT pathway determines cell fate in response to p53

Lei Duan, Carl G. Maki

Intra molecular interactions in the regulation of p53 pathway

Jiandong Chen

TP53 mutations in epithelial ovarian cancer

Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu

Modulation of the p53 family network by RNA-binding proteins

Chris Lucchesi, Jin Zhang, Xinbin Chen

Radiomics in head and neck cancer: from exploration to application

Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller

Prostate cancer radiomics and the promise of radiogenomics

Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack

Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies

Wei Lu, Wengen Chen

The emerging field of radiomics in esophageal cancer: current evidence and future potential

Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin

Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire

Jung H. Suh, Julie D. Saba

Computational methods and opportunities for phosphorylation network medicine

Yian Ann Chen, Steven A. Eschrich

Editorial

Focusing in on radiation induced brain injury

M. Kerry O’Banion

Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic

Naomi Lomeli, Daniela A. Bota

Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma

David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright

New light on the pancreatic cyst conundrum

Nathan A. Berger

HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?

Andrew J. Scott, John C. Wilkinson

Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts

Kristopher A. Lyon, Jason H. Huang

Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4

Nan Ding, Qianzheng Zhu

Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?

Apar Gupta, Nisha Ohri, Bruce G. Haffty

Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents

Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi

CRISPR-based genetic interaction maps inform therapeutic strategies in cancer

Poornima Ramkumar, Martin Kampmann

Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study

Melin J. Khandekar, Rakesh Jain

The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin

Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed

Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer

Joanne P. Young, Timothy J. Price, Susan Parry

Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response

R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang

Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes

Theresa L. Whiteside

TIC10/ONC201—a potential therapeutic in glioblastoma

Georg Karpel-Massler, Markus D. Siegelin

IDH mutational status and the immune system in gliomas: a tale of two tumors?

Bryan D. Choi, William T. Curry

ONC201: a new treatment option being tested clinically for recurrent glioblastoma

Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry

When better still might not be good enough

Waldemar Debinski

Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy

Vincent C. O. Njar

Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28

Leonardo Chicaybam, Prasad S. Adusumilli

Exosome mediated phenotypic changes in lung cancer pathophysiology

Yoshihisa Shimada, John D. Minna

Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma

Aaron D. DeWard, Rebecca J. Critchley-Thorne

From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein

Felicia L. Lenzo, William G. Cance

New incriminating evidence against IGF2

Wen Ding, Lina A. Shehadeh

Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect

Paul Grippo, Ajay V. Maker

Branched chain amino acid metabolism and cancer: the importance of keeping things in context

Elizabeth M. Selwan, Aimee L. Edinger

RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver

Satomi Yamamoto, Tomoo Iwakuma

Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy

Michael J. Baine, Chi Lin

Rogue one: another faction of the Wnt empire implicated in assisting GBM progression

Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed

Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway

Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano

Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems

Li Tian, Ashley Chang, Marites P. Melancon

IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm

James P. White

Low-frequency ultrasound may improve drug penetration in colonic mucosa

Qiubing Chen, Bo Xiao, Didier Merlin

Dividing and conquering the variation among variants in EML4-ALK lung cancer

Trever G. Bivona

Unlocking the epigenetic code of T cell exhaustion

Jiazhu Wu, Huidong Shi

KDM1 links nuclear GSK3β to epigenetic alterations

Weijie Guo, Binhua P. Zhou

Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease

Deepa Rangachari, Daniel B. Costa

Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy

Bhagelu R. Achyut, Ali S. Arbab

Neuroendocrine differentiation in prostate cancer: key epigenetic players

Karishma Gupta, Sanjay Gupta

PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression

Kim A. Brogden, Shireen Vali, Taher Abbasi

Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy

Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias

The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies

Keith T. Schmidt, William D. Figg

Information-dense analysis for information-dense understanding

Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen

The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use

Angel Qin, Nithya Ramnath

Immune infiltration, glioma stratification, and therapeutic implications

Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher

Balancing redox stress: anchorage-independent growth requires reductive carboxylation

Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione

Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy

Fabiana Perna, Michel Sadelain

Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells

Alex J. Gooding, William P. Schiemann

Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?

Nathan A. Berger

Microtubule targeting agents in glioma

Anda-Alexandra Calinescu, Maria G. Castro

Moving molecular subtypes to the clinic in gastric cancer

Joseph Chao, Jeeyun Lee, Samuel J. Klempner

Intraoperative subtyping of lung adenocarcinoma: an unmet need

Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli

Emerging roles of FGF signaling in hepatocellular carcinoma

Nana Zheng, Wenyi Wei, Zhiwei Wang

Tregs, Helios and tumor immunity: the sun has not yet risen

Angela M. Thornton, Ethan M. Shevach

Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1

Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof

Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components

Brandon J. Manley, James J. Hsieh

Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer

Salma Kaochar, Nicholas Mitsiades

Letter to the Editor

Epigenetic regulation of PD-L1 expression and pancreatic cancer response to checkpoint immunotherapy

Chunwan Lu, Kebin Liu

Synthetic lethality vs. synthetic viability due to PARP1 and BRCA2 loss

Xia Ding, Shyam K. Sharan

Correspondence

Targeted attack: mechanisms by which ovarian cancers suppress the immune system

Irina V. Tiper, Tonya J. Webb

Brief Report

The impact of neighborhood disadvantage on health-related quality of life among African American and white cancer survivors

Chien-Ching Li, Alicia K. Matthews, Anjali Asthana, Raj C. Shah

Research Highlight

Butyrate consumption of differentiated colonocytes in the upper crypt promotes homeostatic proliferation of stem and progenitor cells near the crypt base

Scott J. Bultman

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike

Jeffrey J. Tosoian, Emmanuel S. Antonarakis

A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer

Sawsan Rashdan, David E. Gerber

MOAP-1, UBR5 and cisplatin resistance in ovarian cancer

Scott T. Eblen, Amber Bradley

Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer

Weimin Gao

The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)

Theresa L. Whiteside

[¹⁸F]-choline PET/CT as an imaging biomarker for primary liver cancers

Zhenghong Lee

Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best

Yoshio Yamaoka, David Y. Graham

JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function

Theodoros Karantanos, Vassiliki A. Boussiotis

Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer

Angel Qin, Gregory P. Kalemkerian

Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered

Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham

Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells

Praveen Kumar Vemula, Venkatakrishna Rao Jala

Helios—controller of Treg stability and function

Claire Chougnet, David Hildeman

Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation

Jon K. Obst, Marianne D. Sadar

Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase

Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird

Fat lure: adipocytes attract cancer cells out of the prostate

Alexandra M. Blee, Haojie Huang

Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers

Guoli Chen, Ming-Tseh Lin

Editorials

Into the eye of the storm: breast cancer’s somatic mutation landscape points to DNA damage and repair

Joanne Ngeow, Emily Nizialek, Charis Eng

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks

Apratim Mitra, Karl Pfeifer, Ki-Sun Park

The STAMPEDE trial: paradigm-changing data through innovative trial design

Bradley C. Carthon, Emmanuel S. Antonarakis

Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway

Derek B. Oien, Jeremy Chien, Nikki Cheng

Feed your gut with caution!

Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar

Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma

Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma

Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients

Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy

Reinhard W. Schulte, Andrew J. Wroe

Externally modulated theranostic nanoparticles

Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi

Intestinal stem cell injury and protection during cancer therapy

Jian Yu

Cancer stem cells in glioma: challenges and opportunities

Jialiang Wang, Yufang Ma, Michael K. Cooper

Tumor microenvironment and nanotherapeutics

Meenakshi Upreti, Amar Jyoti, Pallavi Sethi

Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury

Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou

Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis

Chang-Lung Lee, Jordan M. Blum, David G. Kirsch

DNA ligases as therapeutic targets

Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest

DNA damage tolerance: a double-edged sword guarding the genome

Gargi Ghosal, Junjie Chen

DNA double strand break repair via non-homologous end-joining

Anthony J. Davis, David J. Chen

DNA crosslinking damage and cancer - a tale of friend and foe

Yaling Huang, Lei Li

Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation

Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan

MDM2 and MDMX: alone and together in regulation of p53

Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan

Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase

Lijian Shao, Lixian Wu, Daohong Zhou

Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment

Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen

SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis

Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos

Normal tissue protection for improving radiotherapy: where are the Gaps?

Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman

Improving chemoradiotherapy with nanoparticle therapeutics

Michael Joseph Eblan, Andrew Zhuang Wang

Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization

Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn

Molecular mechanisms involved in tumor repopulation after radiotherapy

Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li

Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules

Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy

Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar

Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma

Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Below are the latest Translational Cancer Research articles published online ahead of print publication.

Original Article

The causal effects of 2,821 protein level ratios on non-small cell lung cancer: a two-sample Mendelian randomization study

Xinyun Zou, Jinlan Shen, Xiaokai Li, Yong Diao, Ling Zhang

Published online: 08 January 2025

Editorial Commentary

Navigating restriction from interstitial lung disease (ILD) with stereotactic ablative radiotherapy (SABR) in early-stage non-small cell lung cancer: soaring beyond the current treatment paradigm

Ari A. Kassardjian, Jyoti Malhotra, Percy Lee

Published online: 07 January 2025

Case Report: iMDT Corner

A rare case report of colon metastasis from primary oropharyngeal squamous cell carcinoma treated with a combination of surgery, radiotherapy and immunotargeted therapy

Zhijian Xu, Jianjian Lv, Daniel T. Ginat, Yuvnik Trada, Mi Zhou

Published online: 02 January 2025

Original Article

By integrating single-cell RNA sequencing and bulk RNA sequencing, plasma cells signature and tertiary lymphoid structures were verified to contribute to outcome in lung adenocarcinoma

Zetian Gong, Xianchuang Xu, Yaolin Cao, Yanlong Feng, Jiatao Liu, Jinpeng Yang, Wenyu Wang, Hui Gong, Jun Li, Liang Chen, Wei Wang

Published online: 20 December 2024

Original Article

Based on network pharmacology and experimental validation, berberine can inhibit the progression of gastric cancer by modulating oxidative stress

Xiaodong Han, Qiuzan Zhang, Dandan Cao, Yanrong Wang, Sipu Wang, Qijin He, Jingwen Zhao, Xin Chen

Published online: 16 December 2024

Journal highlight more

Translational Cancer Research is an international, open access, peer-reviewed journal indexed in Scopus and Science Citation Index Expanded (SCIE), focusing on original, science-based researches on clinical, basic and translational aspects. It publishes laboratory studies of novel therapeutic interventions, clinical trials which evaluate new treatment paradigms for cancer, results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients and etc.